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Volumn 10, Issue 1, 2013, Pages 2-18

Interferon Beta and Glatiramer Acetate Therapy

Author keywords

Glatiramer acetate; History; Interferon beta; Multiple sclerosis therapeutics; Review

Indexed keywords

BETA INTERFERON; BETA1A INTERFERON; BIOLOGICAL MARKER; GLATIRAMER; INTERFERON BETA SERINE; METHOTREXATE; METHYLPREDNISOLONE; PLACEBO;

EID: 84873155845     PISSN: 19337213     EISSN: 18787479     Source Type: Journal    
DOI: 10.1007/s13311-012-0163-4     Document Type: Review
Times cited : (56)

References (103)
  • 1
    • 33644843896 scopus 로고    scopus 로고
    • Use of interferon-beta in the treatment of multiple sclerosis
    • Derwenskus J, Lublin FD. Use of interferon-beta in the treatment of multiple sclerosis. Adv Neurol 2006; 98: 257-271.
    • (2006) Adv Neurol , vol.98 , pp. 257-271
    • Derwenskus, J.1    Lublin, F.D.2
  • 2
    • 0020287147 scopus 로고
    • Multiple sclerosis (second of two parts)
    • McFarlin DE. Multiple sclerosis (second of two parts). N Engl J Med 1982; 307: 1246-1251.
    • (1982) N Engl J Med , vol.307 , pp. 1246-1251
    • McFarlin, D.E.1
  • 3
    • 0023126661 scopus 로고
    • Exacerbations of multiple sclerosis in patients treated with gamma interferon
    • Panitch HS, Hirsch RL, Haley AS, Johnson KP. Exacerbations of multiple sclerosis in patients treated with gamma interferon. Lancet 1987; 18: 893-895.
    • (1987) Lancet , vol.18 , pp. 893-895
    • Panitch, H.S.1    Hirsch, R.L.2    Haley, A.S.3    Johnson, K.P.4
  • 4
    • 25144445803 scopus 로고    scopus 로고
    • History of modern multiple sclerosis therapy
    • Lublin F. History of modern multiple sclerosis therapy. J Neurol 2005; 252 (Suppl 3): iii3-iii9.
    • (2005) J Neurol , vol.252 , Issue.SUPPL. 3
    • Lublin, F.1
  • 5
    • 0021173394 scopus 로고
    • Systemic alpha-interferon therapy of multiple sclerosis
    • Knobler RL, Panitch HS, Braheny SL, et al. Systemic alpha-interferon therapy of multiple sclerosis. Neurology 1984; 34: 1273-1279.
    • (1984) Neurology , vol.34 , pp. 1273-1279
    • Knobler, R.L.1    Panitch, H.S.2    Braheny, S.L.3
  • 6
    • 0023039442 scopus 로고
    • Systemic recombinant alpha-2 interferon therapy in relapsing multiple sclerosis
    • Camenga DL, Johnson KP, Alter M, et al. Systemic recombinant alpha-2 interferon therapy in relapsing multiple sclerosis. Arch Neurol 1986; 43: 1239-1246.
    • (1986) Arch Neurol , vol.43 , pp. 1239-1246
    • Camenga, D.L.1    Johnson, K.P.2    Alter, M.3
  • 7
    • 0024406788 scopus 로고
    • Interferon-alpha and transfer factor in the treatment of multiple sclerosis: a double-blind, placebo-controlled trial
    • AUSTIMS Research Group
    • AUSTIMS Research Group. Interferon-alpha and transfer factor in the treatment of multiple sclerosis: a double-blind, placebo-controlled trial. J Neurol Neurosurg Psychiatry 1989; 52: 566-574.
    • (1989) J Neurol Neurosurg Psychiatry , vol.52 , pp. 566-574
  • 8
    • 0023038777 scopus 로고
    • Multicentre double-blind study of effect of intrathecally administered natural human fibroblast interferon on exacerbations of multiple sclerosis
    • Jacobs L, Salazar AM, Herndon R, et al. Multicentre double-blind study of effect of intrathecally administered natural human fibroblast interferon on exacerbations of multiple sclerosis. Lancet 1986; 2: 1411-1413.
