Blockade of GABAA receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo- pituitary-adrenal response to hypoglycemia

Diabetes

Volumn 55, Issue 4, 2006, Pages 1080-1087

  Chan, Owen ^a   Zhu, Wanling ^a   Ding, Yuyan ^a   McCrimmon, Rory J ^a   Sherwin, Robert S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

aECF artificial extracellular fluid; GABA aminobutyric acid; HPA, hypothalmo pituitary adrenal; KATP channel, ATP sensitve K+ channel; VMH, ventromedial hypothalamus

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; ADRENALIN; BICUCULLINE METHIODIDE; CORTICOSTERONE; GLUCAGON; GLUCOSE; INSULIN; MUSCIMOL; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; BICUCULLINE; NORADRENALIN;

ADRENALIN BLOOD LEVEL; ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; GABAERGIC SYSTEM; GLUCAGON RELEASE; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE INFUSION; HYPERINSULINEMIA; HYPOGLYCEMIA; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; INSULIN BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ZONA INCERTA; ANIMAL; BLOOD; DRUG EFFECT; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; KINETICS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SECRETION; SPRAGUE DAWLEY RAT;

ANIMALS; BICUCULLINE; BLOOD GLUCOSE; CORTICOSTERONE; EPINEPHRINE; GABA ANTAGONISTS; GLUCAGON; GLUCOSE CLAMP TECHNIQUE; HYPOGLYCEMIA; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; KINETICS; MALE; MUSCIMOL; NOREPINEPHRINE; PITUITARY-ADRENAL SYSTEM; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; VENTROMEDIAL HYPOTHALAMIC NUCLEUS;

EID: 33745327159     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/diabetes.55.04.06.db05-0958     Document Type: Article

References (51)

