Ammodytoxins efficiently release arachidonic acid and induce apoptosis in a motoneuronal cell line in an enzymatic activity-dependent manner

NeuroToxicology

Volumn 35, Issue 1, 2013, Pages 91-100

  Jenko PraŽnikar, Zala ^a   Petan, Toni ^a   Pungerčar, JoŽe ^a  

^a JO EF STEFAN INSTITUTE   (Slovenia)

Author keywords

Apoptosis; Cytotoxicity; Free fatty acid; Motoneuron; Neurotoxicity; Secreted phospholipase A2

Indexed keywords

AMMODYTOXIN; AMMODYTOXIN A; AMMODYTOXIN I2; AMMODYTOXIN L; ARACHIDONIC ACID; CASPASE 3; SECRETORY PHOSPHOLIPASE A2; SNAKE VENOM; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRAIN HEK293; CELL SURFACE; CELL VIABILITY; CONTROLLED STUDY; DNA FRAGMENTATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INTERNALIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOTONEURON; MOUSE; MYOBLAST; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; ARACHIDONIC ACID; CASPASE 3; CELL LINE, TUMOR; CELL MEMBRANE; CELL SURVIVAL; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MOTOR NEURONS; MUTATION; PHOSPHOLIPASES A2, SECRETORY; TIME FACTORS; VIPER VENOMS;

EID: 84873200963     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2012.12.007     Document Type: Article

References (33)

1. 2 regulation of arachidonic acid mobilization. FEBS Lett 2002, 531:2-6.
2. Bazan N.G., Colangelo V., Lukiw W.J. Prostaglandins and other lipid mediators in Alzheimer's disease. Prostaglandins Other Lipid Mediat 2002, 68-69:197-210.
3. 2 but not the group IB, IIA, and V enzymes efficiently release arachidonic acid from adherent mammalian cells. J Biol Chem 2000, 275:3179-3191.
4. 2 inhibitors are also potent blockers of binding to the M-type receptor. Biochemistry 2006, 45:13203-13218.
5. Cao Y., Pearman A.T., Zimmerman G.A., McIntyre T.M., Prescott S.M. Intracellular unesterified arachidonic acid signals apoptosis. Proc Natl Acad Sci USA 2000, 97:11280-11285.
6. Cashman N.R., Durham H.D., Blusztajn J.K., Oda K., Tabira T., Shaw I.T., et al. Neuroblastoma×spinal cord (NSC) hybrid cell lines resemble developing motor neurons. Dev Dyn 1992, 194:209-221.
7. 2+-evoked activation of p38alpha MAPK and JNK1. Toxicology 2009, 262:199-206.
8. 2 activity of β-bungarotoxin is essential for induction of cytotoxicity on cerebellar granule neurons. J Neurobiol 2005, 64:213-223.
9. Dixon R.W., Harris J.B. Nerve terminal damage by β-bungarotoxin: its clinical significance. Am J Pathol 1999, 154:447-455.
10. 2+ entry resulting in apoptosis. J Neurochem 2008, 104:1177-1189.
11. 2, notexin and taipoxin. Exp Neurol 2000, 161:517-526.
12. 2 is internalized into motoneuron-like cells where it is rapidly translocated into the cytosol. Biochim Biophys Acta 2008, 1783:1129-1139.
13. 2 induces apoptosis in motoneuron-like cells. Ann NY Acad Sci 2009, 1152:215-224.
14. 2 enzymes. Toxicon 2003, 42:827-840.
15. 2. Biochemistry 2009, 48:11319-11328.
16. 2. Annu Rev Biochem 2008, 77:495-520.
17. 2 into mammalian motor nerve terminals. Exp Neurol 2009, 219:591-594.
18. 2 revisited. J Biochem 2011, 150:233-255.
19. 2+-dependent apoptosis through the mitochondrial pathway. J Biol Chem 2004, 279:25219-25225.
20. 2 enzymes. Biochemistry 2005, 44:12535-12545.
21. 2+-independent membrane-damaging activity and increases its toxicity. Biochemistry 2007, 46:12795-12809.
22. Poletti A. The polyglutamine tract of androgen receptor: from functions to dysfunctions in motor neurons. Front Neuroendocrinol 2004, 25:1-26.
23. 2 neurotoxins. Biochem J 1999, 341:139-145.
24. Pungerčar J., Prijatelj ŽnidarŠič P., Petan T. Structure-function relationship studies of ammodytoxins and ammodytins by protein engineering. Acta Chim Slov 2011, 58:660-670.
25. 2 from bovine pancreas and Crotalus atrox venom. J Biol Chem 1985, 260:11627-11634.
26. 2 neurotoxins enter neurons, bind specifically to mitochondria, and open their transition pores. J Biol Chem 2008, 283:34013-34020.
27. Sheridan C., Martin S.J. Commitment in apoptosis: slightly dead but mostly alive. Trends Cell Biol 2008, 18:353-357.
28. 2. J Biol Chem 2002, 277:48535-48549.
29. Smiley S.T., Reers M., Mottola-Hartshorn C., Lin M., Chen A., Smith T.W., et al. Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Proc Natl Acad Sci USA 1991, 88:3671-3675.
30. Taylor R.C., Cullen S.P., Martin S.J. Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol 2008, 9:231-241.
31. Toborek M., Malecki A., Garrido R., Mattson M.P., Hennig B., Young B. Arachidonic acid-induced oxidative injury to cultured spinal cord neurons. J Neurochem 1999, 73:684-692.
32. Tseng W.P., Lin-Shiau S.Y. Activation of NMDA receptor partly involved in β-bungarotoxin-induced neurotoxicity in cultured primary neurons. Neurochem Int 2003, 42:333-344.
33. Worrall A.F., Evans C., Wilton D.C. Synthesis of a gene for rat liver fatty-acid-binding protein and its expression in Escherichia coli. Biochem J 1991, 278:365-368.