Effective treatment of mouse sepsis with an inhibitory antibody targeting integrin αvβ5

Critical Care Medicine

Volumn 41, Issue 2, 2013, Pages 546-553

  Su, George ^a   Atakilit, Amha ^a   Li, John T ^a   Wu, Nanyan ^a   Luong, Jacky ^a   Chen, Robert ^a   Bhattacharya, Mallar ^a   Sheppard, Dean ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

antibody; endothelial cell; integrin; sepsis; therapy; transendothelial resistance; vascular leak

Indexed keywords

ALPHAVBETA5 INTEGRIN; IODINE 125; LIPOPOLYSACCHARIDE;

ANIMAL EXPERIMENT; ARTICLE; CECAL LIGATION AND PUNCTURE; CONTROLLED STUDY; EXTRAVASATION; FEMALE; HEMATOCRIT; HUMAN; HUMAN CELL; LEUKOCYTE MIGRATION; MICROVASCULAR ENDOTHELIAL CELL; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PUNCTURE; SEPSIS; UMBILICAL VEIN ENDOTHELIAL CELL; WILD TYPE;

ANIMALS; ANTIBODIES; CECUM; CELL MOVEMENT; CHEMOKINES; CYTOKINES; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; HUMANS; INJECTIONS, INTRAPERITONEAL; LEUKOCYTES; LIGATION; LIPOPOLYSACCHARIDES; MICE; MICE, 129 STRAIN; MICE, KNOCKOUT; PUNCTURES; RECEPTORS, VITRONECTIN; SEPSIS;

EID: 84873385175     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3182711b1e     Document Type: Article

References (39)

