Identification of RNF8 as a ubiquitin ligase involved in targeting the p12 subunit of DNA polymerase 8 for degradation in response to DNA damage

Journal of Biological Chemistry

Volumn 288, Issue 5, 2013, Pages 2941-2950

  Zhang, Sufang ^a   Zhou, Yajing ^a   Sarkeshik, Ali ^b   Yates III, John R ^b   Thomson, Timothy M ^c   Zhang, Zhongtao ^a   Lee, Ernest Y C ^a   Lee, Marietta Y W T ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CLASSICAL APPROACH; CULTURED HUMAN CELL; DNA DAMAGE RESPONSE; DNA DAMAGES; DNA POLYMERASE; EPITHELIAL CELLS; HELA CELL; IN-VIVO; PROTEASOMAL DEGRADATION; PROTEOMIC ANALYSIS; RING FINGER; SIGNALING PATHWAYS; UBIQUITIN LIGASES; UBIQUITIN-CONJUGATING ENZYMES;

BIODEGRADATION; DNA; PURIFICATION;

DAMAGE DETECTION;

DNA DIRECTED DNA POLYMERASE DELTA P12; NUCLEOTIDYLTRANSFERASE; RING FINGER PROTEIN 8; SHORT HAIRPIN RNA; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME PURIFICATION; EPITHELIUM CELL; GENE SILENCING; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; PROTEOMICS; UBIQUITINATION;

ANIMALS; DNA DAMAGE; DNA POLYMERASE III; DNA-BINDING PROTEINS; HALF-LIFE; HELA CELLS; HISTONES; HUMANS; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; POLYUBIQUITIN; PROTEIN TRANSPORT; PROTEOLYSIS; RECOMBINANT FUSION PROTEINS; RNA, SMALL INTERFERING; SUBCELLULAR FRACTIONS; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION; ULTRAVIOLET RAYS;

EID: 84873298852     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.423392     Document Type: Article

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