1H HR-MAS NMR spectroscopy of tumor-induced local metabolic "field-effects" enables colorectal cancer staging and prognostication

Journal of Proteome Research

Volumn 12, Issue 2, 2013, Pages 959-968

  Jiménez, Beatriz ^a   Mirnezami, Reza ^b   Kinross, James ^b   Cloarec, Olivier ^a,c   Keun, Hector C ^a   Holmes, Elaine ^a   Goldin, Robert D ^b   Ziprin, Paul ^b   Darzi, Ara ^b   Nicholson, Jeremy K ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ST MARY S HOSPITAL   (United Kingdom)

^c Korrigan Sciences Ltd   (United Kingdom)

Author keywords

colorectal cancer; high resolution magic angle spinning nuclear magnetic resonance; metabonomics; tissue biopsy

Indexed keywords

ACETIC ACID; ALANINE; BUTYRIC ACID; CHOLINE; CREATINE; FORMIC ACID; GLUCOSE; LACTIC ACID; LEUCINE; PHENYLALANINE; PHOSPHORYLCHOLINE; TAURINE; TYROSINE; VALINE; AMINO ACID; TRIACYLGLYCEROL; TUMOR MARKER;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CANCER SURGERY; CANCER TISSUE; CLINICAL ARTICLE; COLORECTAL CANCER; DISCRIMINANT ANALYSIS; FEMALE; HUMAN; MALE; METABOLITE; PRIORITY JOURNAL; PROTON HIGH RESOLUTION MAGIC ANGLE SPINNING NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; ADENOCARCINOMA; CELL TRANSFORMATION; COLON; COLORECTAL TUMOR; METABOLISM; METABOLOME; METHODOLOGY; MIDDLE AGED; MORTALITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOLOGY; PREDICTIVE VALUE; SURVIVAL; TUMOR MICROENVIRONMENT; VERY ELDERLY;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; AMINO ACIDS; CELL TRANSFORMATION, NEOPLASTIC; CHOLINE; COLON; COLORECTAL NEOPLASMS; DISCRIMINANT ANALYSIS; FEMALE; HUMANS; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOME; MIDDLE AGED; NEOPLASM STAGING; PREDICTIVE VALUE OF TESTS; SURVIVAL ANALYSIS; TRIGLYCERIDES; TUMOR MARKERS, BIOLOGICAL; TUMOR MICROENVIRONMENT;

MLCS; MLOWN;

EID: 84873397556     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr3010106     Document Type: Article

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