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Volumn 282, Issue 1-2, 2009, Pages 34-38

Deep gray matter T2 hypointensity correlates with disability in a murine model of MS

Author keywords

Deep gray matter; EAE; Iron deposition; Magnetic resonance imaging; MRI; MS; Multiple sclerosis; Multiple sclerosis animal model; T2 hypointensity; Theiler's murine encephalitis virus; TMEV

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISABILITY; DISEASE ASSOCIATION; DISEASE COURSE; ENCEPHALITIS VIRUS; GRAY MATTER; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; THALAMUS NUCLEUS;

EID: 67349282356     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2008.12.013     Document Type: Article
Times cited : (29)

References (38)
  • 2
    • 12344335574 scopus 로고    scopus 로고
    • The pathology of multiple sclerosis
    • [vi]
    • Lucchinetti C.F., Parisi J., and Bruck W. The pathology of multiple sclerosis. Neurol Clin 23 1 (2005) 77-105 [vi]
    • (2005) Neurol Clin , vol.23 , Issue.1 , pp. 77-105
    • Lucchinetti, C.F.1    Parisi, J.2    Bruck, W.3
  • 3
    • 20444397769 scopus 로고    scopus 로고
    • Cortical lesions and brain atrophy in MS
    • Kutzelnigg A., and Lassmann H. Cortical lesions and brain atrophy in MS. J Neurol Sci 233 1-2 (2005) 55-59
    • (2005) J Neurol Sci , vol.233 , Issue.1-2 , pp. 55-59
    • Kutzelnigg, A.1    Lassmann, H.2
  • 4
    • 33947519177 scopus 로고    scopus 로고
    • Gray matter involvement in multiple sclerosis
    • Pirko I., Lucchinetti C.F., Sriram S., and Bakshi R. Gray matter involvement in multiple sclerosis. Neurology 68 9 (2007) 634-642
    • (2007) Neurology , vol.68 , Issue.9 , pp. 634-642
    • Pirko, I.1    Lucchinetti, C.F.2    Sriram, S.3    Bakshi, R.4
  • 5
    • 34248643430 scopus 로고    scopus 로고
    • Neuroimaging in multiple sclerosis
    • Zivadinov R., and Cox J.L. Neuroimaging in multiple sclerosis. Int Rev Neurobiol 79 (2007) 449-474
    • (2007) Int Rev Neurobiol , vol.79 , pp. 449-474
    • Zivadinov, R.1    Cox, J.L.2
  • 6
    • 29444453307 scopus 로고    scopus 로고
    • Clinical-magnetic resonance imaging correlations in multiple sclerosis
    • Zivadinov R., and Leist T.P. Clinical-magnetic resonance imaging correlations in multiple sclerosis. J Neuroimaging 15 4 Suppl (2005) 10S-21S
    • (2005) J Neuroimaging , vol.15 , Issue.4 SUPPL
    • Zivadinov, R.1    Leist, T.P.2
  • 7
    • 0035869389 scopus 로고    scopus 로고
    • Gray matter T2 hypointensity is related to plaques and atrophy in the brains of multiple sclerosis patients
    • Bakshi R., Dmochowski J., Shaikh Z.A., and Jacobs L. Gray matter T2 hypointensity is related to plaques and atrophy in the brains of multiple sclerosis patients. J Neurol Sci 185 1 (2001) 19-26
    • (2001) J Neurol Sci , vol.185 , Issue.1 , pp. 19-26
    • Bakshi, R.1    Dmochowski, J.2    Shaikh, Z.A.3    Jacobs, L.4
  • 8
    • 0036141452 scopus 로고    scopus 로고
    • T2 hypointensity in the deep gray matter of patients with multiple sclerosis: a quantitative magnetic resonance imaging study
    • Bakshi R., Benedict R.H., Bermel R.A., Caruthers S.D., Puli S.R., Tjoa C.W., et al. T2 hypointensity in the deep gray matter of patients with multiple sclerosis: a quantitative magnetic resonance imaging study. Arch Neurol 59 1 (2002) 62-68
    • (2002) Arch Neurol , vol.59 , Issue.1 , pp. 62-68
    • Bakshi, R.1    Benedict, R.H.2    Bermel, R.A.3    Caruthers, S.D.4    Puli, S.R.5    Tjoa, C.W.6
  • 9
    • 34147117822 scopus 로고    scopus 로고
    • T1- and T2-based MRI measures of diffuse gray matter and white matter damage in patients with multiple sclerosis
    • Neema M., Stankiewicz J., Arora A., Dandamudi V.S., Batt C.E., Guss Z.D., et al. T1- and T2-based MRI measures of diffuse gray matter and white matter damage in patients with multiple sclerosis. J Neuroimaging 17 Suppl 1 (2007) 16S-21S
