Reducing effect of a combination of phaseolus vulgaris and cynara scolymus extracts on food intake and glycemia in rats

Phytotherapy Research

Volumn 27, Issue 2, 2013, Pages 258-263

  Loi, Barbara ^a   Fantini, Noemi ^a   Colombo, Giancarlo ^a   Gessa, Gian Luigi ^a   Riva, Antonella ^b   Bombardelli, Ezio ^b   Morazzoni, Paolo ^b   Carai, Mauro A M ^a,c  

^a CNR   (Italy)

^b INDENA S P A   (Italy)

^c Cagliari Pharmacological Research Srl   (Italy)

Author keywords

Cynara scolymus (Asteraceae) extract; glycemia; intake of a chocolate flavored beverage; intake of regular food pellets; Phaseolus vulgaris (Fabaceae) extract; rats

Indexed keywords

ARTICHOKE EXTRACT; GLUCOSE; PHASEOLUS VULGARIS EXTRACT; PLANT EXTRACT; STARCH; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANTIDIABETIC ACTIVITY; ARTICHOKE; ARTICLE; BEVERAGE; CACAO; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; DRUG MIXTURE; DRUG POTENTIATION; FEEDING BEHAVIOR; FLAVOR; FLUID INTAKE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; MALE; MONOTHERAPY; NONHUMAN; PHASEOLUS VULGARIS; RAT;

ANIMALS; APPETITE; BEVERAGES; BLOOD GLUCOSE; CYNARA SCOLYMUS; EATING; HYPOGLYCEMIC AGENTS; MALE; PHASEOLUS; PLANT EXTRACTS; RATS; RATS, WISTAR;

ASTERACEAE; CYNARA SCOLYMUS; FABACEAE; PHASEOLUS VULGARIS; RATTUS;

EID: 84873411013     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4704     Document Type: Article

References (25)

