Genotoxic and inflammatory effects of organic extracts from traffic-related particulate matter in human lung epithelial A549 cells: The role of quinones

Toxicology in Vitro

Volumn 27, Issue 2, 2013, Pages 922-931

  Shang, Yu ^a   Fan, Lanlan ^a   Feng, Jialiang ^a   Lv, Senlin ^a   Wu, Minghong ^a   Li, Bing ^b   Zang, Yuan Sheng ^b  

^a SHANGHAI UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cytokines chemokines; DNA damage; Inflammation; Quinones; ROS formation; Traffic related particles

Indexed keywords

1,4 NAPHTHOQUINONE; ANTHRAQUINONE; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; QUINONE DERIVATIVE; RANTES; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYP1A1 GENE; CYP1B1 GENE; CYTOKINE RELEASE; DNA DAMAGE; DRUG CYTOTOXICITY; EPITHELIUM CELL; EXHAUST GAS; GENE EXPRESSION; GENOTOXICITY; HUMAN; HUMAN CELL; INFLAMMATION; INTERLEUKIN 6 GENE; INTERLEUKIN 8 GENE; MCP 1 GENE; MEMBRANE DAMAGE; OXIDATIVE STRESS; PARTICULATE MATTER; RANTES GENE; TUMOR NECROSIS FACTOR GENE; UPREGULATION;

AIR POLLUTANTS; ANTHRAQUINONES; CELL LINE, TUMOR; CELL SURVIVAL; COMET ASSAY; CYTOKINES; DNA DAMAGE; EPITHELIAL CELLS; HUMANS; L-LACTATE DEHYDROGENASE; LUNG; NAPHTHOQUINONES; PARTICULATE MATTER; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; VEHICLE EMISSIONS;

EID: 84873296130     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2013.01.008     Document Type: Article

References (45)

