Immunoproteomic analysis of potential serum biomarker candidates in human glaucoma

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 13, 2012, Pages 8222-8231

  Tezel, Gülgün ^a   Thornton, Ivey L ^a,b   Tong, Melissa G ^a,b   Luo, Cheng ^a   Yang, Xiangjun ^a   Cai, Jian ^a   Powell, David W ^a   Soltau, Joern B ^a,b   Liebmann, Jeffrey M ^c   Ritch, Robert ^c  

^a University of Louisville School of Medicine   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c NEW YORK EYE AND EAR INFIRMARY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; BIOLOGICAL MARKER; CRYOPYRIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DYNEIN ADENOSINE TRIPHOSPHATASE; EPHRIN RECEPTOR A1; HUNTINGTIN; IMMUNOGLOBULIN G; NERVE CELL ADHESION MOLECULE;

AGED; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GLAUCOMA; HUMAN; IMMUNOBLOTTING; IMMUNOREACTIVITY; ION TRAP MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEOMICS; UPREGULATION;

AGED; ANIMALS; AUTOANTIBODIES; AUTOANTIGENS; BIOLOGICAL MARKERS; BLOOD PROTEINS; CHROMATOGRAPHY, LIQUID; COCULTURE TECHNIQUES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EYE PROTEINS; GLAUCOMA, OPEN-ANGLE; HUMANS; IMMUNOBLOTTING; IMMUNOGLOBULIN G; INTRAOCULAR PRESSURE; MIDDLE AGED; OXIDATIVE STRESS; PROTEOMICS; RATS; TANDEM MASS SPECTROMETRY;

EID: 84873333565     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-10076     Document Type: Article

References (67)

