Palmitoylation of serotonin receptors

Biochemical Society Transactions

Volumn 41, Issue 1, 2013, Pages 89-94

  Gorinski, Nataliya ^a   Ponimaskin, Evgeni ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

G protein coupled receptor (GPCR); Palmitoylation; Serotonin (5 hydroxytryptamine); Signal transduction

Indexed keywords

SEROTONIN 1 RECEPTOR; SEROTONIN 4 RECEPTOR; SEROTONIN 7 RECEPTOR; SEROTONIN RECEPTOR;

CONFERENCE PAPER; HUMAN; NONHUMAN; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM;

ENDOCYTOSIS; LIPOYLATION; MODELS, MOLECULAR; PALMITIC ACID; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; RECEPTORS, SEROTONIN;

EID: 84873198547     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20120235     Document Type: Conference Paper

References (52)

1. Mumby, S. M. (1997) Reversible palmitoylation of signaling proteins. Curr. Opin. Cell Biol. 9, 148-154 (Pubitemid 27135980)
2. Dunphy, J. T. and Linder, M. E. (1998) Signalling functions of protein palmitoylation. Biochim. Biophys. Acta 1436, 245-261
3. Escriba, P. V., Wedegaertner, P. B., Goni, F. M. and Vogler, O. (2007) Lipid-protein interactions in GPCR-associated signaling. Biochim. Biophys. Acta 1768, 836-852 (Pubitemid 46452537)
4. Lappano, R. and Maggiolini, M. (2011) G protein-coupled receptors: novel targets for drug discovery in cancer. Nat. Rev. Drug Discovery 10, 47-60
5. Probst, W. C., Snyder, L. A., Schuster, D. I., Brosius, J. and Sealfon, S. C. (1992) Sequence alignment of the G-protein coupled receptor superfamily. DNA Cell Biol. 11, 1-20
6. Ross, E. M. (1995) Protein modification. Palmitoylation in G-protein signaling pathways. Curr. Biol. 5, 107-109
7. Bouvier, M., Moffett, S., Loisel, T. P., Mouillac, B., Hebert, T. and Chidiac, P. (1995) Palmitoylation of G-protein-coupled receptors: a dynamic modification with functional consequences. Biochem. Soc. Trans. 23, 116-120
8. Sachs, K., Maretzki, D., Meyer, C. K. and Hofmann, K. P. (2000) Diffusible ligand all-trans-retinal activates opsin via a palmitoylation- dependent mechanism. J. Biol. Chem. 275, 6189-6194 (Pubitemid 30129905)
9. Moffett, S., Mouillac, B., Bonin, H. and Bouvier, M. (1993) Altered phosphorylation and desensitization patterns of a human β2-adrenergic receptor lacking the palmitoylated Cys341. EMBO J. 12, 349-356 (Pubitemid 23042414)
10. O'Dowd, B. F., Hnatowich, M., Caron, M. G., Lefkowitz, R. J. and Bouvier, M. (1989) Palmitoylation of the human β2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor. J. Biol. Chem. 264, 7564-7569 (Pubitemid 19119173)
11. Okamoto, Y., Ninomiya, H., Tanioka, M., Sakamoto, A., Miwa, S. and Masaki, T. (1998) Cysteine residues in the carboxyl terminal domain of the endothelin-B receptor are required for coupling with G-proteins. J. Cardiovasc. Pharmacol. 31(Suppl. 1), S230-S232 (Pubitemid 128709914)
12. Horstmeyer, A., Cramer, H., Sauer, T., Muller-Esterl, W. and Schroeder, C. (1996) Palmitoylation of endothelin receptor A. Differential modulation of signal transduction activity by post-translational modification. J. Biol. Chem. 271, 20811-20819 (Pubitemid 26281868)
13. Blanpain, C., Wittamer, V., Vanderwinden, J. M., Boom, A., Renneboog, B., Lee, B., Le Poul, E., El Asmar, L., Govaerts, C., Vassart, G. et al. (2001) Palmitoylation of CCR5 is critical for receptor trafficking and efficient activation of intracellular signaling pathways. J. Biol. Chem. 276, 23795-23804
