A neurotoxic secretory phospholipase A2 induces apoptosis in motoneuron-like cells

Annals of the New York Academy of Sciences

Volumn 1152, Issue , 2009, Pages 215-224

  Pražnikar, Zala Jenko ^a   Petan, Toni ^a   Pungerčar, Jože ^a  

^a JO EF STEFAN INSTITUTE   (Slovenia)

Author keywords

Ammodytoxin A; Apoptosis; Cytotoxicity; Motoneuronal cells; Phospholipase A2

Indexed keywords

AMMODYTOXIN A; CASPASE 3; PROPIDIUM IODIDE; SECRETORY PHOSPHOLIPASE A2;

ANIMAL CELL; APOPTOSIS; CELL STRAIN HEK293; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOTONEURON; MOUSE; MYOBLAST; NEUROTOXICITY; NONHUMAN;

EID: 58549119173     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2008.03999.x     Document Type: Conference Paper

References (30)

1. Kini, R.M. 2003. Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes. Toxicon. 42 : 827 840.
2. Kudo, I. & M. Murakami. 2002. Phospholipase A2 enzymes. Prostaglandins Other Lipid Mediat. 68-69 : 3 58.
3. Lee, C.Y. et al. 1984. Mode of neuromuscular blocking action of toxic phospholipases A2 from Vipera ammodytes venom. Arch. Int. Pharmacodyn. Ther. 268 : 313 324.
4. Jenko Pražnikar, Z. et al. (2008. A presynaptically toxic secreted phospholipase A2 is internalized into motoneuron-like cells where it is rapidly translocated into the cytosol. Biochim. Biophys. Acta 1783 : 1129 1139.
5. Pungerčar, J. & I. Križaj. 2007. Understanding the molecular mechanism underlying the presynaptic toxicity of secreted phospholipases A2. Toxicon. 50 : 871 892.
6. Cashman, N.R. et al. 1992. Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons. Dev. Dyn. 194 : 209 221.
7. Piccioni, F. et al. 2002. Androgen receptor with elongated polyglutamine tract forms aggregates that alter axonal trafficking and mitochondrial distribution in motoneuronal processes. FASEB J. 16 : 1418 1420.
8. Menzies, F.M. et al. 2002. Mitochondrial dysfunction in a cell culture model of familial amyotrophic lateral sclerosis. Brain 125 : 1522 1533.
9. Wen, W. et al. 2006. Activated microglial supernatant induced motor neuron cytotoxicity is associated with upregulation of the TNFR1 receptor. Neurosci. Res. 55 : 87 95.
10. Pungerčar, J. et al. 1999. An aromatic, but not a basic, residue is involved in the toxicity of group-II phospholipase A2 neurotoxins. Biochem. J. 341 : 139 145.
11. Radvanyi, F. et al. 1989. A sensitive and continuous fluorometric assay for phospholipase A2 using pyrene-labeled phospholipids in the presence of serum albumin. Anal. Biochem. 177 : 103 109.
12. Smiley, S.T. et al. 1991. Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Proc. Natl. Acad. Sci. USA 88 : 3671 3675.
13. Harris, J.B. et al. 2000. The neurotoxicity of the venom phospholipases A2, notexin and taipoxin. Exp. Neurol. 161 : 517 526.
14. Dixon, R.W. & J.B. Harris. 1999. Nerve terminal damage by b-bungarotoxin: its clinical significance. Am. J. Pathol. 154 : 447 455.
15. Tseng, W.P. & S.Y. Lin-Shiau. 2003. Activation of NMDA receptor partly involved in b-bungarotoxin-induced neurotoxicity in cultured primary neurons. Neurochem. Int. 42 : 333 344.
16. Chen, Y.-J. 2005. Phospholipase A2 activity of b-bungarotoxin is essential for induction of cytotoxicity on cerebellar granule neurons. J. Neurobiol. 64 : 213 223.
17. Thompson, H.J. et al. 1992. Apoptosis in the genesis and prevention of cancer. Cancer Epidemiol. Biomarkers Prev. 7 : 597 602.
18. Hockenbery, D. 1995. Defining apoptosis. Am. J. Pathol. 146 : 16 19.
19. Susin, S.A. et al. 1997. The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis. J. Exp. Med. 186 : 25 37.
20. Moran, J. et al. 1999. Caspase-3 expression by cerebellar granule neurons is regulated by calcium and cyclic AMP. J. Neurochem. 73 : 568 577.
21. Martin, L.J. et al. 1998. Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis. Brain Res. Bull. 46 : 281 309.
22. Ziegler, U. & P. Groscurth. 2004. Morphological features of cell death. News Physiol. Sci. 19 : 124 128.
23. Yagami, T. et al. 2002. Group IB secretory phospholipase A2 induces neuronal cell death via apoptosis. J. Neurochem. 81 : 449 461.
24. Yagami, T. et al. 2002. Human group IIA secretory phospholipase A2 induces neuronal cell death via apoptosis. Mol. Pharmacol. 61 : 114 126.
25. DeCoster, M.A. 2003. Group III secreted phospholipase A2 causes apoptosis in rat primary cortical neuronal cultures. Brain Res. 988 : 20 28.
26. 2+ channels. Brain Res. 960 : 71 80.
27. Hernandez, M. et al. 2002. Secretory phospholipase A2 elicits proinflammatory changes and upregulates the surface expression of Fas ligand in monocytic cells: potential relevance for atherogenesis. Circ. Res. 90 : 38 45.
28. Fuentes, L. et al. 2002. Cooperation between secretory phospholipase A2 and TNF-receptor superfamily signaling: implications for the inflammatory response in atherogenesis. Circ. Res. 91 : 681 688.
29. Boilard, E. et al. 2003. Interaction of low molecular weight group IIA phospholipase A2 with apoptotic human T cells: role of heparan sulfate proteoglycans. FASEB J. 17 : 1068 1080.
30. Lee, C. et al. 2006. Secretory phospholipase A2 induces apoptosis through TNF-alpha and cytochrome c-mediated caspase cascade in murine macrophage RAW 264.7 cells. Eur. J. Pharmacol. 536 : 47 53.