1. An J., Yin L., Shang Y., Zhong Y., Zhang X., Wu M., Yu Z., Sheng G., Fu J., Huang Y. The combined effects of BDE47 and BaP on oxidatively generated NDA damage in LO2 cells and the possible molecular mechanism. Mutat. Res. 2011, 721:192-198.
2. Andrysík Z., Vondráček J., Marvanová S., Ciganek M., Neča J., Pěnčíková K., Mahadevan B., Topinka J., Baird W.M., Kozubík A., Machala M. Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: the role of polycyclic aromatic hydrocarbons. Mutat. Res. 2011, 714:53-62.
3. Baulig A., Poirault J.J., Ausset P., Schins R., Shi T., Baralle D., Dorlhene P., Meyer M., Lefevre R., Baeza-Squiban A., Marano F. Physicochemical characteristics and biological activities of seasonal atmospheric particulate matter sampling in two locations of Paris. Environ. Sci. Technol. 2004, 38:5985-5992.
4. Bisset L.R., Schmid-Grendelmeier P. Chemokines and their receptors in the pathogenesis of allergic asthma: process and perspective. Curr. Opin. Pulm. Med. 2005, 11:35-42.
5. Bolton J.L., Trush M.A., Penning T.M., Dryhurst G., Monks T.J. Role of quinones in toxicology. Chem. Res. Toxicol. 2000, 13:135-160.
6. Brunekreef B., Holgate S.T. Air pollution and health. Lancet 2002, 360:1233-1242.
7. Canepari S., Perrino C., Olivieri F., Astolfi M.L. Characterization of the traffic sources of PM through size-segregated sampling, sequential leaching and ICP analysis. Atmos. Environ. 2008, 42:8161-8175.
8. Chen R., Kan H., Chen B., Huang W., Bai Z., Song G., Pan G., on Behalf of the CAPES Collaborative Group Association of particulate air pollution with daily mortality: the china air pollution and health effects study. Am. J. Epidemiol. 2012, 175:1173-1181.
9. 2.5. Aerosol Sci. Technol. 2004, 38:68-81.
10. Chung S.W., Chung H.Y., Toriba A., Kameda T., Tang N., Kizu R., Hayakawa K. An environmental quinoid polycyclic aromatic hydrocarbon, acenaphthenequinone, modulates cyclooxygenase-2 expression through reactive oxygen species generation and nuclear factor kappa β activation in A549 cells. Toxicol. Sci. 2007, 95:348-355.
11. Collins A.R. The comet assay for DNA damage and repair: principles, applications, and limitations. Mol. Biotechnol. 2004, 26:249-261.
12. de Kok T.M., Driece H.A., Hogervorst J.G., Briedé J.J. Toxicological assessment of ambient and traffic-related particulate matter: a review of recent studies. Mutat. Res. 2006, 613:103-122.
13. Eiguren-Fernandez A., Miguel A.H., Di Stefano E., Schmitz D.A., Cho A.K., Thurairatnam S., Froines J.R. Atmospheric distribution of gas- and particle-phase quinones in Southern California. Aerosol Sci. Technol. 2008, 42:854-861.
14. 2.5 at Changdao Island, China - a rural site in the transport path of the Asian continental outflow. Atmos. Environ. 2007, 41:1924-1935.
15. 2.5 during the 2009 Chinese New Year's holiday in Shanghai. Atmos. Res. 2012, 118:435-444.
16. Foster K.A., Oster C.G., Mayer M.M., Avery M.L., Audus K.L. Characterization of the A549 cell line as a type II pulmonary epithelial cell model for drug metabolism. Exp. Cell Res. 1998, 243:359-366.
17. González-Flecha B. Oxidant mechanisms in response to ambient air particles. Mol. Aspects. Med. 2004, 25:169-182.
18. 2.5) cause mitotic arrest and cell death: effects on DNA, mitochondria, AhR binding and spindle organization. Mutat. Res. 2011, 713:18-31.
19. 2.5. Toxicol. Lett. 2012, 209:136-145.
20. Haarmann-Stemmann T., Bothe H., Abel J. Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways. Biochem. Pharmacol. 2009, 77:508-520.
21. Jalava P.I., Salonen R.O., Pennanen A.S., Happo M.S., Penttinen P., Hälinen A.I., Sillanpää M., Hillamo R., Hirvonen M.R. Effects of solubility of urban air fine and coarse particles on cytotoxic and inflammatory responses in RAW264.7 macrophage cell line. Toxicol. Appl. Pharmacol. 2008, 229:146-160.
22. Klaus V., Hartmann T., Gambini J., Graf P., Stahl W., Hartwig A., Klotz L.O. 1,4-Naphthoquinones as inducers of oxidative damage and stress signaling in HaCaT human keratinocytes. Arch. Biochem. Biophys. 2010, 496:93-100.
23. Kreider M.L., Panko J.M., McAtee B.L., Sweet L.I., Finley B.L. Physical and chemical characterization of tire-related particles: comparison of particles generated using different methodologies. Sci. Total Environ. 2010, 408:652-659.
24. Kumar M.R.S., Aithal K., Rao B.N., Udupa N., Rao B.S.S. Cytotoxic, genotoxic and oxidative stress induced by 1,4-naphthoquinone in B16F1 melanoma tumor cells. Toxicol. In Vitro 2009, 23:242-250.
