Potential T cell epitopes of Mycobacterium tuberculosis that can instigate molecular mimicry against host: implications in autoimmune pathogenesis

BMC Immunology

Volumn 13, Issue , 2012, Pages

  Babu Chodisetti, Sathi ^a   Rai, Pradeep K ^a   Gowthaman, Uthaman ^a   Pahari, Susanta ^a   Agrewala, Javed N ^a  

^a INSTITUTE OF MICROBIAL TECHNOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN; AUTOANTIGEN; BACTERIAL ANTIGEN; EPITOPE; PEPTIDE FRAGMENT; PROTEOME;

ALLELE; ARTICLE; BIOINFORMATICS; HUMAN; IMMUNOPATHOGENESIS; MOLECULAR MIMICRY; MYCOBACTERIOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; T LYMPHOCYTE; AUTOIMMUNE DISEASE; BIOLOGY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CROSS REACTION; EPITOPE MAPPING; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; METABOLISM; PROTEIN BINDING; TUBERCULOSIS;

ANTIGENS, BACTERIAL; AUTOANTIGENS; AUTOIMMUNE DISEASES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; COMPUTATIONAL BIOLOGY; CROSS REACTIONS; EPITOPE MAPPING; EPITOPES, T-LYMPHOCYTE; HLA ANTIGENS; HOST-PATHOGEN INTERACTIONS; HUMANS; MOLECULAR MIMICRY; MYCOBACTERIUM TUBERCULOSIS; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEOME; TUBERCULOSIS;

EID: 84861345846     PISSN: None     EISSN: 14712172     Source Type: Journal    
DOI: 10.1186/1471-2172-13-13     Document Type: Article

References (52)

