Production of α-cuprenene in Xanthophyllomyces dendrorhous: A step closer to a potent terpene biofactory

Microbial Cell Factories

Volumn 12, Issue 1, 2013, Pages

  Melillo, Elena ^a   Setroikromo, Rita ^a   Quax, Wim J ^a   Kayser, Oliver ^b  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b TU DORTMUND UNIVERSITY   (Germany)

Author keywords

cuprenene; Escherichia coli; Metabolic engineering; Saccharomyces cerevisiae; Terpene cell factory; Xanthophyllomyces dendrorhous

Indexed keywords

ALPHA CUPRENENE; ASTAXANTHIN; GENOMIC DNA; RIBOSOME DNA; TERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; COP6 GENE; CULTURE MEDIUM; ESCHERICHIA COLI; FUNGAL GENE; FUNGAL STRAIN; FUNGUS GROWTH; FUNGUS MUTANT; GENE EXPRESSION; GROWTH CURVE; NONHUMAN; SACCHAROMYCES CEREVISIAE; XANTHOPHYLLOMYCES DENDRORHOUS; YEAST;

BASIDIOMYCOTA; ESCHERICHIA COLI; FUNGAL PROTEINS; METABOLIC ENGINEERING; SACCHAROMYCES CEREVISIAE; SESQUITERPENES;

COPRINOPSIS CINEREA; ESCHERICHIA COLI; FUNGI; SACCHAROMYCES CEREVISIAE; XANTHOPHYLLOMYCES DENDRORHOUS;

EID: 84873263109     PISSN: None     EISSN: 14752859     Source Type: Journal    
DOI: 10.1186/1475-2859-12-13     Document Type: Article

References (17)

1. Chou WK, Fanizza I, Uchiyama T, Komatsu M, Ikeda H, Cane DE. Genome mining in Streptomyces avermitilis: cloning and characterization of SAV_76, the synthase for a new sesquiterpene, avermitilol. J Am Chem Soc 2010, 132(26):8850-8851. 10.1021/ja103087w, 2904616, 20536237.
2. Feng Z, Kim JH, Brady SF. Fluostatins produced by the heterologous expression of a TAR reassembled environmental DNA derived type II PKS gene cluster. J Am Chem Soc 2010, 132(34):11902-11903. 10.1021/ja104550p, 2930618, 20690632.
3. Berger RG. Biotechnology of flavours-the next generation. Biotechnol Lett 2009, 31(11):1651-1659. 10.1007/s10529-009-0083-5, 19609491.
4. Linger JG, Adney WS, Darzins A. Heterologous expression and extracellular secretion of cellulolytic enzymes by Zymomonas mobilis. Appl Environ Microbiol 2010, 76(19):6360-6369. 10.1128/AEM.00230-10, 2950452, 20693448.
5. Wen F, Sun J, Zhao H. Yeast surface display of trifunctional minicellulosomes for simultaneous saccharification and fermentation of cellulose to ethanol. Appl Environ Microbiol 2010, 76(4):1251-1260. 10.1128/AEM.01687-09, 2820948, 20023102.
6. Kenny ST, Runic JN, Kaminsky W, Woods T, Babu RP, Keely CM, Blau W, O'Connor KE. Up-cycling of PET (polyethylene terephthalate) to the biodegradable plastic PHA (polyhydroxyalkanoate). Environ Sci Technol 2008, 42(20):7696-7701. 10.1021/es801010e, 18983095.
7. Westfall PJ, Pitera DJ, Lenihan JR, Eng D, Woolard FX, Regentin R, Horning T, Tsuruta H, Melis DJ, Owens A, Fickes S, Diola D, Benjamin KR, Keasling JD, Leavell MD, McPhee DJ, Renninger NS, Newman JD, Paddon CJ. Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin. Proc Natl Acad Sci USA 2012, 109(3):E111-8. 10.1073/pnas.1110740109, 3271868, 22247290.
8. Ajikumar PK, Xiao WH, Tyo KE, Wang Y, Simeon F, Leonard E, Mucha O, Phon TH, Pfeifer B, Stephanopoulos G. Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli. Science 2010, 330(6000):70-74. 10.1126/science.1191652, 3034138, 20929806.
9. Nielsen J, Keasling JD. Synergies between synthetic biology and metabolic engineering. Nat Biotechnol 2011, 29(8):693-695. 10.1038/nbt.1937, 21822239.
10. Schmidt I, Schewe H, Gassel S, Jin C, Buckingham J, Humbelin M, Sandmann G, Schrader J. Biotechnological production of astaxanthin with Phaffia rhodozyma/Xanthophyllomyces dendrorhous. Appl Microbiol Biotechnol 2011, 89(3):555-571. 10.1007/s00253-010-2976-6, 21046372.
11. Muntendam R, Melillo E, Ryden A, Kayser O. Perspectives and limits of engineering the isoprenoid metabolism in heterologous hosts. Appl Microbiol Biotechnol 2009, 84(6):1003-1019. 10.1007/s00253-009-2150-1, 19669755.
12. Melillo E, Muntendam R, Quax WJ, Kayser O. Heterologous expression of pentalenene synthase (PSS) from Streptomyces UC5319 in Xanthophyllomyces dendrorhous. J Biotechnol 2012, 161:302-307. 10.1016/j.jbiotec.2012.05.024, 22771888.
13. Agger S, Lopez-Gallego F, Schmidt-Dannert C. Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus. Mol Microbiol 2009, 72(5):1181-1195. 10.1111/j.1365-2958.2009.06717.x, 2723806, 19400802.
14. Newman JD, Marshall J, Chang M, Nowroozi F, Paradise E, Pitera D, Newman KL, Keasling JD. High-level production of amorpha-4,11-diene in a two-phase partitioning bioreactor of metabolically engineered Escherichia coli. Biotechnol Bioeng 2006, 95(4):684-91. 10.1002/bit.21017, 16878333.
15. Nobbs AH, Vickerman MM, Jenkinson HF. Heterologous expression of Candida albicans cell wall-associated adhesins in Saccharomyces cerevisiae Reveals differential specificities in adherence and biofilm formation and in binding oral Streptococcus gordonii. Eukaryot Cell 2010, 9(10):1622-1634. 10.1128/EC.00103-10, 2950433, 20709785.
16. Niklitschek M, Alcaino J, Barahona S, Sepulveda D, Lozano C, Carmona M, Marcoleta A, Martinez C, Lodato P, Baeza M, Cifuentes V. Genomic organization of the structural genes controlling the astaxanthin biosynthesis pathway of Xanthophyllomyces dendrorhous. Biol Res 2008, 41(1):93-108.
17. Dinh TN, Nagahisa K, Hirasawa T, Furusawa C, Shimizu H. Adaptation of Saccharomyces cerevisiae cells to high ethanol concentration and changes in fatty acid composition of membrane and cell size. PLoS One 2008, 3(7):e2623. 10.1371/journal.pone.0002623, 2440543, 18612424.