1. Cryer PE: Glucose counterregulation: prevention and correction of hypoglycemia in humans. Am J Physiol 264:E149-E155, 1993
2. Cryer PE: Banting Lecture: Hypoglycemia: the limiting factor in the management of IDDM. Diabetes 43:1378-1389, 1994[Abstract]
3. Cryer PE: Hypoglycaemia: the limiting factor in the glycaemic management of type I and type II diabetes. Diabetologia 45:937-948, 2002
4. Gerich JE, Mokan M, Veneman T, Korytkowski M, Mitrakou A: Hypoglycemia unawareness. Endocrine Rev 12:356-371, 1991[Abstract]
5. Donovan CM: Portal vein glucose sensing. Diabetes Nutr Metab 15:308-312, 2002
6. Hevener AL, Bergman RN, Donovan CM: Novel glucosensor for hypoglycemic detection localized to the portal vein. Diabetes 46:1521-1525, 1997[Abstract]
7. Hevener AL, Bergman RN, Donovan CM: Portal vein afferents are critical for the sympathoadrenal response to hypoglycemia. Diabetes 49:8-12, 2000[Abstract]
8. Garcia-Fernandez M, Ortega-Saenz P, Pardal R, Lopez-Barneo J: Glucose sensing cells in the carotid body. Adv Exp Med Biol 536:47-53, 2003
9. Lopez-Barneo J: Oxygen and glucose sensing by carotid body glomus cells. Curr Opin Neurobiol 13:493-499, 2003
10. Pardal R, Lopez-Barneo J: Low glucose-sensing cells in the carotid body. Nat Neurosci 5:197-198, 2002
11. Borg MA, Sherwin RS, Borg WP, Tamborlane WV, Shulman GI: Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats. J Clin Invest 99:361-365, 1997 [Abstract/Free Full Text]
12. Borg MA, Borg WP, Tamborlane WV, Brines ML, Shulman GI, Sherwin RS: Chronic hypoglycemia and diabetes impair counterregulation induced by localized 2-deoxyglucose perfusion of the ventromedial hypothalamus in rats. Diabetes 48:584-587, 1999[Abstract]
13. Dunn-Meynell AA, Govek E, Levin BE: Intracarotid glucose selectively increases Fos-like immunoreactivity in paraventricular, ventromedial and dorsomedial nuclei neurons. Brain Res 748:100-106, 1997
14. Frizzell RT, Jones EM, Davis SN, Biggers DW, Myers SR, Connolly CC, Neal DW, Jaspan JB, Cherrington AD: Counterregulation during hypoglycemia is directed by widespread brain regions. Diabetes 42:1253-1261, 1993 [Abstract]
15. Mobbs CV, Kow LM, Yang XJ: Brain glucose-sensing mechanisms: ubiquitous silencing by aglycemia vs. hypothalamic neuroendocrine responses. Am J Physiol Endocrinol Metab 281:E649-E654, 2001[Abstract/Free Full Text]
16. Ritter S, Dinh TT, Zhang Y: Localization of hindbrain glucoreceptive sites controlling food intake and blood glucose. Brain Res 856:37-47, 2000
17. Sanders NM, Ritter S: Repeated 2-deoxy-D-glucose-induced glucoprivation attenuates Fos expression and glucoregulatory responses during subsequent glucoprivation. Diabetes 49:1865-1874, 2000[Abstract]
18. Song Z, Levin BE, McArdle JJ, Bakhos N, Routh VH: Convergence of pre- and postsynaptic influences on glucosensing neurons in the ventromedial hypothalamic nucleus. Diabetes 50:2673-2681, 2001[Abstract/Free Full Text]
19. Wang R, Liu X, Hentges ST, Dunn-Meynell AA, Levin BE, Wang W, Routh VH: The regulation of glucose-excited neurons in the hypothalamic arcuate nucleus by glucose and feeding-relevant peptides. Diabetes 53:1959-1965, 2004[Abstract/Free Full Text]
20. Borg MA, Tamborlane WV, Shulman GI, Sherwin RS: Local lactate perfusion of the ventromedial hypothalamus suppresses hypoglycemic counterregulation. Diabetes 52:663-666, 2003[Abstract/Free Full Text]
21. Evans ML, McCrimmon RJ, Flanagan DE, Keshavarz T, Fan X, McNay EC, Jacob RJ, Sherwin RS: Hypothalamic ATP-sensitive K+ channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses. Diabetes 53:2542-2551, 2004[Abstract/Free Full Text]
22. McCrimmon RJ, Fan X, Ding Y, Zhu W, Jacob RJ, Sherwin RS: Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus. Diabetes 53:1953-1958, 2004[Abstract/Free Full Text]
23. Miki T, Liss B, Minami K, Shiuchi T, Saraya A, Kashima Y, Horiuchi M, Ashcroft F, Minokoshi Y, Roeper J, Seino S: ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis. Nat Neurosci 4:507-512, 2001
24. Schuit FC, Huypens P, Heimberg H, Pipeleers DG: Glucose sensing in pancreatic β-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus. Diabetes 50:1-11, 2001[Abstract/Free Full Text]
25. Kang L, Routh VH, Kuzhikandathil EV, Gaspers LD, Levin BE: Physiological and molecular characteristics of rat hypothalamic ventromedial nucleus glucosensing neurons. Diabetes 53:549-559, 2004[Abstract/Free Full Text]
26. Tappaz ML, Brownstein MJ, Kopin IJ: Glutamate decarboxylase (GAD) and gamma-aminobutyric acid (GABA) in discrete nuclei of hypothalamus and substantia nigra. Brain Res 125:109-121, 1977
27. McCann SM, Rettori V: Gamma amino butyric acid (GABA) controls anterior pituitary hormone secretion. Adv Biochem Psychopharmacol 42:173-189, 1986
