Dry coating of micronized API powders for improved dissolution of directly compacted tablets with high drug loading

International Journal of Pharmaceutics

Volumn 442, Issue 1-2, 2013, Pages 74-85

  Han, Xi ^a   Ghoroi, Chinmay ^a   Davé, Rajesh ^a  

^a NEW JERSEY INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

API blends; Direct compaction; Dissolution; Dry coating; Fine API powders; Flowability; Ibuprofen; Micronization

Indexed keywords

IBUPROFEN;

ARTICLE; BULK DENSITY; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG COATING; DRUG RELEASE; DRUG SOLUBILITY; MICRONIZATION; MOLECULAR SIZE; PARTICLE SIZE; POWDER; POWDER FLOW; PRIORITY JOURNAL; TABLET COMPRESSION; TABLET FORMULATION;

DRUG COMPOUNDING; EXCIPIENTS; IBUPROFEN; POWDERS; RHEOLOGY; SOLUBILITY; TABLETS;

EID: 84873407674     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.08.004     Document Type: Article

References (60)

1. J. Bajdik, K. Pintye-Hódi, O. Planinšek, Z. Tüske, L. Tasic, G. Regdon Jr.; S. Srčič, and I. Eros Surface treatment of indomethacin agglomerates with Eudragit Drug Dev. Indust. Pharm. 30 2004 381 388
2. L. Beach, J. Ropero, A. Mujumdar, M. Alcalà, R.J. Romañach, and R.N. Davé Near-infrared spectroscopy for the in-line characterization of powder voiding part II: quantification of enhanced flow properties of surface modified active pharmaceutical ingredients J. Pharm. Innov. 5 2010 1 13
3. L.E. Beach Effect of Dry Particle Coating on the Properties of Cohesive Pharmaceutical Powders 2011 New Jersey Institute of Technology Newark
4. R. Bharadwaj, W.R. Ketterhagen, and B.C. Hancock Discrete element simulation study of a Freeman powder rheometer Chem. Eng. Sci. 65 2010 5747 5756
5. A. Castellanos The relationship between attractive interparticle forces and bulk behaviour in dry and uncharged fine powders Adv. Phys. 54 2005 263 376
6. S. Chattoraj, L. Shi, and C.C. Sun Profoundly improving flow properties of a cohesive cellulose powder by surface coating with nano-silica through comilling J. Pharm. Sci. 100 2011 4943 4952
7. Y. Chen, L. Jallo, M.A.S. Quintanilla, and R. Dave Characterization of particle and bulk level cohesion reduction of surface modified fine aluminum powders Colloids Surf. A: Physicochem. Eng. Aspects 361 2010 66 80
8. Y. Chen, M.A.S. Quintanilla, J. Yang, J.M. Valverde, and R.N. Dave Pull-off force of coated fine powders under small consolidation Phys. Rev. E 79 2009 041305
9. Y. Chen, J. Yang, R.N. Dave, and R. Pfeffer Fluidization of coated group C powders AIChE J. 54 2008 104 121
10. Y. Chen, J. Yang, R.N. Dave, and R. Pfeffer Granulation of cohesive Geldart group C powders in a Mini-Glatt fluidized bed by pre-coating with nanoparticles Powder Technol. 191 2009 206 217
11. J. Chingunpitak, S. Puttipipatkhachorn, Y. Tozuka, K. Moribe, and K. Yamamoto Micronization of dihydroartemisinin by rapid expansion of supercritical solutions Drug Dev. Industr. Pharm. 34 2008 609 617
12. M.M. de Villiers Influence of agglomeration of cohesive particles on the dissolution behaviour of furosemide powder Int. J. Pharm. 1996 175 179
13. E. Emery, J. Oliver, T. Pugsley, J. Sharma, and J. Zhou Flowability of moist pharmaceutical powders Powder Technol. 189 2009 409 415
14. M.L. Ezerskii, L.A. Travina, and S.I. Éidel'shtein Use of a jet mill to obtain powders of pharmaceutical preparations Pharm. Chem. J. 6 1972 681 684
15. J.T. Fell, and J.M. Newton Determination of tablet strength by the diametral-compression test J. Pharm. Sci. 59 1970 688 691
16. R. Freeman Measuring the flow properties of consolidated, conditioned and aerated powders - a comparative study using a powder rheometer and a rotational shear cell Powder Technol. 174 2007 25 33