    • (2007) J Neuroimaging , vol.17 , Issue.SUPPL. 1
    • Neema, M.1    Stankiewicz, J.2    Arora, A.3    Dandamudi, V.S.4    Batt, C.E.5    Guss, Z.D.6
  • 10
    • 46849104493 scopus 로고    scopus 로고
    • Historical and clinical perspectives of the Expanded Disability Status Scale
    • Kurtzke J.F. Historical and clinical perspectives of the Expanded Disability Status Scale. Neuroepidemiology 31 1 (2008) 1-9
    • (2008) Neuroepidemiology , vol.31 , Issue.1 , pp. 1-9
    • Kurtzke, J.F.1
  • 11
    • 21344460544 scopus 로고    scopus 로고
    • MRI T2 hypointensity of the dentate nucleus is related to ambulatory impairment in multiple sclerosis
    • Tjoa C.W., Benedict R.H., Weinstock-Guttman B., Fabiano A.J., and Bakshi R. MRI T2 hypointensity of the dentate nucleus is related to ambulatory impairment in multiple sclerosis. J Neurol Sci 234 1-2 (2005) 17-24
    • (2005) J Neurol Sci , vol.234 , Issue.1-2 , pp. 17-24
    • Tjoa, C.W.1    Benedict, R.H.2    Weinstock-Guttman, B.3    Fabiano, A.J.4    Bakshi, R.5
  • 12
    • 35848962708 scopus 로고    scopus 로고
    • Deep grey matter "black T2" on 3 Tesla magnetic resonance imaging correlates with disability in multiple sclerosis
    • Zhang Y., Zabad R.K., Wei X., Metz L.M., Hill M.D., and Mitchell J.R. Deep grey matter "black T2" on 3 Tesla magnetic resonance imaging correlates with disability in multiple sclerosis. Mult Scler 13 7 (2007) 880-883
    • (2007) Mult Scler , vol.13 , Issue.7 , pp. 880-883
    • Zhang, Y.1    Zabad, R.K.2    Wei, X.3    Metz, L.M.4    Hill, M.D.5    Mitchell, J.R.6
  • 13
    • 33746547762 scopus 로고    scopus 로고
    • Cognitive impairment is associated with subcortical magnetic resonance imaging grey matter T2 hypointensity in multiple sclerosis
    • Brass S.D., Benedict R.H., Weinstock-Guttman B., Munschauer F., and Bakshi R. Cognitive impairment is associated with subcortical magnetic resonance imaging grey matter T2 hypointensity in multiple sclerosis. Mult Scler 12 4 (2006) 437-444
    • (2006) Mult Scler , vol.12 , Issue.4 , pp. 437-444
    • Brass, S.D.1    Benedict, R.H.2    Weinstock-Guttman, B.3    Munschauer, F.4    Bakshi, R.5
  • 14
    • 25144486613 scopus 로고    scopus 로고
    • Prediction of longitudinal brain atrophy in multiple sclerosis by gray matter magnetic resonance imaging T2 hypointensity
    • Bermel R.A., Puli S.R., Rudick R.A., Weinstock-Guttman B., Fisher E., Munschauer III F.E., et al. Prediction of longitudinal brain atrophy in multiple sclerosis by gray matter magnetic resonance imaging T2 hypointensity. Arch Neurol 62 9 (2005) 1371-1376
    • (2005) Arch Neurol , vol.62 , Issue.9 , pp. 1371-1376
    • Bermel, R.A.1    Puli, S.R.2    Rudick, R.A.3    Weinstock-Guttman, B.4    Fisher, E.5    Munschauer III, F.E.6
  • 15
    • 35348959427 scopus 로고    scopus 로고
    • Quantitative assessment of iron accumulation in the deep gray matter of multiple sclerosis by magnetic field correlation imaging
    • Ge Y., Jensen J.H., Lu H., Helpern J.A., Miles L., Inglese M., et al. Quantitative assessment of iron accumulation in the deep gray matter of multiple sclerosis by magnetic field correlation imaging. AJNR Am J Neuroradiol 28 9 (2007) 1639-1644
    • (2007) AJNR Am J Neuroradiol , vol.28 , Issue.9 , pp. 1639-1644
    • Ge, Y.1    Jensen, J.H.2    Lu, H.3    Helpern, J.A.4    Miles, L.5    Inglese, M.6
  • 16
    • 0023183497 scopus 로고
    • Reduced signal intensity on MR images of thalamus and putamen in multiple sclerosis: increased iron content?
    • Drayer B., Burger P., Hurwitz B., Dawson D., and Cain J. Reduced signal intensity on MR images of thalamus and putamen in multiple sclerosis: increased iron content?. AJR Am J Roentgenol 149 2 (1987) 357-363
    • (1987) AJR Am J Roentgenol , vol.149 , Issue.2 , pp. 357-363
