Using experimental design to optimize the process parameters in fluidized bed granulation on a semi-full scale

International Journal of Pharmaceutics

Volumn 220, Issue 1-2, 2001, Pages 149-160

  Rambali, B ^a   Baert, L ^b   Massart, D L ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

Central composite design; Fluid bed; Granulation process; Granule properties; Optimization; Regression model

Indexed keywords

AEROSOL; AIR TEMPERATURE; AIRFLOW; ARTICLE; DRUG GRANULATION; EMPIRICISM; FLUIDIZED BED; GEOMETRY; HUMIDITY; METHODOLOGY; MODEL; MOISTURE; PARTICLE SIZE; PRIORITY JOURNAL; REGRESSION ANALYSIS;

RESEARCH DESIGN; TECHNOLOGY, PHARMACEUTICAL;

EID: 0035806250     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00658-5     Document Type: Article

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