메뉴 건너뛰기




Volumn 31, Issue 3, 2013, Pages 621-627

Resveratrol inhibits human nasopharyngeal carcinoma cell growth via blocking pAkt/p70S6K signaling pathways

Author keywords

Apoptosis; Nasopharyngeal carcinoma; Proliferation; Resveratrol

Indexed keywords

CASPASE 3; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INITIATION FACTOR 4E BINDING PROTEIN 1; PROTEIN BCL 2; PROTEIN KINASE B; RESVERATROL; S6 KINASE;

EID: 84873159969     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2013.1237     Document Type: Article
Times cited : (28)

References (35)
  • 2
    • 84866859568 scopus 로고    scopus 로고
    • Targeting Jab1/CSN5 in nasopharyngeal carcinoma
    • Pan Y and Claret FX: Targeting Jab1/CSN5 in nasopharyngeal carcinoma. Cancer Lett 326: 155-160, 2012.
    • (2012) Cancer Lett , vol.326 , pp. 155-160
    • Pan, Y.1    Claret, F.X.2
  • 3
    • 34548631786 scopus 로고    scopus 로고
    • Nasopharyngeal carcinoma: Molecular pathogenesis and therapeutic developments
    • Tao Q and Chan AT: Nasopharyngeal carcinoma: molecular pathogenesis and therapeutic developments. Expert Rev Mol Med 9: 1-24, 2007.
    • (2007) Expert Rev Mol Med , vol.9 , pp. 1-24
    • Tao, Q.1    Chan, A.T.2
  • 4
    • 0035204898 scopus 로고    scopus 로고
    • Nasopharyngeal carcinomas: Analysis of patient, tumor and treatment characteristics determining outcome
    • Erkal HS, Serin M and Cakmak A: Nasopharyngeal carcinomas: analysis of patient, tumor and treatment characteristics determining outcome. Radiother Oncol 61: 247-256, 2001.
    • (2001) Radiother Oncol , vol.61 , pp. 247-256
    • Erkal, H.S.1    Serin, M.2    Cakmak, A.3
  • 5
    • 34548426154 scopus 로고    scopus 로고
    • Nasopharynx cancer: Therapeutic value of chemoradiotherapy
    • O'Sullivan B: Nasopharynx cancer: therapeutic value of chemoradiotherapy. Int J Radiat Oncol Biol Phys 69 (Suppl 2): S118-S121, 2007.
    • (2007) Int J Radiat Oncol Biol Phys , vol.69 , Issue.SUPPL. 2
    • O'Sullivan, B.1
  • 6
    • 0031561513 scopus 로고    scopus 로고
    • Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
    • Jang M, Cai L, Udeani GO, et al: Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275: 218-220, 1997.
    • (1997) Science , vol.275 , pp. 218-220
    • Jang, M.1    Cai, L.2    Udeani, G.O.3
  • 7
    • 33646028804 scopus 로고    scopus 로고
    • Molecular targets of dietary agents for prevention and therapy of cancer
    • Aggarwal BB and Shishodia S: Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71: 1397-1421, 2006.
    • (2006) Biochem Pharmacol , vol.71 , pp. 1397-1421
    • Aggarwal, B.B.1    Shishodia, S.2
  • 8
    • 79955849349 scopus 로고    scopus 로고
    • Multiple beneficial effects of resveratrol and their chemical-biochemical basis
    • Tyihak E, Kiraly-Veghely Z and Moricz AM: Multiple beneficial effects of resveratrol and their chemical-biochemical basis. Nat Prod Commun 6: 631-638, 2011.
    • (2011) Nat Prod Commun , vol.6 , pp. 631-638
    • Tyihak, E.1    Kiraly-Veghely, Z.2    Moricz, A.M.3
  • 9
    • 84863267798 scopus 로고    scopus 로고
    • Cellular and molecular effects of resveratrol in health and disease
    • Yu W, Fu YC and Wang W: Cellular and molecular effects of resveratrol in health and disease. J Cell Biochem 113: 752-759, 2012.
    • (2012) J Cell Biochem , vol.113 , pp. 752-759
    • Yu, W.1    Fu, Y.C.2    Wang, W.3
  • 10
    • 73449089738 scopus 로고    scopus 로고
    • Bax inhibitor-1 mediates apoptosis-resistance in human nasopharyngeal carcinoma cells
    • Zhang M, Li X, Zhang Y and Zhou K: Bax inhibitor-1 mediates apoptosis-resistance in human nasopharyngeal carcinoma cells. Mol Cell Biochem 333: 1-7, 2010.
    • (2010) Mol Cell Biochem , vol.333 , pp. 1-7
    • Zhang, M.1    Li, X.2    Zhang, Y.3    Zhou, K.4
  • 11
    • 79952702980 scopus 로고    scopus 로고
    • Uncovering the role of hypoxia inducible factor-1alpha in skin carcinogenesis
    • Nys K, Maes H, Dudek AM and Agostinis P: Uncovering the role of hypoxia inducible factor-1alpha in skin carcinogenesis. Biochim Biophys Acta 1816: 1-12, 2011.
    • (2011) Biochim Biophys Acta , vol.1816 , pp. 1-12
    • Nys, K.1    Maes, H.2    Dudek, A.M.3    Agostinis, P.4
  • 14
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D and Weinberg RA: Hallmarks of cancer: the next generation. Cell 144: 646-674, 2011.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 15
