A Sardinian map for multiple sclerosis

Future Microbiology

Volumn 8, Issue 2, 2013, Pages 223-232

  Cossu, Davide ^a   Masala, Speranza ^a   Sechi, Leonardo A ^a  

^a UNIVERSITY OF SASSARI   (Italy)

Author keywords

bacteria; environmental; etiology; molecular mimicry; multiple sclerosis; Mycobacterium avium subsp. paratuberculosis

Indexed keywords

HEAT SHOCK PROTEIN;

AUTOIMMUNITY; BACTERIAL GENE; CROSS REACTION; GENE MAPPING; HUMAN; MULTIPLE SCLEROSIS; MYCOBACTERIUM PARATUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW;

DNA, BACTERIAL; HUMANS; ITALY; MODELS, BIOLOGICAL; MULTIPLE SCLEROSIS; MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS;

EID: 84873393052     PISSN: 17460913     EISSN: 17460921     Source Type: Journal    
DOI: 10.2217/fmb.12.135     Document Type: Review

References (65)

1. Gourraud PA, Harbo HF, Hauser SL, Baranzini SE. The genetics of multiple sclerosis: An up-to-date review. Immunol. Rev. 248(1), 87-103 (2012).
2. Pirko I, Johnson AJ, Lohrey AK, Chen Y, Ying J. Deep gray matter T2 hypointensity correlates with disability in a murine model of MS. J. Neurol. Sci. 282(1-2), 34-38 (2009).
3. Kawakami N, Bartholomäus I, Pesic M, Mues M. An autoimmunity odyssey: how autoreactive T cells infiltrate into the CNS. Immunol. Rev. 248(1), 140-155 (2012).
4. Hafler DA, Compston A, Sawcer S et al. Risk alleles for multiple sclerosis identified by a genomewide study. N. Engl. J. Med. 357(9), 851-862 (2007). (Pubitemid 47347319)
5. Oksenberg JR, Baranzini SE. Multiple sclerosis genetics Y is the glass half full, or half empty? Nat. Rev. Neurol. 6(8), 429-437 (2010).
6. Ascherio A, Munger K. Epidemiology of multiple sclerosis: from risk factors to prevention. Semin. Neurol. 28(1), 17-28 (2008). (Pubitemid 351273081)
7. Kakalacheva K, Lunemann JD. Environmental triggers of multiple sclerosis. FEBS Lett. 585(23), 3724-3729 (2011).
8. Javierre BM, Hernando H, Ballestar E. Environmental triggers and epigenetic deregulation in autoimmune disease. Discov. Med. 12(67), 535-545 (2011).
9. Carter CJ. EpsteinYBarr and other viral mimicry of autoantigens, myelin and vitamin D-related proteins and of EIF2B, the cause of vanishing white matter disease: massive mimicry of multiple sclerosis relevant proteins by the Synechococcus phage. Immunopharmacol. Immunotoxicol. 34(1), 21-35 (2012).
10. Gavalas E, Kountouras J, Deretzi G et al. Helicobacter pylori and multiple sclerosis. J. Neuroimmunol. 188(1-2), 187-189; author reply 190 (2007). (Pubitemid 47095028)
11. Contini C, Seraceni S, Cultrera R et al. Chlamydophila pneumoniae infection and its role in neurological disorders. Interdiscip. Perspect. Infect. Dis. 2010, 273573 (2010).
12. Cossu D, Cocco E, Paccagnini D et al. Association of Mycobacterium avium subsp. paratuberculosis with multiple sclerosis in Sardinian patients. PLoS One 6(4), e18482 (2011).
13. Cossu D, Masala S, Cocco E et al. Are Mycobacterium avium subsp. paratuberculosis and EpsteinYBarr virus triggers of multiple sclerosis in Sardinia? Mult. Scler. 18(8), 1181-1184 (2012).
14. Cossu D, Masala S, Cocco E et al. Association of Mycobacterium avium subsp. paratuberculosis infection and SLC11A1 polymorphisms in Sardinian multiple sclerosis patients. J. Infect.Dev. Count. (2012) (In press).
