A presynaptically toxic secreted phospholipase A2 is internalized into motoneuron-like cells where it is rapidly translocated into the cytosol

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1783, Issue 6, 2008, Pages 1129-1139

  Pražnikar, Zala Jenko ^a   Kovačič, Lidija ^a   Rowan, Edward G ^b   Romih, Rok ^c   Rusmini, Paola ^d   Poletti, Angelo ^d   Križaj, Igor ^a   Pungerčar, Jože ^a  

^a JO EF STEFAN INSTITUTE   (Slovenia)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^c UNIVERSITY OF LJUBLJANA   (Slovenia)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

Ammodytoxin; Cytosolic protein; Motoneuron; Neurotoxicity; Secreted phospholipase A2; Synaptic vesicle

Indexed keywords

AMMODYTOXIN A; BINDING PROTEIN; CALMODULIN; F ACTIN; FATTY ACID; FLUORESCENT DYE; GOLD; NANOPARTICLE; PHOSPHOLIPASE A2; PROTEIN 14 3 3; TOXIN;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CROSS LINKING; CYTOSOL; DRUG MECHANISM; ELECTRON MICROSCOPY; EMBRYO; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYDROLYSIS; MAMMAL; MOTONEURON; MOUSE; NEUROTOXICITY; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN INTERACTION; SYNAPSE VESICLE; WILD TYPE;

14-3-3 PROTEINS; ACTINS; ANIMALS; CALMODULIN; CYTOSOL; EXTRACELLULAR SPACE; HUMANS; KIDNEY; MICE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; MOTOR NEURONS; NEUROBLASTOMA; PHOSPHOLIPASES A2, SECRETORY; PRESYNAPTIC TERMINALS; PROTEIN TRANSPORT; SPINAL CORD; VIPER VENOMS;

MAMMALIA;

EID: 43549123546     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2008.01.011     Document Type: Article

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