    • 0034730942 scopus 로고    scopus 로고
    • Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells
    • Schneider Y, Vincent F, Duranton B, et al: Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells. Cancer Lett 158: 85-91, 2000.
    • (2000) Cancer Lett , vol.158 , pp. 85-91
    • Schneider, Y.1    Vincent, F.2    Duranton, B.3
  • 17
    • 33745089904 scopus 로고    scopus 로고
    • Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3'-kinase/Akt pathway and Bcl-2 family proteins
    • Aziz MH, Nihal M, Fu VX, Jarrard DF and Ahmad N: Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3'-kinase/Akt pathway and Bcl-2 family proteins. Mol Cancer Ther 5: 1335-1341, 2006.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1335-1341
    • Aziz, M.H.1    Nihal, M.2    Fu, V.X.3    Jarrard, D.F.4    Ahmad, N.5
  • 18
    • 0037159575 scopus 로고    scopus 로고
    • Resveratrol-induced apoptosis is mediated by p53-dependent pathway in Hep G2 cells
    • Kuo PL, Chiang LC and Lin CC: Resveratrol-induced apoptosis is mediated by p53-dependent pathway in Hep G2 cells. Life Sci 72: 23-34, 2002.
    • (2002) Life Sci , vol.72 , pp. 23-34
    • Kuo, P.L.1    Chiang, L.C.2    Lin, C.C.3
  • 19
    • 33750513819 scopus 로고    scopus 로고
    • Resveratrol exerts its anti-proliferative effect on HepG2 hepatocellular carcinoma cells, by inducing cell cycle arrest, and NOS activation
    • Notas G, Nifli AP, Kampa M, Vercauteren J, Kouroumalis E and Castanas E: Resveratrol exerts its anti-proliferative effect on HepG2 hepatocellular carcinoma cells, by inducing cell cycle arrest, and NOS activation. Biochim Biophys Acta 1760: 1657-1666, 2006.
    • (2006) Biochim Biophys Acta , vol.1760 , pp. 1657-1666
    • Notas, G.1    Nifli, A.P.2    Kampa, M.3    Vercauteren, J.4    Kouroumalis, E.5    Castanas, E.6
  • 20
    • 33645464650 scopus 로고    scopus 로고
    • Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein
    • Kotha A, Sekharam M, Cilenti L, et al: Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein. Mol Cancer Ther 5: 621-629, 2006.
    • (2006) Mol Cancer Ther , vol.5 , pp. 621-629
    • Kotha, A.1    Sekharam, M.2    Cilenti, L.3
  • 21
    • 0036301453 scopus 로고    scopus 로고
    • Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines
    • Joe AK, Liu H, Suzui M, Vural ME, Xiao D and Weinstein IB: Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines. Clin Cancer Res 8: 893-903, 2002.
    • (2002) Clin Cancer Res , vol.8 , pp. 893-903
    • Joe, A.K.1    Liu, H.2    Suzui, M.3    Vural, M.E.4    Xiao, D.5    Weinstein, I.B.6
  • 22
    • 27644508837 scopus 로고    scopus 로고
    • Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1alpha and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells
    • Zhang Q, Tang X, Lu QY, Zhang ZF, Brown J and Le AD: Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1alpha and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells. Mol Cancer Ther 4: 1465-1474, 2005.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1465-1474
    • Zhang, Q.1    Tang, X.2    Lu, Q.Y.3    Zhang, Z.F.4    Brown, J.5    Le, A.D.6
  • 23
    • 79955836106 scopus 로고    scopus 로고
    • Resveratrol prevents inflammation-dependent hepatic melanoma metastasis by inhibiting the secretion and effects of interleukin-18
    • Salado C, Olaso E, Gallot N, et al: Resveratrol prevents inflammation-dependent hepatic melanoma metastasis by inhibiting the secretion and effects of interleukin-18. J Transl Med 9: 59, 2011.
    • (2011) J Transl Med , vol.9 , pp. 59
    • Salado, C.1    Olaso, E.2    Gallot, N.3
  • 25
    • 84861682542 scopus 로고    scopus 로고
    • Resveratrol enhances radiation sensitivity in prostate cancer by inhibiting cell proliferation and promoting cell senescence and apoptosis
    • Fang Y, DeMarco VG and Nicholl MB: Resveratrol enhances radiation sensitivity in prostate cancer by inhibiting cell proliferation and promoting cell senescence and apoptosis. Cancer Sci 103: 1090-1098, 2012.
    • (2012) Cancer Sci , vol.103 , pp. 1090-1098
    • Fang, Y.1    Demarco, V.G.2    Nicholl, M.B.3
  • 26
    • 84860499082 scopus 로고    scopus 로고