15. Cocco E, Sardu C, Massa R et al. Epidemiology of multiple sclerosis in south-western Sardinia. Mult. Scler. 17(11), 1282-1289 (2011).
16. Sardu C, Cocco E, Mereu A et al. Population based study of 12 autoimmune diseases in Sardinia, Italy: prevalence and comorbidity. PLoS One 7(3), e32487 (2012).
17. Sotgiu S, Angius A, Embry A, Rosati G, Musumeci S. Hygiene hypothesis: innate immunity, malaria and multiple sclerosis. Med. Hypotheses 70(4), 819-825 (2008). (Pubitemid 351318081)
18. Gazouli M, Sechi L, Paccagnini D et al. NRAMP1 polymorphism and viral factors in Sardinian multiple sclerosis patients. Can. J. Neurol. Sci. 35(4), 491-494 (2008).
19. Sabatino A, Paccagnini D, Vidali F et al. Detection of Mycobacterium avium subsp. paratuberculosis (MAP)-specific IS900 DNA and antibodies against MAP peptides and lysate in the blood of Crohn's disease patients. Inflamm. Bowel Dis. 17(5), 1254-1255 (2011).
20. Sechi LA, Paccagnini D, Salza S, Pacifico A, Ahmed N, Zanetti S. Mycobacterium avium subspecies paratuberculosis bacteremia in Type 1 diabetes mellitus: An infectious trigger? Clin. Infect. Dis. 46(1), 148-149 (2008). (Pubitemid 351263578)
21. Sisto M, Cucci L, D'Amore M, Dow TC, Mitolo V, Lisi S. Proposing a relationship between Mycobacterium avium subspecies paratuberculosis infection and Hashimoto's thyroiditis. Scand. J. Infect. Dis. 42(10), 787-790 (2010).
22. Turenne CY, Collins DM, Alexander DC, Behr MA. Mycobacterium avium subsp. paratuberculosis and M. avium subsp. avium are independently evolved pathogenic clones of a much broader group of M. avium organisms. J. Bacteriol. 190(7), 2479-2487 (2008). (Pubitemid 351466343)
23. Turenne CY, Wallace R Jr, Behr MA. Mycobacterium avium in the postgenomic era. Clin. Microbiol. Rev. 20(2), 205-229 (2007). (Pubitemid 46709302)
24. Botsaris G, Slana I, Liapi M et al. Rapid detection methods for viable Mycobacterium avium subspecies paratuberculosis in milk and cheese. Int. J. Food Microbiol. 141(Suppl. 1), S87-S90 (2010).
25. Klanicova B, Slana I, Vondruskova H, Kaevska M, Pavlik I. Real-time quantitative PCR detection of Mycobacterium avium subspecies in meat products. J. Food Prot. 74(4), 636-640 (2011).
26. Klanicova B, Slana I, Roubal P, Pavlik I, Kralik P. Mycobacterium avium subsp. paratuberculosis survival during fermentation of soured milk products detected by culture and quantitative real time PCR methods. Int. J. Food Microbiol. 157(2), 150-155 (2012).
27. Lamont EA, Bannantine JP, Armien A, Ariyakumar DS, Sreevatsan S. Identification and characterization of a spore-like morphotype in chronically starved Mycobacterium avium subsp. paratuberculosis cultures. PLoS One 7(1), e30648 (2012).
28. Chiodini RJ, Chamberlin WM, Sarosiek J, McCallum RW. Crohn's disease and the mycobacterioses: A quarter century later. Causation or simple association? Crit. Rev. Microbiol. 38(1), 52-93 (2012).
29. Masala S, Paccagnini D, Cossu D et al. Antibodies recognizing Mycobacterium avium paratuberculosis epitopes cross-react with the beta-cell antigen ZnT8 in Sardinian Type 1 diabetic patients. PLoS One 6(10), e26931 (2011).
