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Volumn 306, Issue 3, 2003, Pages 1058-1067

Multiple injections of pegylated liposomal doxorubicin: Pharmacokinetics and therapeutic activity

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; UNCLASSIFIED DRUG;

EID: 0041430798     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.053413     Document Type: Article
Times cited : (112)

References (39)
  • 1
    • 0032839194 scopus 로고    scopus 로고
    • Controlled destabilization of a liposomal drug delivery system enhances mitoxantrone antitumor activity
    • Adlakha-Hutcheon G, Bally MB, Shew CR, and Madden TD (1999) Controlled destabilization of a liposomal drug delivery system enhances mitoxantrone antitumor activity. Nat Biotechnol 17:775-779.
    • (1999) Nat Biotechnol , vol.17 , pp. 775-779
    • Adlakha-Hutcheon, G.1    Bally, M.B.2    Shew, C.R.3    Madden, T.D.4
  • 2
    • 0025789143 scopus 로고
    • Pharmacokinetics of STEALTH versus conventional liposomes: Effect of dose
    • Allen TM and Hansen CB (1991) Pharmacokinetics of STEALTH versus conventional liposomes: effect of dose. Biochim Biophys Acta 1068:133-141.
    • (1991) Biochim Biophys Acta , vol.1068 , pp. 133-141
    • Allen, T.M.1    Hansen, C.B.2
  • 3
    • 0027220849 scopus 로고
    • Subcutaneous administration of liposomes: A comparison with the intravenous and intraperitoneal routes of injection
    • Allen TM, Hansen CB, and Guo LSS (1993) Subcutaneous administration of liposomes: a comparison with the intravenous and intraperitoneal routes of injection. Biochim Biophys Acta 1150:9-16.
    • (1993) Biochim Biophys Acta , vol.1150 , pp. 9-16
    • Allen, T.M.1    Hansen, C.B.2    Guo, L.S.S.3
  • 5
    • 0025731906 scopus 로고
    • Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo
    • Allen TM, Hansen CB, Martin F, Redemann C, and Yau-Young A (1991) Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo. Biochim Biophys Acta 1066:29-36.
    • (1991) Biochim Biophys Acta , vol.1066 , pp. 29-36
    • Allen, T.M.1    Hansen, C.B.2    Martin, F.3    Redemann, C.4    Yau-Young, A.5
  • 6
    • 0032958460 scopus 로고    scopus 로고
    • Relationship of dose intensity to the induction of palmar-plantar erythrodysesthia by pegylated liposomal doxorubicin in dogs
    • Amantea M, Newman MS, Sullivan TM, Forrest A, and Working PK (1999) Relationship of dose intensity to the induction of palmar-plantar erythrodysesthia by pegylated liposomal doxorubicin in dogs. Hum Exp Toxicol 18:17-26.
    • (1999) Hum Exp Toxicol , vol.18 , pp. 17-26
    • Amantea, M.1    Newman, M.S.2    Sullivan, T.M.3    Forrest, A.4    Working, P.K.5
  • 7
    • 0026503190 scopus 로고
    • Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor
    • Aslakson CJ and Miller FR (1992) Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Cancer Res 52:1399-1405.
    • (1992) Cancer Res , vol.52 , pp. 1399-1405
    • Aslakson, C.J.1    Miller, F.R.2
  • 9
    • 0031822413 scopus 로고    scopus 로고
    • The use of cardiac biopsy to demonstrate reduced cardiotoxicity in AIDS Kaposi's sarcoma patients treated with pegylated liposomal doxorubicin
    • Berry G, Billingham M, Alderman E, Richardson P, Torti F, Lum B, Patek A, and Martin FJ (1998) The use of cardiac biopsy to demonstrate reduced cardiotoxicity in AIDS Kaposi's sarcoma patients treated with pegylated liposomal doxorubicin. Ann Oncol 9:711-716.