    • Resveratrol inhibits cancer cell metabolism by down regulating pyruvate kinase M2 via inhibition of mammalian target of rapamycin
    • Iqbal MA and Bamezai RN: Resveratrol inhibits cancer cell metabolism by down regulating pyruvate kinase M2 via inhibition of mammalian target of rapamycin. PLoS One 7: e36764, 2012.
    • (2012) PLoS One , vol.7
    • Iqbal, M.A.1    Bamezai, R.N.2
  • 27
    • 84861426015 scopus 로고    scopus 로고
    • The anticancer effects of resveratrol: Modulation of transcription factors
    • Whitlock NC and Baek SJ: The anticancer effects of resveratrol: modulation of transcription factors. Nutr Cancer 64: 493-502, 2012.
    • (2012) Nutr Cancer , vol.64 , pp. 493-502
    • Whitlock, N.C.1    Baek, S.J.2
  • 28
    • 0035866404 scopus 로고    scopus 로고
    • Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase
    • She QB, Bode AM, Ma WY, Chen NY and Dong Z: Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase. Cancer Res 61: 1604-1610, 2001.
    • (2001) Cancer Res , vol.61 , pp. 1604-1610
    • She, Q.B.1    Bode, A.M.2    Ma, W.Y.3    Chen, N.Y.4    Dong, Z.5
  • 29
    • 0036962164 scopus 로고    scopus 로고
    • Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism
    • Shih A, Davis FB, Lin HY and Davis PJ: Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism. J Clin Endocrinol Metab 87: 1223-1232, 2002.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1223-1232
    • Shih, A.1    Davis, F.B.2    Lin, H.Y.3    Davis, P.J.4
  • 30
    • 1242342067 scopus 로고    scopus 로고
    • Resveratrol modulates the phosphoinositide 3-kinase pathway through an estrogen receptor alpha-dependent mechanism: Relevance in cell proliferation
    • Pozo-Guisado E, Lorenzo-Benayas MJ and Fernandez-Salguero PM: Resveratrol modulates the phosphoinositide 3-kinase pathway through an estrogen receptor alpha-dependent mechanism: relevance in cell proliferation. Int J Cancer 109: 167-173, 2004.
    • (2004) Int J Cancer , vol.109 , pp. 167-173
    • Pozo-Guisado, E.1    Lorenzo-Benayas, M.J.2    Fernandez-Salguero, P.M.3
  • 31
    • 84155184247 scopus 로고    scopus 로고
    • Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis
    • Yang YP, Chang YL, Huang PI, et al: Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis. J Cell Physiol 227: 976-993, 2012.
    • (2012) J Cell Physiol , vol.227 , pp. 976-993
    • Yang, Y.P.1    Chang, Y.L.2    Huang, P.I.3
  • 32
    • 84866599883 scopus 로고    scopus 로고
    • The β-catenin/TCF complex as a novel target of resveratrol in the Wnt/β-catenin signaling pathway
    • Chen HJ, Hsu LS, Shia YT, Lin MW and Lin CM: The β-catenin/TCF complex as a novel target of resveratrol in the Wnt/β-catenin signaling pathway. Biochem Pharmacol 84: 1143-1153, 2012.
    • (2012) Biochem Pharmacol , vol.84 , pp. 1143-1153
    • Chen, H.J.1    Hsu, L.S.2    Shia, Y.T.3    Lin, M.W.4    Lin, C.M.5
  • 33
    • 73849104914 scopus 로고    scopus 로고
    • Resveratrol increases sensitivity of CNE2 cells to chemotherapeutic drugs under hypoxia
    • (In Chinese)
    • Quan F, Zhang SQ, Bai YX, et al: Resveratrol increases sensitivity of CNE2 cells to chemotherapeutic drugs under hypoxia. Zhong Xi Yi Jie He Xue Bao 7: 952-957, 2009 (In Chinese).
    • (2009) Zhong Xi Yi Jie He Xue Bao , vol.7 , pp. 952-957
    • Quan, F.1    Zhang, S.Q.2    Bai, Y.X.3
  • 34
    • 78349305821 scopus 로고    scopus 로고
    • Resveratrol-induced p53-independent apoptosis of human nasopharyngeal carcinoma cells is correlated with the downregulation of Δnp63
    • Chow SE, Wang JS, Chuang SF, et al: Resveratrol-induced p53-independent apoptosis of human nasopharyngeal carcinoma cells is correlated with the downregulation of ΔNp63. Cancer Gene Ther 17: 872-882, 2010.
    • (2010) Cancer Gene Ther , vol.17 , pp. 872-882
    • Chow, S.E.1    Wang, J.S.2    Chuang, S.F.3
  • 35
    • 78650630361 scopus 로고    scopus 로고
    • Resveratrol induces apoptosis of human nasopharyngeal carcinoma cells via activation of multiple apoptotic pathways
    • Huang TT, Lin HC, Chen CC, et al: Resveratrol induces apoptosis of human nasopharyngeal carcinoma cells via activation of multiple apoptotic pathways. J Cell Physiol 226: 720-728, 2011.
    • (2011) J Cell Physiol , vol.226 , pp. 720-728
    • Huang, T.T.1    Lin, H.C.2    Chen, C.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.