1. Mueller DL. Mechanisms maintaining peripheral tolerance. Nat Immunol 2010, 11(1):21-27. 10.1038/ni.1817, 20016506.
2. Bach JF. Infections and autoimmune diseases. J Autoimmun 2005, 25(Suppl):74-80.
3. Wucherpfennig KW, Strominger JL. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 1995, 80(5):695-705. 10.1016/0092-8674(95)90348-8, 7534214.
4. Birnbaum G, Kotilinek L. Heat shock or stress proteins and their role as autoantigens in multiple sclerosis. Ann N Y Acad Sci 1997, 835:157-167. 10.1111/j.1749-6632.1997.tb48627.x, 9616771.
5. Kovvali G, Das KM. Molecular mimicry may contribute to pathogenesis of ulcerative colitis. FEBS Lett 2005, 579(11):2261-2266. 10.1016/j.febslet.2005.02.073, 15848155.
6. Goverman J. Autoimmune T cell responses in the central nervous system. Nat Rev Immunol 2009, 9(6):393-407. 10.1038/nri2550, 2813731, 19444307.
7. Benoist C, Mathis D. Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry?. Nat Immunol 2001, 2(9):797-801. 10.1038/ni0901-797, 11526389.
8. Fielder M, Pirt SJ, Tarpey I, Wilson C, Cunningham P, Ettelaie C, Binder A, Bansal S, Ebringer A. Molecular mimicry and ankylosing spondylitis: possible role of a novel sequence in pullulanase of Klebsiella pneumoniae. FEBS Lett 1995, 369(2-3):243-248. 10.1016/0014-5793(95)00760-7, 7649265.
9. McClain MT, Heinlen LD, Dennis GJ, Roebuck J, Harley JB, James JA. Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry. Nat Med 2005, 11(1):85-89. 10.1038/nm1167, 15619631.
10. Gowthaman U, Chodisetti SB, Agrewala JN. T cell help to B cells in germinal centers: putting the jigsaw together. Int Rev Immunol 2010, 29(4):403-420. 10.3109/08830185.2010.496503, 20635881.
11. Singh V, Gowthaman U, Jain S, Parihar P, Banskar S, Gupta P, Gupta UD, Agrewala JN. Coadministration of interleukins 7 and 15 with bacille Calmette-Guerin mounts enduring T cell memory response against Mycobacterium tuberculosis. J Infect Dis 2010, 202(3):480-489. 10.1086/653827, 20569158.
12. Acevedo-Vasquez E, Ponce de Leon D, Gamboa-Cardenas R. Latent infection and tuberculosis disease in rheumatoid arthritis patients. Rheum Dis Clin North Am 2009, 35(1):163-181. 10.1016/j.rdc.2009.03.008, 19481003.
13. Ghosh K, Patwardhan M, Pradhan V. Mycobacterium tuberculosis infection precipitates SLE in patients from endemic areas. Rheumatol Int 2009, 29(9):1047-1050. 10.1007/s00296-009-0903-x, 19360412.
14. Res PC, Schaar CG, Breedveld FC, van Eden W, van Embden JD, Cohen IR, de Vries RR. Synovial fluid T cell reactivity against 65 kD heat shock protein of mycobacteria in early chronic arthritis. Lancet 1988, 2(8609):478-480.
15. Van Eden W, Thole JE, van der Zee R, Noordzij A, van Embden JD, Hensen EJ, Cohen IR. Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis. Nature 1988, 331(6152):171-173. 10.1038/331171a0, 2448638.
16. Esaguy N, Aguas AP, van Embden JD, Silva MT. Mycobacteria and human autoimmune disease: direct evidence of cross-reactivity between human lactoferrin and the 65-kilodalton protein of tubercle and leprosy bacilli. Infect Immun 1991 59(3):1117-1125.
17. Van Eden W, Holoshitz J, Nevo Z, Frenkel A, Klajman A, Cohen IR. Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans. Proc Natl Acad Sci USA 1985, 82(15):5117-5120. 10.1073/pnas.82.15.5117, 390510, 3927297.
18. Salvetti M, Buttinelli C, Ristori G, Carbonari M, Cherchi M, Fiorelli M, Grasso MG, Toma L, Pozzilli C. T-lymphocyte reactivity to the recombinant mycobacterial 65- and 70-kDa heat shock proteins in multiple sclerosis. J Autoimmun 1992, 5(6):691-702. 10.1016/0896-8411(92)90186-T, 1489484.
19. Birnbaum G, Kotilinek L, Albrecht L. Spinal fluid lymphocytes from a subgroup of multiple sclerosis patients respond to mycobacterial antigens. Ann Neurol 1993, 34(1):18-24. 10.1002/ana.410340106, 8517675.