    • (1998) Ann Oncol , vol.9 , pp. 711-716
    • Berry, G.1    Billingham, M.2    Alderman, E.3    Richardson, P.4    Torti, F.5    Lum, B.6    Patek, A.7    Martin, F.J.8
  • 10
    • 0037427961 scopus 로고    scopus 로고
    • Rate of biodistribution of STEALTH liposomes to tumor and skin: Influence of liposome diameter and implications for toxicity and therapeutic activity
    • Charrois GJR and Allen TM (2003) Rate of biodistribution of STEALTH liposomes to tumor and skin: influence of liposome diameter and implications for toxicity and therapeutic activity. Biochim Biophys Acta 1609:102-108.
    • (2003) Biochim Biophys Acta , vol.1609 , pp. 102-108
    • Charrois, G.J.R.1    Allen, T.M.2
  • 12
    • 0029041515 scopus 로고
    • Liposomal doxorubicin-induced toxicity: Depletion and impairment of phagocytic activity of liver macrophages
    • Daemen T, Hofstede G, Ten Kate MT, Bakker-Woudenberg IA, and Scherphof GL (1995) Liposomal doxorubicin-induced toxicity: depletion and impairment of phagocytic activity of liver macrophages. Int J Cancer 61:716-721.
    • (1995) Int J Cancer , vol.61 , pp. 716-721
    • Daemen, T.1    Hofstede, G.2    Ten Kate, M.T.3    Bakker-Woudenberg, I.A.4    Scherphof, G.L.5
  • 13
    • 0013909023 scopus 로고
    • Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey and man
    • Freireich EJ, Gehan EA, Rall DP, Schmidt LH, and Skipper HE (1966) Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey and man. Cancer Chemother Rep 50:219-244.
    • (1966) Cancer Chemother Rep , vol.50 , pp. 219-244
    • Freireich, E.J.1    Gehan, E.A.2    Rall, D.P.3    Schmidt, L.H.4    Skipper, H.E.5
  • 14
    • 0042210779 scopus 로고    scopus 로고
    • Stealth liposomal doxorubicin: An analysis of the effect of dose on tumor targeting and therapy
    • (Gregoriadis G and Florence AT eds) 17-21 December 2001, University of London, School of Pharmacy, London, England
    • Gabizon A (2001) Stealth liposomal doxorubicin: an analysis of the effect of dose on tumor targeting and therapy, Fifth International Conference: Liposome Advances: Progress in Drug and Vaccine Delivery (Gregoriadis G and Florence AT eds) 17-21 December 2001, University of London, School of Pharmacy, London, England.
    • (2001) Fifth International Conference: Liposome Advances: Progress in Drug and Vaccine Delivery
    • Gabizon, A.1
  • 15
    • 0028349925 scopus 로고
    • Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes
    • Gabizon A, Catane R, Uziely B, Kaufman B, Safra T, Cohen R, Martin F, Huang A, and Barenholz Y (1994a) Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes, Cancer Res 54:987-992.
    • (1994) Cancer Res , vol.54 , pp. 987-992
    • Gabizon, A.1    Catane, R.2    Uziely, B.3    Kaufman, B.4    Safra, T.5    Cohen, R.6    Martin, F.7    Huang, A.8    Barenholz, Y.9
  • 19
  • 20
    • 0036597855 scopus 로고    scopus 로고
    • EORTC 10968: A phase I clinical and pharmacokinetic study of polyethylene glycol liposomal doxorubicin (Caelyx, Doxil) at a 6-week interval in patients with metastatic breast cancer
    • Hamilton A, Biganzoli L, Coleman R, Mauriac L, Hennebert P, Awada A, Nooij M, Beex L, Piccart M, Van Hoorebeeck I, et al. (2002) EORTC 10968: a phase I clinical and pharmacokinetic study of polyethylene glycol liposomal doxorubicin (Caelyx, Doxil) at a 6-week interval in patients with metastatic breast cancer. Ann Oncol 13:910-918.
    • (2002) Ann Oncol , vol.13 , pp. 910-918
    • Hamilton, A.1    Biganzoli, L.2    Coleman, R.3    Mauriac, L.4    Hennebert, P.5    Awada, A.6    Nooij, M.7    Beex, L.8    Piccart, M.9    Van Hoorebeeck, I.10
  • 21
    • 0034834658 scopus 로고    scopus 로고
    • The costs and efficacy of liposomal doxorubicin in platinum-refractory ovarian cancer in heavily pretreated patients
    • Hensley ML, Hoppe B, Leon L, Sabbatini P, Aghajanian C, Chi D, and Spriggs DR (2001) The costs and efficacy of liposomal doxorubicin in platinum-refractory ovarian cancer in heavily pretreated patients. Gynecol Oncol 82:464-469.
