Acute mitochondrial inhibition by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) 1/2 inhibitors regulates proliferation

Journal of Biological Chemistry

Volumn 288, Issue 5, 2013, Pages 2933-2940

  Ripple, Maureen O ^a   Kim, Namjoon ^a   Springett, Roger ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPROLIFERATIVE EFFECT; DOSE-DEPENDENT; ELECTRON TRANSPORT CHAIN; HEME OXIDATION; LIVING CELL; METABOLIC ANALYSIS; MITOCHONDRIAL FUNCTION; MITOCHONDRIAL METABOLISM; MITOGEN ACTIVATED PROTEIN KINASE; ORALLY ACTIVE; OXIDATION STATE; OXYGEN CONSUMPTION; REAL TIME; SIGNAL-REGULATED KINASE; SIGNALING PATHWAYS; SMALL MOLECULES; UNCOUPLERS;

METABOLISM; PHOSPHORYLATION; PORPHYRINS;

ENZYMES;

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; HEME; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE KINASE INHIBITOR I; OXYGEN; PROTEIN SERINE THREONINE KINASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; MITOCHONDRION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN DEPLETION;

BUTADIENES; CELL PROLIFERATION; CYTOCHROMES C; ELECTRON TRANSPORT; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HL-60 CELLS; HUMANS; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NITRILES; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS;

EID: 84873315908     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.430082     Document Type: Article

References (41)