1. Angus DC, Linde-Zwirble WT, Lidicker J, et al: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29:1303-1310
2. Murphy SL: Deaths: Final data for 1998. Natl Vital Stat Rep 2000; 48:1-105
3. Martin GS, Mannino DM, Eaton S, et al: The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003; 348:1546-1554
4. Hotchkiss RS, Karl IE: The pathophysiology and treatment of sepsis. N Engl J Med 2003; 348:138-150
5. Michel CC: The transport of albumin: A critique of the vesicular system in transendothelial transport. Am Rev Respir Dis 1992; 146(5 Pt 2): S32-S36
6. Renkin EM: Capillary transport of macromolecules: Pores and other en-dothelial pathways. J Appl Physiol 1985; 58:315-325
7. Groeneveld AB: Vascular pharmacology of acute lung injury and acute respiratory distress syndrome. Vascul Pharmacol 2002; 39:247-256
8. Mura M, Dos Santos CC, Stewart D, et al: Vascular endothelial growth factor and related molecules in acute lung injury. J Appl Physiol 2004; 97:1605-1617
9. Bernard GR, Artigas A, Brigham KL, et al: The American-European Consensus Conference on ARDS. Defnitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994; 149(3 Pt 1): 818-824
10. Bernard GR, Artigas A, Brigham KL, et al: Report of the American-European consensus conference on ARDS: Defnitions, mechanisms, relevant outcomes and clinical trial coordination. The Consensus Committee. Intensive Care Med 1994; 20:225-232
11. Matthay MA, Zimmerman GA, Esmon C, et al: Future research direc-tionsin acute lung injury: Summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med 2003; 167:1027-1035
12. van Nieuw Amerongen G P, van Hinsbergh VW: Targets for pharmacological intervention of endothelial hyperpermeability and barrier function. Vascul Pharmacol 2002; 39:257-272
13. Garcia JG, Davis HW, Patterson CE: Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation. J Cell Physiol 1995; 163:510-522
14. Lum H, Malik AB: Regulation of vascular endothelial barrier function. Am J Physiol 1994; 267(3 Pt 1):L223-L241
15. Dudek SM, Garcia JG: Cytoskeletal regulation of pulmonary vascular permeability. J Appl Physiol 2001; 91:1487-1500
16. Lum H, Malik AB: Mechanisms of increased endothelial permeability. Can J Physiol Pharmacol 1996; 74:787-800
17. Lampugnani MG, Resnati M, Dejana E, et al: The role of integrins in the maintenance of endothelial monolayer integrity. J Cell Biol 1991; 112:479-490
18. Eliceiri BP, Puente XS, Hood JD, et al: Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. J Cell Biol 2002; 157:149-160
19. Su G, Hodnett M, Wu N, et al: Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function. Am J Respir Cell Mol Biol 2007; 36:377-386
20. Huang X, Griffths M, Wu J, et al: Normal development, wound healing, and adenovirus susceptibility in beta5-defcient mice. Mol Cell Biol 2000; 20:755-759
21. Baluk P, Thurston G, Murphy TJ, et al: Neurogenic plasma leakage in mouse airways. Br J Pharmacol 1999; 126:522-528
22. Rittirsch D, Huber-Lang MS, Flierl MA, et al: Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc 2009; 4:31-36
23. Manley MO, O'Riordan MA, Levine AD, et al: Interleukin 10 extends the effectiveness of standard therapy during late sepsis with serum interleukin 6 levels predicting outcome. Shock 2005; 23:521-526
24. Jaganathan BG, Ruester B, Dressel L, et al: Rho inhibition induces migration of mesenchymal stromal cells. Stem Cells 2007; 25:1966-1974
25. Gong P, Angelini DJ, Yang S, et al: TLR4 signaling is coupled to SRC family kinase activation, tyrosine phosphorylation of zonula adherens proteins, and opening of the paracellular pathway in human lung mi-crovascular endothelia. J Biol Chem 2008; 283:13437-13449
26. Kolosova IA, Mirzapoiazova T, Moreno-Vinasco L, et al: Protective effect of purinergic agonist ATPgammaS against acute lung injury. Am J Physiol Lung Cell Mol Physiol 2008; 294:L319-L324
27. Bogatcheva NV, Zemskova MA, Kovalenkov Y, et al: Molecular mechanisms mediating protective effect of cAMP on lipopolysaccharide (LPS)-induced human lung microvascular endothelial cells (HLMVEC) hyperpermeability. J Cell Physiol 2009; 221:750-759
28. Dinarello CA: Proinfammatory and anti-infammatory cytokines as mediators in the pathogenesis of septic shock. Chest 1997; 112(Suppl 6):321S-329S
29. Lubin FD, Segal M, McGee DW: Regulation of epithelial cell cytokine responses by the alpha3beta1 integrin. Immunology 2003; 108:204-210
30. Henderson RB, Lim LH, Tessier PA, et al: The use of lymphocyte function-associated antigen (LFA)-1-defcient mice to determine the role of LFA-1, Mac-1, and alpha4 integrin in the infammatory response of neutrophils. J Exp Med 2001; 194:219-226
31. Andrew DP, Spellberg JP, Takimoto H, et al: Transendothelial migration and traffcking of leukocytes in LFA-1-defcient mice. Eur J Immunol 1998; 28:1959-1969
32. Rosen H, Gordon S: Monoclonal antibody to the murine type 3 complement receptor inhibits adhesion of myelomonocytic cells in vitro and infammatory cell recruitment in vivo. J Exp Med 1987; 166:1685-1701
33. Riedemann NC, Guo R F, Ward PA: The enigma of sepsis. J Clin Invest 2003; 112:460-467
34. Riedemann NC, Guo R F, Ward PA: Novel strategies for the treatment of sepsis. Nat Med 2003; 9:517-524
35. Bernard GR, Vincent JL, Laterre PF, et al; Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group: Effca-cy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344:699-709
36. de Jong MD, Simmons CP, Thanh TT, et al: Fatal outcome of human infuenza A (H5N1) is associated with high viral load and hypercytokin-emia. Nat Med 2006; 12:1203-1207
37. Kobasa D, Jones SM, Shinya K, et al: Aberrant innate immune response in lethal infection of macaques with the 1918 infuenza virus. Nature 2007; 445:319-323
38. Villa P, Sartor G, Angelini M, et al: Pattern of cytokines and pharmaco-modulation in sepsis induced by cecal ligation and puncture compared with that induced by endotoxin. Clin Diagn Lab Immunol 1995; 2:549-553
39. Benjamim CF, Canetti C, Cunha FQ, et al: Opposing and hierarchical roles of leukotrienes in local innate immune versus vascular responses in a model of sepsis. J Immunol 2005; 174:1616-1620