    • (1986) Lancet , vol.2 , pp. 1411-1413
    • Jacobs, L.1    Salazar, A.M.2    Herndon, R.3
  • 10
    • 0032579369 scopus 로고    scopus 로고
    • Regulation of type I interferon gene expression by interferon regulatory factor-3
    • Schafer SL, Lin R, Moore PA, Hiscott J, Pitha PM. Regulation of type I interferon gene expression by interferon regulatory factor-3. J Biol Chem 1998; 273: 2714-2720.
    • (1998) J Biol Chem , vol.273 , pp. 2714-2720
    • Schafer, S.L.1    Lin, R.2    Moore, P.A.3    Hiscott, J.4    Pitha, P.M.5
  • 12
    • 2642521060 scopus 로고    scopus 로고
    • IFN-beta1a and IFN-beta1b have different patterns of influence on cytokines
    • Sega S, Wraber B, Mesec A, Horvat A, Ihan A. IFN-beta1a and IFN-beta1b have different patterns of influence on cytokines. Clin Neurol Neurosurg 2004; 106: 255-258.
    • (2004) Clin Neurol Neurosurg , vol.106 , pp. 255-258
    • Sega, S.1    Wraber, B.2    Mesec, A.3    Horvat, A.4    Ihan, A.5
  • 13
    • 79958108785 scopus 로고    scopus 로고
    • The mechanism of action of interferon-beta in relapsing multiple sclerosis
    • Kieseier BC. The mechanism of action of interferon-beta in relapsing multiple sclerosis. CNS Drugs 2011; 25: 491-502.
    • (2011) CNS Drugs , vol.25 , pp. 491-502
    • Kieseier, B.C.1
  • 14
    • 67349254137 scopus 로고    scopus 로고
    • Interferon-beta modifies the peripheral blood cell cytokine secretion in patients with multiple sclerosis
    • Mirandola SR, Hallal DE, Farias AS, et al. Interferon-beta modifies the peripheral blood cell cytokine secretion in patients with multiple sclerosis. Int Immunopharmacol 2009; 9: 824-830.
    • (2009) Int Immunopharmacol , vol.9 , pp. 824-830
    • Mirandola, S.R.1    Hallal, D.E.2    Farias, A.S.3
  • 15
    • 17044431775 scopus 로고    scopus 로고
    • Th1 and Th2 lymphocyte migration across the human BBB is specifically regulated by interferon beta and copolymer-1
    • Prat A, Biernacki K, Antel JP. Th1 and Th2 lymphocyte migration across the human BBB is specifically regulated by interferon beta and copolymer-1. J Autoimmun 2005; 24: 119-124.
    • (2005) J Autoimmun , vol.24 , pp. 119-124
    • Prat, A.1    Biernacki, K.2    Antel, J.P.3
  • 16
    • 77955665655 scopus 로고    scopus 로고
    • Overlapping and distinct mechanisms of action of multiple sclerosis therapies
    • Graber JJ, McGraw CA, Kimbrough D, Dhib-Jalbut S. Overlapping and distinct mechanisms of action of multiple sclerosis therapies. Clin Neurol Neurosurg 2010; 112: 583-591.
    • (2010) Clin Neurol Neurosurg , vol.112 , pp. 583-591
    • Graber, J.J.1    McGraw, C.A.2    Kimbrough, D.3    Dhib-Jalbut, S.4
  • 17
    • 58449083627 scopus 로고    scopus 로고
    • Heterogeneity in response to interferon beta in patients with multiple sclerosis: a 3-year monthly imaging study
    • Chiu AW, Richert N, Ehrmantraut M, et al. Heterogeneity in response to interferon beta in patients with multiple sclerosis: a 3-year monthly imaging study. Arch Neurol 2009; 66: 39-43.