1. Hanahan, D., and Weinberg, R. A. (2000) The hallmarks of cancer. Cell 100, 57-70
2. Shaw, R. J., and Cantley, L. C. (2006) Ras, PI (3) K and mTOR signalling control tumour cell growth. Nature 441, 424-430
3. Frémin, C., and Meloche, S. (2010) From basic research to clinical development of MEK1/2 inhibitors for cancer therapy. J. Hematol. Oncol. 3, 8
4. Roberts, P. J., and Der, C. J. (2007) Targeting the Raf-MEK-ERK mitogenactivated protein kinase cascade for the treatment of cancer. Oncogene 26, 3291-3310
5. Sebolt-Leopold, J. S. (2008) Advances in the development of cancer therapeutics directed against the RAS-mitogen-activated protein kinase pathway. Clin. Cancer Res. 14, 3651-3656
6. Pagès, G., Lenormand, P., L'Allemain, G., Chambard, J. C., Meloche, S., and Pouysségur, J. (1993) Mitogen-activated protein kinases p42MAPK and p44 MAPK are required for fibroblast proliferation. Proc. Natl. Acad. Sci. U. S. A. 90, 8319-8323
7. Osborne, J. K., Zaganjor, E., and Cobb, M. H. (2012) Signal control through Raf: in sickness and in health. Cell Res. 22, 14-22
8. Paz, C., Poderoso, C., Maloberti, P., Cornejo Maciel, F., Mendez, C., Poderoso, J. J., and Podestá, E. J. (2009) Detection of a mitochondrial kinase complex that mediates PKA-MEK-ERK-dependent phosphorylation of mitochondrial proteins involved in the regulation of steroid biosynthesis. Methods Enzymol. 457, 169-192
9. Liu, X., Yan, S., Zhou, T., Terada, Y., and Erikson, R. L. (2004) The MAP kinase pathway is required for entry into mitosis and cell survival. Oncogene 23, 763-776
10. Steelman, L. S., Franklin, R. A., Abrams, S. L., Chappell, W., Kempf, C. R., Bäsecke, J., Stivala, F., Donia, M., Fagone, P., Nicoletti, F., Libra, M., Ruvolo, P., Ruvolo, V., Evangelisti, C., Martelli, A. M., and McCubrey, J. A. (2011) Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy. Leukemia 25, 1080-1094
11. Berra, E., Pagès, G., and Pouysségur, J. (2000) MAP kinases and hypoxia in the control of VEGF expression. Cancer Metastasis Rev. 19, 139-145
12. Meloche, S., and Pouysségur, J. (2007) The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1 to S phase transition. Oncogene 26, 3227-3239
13. Klesse, L. J., Meyers, K. A., Marshall, C. J., and Parada, L. F. (1999) Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells. Oncogene 18, 2055-2068
14. Newbern, J. M., Li, X., Shoemaker, S. E., Zhou, J., Zhong, J., Wu, Y., Bonder, D., Hollenback, S., Coppola, G., Geschwind, D. H., Landreth, G. E., and Snider, W. D. (2011) Specific functions for ERK/MAPK signaling during PNS development. Neuron 69, 91-105
15. 2. Role in cell survival following oxidant injury. J. Biol. Chem. 271, 4138-4142
16. Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., Davis, N., Dicks, E., Ewing, R., Floyd, Y., Gray, K., Hall, S., Hawes, R., Hughes, J., Kosmidou, V., Menzies, A., Mould, C., Parker, A., Stevens, C., Watt, S., Hooper, S., Wilson, R., Jayatilake, H., Gusterson, B. A., Cooper, C., Shipley, J., Hargrave, D., Pritchard-Jones, K., Maitland, N., Chenevix-Trench, G., Riggins, G. J., Bigner, D. D., Palmieri, G., Cossu, A., Flanagan, A., Nicholson, A., Ho, J. W., Leung, S. Y., Yuen, S. T., Weber, B. L., Seigler, H. F., Darrow, T. L., Paterson, H., Marais, R., Marshall, C. J., Wooster, R., Stratton, M. R., and Futreal, P. A. (2002) Mutations of the BRAF genein human cancer. Nature 417, 949-954
17. Brose, M. S., Volpe, P., Feldman, M., Kumar, M., Rishi, I., Gerrero, R., Einhorn, E., Herlyn, M., Minna, J., Nicholson, A., Roth, J. A., Albelda, S. M., Davies, H., Cox, C, Brignell, G., Stephens, P., Futreal, P. A., Wooster, R., Stratton, M. R., and Weber, B. L. (2002) BRAF and RAS mutations in human lung cancer and melanoma. Cancer Res. 62, 6997-7000
18. Morgan, M. A., Dolp, O., and Reuter, C. W. (2001) Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling. Blood 97, 1823-1834
19. Milella, M., Kornblau, S. M., Estrov, Z., Carter, B. Z., Lapillonne, H., Harris, D., Konopleva, M., Zhao, S., Estey, E., and Andreeff, M. (2001) Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia. J. Clin. Invest. 108, 851-859
20. Collins, S. J. (1987) The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. Blood 70, 1233-1244