1. Arion WJ, Canfield WK, Ramos FC, et al,. 1997. Chlorogenic acid and hydroxynitrobenzaldehyde: new inhibitors of hepatic glucose 6-phosphatase. Arch Biochem Biophys 339: 315-322.
2. Boivin M, Zinsmeister AR, Go VL, Di Magno EP,. 1987. Effect of a purified amylase inhibitor on carbohydrate metabolism after a mixed meal in healthy humans. Mayo Clinic Proc 62: 249-255.
3. Brugge WR, Rosenfeld MS,. 1987. Impairment of starch absorption by a potent amylase inhibitor. Am J Gastroenterol 82: 718-722.
4. Carai MAM, Fantini N, Loi B, Colombo G, Riva A, Morazzoni P,. 2009. Potential efficacy of preparations deriving from Phaseolus vulgaris in the control of appetite, energy intake, and carbohydrate metabolism. Diabetes Metab Syn Obes Targ Ther 2: 145-153.
5. Carai MAM, Fantini N, Loi B, et al,. 2011. Multiple cycles of repeated treatments with a Phaseolus vulgaris dry extract reduce food intake and body weight in obese rats. Br J Nutr 106: 762-768.
6. Celleno L, Tolaini MV, D'Amore A, Perricone NV, Preuss HG,. 2007. A Dietary supplement containing standardized Phaseolus vulgaris extract influences body composition of overweight men and women. Int J Med Sci 4: 45-52.
7. Donatucci DA, Liener IE, Gross CJ,. 1987. Binding of navy bean (Phaseolus vulgaris) lectin to the intestinal cells of the rat and its effect on the absorption of glucose. J Nutr 117: 2154-2160.
8. Fantini N, Cabras C, Lobina C, et al,. 2009. Reducing effect of a Phaseolus vulgaris dry extract on food intake, body weight, and glycemia in rats. J Agric Food Chem 57: 9316-9323.
9. Fantini N, Colombo G, Giori A, et al,. 2011. Evidence of glycemia-lowering effect by a Cynara scolymus L. extract in normal and obese rats. Phytother Res 25: 463-466.
10. Helmstädter A,. 2007. Antidiabetic drugs used in Europe prior to the discovery of insulin. Pharmazie 62: 717-720.
11. Hernandez-Galicia E, Aguilar-Contreras A, Aguilar-Santamaria L, et al,. 2002. Studies on hypoglycemic activity of Mexican medicinal plants. Proc West Pharmacol Soc 45: 118-124.
12. Herzig KH, Bardocz S, Grant G, Nustede R, Fölsch UR, Pusztai A,. 1997. Red kidney bean lectin is a potent cholecystokinin releasing stimulus in the rat inducing pancreatic growth. Gut 41: 333-338.
13. Layer P, Carlson GL, Di Magno EP,. 1985. Partially purified white bean amylase inhibitor reduces starch digestion in vitro and inactivates intraduodenal amylase in humans. Gastroenterology 88: 1895-1902.
14. Layer P, Zinsmeister AR, Di Magno EP,. 1986. Effects of decreasing intraluminal amylase activity on starch digestion and postprandial gastrointestinal function in humans. Gastroenterology 91: 41-48.
15. Lee SC, Gepts PL, Whitaker JR,. 2002. Protein structures of common bean (Phaseolus vulgaris) α-amylase inhibitors. J Agric Food Chem 50: 6618-6627.
16. Maccioni P, Colombo G, Riva A, et al,. 2010. Reducing effect of a Phaseolus vulgaris dry extract on operant self-administration of a chocolate-flavoured beverage in rats. Br J Nutr 104: 624-628.
17. Matsui T, Ogunwande IA, Abesundara KJ, Matsumoto K,. 2006. Anti-hyperglycemic potential of natural products. Med Chem 6: 349-356.
18. Nazni P, Poongodi Vijayakumar T, Alagianambi P, Amirthaveni M,. 2006. Hypoglycemic and hypolipidemic effect of Cynara scolymus among selected type 2 diabetic individuals. Pakistan J Nutr 5: 147-151.
19. Nomikos T, Detopulou P, Frogopulou E, Pliakis E, Antonopoulou S,. 2007. Boiled wild artichoke reduces postprandial glycemic and insulinemic responses in normal subjects but has no effect on metabolic syndrome patients. Nutr Res 27: 741-749.
20. Pusztai A, Grant G, Duguid T, et al,. 1995. Inhibition of starch digestion by α-amylase inhibitor reduces the efficiency of utilization of dietary proteins and lipids and retards the growth of rats. J Nutr 125: 1554-1562.
21. Pusztai A, Bardocz S, Ewen SWB,. 2008. Uses of plant lectins in bioscience and biomedicine. Front Biosci 13: 1130-1140.
22. Rondanelli M, Giacosa A, Orsini F, Opizzi A, Villani S,. 2011. Appetite control and glycaemia reduction in overweight subjects treated with a combination of two highly standardized extracts from Phaseolus vulgaris and Cynara scolymus. Phytother Res doi: 10.1002/ptr.3425, 2011.
23. Santimone M, Koukiekolo R, Moreau Y, et al,. 2004. Porcine pancreatic alpha-amylase inhibition by the kidney bean (Phaseolus vulgaris) inhibitor (α-AI1) and structural changes in the α-amylase inhibitor complex. Biochim Biophys Acta 1696: 181-190.
24. Tormo MA, Gil-Exojo I, Romero de Tejada A, Campillo JE,. 2004. Hypoglycaemic and anorexigenic activities of an α-amylase inhibitor from white kidney beans (Phaseolus vulgaris) in Wistar rats. Br J Nutr 92: 785-790.
25. Udani J, Hardy M, Madsen DC,. 2004. Blocking carbohydrate absorption and weight loss: a clinical trial using Phase 2 brand proprietary fractionated white bean extract. Altern Med Rev 9: 13: 32-37.