    • (2009) Arch Neurol , vol.66 , pp. 39-43
    • Chiu, A.W.1    Richert, N.2    Ehrmantraut, M.3
  • 18
    • 0027521002 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebocontrolled trial. UBC MS/MRI study group and the IFNB multiple sclerosis study group
    • Paty DW, Li DK. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebocontrolled trial. UBC MS/MRI study group and the IFNB multiple sclerosis study group. Neurology 1993; 43: 662-667.
    • (1993) Neurology , vol.43 , pp. 662-667
    • Paty, D.W.1    Li, D.K.2
  • 19
    • 0029161628 scopus 로고
    • Interferon beta-1b in the treatment of multiple sclerosis: final outcome of the randomized controlled trial
    • The IFNB Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group
    • The IFNB Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group. Interferon beta-1b in the treatment of multiple sclerosis: final outcome of the randomized controlled trial. Neurology 1995; 45: 1277-1285.
    • (1995) Neurology , vol.45 , pp. 1277-1285
  • 20
    • 0008678962 scopus 로고    scopus 로고
    • Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG)
    • Jacobs LD, Cookfair DL, Rudick RA, et al. Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG). Ann Neurol 1996; 39: 285-294.
    • (1996) Ann Neurol , vol.39 , pp. 285-294
    • Jacobs, L.D.1    Cookfair, D.L.2    Rudick, R.A.3
  • 21
    • 0345601517 scopus 로고    scopus 로고
    • Randomised double-blind placebocontrolled study of interferon beta-1a in relapsing/remitting multiple sclerosis
    • PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group
    • PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group. Randomised double-blind placebocontrolled study of interferon beta-1a in relapsing/remitting multiple sclerosis. Lancet 1998; 352: 1498-1504.
    • (1998) Lancet , vol.352 , pp. 1498-1504
  • 22
    • 0032864616 scopus 로고    scopus 로고
    • Magnetic resonance imaging results of the PRISMS trial: a randomized, double-blind, placebo-controlled study of interferon-beta1a in relapsingremitting multiple sclerosis. Prevention of relapses and disability by interferon-beta1a subcutaneously in multiple sclerosis
    • Li DK, Paty DW. Magnetic resonance imaging results of the PRISMS trial: a randomized, double-blind, placebo-controlled study of interferon-beta1a in relapsingremitting multiple sclerosis. Prevention of relapses and disability by interferon-beta1a subcutaneously in multiple sclerosis. Ann Neurol 1999; 46: 197-206.
    • (1999) Ann Neurol , vol.46 , pp. 197-206
    • Li, D.K.1    Paty, D.W.2
  • 23
    • 0344809968 scopus 로고    scopus 로고
    • Evidence of interferon beta-1a dose response in relapsing-remitting MS: the OWIMS study
    • The Once Weekly Interferon for MS Study Group
    • The Once Weekly Interferon for MS Study Group. Evidence of interferon beta-1a dose response in relapsing-remitting MS: the OWIMS study. Neurology 1999; 53: 679-686.
    • (1999) Neurology , vol.53 , pp. 679-686
  • 24
    • 0034727059 scopus 로고    scopus 로고
    • Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. CHAMPS study group
    • Jacobs LD, Beck RW, Simon JH, et al. Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. CHAMPS study group. N Engl J Med 2000; 343: 898-904.
    • (2000) N Engl J Med , vol.343 , pp. 898-904
    • Jacobs, L.D.1    Beck, R.W.2    Simon, J.H.3
  • 25
    • 0035912520 scopus 로고    scopus 로고
    • Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study
    • Comi G, Filippi M, Barkhof F, et al. Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study. Lancet 2001; 357: 1576-1582.
    • (2001) Lancet , vol.357 , pp. 1576-1582
    • Comi, G.1    Filippi, M.2    Barkhof, F.3
  • 26
    • 33749661011 scopus 로고    scopus 로고
    • Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes
    • Kappos L, Polman CH, Freedman MS, et al. Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes. Neurology 2006; 67: 1242-1249.