    • (2001) Gynecol Oncol , vol.82 , pp. 464-469
    • Hensley, M.L.1    Hoppe, B.2    Leon, L.3    Sabbatini, P.4    Aghajanian, C.5    Chi, D.6    Spriggs, D.R.7
  • 22
    • 0032713936 scopus 로고    scopus 로고
    • Direct comparison of liposomal doxorubicin with or without polyethylene glycol coating in C-26 tumor-bearing mice: Is surface coating with polyethylene glycol beneficial?
    • Hong R-L, Huang C-J, Tseng Y-L, Pang VF, Chen S-T, Liu J-J, and Chang F-H (1999) Direct comparison of liposomal doxorubicin with or without polyethylene glycol coating in C-26 tumor-bearing mice: is surface coating with polyethylene glycol beneficial? Clin Cancer Res 5:3645-3652.
    • (1999) Clin Cancer Res , vol.5 , pp. 3645-3652
    • Hong, R.-L.1    Huang, C.-J.2    Tseng, Y.-L.3    Pang, V.F.4    Chen, S.-T.5    Liu, J.-J.6    Chang, F.-H.7
  • 23
    • 0034671219 scopus 로고    scopus 로고
    • Efficacy of liposomes and hyperthermia in a human tumor xenograft model: Importance of triggered drug release
    • Kong G, Anyarambhatla G, Petros WP, Braun RD, Colvin OM, Needham D, and Dewhirst MW (2000) Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release. Cancer Res 60:6950-6957.
    • (2000) Cancer Res , vol.60 , pp. 6950-6957
    • Kong, G.1    Anyarambhatla, G.2    Petros, W.P.3    Braun, R.D.4    Colvin, O.M.5    Needham, D.6    Dewhirst, M.W.7
  • 24
    • 0034919260 scopus 로고    scopus 로고
    • Visualization of bioavailable liposomal doxorubicin using a non-perturbing confocal imaging technique
    • Krishna R, Ghiu G, and Mayer LD (2001) Visualization of bioavailable liposomal doxorubicin using a non-perturbing confocal imaging technique. Histol Histopathol 16:693-699.
    • (2001) Histol Histopathol , vol.16 , pp. 693-699
    • Krishna, R.1    Ghiu, G.2    Mayer, L.D.3
  • 26
    • 0034284335 scopus 로고    scopus 로고
    • Correlation of toxicity with pharmacokinetics of pegylated liposomal doxorubicin (Doxil) in metastatic breast carcinoma
    • Lyass O, Uziely B, Ben-Yosef R, Tzemach D, Heshing NI, Lotem M, Brufman G, and Gabizon A (2000) Correlation of toxicity with pharmacokinetics of pegylated liposomal doxorubicin (Doxil) in metastatic breast carcinoma. Cancer 89:1037-1047.
    • (2000) Cancer , vol.89 , pp. 1037-1047
    • Lyass, O.1    Uziely, B.2    Ben-Yosef, R.3    Tzemach, D.4    Heshing, N.I.5    Lotem, M.6    Brufman, G.7    Gabizon, A.8
  • 27
    • 0034000453 scopus 로고    scopus 로고
    • Tumor vascular permeability and the ERP effect in macromolecular therapeutics: A review
    • Maeda H, Wu J, Sawa T, Matsumura Y, and Hori K (2000) Tumor vascular permeability and the ERP effect in macromolecular therapeutics: a review. J Control Release 65:271-284.
    • (2000) J Control Release , vol.65 , pp. 271-284
    • Maeda, H.1    Wu, J.2    Sawa, T.3    Matsumura, Y.4    Hori, K.5
  • 28
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer chemotherapy; mechanism of tumoritropic accumulation of proteins and the antitumor agent SMANCS
    • Matsumura Y and Maeda H (1986) A new concept for macromolecular therapeutics in cancer chemotherapy; mechanism of tumoritropic accumulation of proteins and the antitumor agent SMANCS. Cancer Res 6:6387-6392.
