Multiple functions of a glioblastoma fusion oncogene

Journal of Clinical Investigation

Volumn 123, Issue 2, 2013, Pages 548-551

  Babic, Ivan ^a   Mischel, Paul S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC TRIOXIDE; CRIZOTINIB; FIBROBLAST GROWTH FACTOR RECEPTOR 3; RETINOIC ACID;

3' UNTRANSLATED REGION; ALTERNATIVE RNA SPLICING; ANEUPLOIDY; BINDING SITE; CHROMOSOMAL INSTABILITY; CHROMOSOME TRANSLOCATION; COLON CARCINOMA; FUSION GENE; GENE FUSION; GLIOBLASTOMA; GLIOBLASTOMA FUSION ONCOGENE; HUMAN; LUNG NON SMALL CELL CANCER; ONCOGENE; PATHOGENICITY; PRIORITY JOURNAL; PROSTATE CANCER; REVIEW; RNA SEQUENCE; TUMOR GROWTH; UTERINE CERVIX CANCER;

ANIMALS; BRAIN NEOPLASMS; GENE FUSION; GLIOBLASTOMA; HUMANS; MALE; MICRORNAS; MICROTUBULE-ASSOCIATED PROTEINS; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 3;

EID: 84873336376     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI67658     Document Type: Review

References (21)

1. Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008;455(7216):1061-1068.
2. Parsons DW, et al. An integrated genomic analysis of human glioblastoma multiforme. Science. 2008;321(5897):1807-1812.
3. Verhaak RG, et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDG-FRA, IDH1, EGFR, and NF1. Cancer Cell. 2010;17(1):98-110.
4. Noushmehr H, et al. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell. 2010;17(5):510-522.
5. Sturm D, et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell. 2012;22(4):425-437.
6. Perrotti D, Jamieson C, Goldman J, Skorski T. Chronic myeloid leukemia: mechanisms of blastic transformation. J Clin Invest. 2010;120(7):2254-2264.
7. Lallemand-Breitenbach V, Zhu J, Chen Z, De Thé H. Curing APL through PML/RARA degradation by As2O3. Trends Mol Med. 2012;18(1):36-42.
8. Soda M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007;448(7153):561-566.
9. Gerber DE, Minna JD. ALK inhibition for nonsmall cell lung cancer: from discovery to therapy in record time. Cancer Cell. 2010;18(6):548-551.
10. Lessnick SL, Ladanyi M. Molecular pathogenesis of Ewing sarcoma: new therapeutic and transcriptional targets. Annu Rev Pathol. 2012;7:145-159.
11. Prensner JR, Chinnaiyan AM. Oncogenic gene fusions in epithelial carcinomas. Curr Opin Genet Dev. 2009;19(1):82-91.
12. Parker BC, et al. The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma. J Clin Invest. 2013;123(2):855-865.
13. Singh D, et al. Transforming fusions of FGFR and TACC genes in human glioblastoma. Science. 2012;337(6099):1231-1235.
14. Cappellen D, et al. Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas. Nat Genet. 1999;23(1):18-20.
15. Eswarakumar VP, Lax I, Schlessinger J. Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev. 2005;16(2):139-149.
16. Fenton TR, et al. Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. Proc Natl Acad Sci U S A. 2012;109(35):14164-14169.
17. Gergely F, Kidd D, Jeffers K, Wakefield JG, Raff JW. D-TACC: a novel centrosomal protein required for normal spindle function in the early Drosophila embryo. EMBO J. 2000;19(2):241-252.
18. Still IH, Vince P, Cowell JK. The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines. Genomics. 1999;58(2):165-170.
19. Fabian MR, Sonenberg N, Filipowicz W. Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem. 2010;79:351-379.
20. Mayr C, Bartel DP. Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. Cell. 2009;138(4):673-684.
21. Sandberg R, Neilson JR, Sarma A, Sharp PA, Burge CB. Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites. Science. 2008;320(5883):1643-1647.