    • (2006) Neurology , vol.67 , pp. 1242-1249
    • Kappos, L.1    Polman, C.H.2    Freedman, M.S.3
  • 27
    • 83555166210 scopus 로고    scopus 로고
    • Comparison of two dosing frequencies of subcutaneous interferon beta-1a in patients with a first clinical demyelinating event suggestive of multiple sclerosis (REFLEX): a phase 3 randomised controlled trial
    • Comi G, De Stefano N, Freedman MS, et al. Comparison of two dosing frequencies of subcutaneous interferon beta-1a in patients with a first clinical demyelinating event suggestive of multiple sclerosis (REFLEX): a phase 3 randomised controlled trial. Lancet Neurol 2012; 11: 33-41.
    • (2012) Lancet Neurol , vol.11 , pp. 33-41
    • Comi, G.1    de Stefano, N.2    Freedman, M.S.3
  • 28
    • 79952501096 scopus 로고    scopus 로고
    • Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria
    • Polman CH, Reingold SC, Banwell B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the "McDonald criteria". Ann Neurol 2011; 69: 292-302.
    • (2011) Ann Neurol , vol.69 , pp. 292-302
    • Polman, C.H.1    Reingold, S.C.2    Banwell, B.3
  • 29
    • 34547530045 scopus 로고    scopus 로고
    • Interferon beta in multiple sclerosis: how much BENEFIT?
    • Pittock SJ. Interferon beta in multiple sclerosis: how much BENEFIT? Lancet 2007; 370: 363-364.
    • (2007) Lancet , vol.370 , pp. 363-364
    • Pittock, S.J.1
  • 30
    • 0036201067 scopus 로고    scopus 로고
    • Interferon beta-1a for early multiple sclerosis: CHAMPS trial subgroup analyses
    • Beck RW, Chandler DL, Cole SR, et al. Interferon beta-1a for early multiple sclerosis: CHAMPS trial subgroup analyses. Ann Neurol 2002; 51: 481-490.
    • (2002) Ann Neurol , vol.51 , pp. 481-490
    • Beck, R.W.1    Chandler, D.L.2    Cole, S.R.3
  • 32
    • 33645100122 scopus 로고    scopus 로고
    • IM interferon beta-1a delays definite multiple sclerosis 5 years after a first demyelinating event
    • Kinkel RP, Kollman C, O'Connor P, et al. IM interferon beta-1a delays definite multiple sclerosis 5 years after a first demyelinating event. Neurology 2006; 66: 678-684.
    • (2006) Neurology , vol.66 , pp. 678-684
    • Kinkel, R.P.1    Kollman, C.2    O'Connor, P.3
  • 33
    • 0032494792 scopus 로고    scopus 로고
    • Placebo-controlled multicentre randomised trial of interferon beta-1b in treatment of secondary progressive multiple sclerosis
    • European Study Group on interferon beta-1b in secondary progressive MS
    • European Study Group on interferon beta-1b in secondary progressive MS. Placebo-controlled multicentre randomised trial of interferon beta-1b in treatment of secondary progressive multiple sclerosis. Lancet 1998; 352: 1491-1497.
    • (1998) Lancet , vol.352 , pp. 1491-1497
  • 35
    • 80054722792 scopus 로고    scopus 로고
    • Improving power to detect disease progression in multiple sclerosis through alternative analysis strategies
    • Healy B, Chitnis T, Engler D. Improving power to detect disease progression in multiple sclerosis through alternative analysis strategies. J Neurol 2011; 258: 1812-1819.
    • (2011) J Neurol , vol.258 , pp. 1812-1819
    • Healy, B.1    Chitnis, T.2    Engler, D.3
  • 36
    • 8844222623 scopus 로고    scopus 로고
    • Interferon beta-1b in secondary progressive MS: results from a 3-year controlled study
    • North American Study Group on Interferon beta-1b in Secondary Progressive MS
    • Panitch H, Miller A, Paty D, Weinshenker B. North American Study Group on Interferon beta-1b in Secondary Progressive MS. Interferon beta-1b in secondary progressive MS: results from a 3-year controlled study. Neurology 2004; 63: 1788-1795.