1. Tezel G. Immune regulation towards immunomodulation for neuroprotection in glaucoma. Curr Opin Pharmacol. In press.
2. Maruyama I, Ohguro H, Ikeda Y. Retinal ganglion cells recognized by serum autoantibody against gamma-enolase found in glaucoma patients. Invest Ophthalmol Vis Sci. 2000;41:1657-1665.
3. Tezel G, Wax MB. Glaucoma. Chem Immunol Allergy. 2007;92:221-227.
4. Reichelt J, Joachim SC, Pfeiffer N, Grus FH. Analysis of autoantibodies against human retinal antigens in sera of patients with glaucoma and ocular hypertension. Curr Eye Res. 2008;33:253-261.
5. Dervan EW, Chen H, Ho SL, et al. Protein macroarray profiling of serum autoantibodies in pseudoexfoliation glaucoma. Invest Ophthalmol Vis Sci. 2010;51:2968-2975.
6. Tezel G. The role of glia, mitochondria, and the immune system in glaucoma. Invest Ophthalmol Vis Sci. 2009;50:1001-1012.
7. Joachim SC, Grus FH, Kraft D, et al. Complex antibody profile changes in an experimental autoimmune glaucoma animal model. Invest Ophthalmol Vis Sci. 2009;50:4734-4742.
8. Wax MB, Tezel G, Edward PD. Clinical and ocular histopathological findings in a patient with normal-pressure glaucoma. Arch Ophthalmol. 1998;116:993-1001.
9. Tezel G, Wax MB. The mechanisms of hsp27 antibody-mediated apoptosis in retinal neuronal cells. J Neurosci. 2000;20:3552-3562.
10. Laspas P, Gramlich OW, Muller HD, et al. Autoreactive antibodies and loss of retinal ganglion cells in rats induced by immunization with ocular antigens. Invest Ophthalmol Vis Sci. 2011;52:8835-8848.
11. Joachim SC, Gramlich OW, Laspas P, et al. Retinal ganglion cell loss is accompanied by antibody depositions and increased levels of microglia after immunization with retinal antigens. PLoS One. 2012;7:e40616.
12. Ding QJ, Cook AC, Dumitrescu AV, Kuehn MH. Lack of immunoglobulins does not prevent C1q binding to RGC and does not alter the progression of experimental glaucoma. Invest Ophthalmol Vis Sci. 2012;53:6370-6377.
13. Coutinho A, Kazatchkine MD, Avrameas S. Natural autoantibodies. Curr Opin Immunol. 1995;7:812-818.
14. Shoenfeld Y, Toubi E. Protective autoantibodies: role in homeostasis, clinical importance, and therapeutic potential. Arthritis Rheum. 2005;52:2599-2606.
15. Wax MB, Tezel G, Yang J, et al. Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand. J Neurosci. 2008;28:12085-12096.
16. Joachim SC, Wax MB, Seidel P, Pfeiffer N, Grus FH. Enhanced characterization of serum autoantibody reactivity following HSP 60 immunization in a rat model of experimental autoimmune glaucoma. Curr Eye Res. 2010;35:900-908.
17. Boehm N, Wolters D, Thiel U, et al. New insights into autoantibody profiles from immune privileged sites in the eye: a glaucoma study. Brain Behav Immun. 2011;26:96-102.
18. Wax MB, Tezel G, Kawase K, Kitazawa Y. Serum autoantibodies to heat shock proteins in glaucoma patients from Japan and the United States. Ophthalmology. 2001;108:296-302.
19. Grus FH, Joachim SC, Bruns K, Lackner KJ, Pfeiffer N, Wax MB. Serum autoantibodies to alpha-fodrin are present in glaucoma patients from Germany and the United States. Invest Ophthalmol Vis Sci. 2006;47:968-976.
20. Tezel G, Yang X, Luo C, et al. Hemoglobin expression and regulation in glaucoma: insights into retinal ganglion cell oxygenation. Invest Ophthalmol Vis Sci. 2010;51:907-919.
21. Tezel G, Yang X, Luo C, et al. Oxidative stress and the regulation of complement activation in human glaucoma. Invest Ophthalmol Vis Sci. 2010;51:5071-5082.
22. Luo C, Yang X, Kain AD, Powell DW, Kuehn MH, Tezel G. Glaucomatous tissue stress and the regulation of immune response through glial toll-like receptor signaling. Invest Ophthalmol Vis Sci. 2010;51:5697-5707.
23. Yang X, Luo C, Cai J, et al. Neurodegenerative and inflammatory pathway components linked to TNF-alpha/TNFR1 signaling in the glaucomatous human retina. Invest Ophthalmol Vis Sci. 2011;52: 8442-8454.
24. Keller A, Nesvizhskii AI, Kolker E, Aebersold R. Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search. Anal Chem. 2002;74:5383-5392.
25. Nesvizhskii AI, Keller A, Kolker E, Aebersold R. A statistical model for identifying proteins by tandem mass spectrometry. Anal Chem. 2003;75:4646-4658.
26. Powell DW, Weaver CM, Jennings JL, et al. Cluster analysis of mass spectrometry data reveals a novel component of SAGA. Mol Cell Biol. 2004;24:7249-7259.
27. Tezel G, Wax MB. Increased production of tumor necrosis factoralpha by glial cells exposed to simulated ischemia or elevated hydrostatic pressure induces apoptosis in cocultured retinal ganglion cells. J Neurosci. 2000;20:8693-8700.
28. Tezel G, Yang X, Luo C, Peng Y, Sun SL, Sun D. Mechanisms of immune system activation in glaucoma: oxidative stress-stimulated antigen presentation by the retina and optic nerve head glia. Invest Ophthalmol Vis Sci. 2007;48:705-714.
29. Davies MJ, Fu S, Wang H, Dean RT. Stable markers of oxidant damage to proteins and their application in the study of human disease. Free Radic Biol Med. 1999;27:1151-1163.
30. Houde D, Kauppinen P, Mhatre R, Lyubarskaya Y. Determination of protein oxidation by mass spectrometry and method transfer to quality control. J Chromatogr A. 2006;1123:189-198.
31. Fedorova M, Kuleva N, Hoffmann R. Identification of cysteine, methionine and tryptophan residues of actin oxidized in vivo during oxidative stress. J Proteome Res. 2010;9:1598-1609.
32. Stadtman ER, Moskovitz J, Levine RL. Oxidation of methionine residues of proteins: biological consequences. Antioxid Redox Signal. 2003;5:577-582.
33. Davies MJ. The oxidative environment and protein damage. Biochim Biophys Acta. 2005;1703:93-109.
34. Long LH, Wu PF, Guan XL, et al. Determination of protein-bound methionine oxidation in the hippocampus of adult and old rats by LC-ESI-ITMS method after microwave-assisted proteolysis. Anal Bioanal Chem. 2011;399:2267-2274.