21. Hollis, V. S., Palacios-Callender, M., Springett, R. J., Delpy, D. T., and Moncada, S. (2003) Monitoring cytochrome redox changes in the mitochondria of intact cells using multi-wavelength visible light spectroscopy. Biochim. Biophys. Acta 1607, 191-202
22. Haller, T., Ortner, M., and Gnaiger, E. (1994) A respirometer for investigating oxidative cell metabolism: toward optimization of respiratory studies. Anal. Biochem. 218, 338-342
23. Kim, N, Ripple, M. O., and Springett, R. (2011) Spectral components of the a-band of cytochrome oxidase. Biochim. Biophys. Acta 1807, 779-787
24. Yu, L., Xu, J. X., Haley, P. E., and Yu, C. A. (1987) Properties of bovine heart mitochondrial cytochrome b560. J. Biol. Chem. 262, 1137-1143
25. Dokladda, K., Green, K. A., Pan, D. A., and Hardie, D. G. (2005) PD98059 and U0126 activate AMP-activated protein kinase by increasing the cellular AMPATP ratio and not via inhibition of the MAP kinase pathway. FEBSLett. 579, 236-240
26. Degli Esposti, M. (1998) Inhibitors of NADH-ubiquinone reductase: an overview. Biochim. Biophys. Acta 1364, 222-235
27. Wortzel, I., and Seger, R. (2011) The ERK cascade: distinct functions within various subcellular organelles. Genes Cancer 2, 195-209
28. Nowak, G., Clifton, G. L., Godwin, M. L., and Bakajsova, D. (2006) Activation of ERK1/2 pathway mediates oxidant-induced decreases in mitochondrial function in renal cells. Am. J. Physiol. Renal. Physiol. 291, F840-855
29. Becker, T., Böttinger, L., and Pfanner, N. (2012) Mitochondrial protein import: from transport pathways to an integrated network. Trends Biochem. Sci. 37, 85-91
30. Efremov, R. G., Baradaran, R., and Sazanov, L. A. (2010) The architecture of respiratory complex I. Nature 465, 441-445
31. Papa, S., Sardanelli, A. M., Scacco, S., Petruzzella, V., Technikova-Dobrova, Z., Vergari, R., and Signorile, A. (2002) The NADH: ubiquinone oxidoreductase (complex I) of the mammalian respiratory chain and the cAMP cascade. J. Bioenerg. Biomembr. 34, 1-10
32. Chen, R., Fearnley, I. M., Peak-Chew, S. Y., and Walker, J. E. (2004) The phosphorylation of subunits of complex I from bovine heart mitochondria. J. Biol. Chem. 279, 26036-26045
33. Schilling, B., Bharath, M. M. S., Row, R. H., Murray, J., Cusack, M. P., Capaldi, R. A., Freed, C. R., Prasad, K. N, Andersen, J. K., and Gibson, B. W. (2005) Rapid purification and mass spectrometric characterization of mitochondrial NADH dehydrogenase (complex I) from rodent brain and a dopaminergic neuronal cell line. Mol. Cell. Proteomics. 4, 84-96
34. Steinlechner-Maran, R., Eberl, T., Kunc, M., Margreiter, R., and Gnaiger, E. (1996) Oxygen dependence of respiration in coupled and uncoupled endothelial cells. Am. J. Physiol. 271, C2053-2061
35. Kim, N, Ripple, M. O., and Springett, R. (2012) Measurement of the mitochondrial membrane potential and pH gradient from the redox Poise of the hemes of the bc1 complex. Biophys. J. 102, 1194-1203
36. Ripple, M. O., Kalmadi, S., and Eastman, A. (2005) Inhibition of either phosphatidylinositol 3-kinase/Akt or the mitogen/extracellular-regulated kinase, MEK/ERK, signaling pathways suppress growth of breast cancer cell lines, but MEK/ERK signaling is critical for cell survival. Breast Cancer Res. Treat. 93, 177-188
37. De Silva, D. R., Jones, E. A., Favata, M. F., Jaffee, B. D., Magolda, R. L., Trzaskos, J. M., and Scherle, P. A. (1998) Inhibition of mitogen-activated protein kinase kinase blocks T cell proliferation but does not induce or prevent anergy. J. Immunol. 160, 4175-4181
38. Bost, F., McKay, R., Dean, N., and Mercola, D. (1997) The JUN kinase/stress-activated protein kinase pathway is required for epidermal growth factor stimulation of growth of human A549 lung carcinoma cells. J. Biol. Chem. 272, 33422-33429
39. Hotokezaka, H., Sakai, E., Kanaoka, K., Saito, K., Matsuo, K., Kitaura, H., Yoshida, N., and Nakayama, K. (2002) U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells. J. Biol. Chem. 277, 47366-47372
40. Gysin, S., Lee, S. H., Dean, N. M., and McMahon, M. (2005) Pharmacologic inhibition of RAF3MEK3ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1. Cancer Res. 65, 4870-4880
41. Beloueche-Babari, M., Jackson, L. E., Al-Saffar, N. M., Workman, P., Leach, M. O., and Ronen, S. M. (2005) Magnetic resonance spectroscopy monitoring of mitogen-activated protein kinase signaling inhibition. Cancer Res. 65, 3356-3363