17. Freeman, T.; Moolchandani, V.; Hoag, S.W.; Fu, X.; 2011. Capsule Filling Performance of Powdered Formulations in Relation to Flow Characteristics UK-China Particle Technology Forum III.
18. D. Geldart, E.C. Abdullah, and A. Verlinden Characterisation of dry powders Powder Technol. 190 2009 70 74
19. Ghoroi, C.; Gurumurthy, L.; McDaniel, D.J.; Jallo, L.J.; Davé, R.N.; 2012. Multi-faceted characterization of pharmaceutical powders to discern the influence of surface modification. Powder Technol.; in press-a, http://dx.doi.org/10.1016/j.powtec.2012.05.039.
20. Ghoroi, C.; Han, X.; To, D.; Jallo, L.; Gurumurthy, L.; Davé, R.N.; 2012. Dispersion of fine and ultrafine powders through surface modification and rapid expansion. Chem. Eng. Sci.; in press-b, http://dx.doi.org/10.1016/j.ces.2012.02.038.
21. R.O. Grey, and J.K. Beddow On the Hausner Ratio and its relationship to some properties of metal powders Powder Technol. 2 1969 323 326
22. X. Han, C. Ghoroi, D. To, Y. Chen, and R. Davé Simultaneous micronization and surface modification for improvement of flow and dissolution of drug particles Int. J. Pharm. 415 2011 185 195
23. Hancock, B.C.; 2004. Identifying Candidates for Direct Compression Using Material-Sparing Formulation Tools, AAPS Annual Meeting.
24. J.S. Hardman, and B.A. Lilley Deformation of particles during briquetting Nature 228 1970 353 355
25. J.T. Hargrove, W.S. Maxson, and A. Colston Wentz Absorption of oral progesterone is influenced by vehicle and particle size Am. J. Obstetr. Gynecol. 161 1989 948 951
26. L.J. Jallo, C. Ghoroi, L. Gurumurthy, U. Patel, and R.N. Davé Improvement of flow and bulk density of pharmaceutical powders using surface modification Int. J. Pharm. 423 2012 213 225
27. A.W. Jenike Andrew W. Jenike, Preparation and Evaluation of Nanosuspensions for Enhancing the Dissolution of Poorly Soluble Drugs 1964 University of Utah Salt Lake City, Utah
28. P. Kocbek, S. Baumgartner, and J. Kristl Preparation and evaluation of nanosuspensions for enhancing the dissolution of poorly soluble drugs Int. J. Pharm. 312 2006 179 186
29. H.O. Kono, C.C. Huang, and M. Xi Function and mechanism of flow conditioners under various loading pressure conditions in bulk powders Powder Technol. 63 1990 81 86
30. V. Kumar, M. de la Luz Reus-Medina, and D. Yang Preparation, characterization, and tabletting properties of a new cellulose-based pharmaceutical aid Int. J. Pharm. 235 2002 129 140
31. F. Lavoie, L. Cartilier, and R. Thibert New methods characterizing avalanche behavior to determine powder flow Pharm. Res. 19 2002 887 893
32. N.O. Lindberg, M. Pålsson, A.C. Pihl, R. Freeman, T. Freeman, H. Zetzener, and G. Enstad Flowability measurements of pharmaceutical powder mixtures with poor flow using five different techniques Drug Dev. Industr. Pharm. 30 2004 785 791
33. L.X. Liu, I. Marziano, A.C. Bentham, J.D. Litster, E.T. White, and T. Howes Effect of particle properties on the flowability of ibuprofen powders Int. J. Pharm. 362 2008 109 117
34. G.G. Liversidge, and K.C. Cundy Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs Int. J. Pharm. 125 1995 91 97
35. E. Merisko-Liversidge, G.G. Liversidge, and E.R. Cooper Nanosizing: a formulation approach for poorly-water-soluble compounds Eur. J. Pharm. Sci. 18 2003 113 120
36. N. Midoux, P. Hosek, L. Pailleres, and J.R. Authelin Micronization of pharmaceutical substances in a spiral jet mill Powder Technol. 104 1999 113 120
37. O.M. Milhem, C. Myles, N.B. McKeown, D. Attwood, and A. D'Emanuele Polyamidoamine Starburst® dendrimers as solubility enhancers Int. J. Pharm. 197 2000 239 241
38. O. Molerus Effect of interparticle cohesive forces on the flow behaviour of powders Powder Technol. 20 1978 161 175