14. Barnes, N. M. and Sharp, T. (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38, 1083-1152 (Pubitemid 29292403)
15. Maurer-Spurej, E., Pittendreigh, C. and Solomons, K. (2004) The influence of selective serotonin reuptake inhibitors on human platelet serotonin. Thromb. Haemostasis 91, 119-128 (Pubitemid 38120206)
16. Pucadyil, T. J., Kalipatnapu, S. and Chattopadhyay, A. (2005) The serotonin1A receptor: a representative member of the serotonin receptor family. Cell. Mol. Neurobiol. 25, 553-580 (Pubitemid 41186261)
17. Kobe, F., Renner, U., Woehler, A., Wlodarczyk, J., Papusheva, E., Bao, G., Zeug, A., Richter, D. W., Neher, E. and Ponimaskin, E. (2008) Stimulationand palmitoylation-dependent changes in oligomeric conformation of serotonin 5-HT1A receptors. Biochim. Biophys. Acta 1783, 1503-1516
18. Renner, U., Zeug, A., Woehler, A., Niebert, M., Dityatev, A., Dityateva, G., Gorinski, N., Guseva, D., Abdel-Galil, D., Frohlich, M et al. (2012) Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking. J. Cell Sci. 125, 2486-2499
19. Koiv, K. and Harro, J. (2010) Differences in 5-HT1A receptor-mediated hypothermia in rats with low or high exploratory activity. Behav. Pharmacol. 21, 765-768
20. Luo, F. F., Han, F. and Shi, Y. X. (2011) Changes in 5-HT1A receptor in the dorsal raphe nucleus in a rat model of post-traumatic stress disorder. Mol. Med. Rep. 4, 843-847
21. Yuan, Q., Joiner, W. J. and Sehgal, A. (2006) A sleep-promoting role for the Drosophila serotonin receptor 1A. Curr. Biol. 16, 1051-1062 (Pubitemid 43815749)
22. Albert, P. R. (2012) Transcriptional regulation of the 5-HT1A receptor: implications for mental illness. Philos. Trans. R. Soc. London Ser. B 367, 2402-2415
23. Papoucheva, E., Dumuis, A., Sebben, M., Richter, D. W. and Ponimaskin, E. G. (2004) The 5-hydroxytryptamine (1A) receptor is stably palmitoylated, and acylation is critical for communication of receptor with Gi protein. J. Biol. Chem. 279, 3280-3291 (Pubitemid 38140562)
24. Renner, U., Glebov, K., Lang, T., Papusheva, E., Balakrishnan, S., Keller, B., Richter, D. W., Jahn, R. and Ponimaskin, E. (2007) Localization of the mouse 5-hydroxytryptamine (1A) receptor in lipid microdomains depends on its palmitoylation and is involved in receptor-mediated signaling. Mol. Pharmacol. 72, 502-513 (Pubitemid 47347285)
25. Woehler, A., Wlodarczyk, J. and Ponimaskin, E. G. (2009) Specific oligomerization of the 5-HT1A receptor in the plasma membrane. Glycoconjugate J. 26, 749-756
26. Ng, G. Y., George, S. R., Zastawny, R. L., Caron, M., Bouvier, M., Dennis, M. and O'Dowd, B. F. (1993) Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition. Biochemistry 32, 11727-11733
27. 4 receptors, a place in the sun: act two. Curr. Opin. Pharmacol. 11, 87-93
28. 4 receptors: history, molecular pharmacology and brain functions. Neuropharmacology 55, 922-931
29. Jean, L., Thomas, B., Tahiri-Alaoui, A., Shaw, M. and Vaux, D. J. (2007) Heterologous amyloid seeding: revisiting the role of acetylcholinesterase in Alzheimer's disease. PLoS ONE 2, e652
30. 4 receptors in brain tissues from patients with neurodegenerative disorders. Behav. Brain Res. 73, 249-252 (Pubitemid 26008791)
31. 4 splice variant. J. Neurochem. 74, 478-489 (Pubitemid 30053719)