    • Drayer, B.1    Burger, P.2    Hurwitz, B.3    Dawson, D.4    Cain, J.5
  • 17
    • 1842556542 scopus 로고    scopus 로고
    • The role of iron in the pathogenesis of experimental allergic encephalomyelitis and multiple sclerosis
    • Levine S.M., and Chakrabarty A. The role of iron in the pathogenesis of experimental allergic encephalomyelitis and multiple sclerosis. Ann N Y Acad Sci 1012 (2004) 252-266
    • (2004) Ann N Y Acad Sci , vol.1012 , pp. 252-266
    • Levine, S.M.1    Chakrabarty, A.2
  • 18
    • 0032514957 scopus 로고    scopus 로고
    • Iron deposits in the central nervous system of SJL mice with experimental allergic encephalomyelitis
    • Forge J.K., Pedchenko T.V., and LeVine S.M. Iron deposits in the central nervous system of SJL mice with experimental allergic encephalomyelitis. Life Sci 63 25 (1998) 2271-2284
    • (1998) Life Sci , vol.63 , Issue.25 , pp. 2271-2284
    • Forge, J.K.1    Pedchenko, T.V.2    LeVine, S.M.3
  • 19
    • 0032522199 scopus 로고    scopus 로고
    • Desferrioxamine suppresses experimental allergic encephalomyelitis induced by MBP in SJL mice
    • Pedchenko T.V., and LeVine S.M. Desferrioxamine suppresses experimental allergic encephalomyelitis induced by MBP in SJL mice. J Neuroimmunol 84 2 (1998) 188-197
    • (1998) J Neuroimmunol , vol.84 , Issue.2 , pp. 188-197
    • Pedchenko, T.V.1    LeVine, S.M.2
  • 20
    • 0041709345 scopus 로고    scopus 로고
    • Iron-deficient mice fail to develop autoimmune encephalomyelitis
    • Grant S.M., Wiesinger J.A., Beard J.L., and Cantorna M.T. Iron-deficient mice fail to develop autoimmune encephalomyelitis. J Nutr 133 8 (2003) 2635-2638
    • (2003) J Nutr , vol.133 , Issue.8 , pp. 2635-2638
    • Grant, S.M.1    Wiesinger, J.A.2    Beard, J.L.3    Cantorna, M.T.4
  • 21
    • 39549114148 scopus 로고    scopus 로고
    • Deferiprone, an orally deliverable iron chelator, ameliorates experimental autoimmune encephalomyelitis
    • Mitchell K.M., Dotson A.L., Cool K.M., Chakrabarty A., Benedict S.H., and LeVine S.M. Deferiprone, an orally deliverable iron chelator, ameliorates experimental autoimmune encephalomyelitis. Mult Scler 13 9 (2007) 1118-1126
    • (2007) Mult Scler , vol.13 , Issue.9 , pp. 1118-1126
    • Mitchell, K.M.1    Dotson, A.L.2    Cool, K.M.3    Chakrabarty, A.4    Benedict, S.H.5    LeVine, S.M.6
  • 22
    • 33745728404 scopus 로고    scopus 로고
    • How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis
    • Steinman L., and Zamvil S.S. How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis. Ann Neurol 60 1 (2006) 12-21
    • (2006) Ann Neurol , vol.60 , Issue.1 , pp. 12-21
    • Steinman, L.1    Zamvil, S.S.2
  • 23
    • 1342345214 scopus 로고    scopus 로고
    • The CD4-Th1 model for multiple sclerosis: a critical [correction of crucial] re-appraisal
    • Lassmann H., and Ransohoff R.M. The CD4-Th1 model for multiple sclerosis: a critical [correction of crucial] re-appraisal. Trends Immunol 25 3 (2004) 132-137
    • (2004) Trends Immunol , vol.25 , Issue.3 , pp. 132-137
    • Lassmann, H.1    Ransohoff, R.M.2
  • 24
    • 28544450761 scopus 로고    scopus 로고
    • Experimental allergic encephalomyelitis: a misleading model of multiple sclerosis
    • Sriram S., and Steiner I. Experimental allergic encephalomyelitis: a misleading model of multiple sclerosis. Ann Neurol 58 6 (2005) 939-945
    • (2005) Ann Neurol , vol.58 , Issue.6 , pp. 939-945
    • Sriram, S.1    Steiner, I.2
  • 25
    • 13944270265 scopus 로고    scopus 로고
    • Contrasting murine models of MS
    • Nelson A.L., Bieber A.J., and Rodriguez M. Contrasting murine models of MS. Int MS J 11 3 (2004) 95-99
    • (2004) Int MS J , vol.11 , Issue.3 , pp. 95-99
    • Nelson, A.L.1    Bieber, A.J.2    Rodriguez, M.3
  • 26
    • 0023494731 scopus 로고
    • Theiler's murine encephalomyelitis: a model of demyelination and persistence of virus