30. Rosu V, Ahmed N, Paccagnini D et al. Specific immunoassays confirm association of Mycobacterium avium subsp. paratuberculosis with Type-1 but not Type-2 diabetes mellitus. PLoS One 4(2), e4386 (2009).
31. Nielsen SS, Toft N. A review of prevalences of paratuberculosis in farmed animals in Europe. Prev. Vet. Med. 88(1), 1-14 (2009).
32. Pozzato N, Capello K, Comin A et al. Prevalence of paratuberculosis infection in dairy cattle in northern Italy. Prev. Vet. Med. 102(1), 83-86 (2011).
33. Fridriksdottir V, Gunnarsson E, Sigurdarson S, Gudmundsdottir KB. Paratuberculosis in Iceland: epidemiology and control measures, past and present. Vet. Microbiol. 77(3-4), 263-267 (2000).
34. Benedikz J, Stefansson M, Guomundsson J et al. The natural history of untreated multiple sclerosis in Iceland. A total population-based 50 year prospective study. Clin. Neurol. Neurosurg. 104(3), 208-210 (2002). (Pubitemid 34799912)
35. Kurtzke JF. Multiple sclerosis in time and space Y geographic clues to cause. J. Neurovirol. 6(Suppl. 2), S134-S140 (2000). (Pubitemid 30348927)
36. Sawcer S, Hellenthal G, Pirinen M et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476(7359), 214-219 (2011).
37. Purdie AC, Plain KM, Begg DJ, de Silva K, Whittington RJ. Candidate gene and genome-wide association studies of Mycobacterium avium subsp. paratuberculosis infection in cattle and sheep: A review. Comp. Immunol. Microbiol. Infect. Dis. 34(3), 197-208 (2011).
38. Meilang Q, Zhang Y, Zhang J et al. Polymorphisms in the SLC11A1 gene and tuberculosis risk: A meta-analysis update. Int. J. Tuberc. Lung Dis. 16(4), 437-446 (2012).
39. Nugraha J, Anggraini R. NRAMP1 polymorphism and susceptibility to lung tuberculosis in Surabaya, Indonesia. Southeast Asian J. Trop. Med. Public Health 42(2), 338-341 (2011).
40. Singh A, Gaughan JP, Kashyap VK. SLC11A1 and VDR gene variants and susceptibility to tuberculosis and disease progression in east India. Int. J. Tuberc. Lung Dis. 15(11), 1468-1474, i (2011).
41. Li X, Yang Y, Zhou F et al. SLC11A1 (NRAMP1) polymorphisms and tuberculosis susceptibility: updated systematic review and meta-analysis. PLoS One 6(1), e15831 (2011).
42. Ruiz-Larranaga O, Garrido JM, Manzano C et al. Identification of single nucleotide polymorphisms in the bovine solute carrier family 11 member 1 (SLC11A1) gene and their association with infection by Mycobacterium avium subspecies paratuberculosis. J. Dairy Sci. 93(4), 1713-1721 (2010).
43. Paccagnini D, Sieswerda L, Rosu V et al. Linking chronic infection and autoimmune diseases: Mycobacterium avium subspecies paratuberculosis, SLC11A1 polymorphisms and Type-1 diabetes mellitus. PLoS One 4(9), e7109 (2009).
44. Yang JH, Downes K, Howson JM et al. Evidence of association with Type 1 diabetes in the SLC11A1 gene region. BMC Med. Genet. 12, 59 (2011).
45. Sechi LA, Gazouli M, Sieswerda LE et al. Relationship between Crohn's disease, infection with Mycobacterium avium subspecies paratuberculosis and SLC11A1 gene polymorphisms in Sardinian patients. World J. Gastroenterol. 12(44), 7161-7164 (2006). (Pubitemid 44890646)
46. Polman CH, Reingold SC, Banwell B et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann. Neurol. 69(2), 292-302 (2011).
47. Chastain EM, Miller SD. Molecular mimicry as an inducing trigger for CNS autoimmune demyelinating disease. Immunol. Rev. 245(1), 227-238 (2012).