25. Li N., Xia T., Nel A.E. The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles. Free Radic. Biol. Med. 2008, 44:1689-1699.
26. Li N., Harkema J.R., Lewandowski R.P., Wang M.Y., Bramble L.A., Gookin G.R., Ning Z., Kleinman M.T., Sioutas C., Nel A.E. Ambient ultrafine particles provide a strong adjuvant effect in the secondary immune response: implication for traffic-related asthma flares. Am. J. Physiol. Lung Cell Mol. Physiol. 2010, 299:L374-L383.
27. Li Y., Zhu T., Zhao J., Xu B. Interactive enhancements of ascorbic acid and iron in hydroxyl radical generation in quinone redox cycling. Environ. Sci. Technol. 2012, 46:10302-10309.
28. Maier K.L., Alessandrini F., Beck-Speier I., Hofer T.P., Diabaté S., Bitterle E., Stöger T., Jakob T., Behrendt H., Horsch M., Beckers J., Ziesenis A., Hültner L., Frankenberger M., Krauss-Etschmann S., Schulz H. Health effects of ambient particulate matter - biological mechanisms and inflammatory responses to in vitro and in vivo particle exposures. Inhal. Toxicol. 2008, 20:319-337.
29. Mantecca P., Farina F., Moschini E., Gallinotti D., Gualtieri M., Rohr A., Sancini G., Palestini P., Camatini M. Comparative acute lung inflammation induced by atmospheric PM and size-fractionated tire particles. Toxicol. Lett. 2010, 198:244-254.
30. Nebert D.W., Dalton T.P., Okey A.B., Gonzalez F.J. Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. J. Biol. Chem. 2004, 279:23847-23850.
31. Oda J., Nomura S., Yasuhara A., Shibamoto T. Mobile sources of atmospheric polycyclic aromatic hydrocarbons in a roadway tunnel. Atmos. Environ. 2001, 3:4819-4827.
32. Øvrevik J., Arlt V.M., Øya E., Nagy E., Mollerup S., Phillips D.H., Låg M., Holme J.A. Differential effects of nitro-PAHs and amino-PAHs on cytokine and chemokine responses in human bronchial epithelial BEAS-2B cells. Toxicol. Appl. Pharmacol. 2010, 242:270-280.
33. Pöschl U. Atmospheric aerosols: composition, transformation, climate and health effects. Angew. Chem. Int. Ed. Engl. 2005, 44:7520-7540.
34. Roosbroeck S.V., Hoek G., Meliefste K., Janssen N.A.H., Brunekreef B. Validity of residential traffic intensity as an estimate of long-term personal exposure to traffic-related air pollution among adults. Environ. Sci. Technol. 2008, 42:1337-1344.
35. Salam M.T., Islam T., Gilliland F.D. Recent evidence for adverse effects of residential proximity to traffic sources on asthma. Curr. Opin. Pulm. Med. 2008, 14:3-8.
36. Shang Y., Chen C., Li Y., Zhao J., Zhu T. Hydroxyl radical generation mechanism during the redox cycling process of 1,4-naphthoquinone. Environ. Sci. Technol. 2012, 46:2935-2942.
37. Siraki A.G., Chan T.S., O'Brien P.J. Application of quantitative structure-toxicity relationships for the comparison of the cytotoxicity of 14 p-benzoquinone congeners in primary cultured rat hepatocytes versus PC12 cells. Toxicol. Sci. 2004, 81:148-159.
38. Spira-Cohen A., Chen L.C., Kendall M., Sheesley R., Thurston G.D. Personal exposures to traffic-related particle pollution among children with asthma in the South Bronx, NY. J. Expo. Sci. Environ. Epidemiol. 2010, 20:446-456.
39. Tice R.R., Agurell E., Anderson D., Burlinson B., Hartmann A., Kobayashi H., Miyamae Y., Rojas E., Ryu J.C., Sasaki Y.F. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen. 2000, 35:206-221.
40. Tsai P.Y., Ka S.M., Chao T.K., Chang J.M., Lin S.H., Li C.Y., Kuo M.T., Chen P., Chen A. Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice. Free Radic. Biol. Med. 2011, 50:1503-1516.
41. Vinzents P.S., Møller P., Sørensen M., Knudsen L.E., Hertel O., Jensen F.P., Schibye B., Loft S. Personal exposure to ultrafine particles and oxidative DNA damage. Environ. Health Perspect. 2005, 113:1485-1490.
42. Walgraeve C., Demeestere K., Dewulf J., Zimmermann R., Langenhove H.V. Oxygenated polycyclic aromatic hydrocarbons in atmospheric particulate matter: molecular characterization and occurrence. Atmos. Environ. 2010, 44:1831-1846.
43. Wei Y., Han I., Hu M., Shao M., Zhang J., Tang X. Personal exposure to particulate PAHs and anthraquinone and oxidative DNA damages in humans. Chemosphere 2010, 81:1280-1285.
44. Weldy C.S., Wilkerson H.-W., Larson T.V., Stewart J.A., Kavanagh T.J. Diesel particulate exposed macrophages alter endothelial cell expression of eNOS, iNOS, MCP1, and glutathione synthesis genes. Toxicol. In Vitro 2011, 25:2064-2073.
45. Zhang P., Wen Y., An J., Yu Y.-X., Wu M.-H., Zhang X.-Y. DNA damage induced by three major metabolites of 1,3-butadiene in human hepatocyte L02 cells. Mutat. Res. 2012, 747:240-245.