28. Narita K, Nishihara M, Takahashi M: Concomitant regulation of running activity and metabolic change by the ventromedial nucleus of the hypothalamus. Brain Res 642:290-296, 1994
29. Nonogaki K, Iguchi A, Sakamoto N: Bicuculline methiodide influences the central nervous system to produce hyperglycemia in rats. J Neuroendocrinol 6:443-446, 1994
30. Soltis RP, DiMicco JA: Interaction of hypothalamic GABAA and excitatory amino acid receptors controlling heart rate in rats. Am J Physiol 261:R427-R433, 1991
31. During MJ, Leone P, Davis KE, Kerr D, Sherwin RS: Glucose modulates rat substantia nigra GABA release in vivo via ATP-sensitive potassium channels. J Clin Invest 95:2403-2408, 1995
32. Beverly JL, de Vries MG, Beverly MF, Arseneau LM: Norepinephrine mediates glucoprivic-induced increase in GABA in the ventromedial hypothalamus of rats. Am J Physiol Regul Integr Comp Physiol 279:R990-R996, 2000 [Abstract/Free Full Text]
33. Beverly JL, de Vries MG, Bouman SD, Arseneau LM: Noradrenergic and GABAergic systems in the medial hypothalamus are activated during hypoglycemia. Am J Physiol Regul Integr Comp Physiol 280:R563-R569, 2001 [Abstract/Free Full Text]
34. Giordano R, Grottoli S, Brossa P, Pellegrino M, Destefanis S, Lanfranco F, Gianotti L, Ghigo E, Arvat E: Alprazolam (a benzodiazepine activating GABA receptor) reduces the neuroendocrine responses to insulin-induced hypoglycaemia in humans. Clin Endocrinol (Oxf) 59:314-320, 2003
35. Van Vugt DA, Washburn DL, Farley AE, Reid RL: Hypoglycemia-induced inhibition of LH and stimulation of ACTH secretion in the rhesus monkey is blocked by alprazolam. Neuroendocrinology 65:344-352, 1997
36. Smith D, Pernet A, Rosenthal JM, Bingham EM, Reid H, Macdonald IA, Amiel SA: The effect of modafinil on counter-regulatory and cognitive responses to hypoglycaemia. Diabetologia 47:1704-1711, 2004
37. Beverly JL, Beverly MF, Meguid,MM: Alterations in extracellular GABA in the ventral hypothalamus of rats in response to acute glucoprivation. Am J Physiol 269:R1174-R1178, 1995
38. Chan O, Chan S, Inouye K, Shum K, Matthews SG, Vranic M: Diabetes impairs hypothalamo-pituitary-adrenal (HPA) responses to hypoglycemia, and insulin treatment normalizes HPA but not epinephrine responses. Diabetes 51:1681-1689, 2002[Abstract/Free Full Text]
39. Paxinos G, Watson C: The Rat Brain in Stereotaxic Coordinates. 3rd ed. San Diego, CA, Academic Press, 1997
40. de Vries MG, Arseneau LM, Lawson ME, Beverly JL: Extracellular glucose in rat ventromedial hypothalamus during acute and recurrent hypoglycemia. Diabetes 52:2767-2773, 2003[Abstract/Free Full Text]
41. McNay EC, Sherwin RS: From artificial cerebro-spinal fluid (aCSF) to artificial extracellular fluid (aECF): microdialysis perfusate composition effects on in vivo brain ECF glucose measurements. J Neurosci Methods 132:35-43, 2004
42. Routh VH: Glucosensing neurons in the ventromedial hypothalamic nucleus (VMN) and hypoglycemia-associated autonomic failure (HAAF). Diabete Metab Res Rev 19:348-356, 2003
43. Routh VH: Glucose-sensing neurons: are they physiologically relevant? Physiol Behav 76:403-413, 2002
44. Lang CH: Inhibition of central GABAA receptors enhances hepatic glucose production and peripheral glucose uptake. Brain Res Bull 37:611-616, 1995
45. Shuaib A, Ijaz MS, Waqar T, Voll C, Kanthan R, Miyashita H, Liu L: Insulin elevates hippocampal GABA levels during ischemia: this is independent of its hypoglycemic effect. Neuroscience 67:809-814, 1995
46. DeRosa MA, Cryer PE: Hypoglycemia and the sympathoadrenal system: neurogenic symptoms are largely the result of sympathetic neural, rather than adrenomedullary, activation. Am J Physiol Endocrinol Metab 287: E32-E41, 2004[Abstract/Free Full Text]
47. Sudo M, Minokoshi Y, Shimazu T: Ventromedial hypothalamic stimulation enhances peripheral glucose uptake in anesthetized rats. Am J Physiol 261:E298-E303, 1991
48. Yoshimatsu H, Egawa M, Bray GA: Sympathetic nerve activity after discrete hypothalamic injections of L-glutamate. Brain Res 601:121-128, 1993
49. Evans SB, Wilkinson CW, Gronbeck P, Bennett JL, Zavosh A, Taborsky GJ Jr, Figlewicz DP: Inactivation of the DMH selectively inhibits the ACTH and corticosterone responses to hypoglycemia. Am J Physiol Regul Integr Comp Physiol 286:R123-R128, 2004[Abstract/Free Full Text]
50. Tsujii S, Bray GA: GABA-related feeding control in genetically obese rats. Brain Res 540:48-54, 1991
51. Ohtani N, Ohta M, Sugano T: Microdialysis study of modification of hypothalamic neurotransmitters in streptozotocin-diabetic rats. J Neurochem 69:1622-1628, 1997