Synthesis, characterization and target protein binding of drug-conjugated quantum dots in vitro and in living cells

Nanotechnology

Volumn 24, Issue 7, 2013, Pages

  Choi, Youngseon ^a   Kim, Minjung ^a   Cho, Yoojin ^a   Yun, Eunsuk ^a   Song, Rita ^a  

^a Institute Pasteur Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AGAROSE GEL ELECTROPHORESIS; ANTICANCER DRUG; BIO-IMAGING; CELL BIOLOGY; CELLULAR LEVELS; CELLULAR UPTAKE; CHEMICAL BIOLOGY; CHO CELL; COLOCALIZATION; DIHYDROFOLATE REDUCTASE; DISTRIBUTION PATTERNS; DRUG ACTION; DRUG DISCOVERY; ENDOSOMES; FLUORESCENT PROBES; HIGH AFFINITY BINDING; IN-VITRO; LIVING CELL; MODEL DRUGS; SPECIFIC INTERACTION; TARGET PROTEINS;

BIOCHEMISTRY; CELLS; CYTOLOGY; DRUG PRODUCTS; ELECTROPHORESIS; FLUORESCENCE MICROSCOPY; MOLECULAR BIOLOGY; PROTEINS; SEMICONDUCTOR QUANTUM DOTS;

BIOSYNTHESIS;

DIHYDROFOLATE REDUCTASE; METHOTREXATE; POLYMER; QUANTUM DOT;

ANIMAL; ARTICLE; CELL SURVIVAL; CHEMISTRY; CHO CELL; CRICETULUS; DRUG EFFECT; ENDOCYTOSIS; ENZYMOLOGY; ESCHERICHIA COLI; GEL MOBILITY SHIFT ASSAY; HAMSTER; METABOLISM; PROTEIN BINDING; ULTRAVIOLET SPECTROPHOTOMETRY;

ANIMALS; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENDOCYTOSIS; ESCHERICHIA COLI; METHOTREXATE; POLYMERS; PROTEIN BINDING; QUANTUM DOTS; SPECTROPHOTOMETRY, ULTRAVIOLET; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 84873289030     PISSN: 09574484     EISSN: 13616528     Source Type: Journal    
DOI: 10.1088/0957-4484/24/7/075101     Document Type: Article

References (39)