35. Desmetz C, Maudelonde T, Mange A, Solassol J. Identifying autoantibody signatures in cancer: a promising challenge. Expert Rev Proteomics. 2009;6:377-386.
36. Georgieva Y, Konthur Z. Design and screening of M13 phage display cDNA libraries. Molecules. 2011;16:1667-1681.
37. Kim Y, Caberoy NB, Alvarado G, Davis JL, Feuer WJ, Li W. Identification of Hnrph3 as an autoantigen for acute anterior uveitis. Clin Immunol. 2011;138:60-66.
38. Duan X, Xue P, Wang N, Dong Z, Lu Q, Yang F. Proteomic analysis of aqueous humor from patients with primary open angle glaucoma. Mol Vis. 2010;16:2839-2846.
39. Bouhenni RA, Al Shahwan S, Morales J, et al. Identification of differentially expressed proteins in the aqueous humor of primary congenital glaucoma. Exp Eye Res. 2011;92:67-75.
40. Matt P, Fu Z, Fu Q, Van Eyk JE. Biomarker discovery: proteome fractionation and separation in biological samples. Physiol Genomics. 2008;33:12-17.
41. Hanash SM, Pitteri SJ, Faca VM. Mining the plasma proteome for cancer biomarkers. Nature. 2008;452:571-579.
42. Anderson L, Hunter CL. Quantitative mass spectrometric multiple reaction monitoring assays for major plasma proteins. Mol Cell Proteomics. 2006;5:573-588.
43. Tezel G, Yang X. Caspase-independent component of retinal ganglion cell death, in vitro. Invest Ophthalmol Vis Sci. 2004;45:4049-4059.
44. McKinnon SJ, Lehman DM, Tahzib NG, et al. Baculoviral IAP repeatcontaining-4 protects optic nerve axons in a rat glaucoma model. Mol Ther. 2002;5:780-787.
45. Martin KR, Quigley HA, Valenta D, Kielczewski J, Pease ME. Optic nerve dynein motor protein distribution changes with intraocular pressure elevation in a rat model of glaucoma. Exp Eye Res. 2006;83: 255-262.
46. Schmidt JF, Agapova OA, Yang P, Kaufman PL, Hernandez MR. Expression of ephrinB1 and its receptor in glaucomatous optic neuropathy. Br J Ophthalmol. 2007;91:1219-1224.
47. Ricard CS, Pena JD, Hernandez MR. Differential expression of neural cell adhesion molecule isoforms in normal and glaucomatous human optic nerve heads. Brain Res Mol Brain Res. 1999;74:69-82.
48. Agapova OA, Kaufman PL, Hernandez MR. Androgen receptor and NFkB expression in human normal and glaucomatous optic nerve head astrocytes in vitro and in experimental glaucoma. Exp Eye Res. 2006;82:1053-1059.
49. Pupjalis D, Goetsch J, Kottas DJ, Gerke V, Rescher U. Annexin A1 released from apoptotic cells acts through formyl peptide receptors to dampen inflammatory monocyte activation via JAK/STAT/SOCS signalling. EMBO Mol Med. 2011;3:102-114.
50. Zhang Z, Huang L, Zhao W, Rigas B. Annexin 1 induced by antiinflammatory drugs binds to NF-kappaB and inhibits its activation: anticancer effects in vitro and in vivo. Cancer Res. 2010;70:2379-2388.
51. Kretz CC, Norpo M, Abeler-Dorner L, et al. Anti-annexin 1 antibodies: a new diagnostic marker in the serum of patients with discoid lupus erythematosus. Exp Dermatol. 2010;19:919-921.
52. Li GY, Osborne NN. Oxidative-induced apoptosis to an immortalized ganglion cell line is caspase independent but involves the activation of poly(ADP-ribose)polymerase and apoptosis-inducing factor. Brain Res. 2008;1188:35-43.
53. Munemasa Y, Kitaoka Y, Kuribayashi J, Ueno S. Modulation of mitochondria in the axon and soma of retinal ganglion cells in a rat glaucoma model. J Neurochem. 2010;115:1508-1519.
54. Chen L, Lukas TJ, Hernandez MR. Hydrostatic pressure-dependent changes in cyclic AMP signaling in optic nerve head astrocytes from Caucasian and African American donors. Mol Vis. 2009;15:1664-1672.
55. Meyer-Franke A, Kaplan MR, Pfrieger FW, Barres BA. Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture. Neuron. 1995;15:805-819.
56. Oh H, Kim H, Ahn M, et al. Immunohistochemical localization of cyclic AMP-responsive element binding protein (CREB)-binding protein in the pig retina during postnatal development. Anat Cell Biol. 2011;44:143-150.
57. Mali RS, Zhang XM, Chintala SK. A decrease in phosphorylation of cAMP-response element-binding protein (CREBP) promotes retinal degeneration. Exp Eye Res. 2011;92:528-536.
58. Goldshmit Y, McLenachan S, Turnley A. Roles of Eph receptors and ephrins in the normal and damaged adult CNS. Brain Res Rev. 2006; 52:327-345.
59. Bevins N, Lemke G, Reber M. Genetic dissection of EphA receptor signaling dynamics during retinotopic mapping. J Neurosci. 2011;31: 10302-10310.
60. Dunmire JJ, Bouhenni R, Hart ML, et al. Novel serum proteomic signatures in a non-human primate model of retinal injury. Mol Vis. 2011;17:779-791.
61. Cattaneo E, Zuccato C, Tartari M. Normal huntingtin function: an alternative approach to Huntington's disease. Nat Rev Neurosci. 2005;6:919-930.
62. Li XJ, Li S. Proteasomal dysfunction in aging and Huntington disease. Neurobiol Dis. 2011;43:4-8.
63. Helmlinger D, Yvert G, Picaud S, et al. Progressive retinal degeneration and dysfunction in R6 Huntington's disease mice. Hum Mol Genet. 2002;11:3351-3359.
64. Yang J, Yang P, Tezel G, Patil RV, Hernandez MR, Wax MB. Induction of HLA-DR expression in human lamina cribrosa astrocytes by cytokines and simulated ischemia. Invest Ophthalmol Vis Sci. 2001; 42:365-371.
65. Tezel G, Luo C, Yang X. Accelerated aging in glaucoma: immunohistochemical assessment of advanced glycation end products in the human retina and optic nerve head. Invest Ophthalmol Vis Sci. 2007; 48:1201-1211.
66. Tezel G. The immune response in glaucoma: a perspective on the roles of oxidative stress. Exp Eye Res. 2011;93:178-186.
67. Tezel G, Yang X, Cai J. Proteomic identification of oxidatively modified retinal proteins in a chronic pressure-induced rat model of glaucoma. Invest Ophthalmol Vis Sci. 2005;46:3177-3187.