Development, validation and pilot screening of an in vitro multi-cellular three-dimensional cancer spheroid assay for anti-cancer drug testing

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 4, 2013, Pages 922-931

  Lama, Rati ^a   Zhang, Lin ^a   Naim, Janine M ^a   Williams, Jennifer ^a   Zhou, Aimin ^a   Su, Bin ^a  

^a CLEVELAND STATE UNIVERSITY   (United States)

Author keywords

2D monolayer; 3D spheroid; Anti cancer; Drug discovery

Indexed keywords

ANTINEOPLASTIC AGENT; COLCHICINE; INDIBULIN; N [2 [(4 HYDROXYPHENYL)AMINO] 3 PYRIDINYL] 4 METHOXYBENZENESULFONAMIDE; PACLITAXEL; TUBULIN INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL ASSAY; CELL PROLIFERATION; CELL STRAIN H292; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATIONAL STUDY; COST EFFECTIVENESS ANALYSIS; DRUG EFFICACY; DRUG POTENCY; DRUG RESEARCH; DRUG SCREENING; DRUG STRUCTURE; IC 50; IN VITRO STUDY; INCUBATION TIME; LUNG NON SMALL CELL CANCER; MONOLAYER CULTURE; MULTICELLULAR SPHEROID; MULTICELLULAR THREE DIMENSIONAL CANCER SPHEROID ASSAY; PILOT STUDY; STANDARDIZATION; TUMOR SPHEROID; VALIDATION PROCESS;

ANTINEOPLASTIC AGENTS; CELL CULTURE TECHNIQUES; CELL SURVIVAL; DRUG EVALUATION, PRECLINICAL; HUMANS; KINETICS; PACLITAXEL; SPHEROIDS, CELLULAR; SULFONAMIDES; TUBULIN MODULATORS; TUMOR CELLS, CULTURED;

EID: 84873291429     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.12.007     Document Type: Article

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