1. Rajendran L, Knoelker H-J and Simons K 2010 Subcellular targeting strategies for drug design and delivery Nature Rev. Drug Discov. 9 29-42
2. Rudin M and Weissleder R 2003 Molecular imaging in drug discovery and development Nature Rev. Drug Discov. 2 123-31 (Pubitemid 37361644)
3. Giepmans B N G, Adams S R, Ellisman M H and Tsien R Y 2006 The fluorescent toolbox for assessing protein location and function Science 312 217-24
4. Miller L W and Cornish V W 2005 Selective chemical labeling of proteins in living cells Curr. Opin. Chem. Biol. 9 56-61 (Pubitemid 40208625)
5. Zhang Y, Chen W, Feng D, Shi W, Li X and Ma H 2012 A spectroscopic off-on probe for simple and sensitive detection of carboxylesterase activity and its application to cell imaging Analyst 137 716-21
6. Kim T I, Park J, Park S, Choi Y and Kim Y 2011 Visualization of tyrosinase activity in melanoma cells by a BODIPY-based fluorescent probe Chem. Commun. 47 12640-2
7. Jaiswal J K, Mattoussi H, Mauro J M and Simon S M 2003 Long-term multiple color imaging of live cells using quantum dot bioconjugates Nature Biotechnol. 21 47-51 (Pubitemid 36055826)
8. Alivisatos P 2004 The use of nanocrystals in biological detection Nature Biotechnol. 22 47-52 (Pubitemid 38057955)
9. Michalet X, Pinaud F F, Bentolila L A, Tsay J M, Doose S, Li J J, Sundaresan G, Wu A M, Gambhir S S and Weiss S 2005 Quantum dots for live cells, in vivo imaging, and diagnostics Science 307 538-44 (Pubitemid 40165671)
10. Hild W A, Breunig M and Goepferich A 2008 Quantum dots - nano-sized probes for the exploration of cellular and intracellular targeting Eur. J. Pharm. Biopharm. 68 153-68
11. Lidke D S, Nagy P, Heintzmann R, Arndt-Jovin D J, Post J N, Grecco H E, Jares-Erijman E A and Jovin T M 2004 Quantum dot ligands provide new insights into erbB/HER receptor-mediated signal transduction Nature Biotechnol. 22 198-203 (Pubitemid 38160535)
12. Lee J, Choi Y, Kim K, Hong S, Park H Y, Lee T, Cheon G J and Song R 2010 Characterization and cancer cell specific binding properties of anti-EGFR antibody conjugated quantum dots Bioconjug. Chem. 21 940-6
13. Choi Y, Kim K, Hong S, Kim H, Kwon Y-J and Song R 2011 Intracellular protein target detection by quantum dots optimized for live cell imaging Bioconjug. Chem. 22 1576-86
14. Kim M J, Lee J Y, Nehrbass U, Song R and Choi Y 2012 Detection of melanoma using antibody-conjugated quantum dots in a coculture model for high-throughput screening system Analyst 137 1440-5
15. Doane T L and Burda C 2012 The unique role of nanoparticles in nanomedicine: imaging, drug delivery and therapy Chem. Soc. Rev. 41 2885-911
16. Rosenthal S J, Tomlinson A, Adkins E M, Schroeter S, Adams S, Swafford L, McBride J, Wang Y Q, DeFelice L J and Blakely R D 2002 Targeting cell surface receptors with ligand-conjugated nanocrystals J. Am. Chem. Soc. 124 4586-94 (Pubitemid 34464996)
17. Gussin H A, Tomlinson I D, Little D M, Warnement M R, Qian H H, Rosenthal S J and Pepperberg D R 2006 Binding of muscimol-conjugated quantum dots to GABA(c) receptors J. Am. Chem. Soc. 128 15701-13 (Pubitemid 44894111)
18. Byrne S J et al 2007 Synthesis, characterisation, and biological studies of CdTe quantum dot-naproxen conjugates ChemMedChem. 2 183-6
19. Clarke S J, Hollmann C A, Zhang Z J, Suffern D, Bradforth S E, Dimitrijevic N M, Minarik W G and Nadeau J L 2006 Photophysics of dopamine-modified quantumdots and effects on biological systems Nature Mater. 5 409-17
20. Freeman R, Bahshi L, Finder T, Gill R and Willner I 2009 Competitive analysis of saccharides or dopamine by boronic acid-functionalized CdSe-ZnS quantum dots Chem. Commun. 7 764-6
21. Kovtun O, Tomlinson I D, Sakrikar D S, Chang J C, Blakely R D and Rosenthal S J 2011 Visualization of the cocaine-sensitive dopamine transporter with ligand-conjugated quantum dots ACS Chem. Neurosci. 2 370-8
22. Rajagopalan P T R, Zhang Z Q, McCourt L, Dwyer M, Benkovic S J and Hammes G G 2002 Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics Proc. Natl Acad. Sci. USA 99 13481-6 (Pubitemid 35215407)
23. Cayley P J, Dunn S M J and King R W 1981 Kinetics of substrate, coenzyme, and inhibitor binding to Escherichia-coli dihydrofolate-reductase Biochemistry 20 874-9 (Pubitemid 11097550)
24. Sawaya M R and Kraut J 1997 Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence Biochemistry 36 586-603 (Pubitemid 27057006)
25. Appleman J R, Prendergast N, Delcamp T J, Freisheim J H and Blakley R L 1988 Kinetics of the formation and isomerization of methotrexate complexes of recombinant human dihydrofolate-reductase J. Biol. Chem. 263 10304-13
26. Choi Y, Kim H P, Hong S M, Ryu J Y, Han S J and Song R 2009 In situ visualization of gene expression using polymer-coated quantum-dot-DNA conjugates Small 5 2085-91
27. Kono K, Liu M J and Frechet J M J 1999 Design of dendritic macromolecules containing folate or methotrexate residues Bioconjug. Chem. 10 1115-21
28. Majoros I J, Thomas T P, Mehta C B and Baker J R Jr 2005 Poly(amidoamine) dendrimer-based multifunctional engineered nanodevice for cancer therapy J. Med. Chem. 48 5892-9 (Pubitemid 41324600)
29. Gurdag S, Khandare J, Stapels S, Matherly L H and Kannan R M 2006 Activity of dendrimer-methotrexate conjugates on methotrexate-sensitive and -resistant cell lines Bioconjug. Chem. 17 275-83
30. Delcamp T J, Susten S S, Blankenship D T and Freisheim J H 1983 Purification and characterization of dihydrofolate-reductase from methotrexate-resistant human-lymphoblastoid cells Biochemistry 22 633-9 (Pubitemid 13158106)
31. Bentzen E L, Tomlinson I D, Mason J, Gresch P, Warnement M R, Wright D, Sanders-Bush E, Blakely R and Rosenthal S J 2005 Surface modification to reduce nonspecific binding of quantum dots in live cell assays Bioconjug. Chem. 16 1488-94 (Pubitemid 41681516)
32. Chang E, Yu W W, Colvin V L and Drezek R 2005 Quantifying the influence of surface coatings on quantum dot uptake in cells J. Biomed. Nanotechnol. 1 397-401
33. Antony A C 1992 The biological chemistry of folate receptors Blood 79 2807-20
34. Li M-H, Choi S K, Thomas T P, Desai A, Lee K-H, Kotlyar A, Holl M M B and Baker J R Jr 2012 Dendrimer-based multivalent methotrexates as dual acting nanoconjugates for cancer cell targeting Eur. J. Med. Chem. 47 560-72
35. Remy I, Wilson I A and Michnick S W 1999 Erythropoietin receptor activation by a ligand-induced conformation change Science 283 990-3 (Pubitemid 29100257)
36. Remy I and Michnick S W 2001 Visualization of biochemical networks in living cells Proc. Natl Acad. Sci. USA 98 7678-83 (Pubitemid 32642620)
37. Shin J S and Abraham S N 2001 Cell biology - Caveolae - not just craters in the cellular landscape Science 293 1447-8 (Pubitemid 32801540)
38. Anderson R G W 1998 The caveolae membrane system Annu. Rev. Biochem. 67 199-225 (Pubitemid 28411129)
39. Uga H, Kuramori C, Tsuboi Y, Tanaka H, Hatakeyama H, Yamaguchi Y, Takahashi T, Kizaki M and Handa H 2006 A new mechanism of methotrexate action revealed by target screening with affinity beads Mol. Pharmacol. 70 1832-9