20. Salvetti M, Ristori G, Buttinelli C, Fiori P, Falcone M, Britton W, Adams E, Paone G, Grasso MG, Pozzilli C. The immune response to mycobacterial 70-kDa heat shock proteins frequently involves autoreactive T cells and is quantitatively disregulated in multiple sclerosis. J Neuroimmunol 1996, 65(2):143-153. 10.1016/0165-5728(96)00013-6, 8964896.
21. Mor F, Cohen IR. T cells in the lesion of experimental autoimmune encephalomyelitis. Enrichment for reactivities to myelin basic protein and to heat shock proteins. J Clin Invest 1992, 90(6):2447-2455. 10.1172/JCI116136, 443401, 1281835.
22. Mustafa AS, Al-Attiyah R, Hanif SN, Shaban FA. Efficient testing of large pools of Mycobacterium tuberculosis RD1 peptides and identification of major antigens and immunodominant peptides recognized by human Th1 cells. Clin Vaccine Immunol 2008, 15(6):916-924. 10.1128/CVI.00056-08, 2446621, 18400977.
23. Mustafa AS. Th1 cell reactivity and HLA-DR binding prediction for promiscuous recognition of MPT63 (Rv1926c), a major secreted protein of Mycobacterium tuberculosis. Scand J Immunol 2009, 69(3):213-222. 10.1111/j.1365-3083.2008.02221.x, 19281533.
24. Mustafa AS. In silico binding predictions for identification of HLA-DR-promiscuous regions and epitopes of Mycobacterium tuberculosis protein MPT64 (Rv1980c) and their recognition by human Th1 cells. Med Princ Pract 2010, 19(5):367-372. 10.1159/000316375, 20639660.
25. Gowthaman U, Agrewala JN. In silico methods for predicting T-cell epitopes: Dr Jekyll or Mr Hyde?. Expert Rev Proteomics 2009, 6(5):527-537. 10.1586/epr.09.71, 19811074.
26. Agrewala JN, Wilkinson RJ. Influence of HLA-DR on the phenotype of CD4+ T lymphocytes specific for an epitope of the 16-kDa alpha-crystallin antigen of Mycobacterium tuberculosis. Eur J Immunol 1999, 29(6):1753-1761. 10.1002/(SICI)1521-4141(199906)29:06<1753::AID-IMMU1753>3.0.CO;2-B, 10382737.
27. Gowthaman U, Agrewala JN. In silico tools for predicting peptides binding to HLA-class II molecules: more confusion than conclusion. J Proteome Res 2008, 7(1):154-163. 10.1021/pr070527b, 18034454.
28. Lin HH, Ray S, Tongchusak S, Reinherz EL, Brusic V. Evaluation of MHC class I peptide binding prediction servers: applications for vaccine research. BMC Immunology 2008, 9:8. 10.1186/1471-2172-9-8, 2323361, 18366636.
29. Lin HH, Zhang GL, Tongchusak S, Reinherz EL, Brusic V. Evaluation of MHC-II peptide binding prediction servers: applications for vaccine research. BMC Bioinformatics 2008, 9(Suppl 12):S22. 10.1186/1471-2105-9-S12-S22, 2638162, 19091022.
30. Nielsen M, Lundegaard C, Worning P, Hvid CS, Lamberth K, Buus S, Brunak S, Lund O. Improved prediction of MHC class I and class II epitopes using a novel Gibbs sampling approach. Bioinformatics 2004, 20(9):1388-1397. 10.1093/bioinformatics/bth100, 14962912.
31. Lima T, Auchincloss AH, Coudert E, Keller G, Michoud K, Rivoire C, Bulliard V, de Castro E, Lachaize C, Baratin D, et al. HAMAP: a database of completely sequenced microbial proteome sets and manually curated microbial protein families in UniProtKB/Swiss-Prot. Nucleic Acids Res 2009, (37 Database):D471-478.
32. Gasteiger E, Gattiker A, Hoogland C, Ivanyi I, Appel RD, Bairoch A. ExPASy: The proteomics server for in-depth protein knowledge and analysis. Nucleic Acids Res 2003, 31(13):3784-3788. 10.1093/nar/gkg563, 168970, 12824418.
33. The universal protein resource (UniProt). Nucleic Acids Res 2008, (36 Database):D190-195.
34. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ. Basic local alignment search tool. J Mol Biol 1990, 215(3):403-410.