39. M.P. Mullarney, L.E. Beach, R.N. Davé, B.A. Langdon, M. Polizzi, and D.O. Blackwood Applying dry powder coatings to pharmaceutical powders using a comil for improving powder flow and bulk density Powder Technol. 212 2011 397 402
40. A. Nokhodchi, M. Maghsoodi, D. Hassan-Zadeh, and M. Barzegar-Jalali Preparation of agglomerated crystals for improving flowability and compactibility of poorly flowable and compactible drugs and excipients Powder Technol. 175 2007 73 81
41. A.A. Noyes, and W.R. Whitney The rate of solution of solid substances in their own solutions J. Am. Chem. Soc. 19 1897 930 934
42. M. Perrut, J. Jung, and F. Leboeuf Enhancement of dissolution rate of poorly-soluble active ingredients by supercritical fluid processes: Part I: micronization of neat particles Int. J. Pharm. 288 2005 3 10
43. B. Rambali, L. Baert, and D.L. Massart Using experimental design to optimize the process parameters in fluidized bed granulation on a semi-full scale Int. J. Pharm. 220 2001 149 160
44. M. Ramlakhan, C.Y. Wu, S. Watano, R.N. Dave, and R. Pfeffer Dry particle coating using magnetically assisted impaction coating: modification of surface properties and optimization of system and operating parameters Powder Technol. 112 2000 137 148
45. N. Rasenack, and B.W. Müller Ibuprofen crystals with optimized properties Int. J. Pharm. 245 2002 9 24
46. E. Ryshkewitch Compression strength of porous sintered alumina and zirconia J. Am. Ceram. Soc. 36 1953 65 68
47. D. Schulze Powders and Bulk Solids 2008 Springer
48. Staniforth, J.; 2002. Pharmaceutics: The Science of Dosage Form Design, 2nd ed. Churchill Livingstone.
49. C. Sun, and D.J.W. Grant Influence of crystal structure on the tableting properties of sulfamerazine polymorphs Pharm. Res. 18 2001 274 280
50. C.C. Sun Setting the bar for powder flow properties in successful high speed tableting Powder Technol. 201 2010 106 108
51. S.B. Tan, and J.M. Newton Powder flowability as an indication of capsule filling performance Int. J. Pharm. 61 1990 145 155
52. K. Thalberg, D. Lindholm, and A. Axelsson Comparison of different flowability tests for powders for inhalation Powder Technol. 146 2004 206 213
53. C.K. Tye, C. Sun, and G.E. Amidon Evaluation of the effects of tableting speed on the relationships between compaction pressure, tablet tensile strength, and tablet solid fraction J. Pharm. Sci. 94 2005 465 472
54. J.M. Valverde, A. Ramos, A. Castellanos, and P. Keith Watson The tensile strength of cohesive powders and its relationship to consolidation, free volume and cohesivity Powder Technol. 97 1998 237 245
55. M. Vogt, K. Kunath, and J.B. Dressman Dissolution enhancement of fenofibrate by micronization, cogrinding and spray-drying: comparison with commercial preparations Eur. J. Pharm. Biopharm. 68 2008 283 288
56. P. Wang, L. Zhu, S. Teng, Q. Zhang, M.-W. Young, and C. Gogos A novel process for simultaneous milling and coating of particulates Powder Technol. 193 2009 65 68
57. C.R. Wassgren, M.L. Hunt, P.J. Freese, J. Palamara, and C.E. Brennen Effects of vertical vibration on hopper flows of granular material Phys. Fluids 14 2002 3439 3448
58. Yang, J.; Dave, R.; Gogos, C.; Zhu, L.; Young, M.W.; Fishbein, L.; Schepige, B.; Bonnett, P.; 2006. In situ milling and coating within a fluid energy mill. Int. Annu. Conf. ICT 37th, 2/1-2/13.
59. J. Yang, A. Sliva, A. Banerjee, R.N. Dave, and R. Pfeffer Dry particle coating for improving the flowability of cohesive powders Powder Technol. 158 2005 21 33
60. Q.T. Zhou, L. Qu, I. Larson, P.J. Stewart, and D.A.V. Morton Improving aerosolization of drug powders by reducing powder intrinsic cohesion via a mechanical dry coating approach Int. J. Pharm. 394 2010 50 59