48. Gandhi R, Laroni A, Weiner HL. Role of the innate immune system in the pathogenesis of multiple sclerosis. J. Neuroimmunol. 221(1-2), 7-14 (2010).
49. Brink BP, Veerhuis R, Breij EC, van der Valk P, Dijkstra CD, Bo L. The pathology of multiple sclerosis is location-dependent: no significant complement activation is detected in purely cortical lesions. J. Neuropathol. Exp. Neurol. 64(2), 147-155 (2005). (Pubitemid 40349313)
50. Rossi S, Studer V, Motta C et al. Inflammation inhibits GABA transmission in multiple sclerosis. Mult. Scler. 18(11), 1633-1635 (2012).
51. Newcombe J, Uddin A, Dove R et al. Glutamate receptor expression in multiple sclerosis lesions. Brain Pathol. 18(1), 52-61 (2008).
52. Bolton C, Paul C. Glutamate receptors in neuroinflammatory demyelinating disease. Mediators Inflamm. (2), 93684 (2006).
53. Hayes SM, Laird RM. Genetic requirements for the development and differentiation of interleukin-17-producing gd T cells. Crit. Rev. Immunol. 32(1), 81-95 (2012).
54. Kilfoyle DH, Dyck PJ, Wu Y et al. Myelin protein zero mutation His39Pro: hereditary motor and sensory neuropathy with variable onset, hearing loss, restless legs and multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 77(8), 963-966 (2006). (Pubitemid 44174086)
55. Mayer MC, Meinl E. Glycoproteins as targets of autoantibodies in CNS inflammation: MOG and more. Ther. Adv. Neurol. Disord. 5(3), 147-159 (2012).
56. Rajaiah R, Moudgil KD. Heat-shock proteins can promote as well as regulate autoimmunity. Autoimmun. Rev. 8(5), 388-393 (2009).
57. Dow CT. M. paratuberculosis heat shock protein 65 and human diseases: bridging infection and autoimmunity. Autoimmune Dis. 2012, 150824 (2012)
58. Mansilla MJ, Montalban X, Espejo C. Heat shock protein 70: roles in multiple sclerosis. Mol. Med. 18, 1018-1028 (2012).
59. Yokota S, Chiba S, Furuyama H, Fujii N. Cerebrospinal fluids containing anti-HSP70 autoantibodies from multiple sclerosis patients augment HSP70-induced proinflammatory cytokine production in monocytic cells. J. Neuroimmunol. 218(1-2), 129-133 (2010).
60. Rees A, Scoging A, Mehlert A, Young DB, Ivanyi J. Specificity of proliferative response of human CD8 clones to mycobacterial antigens. Eur. J. Immunol. 18(12), 1881-1887 (1988). (Pubitemid 19046200)
61. Babu Chodisetti S, Rai PK, Gowthaman U et al. Potential T cell epitopes of Mycobacterium tuberculosis that can instigate molecular mimicry against host: implications in autoimmune pathogenesis. BMC Immunol. 13, 13 (2012).
62. Khare S, Lawhon SD, Drake KL et al. Systems biology analysis of gene expression during in vivo Mycobacterium avium paratuberculosis enteric colonization reveals role for immune tolerance. PLoS One 7(8), e42127 (2012).
63. Aszalos Z. [Neurological and psychiatric aspects of some gastrointestinal diseases.] Orv. Hetil. 149(44), 2079-2086 (2008).
64. Berer K, Mues M, Koutrolos M et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature 479(7374), 538-541 (2011).
65. Achiron A, Grotto I, Balicer R, Magalashvili D, Feldman A, Gurevich M. Microarray analysis identifies altered regulation of nuclear receptor family members in the predisease state of multiple sclerosis. Neurobiol. Dis. 38(2), 201-209 (2010).