32. 4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain. Mol. Pharmacol. 55, 910-920 (Pubitemid 29214611)
33. 4 receptors are they in unique active states? EMBO Rep. 2, 61-67 (Pubitemid 32229723)
34. Claeysen, S., Sebben, M., Becamel, C., Eglen, R. M., Clark, R. D., Bockaert, J. and Dumuis, A. (2000) Pharmacological properties of 5-hydroxytryptamine (4) receptor antagonists on constitutively active wild-type and mutated receptors. Mol. Pharmacol. 58, 136-144 (Pubitemid 30452536)
35. Cardenas, C. G., Del Mar, L. P., Cooper, B. Y. and Scroggs, R. S. (1997) 5HT4 receptors couple positively to tetrodotoxin-insensitive sodium channels in a subpopulation of capsaicin-sensitive rat sensory neurons. J. Neurosci. 17, 7181-7189 (Pubitemid 27413249)
36. Heine, M., Ponimaskin, E., Bickmeyer, U. and Richter, D. W. (2002) 5-HT-receptor-induced changes of the intracellular cAMP level monitored by a hyperpolarization-activated cation channel. Pflü gers Arch. 443, 418-426 (Pubitemid 34098531)
37. 13 protein. J. Biol. Chem. 277, 20812-20819 (Pubitemid 34967387)
38. 4 receptor signalling. EMBO J. 28, 2706-2718
39. Ponimaskin, E. G., Schmidt, M. F., Heine, M., Bickmeyer, U. and Richter, D. W. (2001) 5-Hydroxytryptamine 4 (a) receptor expressed in Sf9 cells is palmitoylated in an agonist-dependent manner. Biochem. J. 353, 627-634 (Pubitemid 32158331)
40. Ponimaskin, E. G., Heine, M., Joubert, L., Sebben, M., Bickmeyer, U., Richter, D. W. and Dumuis, A. (2002) The 5-hydroxytryptamine (4a) receptor is palmitoylated at two different sites, and acylation is critically involved in regulation of receptor constitutive activity. J. Biol. Chem. 277, 2534-2546 (Pubitemid 34953277)
41. Ponimaskin, E., Dumuis, A., Gaven, F., Barthet, G., Heine, M., Glebov, K., Richter, D. W. and Oppermann, M. (2005) Palmitoylation of the 5-hydroxytryptamine4a receptor regulates receptor phosphorylation, desensitization, and β-arrestin-mediated endocytosis. Mol. Pharmacol. 67, 1434-1443 (Pubitemid 40594142)
42. 7 receptor research. Trends Pharmacol. Sci. 25, 481-486 (Pubitemid 39149704)
43. 7 (a). J. Biol. Chem. 278, 3098-3104 (Pubitemid 36801219)
44. 12-protein to regulate gene transcription and neuronal morphology. J. Neurosci. 25, 7821-7830 (Pubitemid 41208654)
45. 12 signaling regulates neuronal morphology and function in an age-dependent manner. J. Neurosci. 32, 2915-2930
46. 7) receptor isoforms in human and rat produced by alternative splicing: species differences due to altered intron-exon organization. J. Neurochem. 68, 1372-1381 (Pubitemid 27133044)
47. Lovenberg, T. W., Baron, B. M., de Lecea, L., Miller, J. D., Prosser, R. A., Rea, M. A., Foye, P. E., Racke, M., Slone, A. L., Siegel, B. W. et al. (1993) A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms. Neuron 11, 449-458 (Pubitemid 23287072)
48. 1A receptors in discrete regions of the circadian timing system in hamsters. Brain Res. 829, 39-45 (Pubitemid 29251682)
49. 7 receptor and disorders of the nervous system: an overview. Psychopharmacology 206, 345-354
50. 7 (a) receptor is modulated by the palmitoylation of its C-terminal domain. Biochim. Biophys. Acta 1793, 1646-1655
51. 7 receptor (long form); antagonist profile of SB-258719. Br. J. Pharmacol. 124, 1300-1306 (Pubitemid 28333956)
52. 7 serotonin receptor splice variants: constitutive activity and inverse agonist effects. Br. J. Pharmacol. 135, 1563-1571 (Pubitemid 34270929)