    • (1986) Cancer Res , vol.6 , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 29
    • 0031002490 scopus 로고    scopus 로고
    • The role of tumor-associated macrophages in the delivery of liposomal doxorubicin to solid murine fibrosarcoma tumors
    • Mayer LD, Dougherty G, Harasym TO, and Bally MB (1997) The role of tumor-associated macrophages in the delivery of liposomal doxorubicin to solid murine fibrosarcoma tumors. J Pharmacol Exp Ther 280:1406-1414.
    • (1997) J Pharmacol Exp Ther , vol.280 , pp. 1406-1414
    • Mayer, L.D.1    Dougherty, G.2    Harasym, T.O.3    Bally, M.B.4
  • 31
    • 0031055830 scopus 로고    scopus 로고
    • Phase II study of liposomal doxorubicin in refractory ovarian cancer: Antitumor activity and toxicity modification by liposomal encapsulation
    • Muggia F, Hainsworth JD, Jeffers S, Miller P, Groshen S, Tan M, Roman L, Uziely B, Muderspach L, Garcia A, et al. (1997) Phase II study of liposomal doxorubicin in refractory ovarian cancer: antitumor activity and toxicity modification by liposomal encapsulation. J Clin Oncol 15:987-993.
    • (1997) J Clin Oncol , vol.15 , pp. 987-993
    • Muggia, F.1    Hainsworth, J.D.2    Jeffers, S.3    Miller, P.4    Groshen, S.5    Tan, M.6    Roman, L.7    Uziely, B.8    Muderspach, L.9    Garcia, A.10
  • 32
    • 0034161921 scopus 로고    scopus 로고
    • A new tempertature-sensitive liposome for use with mild hyperthermia: Characterization and testing in a human tumour xenograft model
    • Needham D, Anyarambhatla G, Kong G, and Dewhirst MW (2000) A new tempertature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumour xenograft model. Cancer Res 60:1197-1201.
    • (2000) Cancer Res , vol.60 , pp. 1197-1201
    • Needham, D.1    Anyarambhatla, G.2    Kong, G.3    Dewhirst, M.W.4
  • 35
    • 0030959798 scopus 로고    scopus 로고
    • Treatment of advanced breast cancer with sterically stabilized liposomal doxorubicin: Results of a multicenter phase II trial
    • Ranson MR, Carmichael J, O'Byrne K, Stewart S, Smith D, and Howell A (1997) Treatment of advanced breast cancer with sterically stabilized liposomal doxorubicin: results of a multicenter phase II trial. J Clin Oncol 15:3185-3191.
    • (1997) J Clin Oncol , vol.15 , pp. 3185-3191
    • Ranson, M.R.1    Carmichael, J.2    O'Byrne, K.3    Stewart, S.4    Smith, D.5    Howell, A.6
  • 37
    • 0031930151 scopus 로고    scopus 로고
    • Doxorubicin entrapped in sterically stabilzed liposomes: Effects on bacterial blood clearance of the mononucear phagocyte system
    • Storm G, ten Kate MT, Working PK, and Bakker-Woudenberg IAJM (1998) Doxorubicin entrapped in sterically stabilzed liposomes: effects on bacterial blood clearance of the mononucear phagocyte system. Clin Cancer Res 3:111-115.
    • (1998) Clin Cancer Res , vol.3 , pp. 111-115
    • Storm, G.1    Ten Kate, M.T.2    Working, P.K.3    Bakker-Woudenberg, I.A.J.M.4
  • 39
    • 0029765442 scopus 로고    scopus 로고
    • Pharmacological-toxocological expert report: Caelyx (Stealth liposomal doxorubicin HCl)
    • Working P and Dayan AD (1996) Pharmacological-toxocological expert report: Caelyx (Stealth liposomal doxorubicin HCl). Hum Exp Toxicol 15:751-785.
    • (1996) Hum Exp Toxicol , vol.15 , pp. 751-785
    • Working, P.1    Dayan, A.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.