    • Rodriguez M., Oleszak E., and Leibowitz J. Theiler's murine encephalomyelitis: a model of demyelination and persistence of virus. Crit Rev Immunol 7 4 (1987) 325-365
    • (1987) Crit Rev Immunol , vol.7 , Issue.4 , pp. 325-365
    • Rodriguez, M.1    Oleszak, E.2    Leibowitz, J.3
  • 27
    • 0032752573 scopus 로고    scopus 로고
    • Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler's virus-infected mice
    • Katz-Levy Y., Neville K.L., Girvin A.M., Vanderlugt C.L., Pope J.G., Tan L.J., et al. Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler's virus-infected mice. J Clin Invest 104 5 (1999) 599-610
    • (1999) J Clin Invest , vol.104 , Issue.5 , pp. 599-610
    • Katz-Levy, Y.1    Neville, K.L.2    Girvin, A.M.3    Vanderlugt, C.L.4    Pope, J.G.5    Tan, L.J.6
  • 28
    • 0036398113 scopus 로고    scopus 로고
    • Theiler's virus infection of the mouse, or: of the importance of studying animal models
    • Brahic M. Theiler's virus infection of the mouse, or: of the importance of studying animal models. Virology 301 1 (2002) 1-5
    • (2002) Virology , vol.301 , Issue.1 , pp. 1-5
    • Brahic, M.1
  • 29
    • 40949128231 scopus 로고    scopus 로고
    • Multiple sclerosis: pathogenesis and MR imaging features of T1 hypointensities in a [corrected] murine model
    • Pirko I., Nolan T.K., Holland S.K., and Johnson A.J. Multiple sclerosis: pathogenesis and MR imaging features of T1 hypointensities in a [corrected] murine model. Radiology 246 3 (2008) 790-795
    • (2008) Radiology , vol.246 , Issue.3 , pp. 790-795
    • Pirko, I.1    Nolan, T.K.2    Holland, S.K.3    Johnson, A.J.4
  • 30
    • 16344363426 scopus 로고    scopus 로고
    • Magnetic resonance imaging, microscopy, and spectroscopy of the central nervous system in experimental animals
    • Pirko I., Fricke S.T., Johnson A.J., Rodriguez M., and Macura S.I. Magnetic resonance imaging, microscopy, and spectroscopy of the central nervous system in experimental animals. NeuroRx 2 2 (2005) 250-264
    • (2005) NeuroRx , vol.2 , Issue.2 , pp. 250-264
    • Pirko, I.1    Fricke, S.T.2    Johnson, A.J.3    Rodriguez, M.4    Macura, S.I.5
  • 31
    • 0035437715 scopus 로고    scopus 로고
    • The biomedical imaging resource at Mayo Clinic
    • Robb R.A. The biomedical imaging resource at Mayo Clinic. IEEE Trans Med Imaging 20 9 (2001) 854-867
    • (2001) IEEE Trans Med Imaging , vol.20 , Issue.9 , pp. 854-867
    • Robb, R.A.1
  • 32
    • 0033302642 scopus 로고    scopus 로고
    • 3-D visualization in biomedical applications
    • Robb R.A. 3-D visualization in biomedical applications. Annu Rev Biomed Eng 1 (1999) 377-399
    • (1999) Annu Rev Biomed Eng , vol.1 , pp. 377-399
    • Robb, R.A.1
  • 33
    • 0021740750 scopus 로고
    • Inhibition of autoimmune neuropathological process by treatment with an iron-chelating agent
    • Bowern N., Ramshaw I.A., Clark I.A., and Doherty P.C. Inhibition of autoimmune neuropathological process by treatment with an iron-chelating agent. J Exp Med 160 5 (1984) 1532-1543
    • (1984) J Exp Med , vol.160 , Issue.5 , pp. 1532-1543
    • Bowern, N.1    Ramshaw, I.A.2    Clark, I.A.3    Doherty, P.C.4
  • 34
    • 0023781183 scopus 로고
    • Inhibition of allergic encephalomyelitis by the iron chelating agent desferrioxamine: differential effect depending on type of sensitizing encephalitogen
    • Willenborg D.O., Bowern N.A., Danta G., and Doherty P.C. Inhibition of allergic encephalomyelitis by the iron chelating agent desferrioxamine: differential effect depending on type of sensitizing encephalitogen. J Neuroimmunol 17 2 (1988) 127-135
    • (1988) J Neuroimmunol , vol.17 , Issue.2 , pp. 127-135
    • Willenborg, D.O.1    Bowern, N.A.2    Danta, G.3    Doherty, P.C.4


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