JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 6, 2013, Pages 2377-2382

  Du, Hongjun ^a,b,c   Sun, Xufang ^b,d   Guma, Monica ^e,f,g   Luo, Jing ^b   Ouyang, Hong ^b   Zhang, Xiaohui ^b,c   Zeng, Jing ^b   Quach, John ^b   Nguyen, Duy H ^b   Shaw, Peter X ^b   Karin, Michael ^e,f   Zhang, Kang ^b,c,h  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c SICHUAN UNIVERSITY   (China)

^d HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^e Laboratory of Gene Regulation and Signal Transduction   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYL VALYL ALANYL ASPARTIC ACID FLUOROMETHYLKETONE; STRESS ACTIVATED PROTEIN KINASE 1; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; ENZYME INHIBITION; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETINA MACULA AGE RELATED DEGENERATION; SUBRETINAL NEOVASCULARIZATION;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; CHOROIDAL NEOVASCULARIZATION; CYSTEINE PROTEINASE INHIBITORS; CYTOKINES; DISEASE MODELS, ANIMAL; HUMANS; INFLAMMATION MEDIATORS; MACROPHAGES; MACULAR DEGENERATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 8; OXIDATIVE STRESS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84873420939     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1221729110     Document Type: Article

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