Susceptibility to intestinal tumorigenesis in folate-deficient mice may be influenced by variation in one-carbon metabolism and DNA repair

Journal of Nutritional Biochemistry

Volumn 22, Issue 11, 2011, Pages 1022-1029

  Knock, Erin ^a   Deng, Liyuan ^a   Krupenko, Natalia ^b   Mohan, Ryan D ^c   Wu, Qing ^a   Leclerc, Daniel ^a   Gupta, Sapna ^d   Elmore, C Lee ^e   Kruger, Warren ^d   Tini, Marc ^c   Rozen, Rima ^a  

^a MONTREAL CHILDREN S HOSPITAL   (Canada)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

^d FOX CHASE CANCER CENTER   (United States)

^e UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Cancer; DNA damage; Folate; Metabolism; One carbon donor; Repair

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CARBON; DNA; DNA GLYCOSYLTRANSFERASE; DNA POLYMERASE; FOLIC ACID; METHIONINE; SERINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER SUSCEPTIBILITY; CARBON METABOLISM; CARCINOGENESIS; DNA REPAIR; FOLIC ACID DEFICIENCY; INTESTINE TUMOR; MOUSE; NONHUMAN; PROTEIN EXPRESSION;

AMINOHYDROLASES; ANIMALS; COLORECTAL NEOPLASMS; DIET; DNA METHYLATION; DNA POLYMERASE BETA; DNA REPAIR; FOLIC ACID; FOLIC ACID DEFICIENCY; FORMATE-TETRAHYDROFOLATE LIGASE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP); METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MULTIENZYME COMPLEXES; RNA, MESSENGER; SERINE; TETRAHYDROFOLATES; URACIL-DNA GLYCOSIDASE;

MUS;

EID: 80054061671     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2010.07.015     Document Type: Article

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