35. Gowthaman U, Chodisetti SB, Parihar P, Agrewala JN. Evaluation of different generic in silico methods for predicting HLA class I binding peptide vaccine candidates using a reverse approach. Amino Acids 2010, 39(5):1333-1342. 10.1007/s00726-010-0579-2, 20379752.
36. Tong JC, Zhang GL, Tan TW, August JT, Brusic V, Ranganathan S. Prediction of HLA-DQ3.2beta ligands: evidence of multiple registers in class II binding peptides. Bioinformatics 2006, 22(10):1232-1238. 10.1093/bioinformatics/btl071, 16510499.
37. Harrison LC, Honeyman MC, Trembleau S, Gregori S, Gallazzi F, Augstein P, Brusic V, Hammer J, Adorini L. A peptide-binding motif for I-A(g7), the class II major histocompatibility complex (MHC) molecule of NOD and Biozzi AB/H mice. J Exp Med 1997, 185(6):1013-1021. 10.1084/jem.185.6.1013, 2196246, 9091575.
38. Casanova JL, Abel L. Genetic dissection of immunity to mycobacteria: the human model. Annu Rev Immunol 2002, 20:581-620. 10.1146/annurev.immunol.20.081501.125851, 11861613.
39. Bellamy R, Hill AV. Genetic susceptibility to mycobacteria and other infectious pathogens in humans. Curr Opin Immunol 1998, 10(4):483-487. 10.1016/S0952-7915(98)80125-8, 9722927.
40. Butler MH, Hayashi A, Ohkoshi N, Villmann C, Becker CM, Feng G, De Camilli P, Solimena M. Autoimmunity to gephyrin in Stiff-Man syndrome. Neuron 2000, 26(2):307-312. 10.1016/S0896-6273(00)81165-4, 10839351.
41. Lutton JD, Winston R, Rodman TC. Multiple sclerosis: etiological mechanisms and future directions. Exp Biol Med (Maywood) 2004, 229(1):12-20.
42. Wucherpfennig KW. Mechanisms for the induction of autoimmunity by infectious agents. J Clin Invest 2001, 108(8):1097-1104. 209539, 11602615.
43. Shoenfeld Y, Gilburd B, Abu-Shakra M, Amital H, Barzilai O, Berkun Y, Blank M, Zandman-Goddard G, Katz U, Krause I, et al. The mosaic of autoimmunity: genetic factors involved in autoimmune diseases--2008. Isr Med Assoc J 2008, 10(1):3-7.
44. Shoenfeld Y, Zandman-Goddard G, Stojanovich L, Cutolo M, Amital H, Levy Y, Abu-Shakra M, Barzilai O, Berkun Y, Blank M, et al. The mosaic of autoimmunity: hormonal and environmental factors involved in autoimmune diseases--2008. Isr Med Assoc J 2008, 10(1):8-12.
45. Kivity S, Agmon-Levin N, Blank M, Shoenfeld Y. Infections and autoimmunity--friends or foes?. Trends Immunol 2009, 30(8):409-414. 10.1016/j.it.2009.05.005, 19643667.
46. Fae KC, da Silva DD, Oshiro SE, Tanaka AC, Pomerantzeff PM, Douay C, Charron D, Toubert A, Cunningham MW, Kalil J, et al. Mimicry in recognition of cardiac myosin peptides by heart-intralesional T cell clones from rheumatic heart disease. J Immunol 2006, 176(9):5662-5670.
47. Oldstone MB. Molecular mimicry and immune-mediated diseases. Faseb J 1998, 12(13):1255-1265.
48. Fujinami RS, Oldstone MB. Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity. Science 1985, 230(4729):1043-1045. 10.1126/science.2414848, 2414848.
49. Sabater L, Gomez-Choco M, Saiz A, Graus F. BR serine/threonine kinase 2: a new autoantigen in paraneoplastic limbic encephalitis. J Neuroimmunol 2005, 170(1-2):186-190. 10.1016/j.jneuroim.2005.08.011, 16165222.
50. Sato S, Kuwana M, Hirakata M. Clinical characteristics of Japanese patients with anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibodies. Rheumatology (Oxford) 2007, 46(5):842-845.
51. Ohosone Y, Ishida M, Takahashi Y, Matsumura M, Hirakata M, Kawahara Y, Nishikawa T, Mimori T. Spectrum and clinical significance of autoantibodies against transfer RNA. Arthritis Rheum 1998, 41(9):1625-1631. 10.1002/1529-0131(199809)41:9<1625::AID-ART13>3.0.CO;2-D, 9751095.
52. Matsushita T, Hasegawa M, Fujimoto M, Hamaguchi Y, Komura K, Hirano T, Horikawa M, Kondo M, Orito H, Kaji K, et al. Clinical evaluation of anti-aminoacyl tRNA synthetase antibodies in Japanese patients with dermatomyositis. J Rheumatol 2007, 34(5):1012-1018.