    • (2004) Neurology , vol.63 , pp. 1788-1795
    • Panitch, H.1    Miller, A.2    Paty, D.3    Weinshenker, B.4
  • 37
    • 0035849496 scopus 로고    scopus 로고
    • Randomized controlled trial of interferon- beta-1a in secondary progressive MS: clinical results
    • Secondary Progressive Efficacy Clinical Trial of Recombinant Interferon-Beta-1a in MS (SPECTRIMS) Study Group
    • Secondary Progressive Efficacy Clinical Trial of Recombinant Interferon-Beta-1a in MS (SPECTRIMS) Study Group. Randomized controlled trial of interferon- beta-1a in secondary progressive MS: clinical results. Neurology 2001; 56: 1496-1504.
    • (2001) Neurology , vol.56 , pp. 1496-1504
  • 38
    • 0037056364 scopus 로고    scopus 로고
    • Benefit of interferon beta-1a on MSFC progression in secondary progressive MS
    • Cohen JA, Cutter GR, Fischer JS, et al. Benefit of interferon beta-1a on MSFC progression in secondary progressive MS. Neurology 2002; 59: 679-687.
    • (2002) Neurology , vol.59 , pp. 679-687
    • Cohen, J.A.1    Cutter, G.R.2    Fischer, J.S.3
  • 39
    • 0032919071 scopus 로고    scopus 로고
    • Development of a multiple sclerosis functional composite as a clinical trial outcome measure
    • Cutter GR, Baier ML, Rudick RA, et al. Development of a multiple sclerosis functional composite as a clinical trial outcome measure. Brain 1999; 122: 871-882.
    • (1999) Brain , vol.122 , pp. 871-882
    • Cutter, G.R.1    Baier, M.L.2    Rudick, R.A.3
  • 40
    • 1942421718 scopus 로고    scopus 로고
    • Multicentre, randomised, double blind, placebo controlled, phase III study of weekly, low dose, subcutaneous interferon beta-1a in secondary progressive multiple sclerosis
    • Andersen O, Elovaara I, Farkkila M, et al. Multicentre, randomised, double blind, placebo controlled, phase III study of weekly, low dose, subcutaneous interferon beta-1a in secondary progressive multiple sclerosis. J Neurol Neurosurg Psychiatry 2004; 75: 706-710.
    • (2004) J Neurol Neurosurg Psychiatry , vol.75 , pp. 706-710
    • Andersen, O.1    Elovaara, I.2    Farkkila, M.3
  • 41
    • 0037435526 scopus 로고    scopus 로고
    • Interferon beta-1a in primary progressive MS: an exploratory, randomized, controlled trial
    • Leary SM, Miller DH, Stevenson VL, et al. Interferon beta-1a in primary progressive MS: an exploratory, randomized, controlled trial. Neurology 2003; 60: 44-51.
    • (2003) Neurology , vol.60 , pp. 44-51
    • Leary, S.M.1    Miller, D.H.2    Stevenson, V.L.3
  • 42
    • 0037180479 scopus 로고    scopus 로고
    • Randomized, comparative study of interferon beta-1a treatment regimens in MS: the EVIDENCE trial
    • Panitch H, Goodin DS, Francis G, et al. Randomized, comparative study of interferon beta-1a treatment regimens in MS: the EVIDENCE trial. Neurology 2002; 59: 1496-1506.
    • (2002) Neurology , vol.59 , pp. 1496-1506
    • Panitch, H.1    Goodin, D.S.2    Francis, G.3
  • 43
    • 20844456591 scopus 로고    scopus 로고
    • Enhanced benefit of increasing interferon beta-1a dose and frequency in relapsing multiple sclerosis: the EVIDENCE study
    • Schwid SR, Thorpe J, Sharief M, et al. Enhanced benefit of increasing interferon beta-1a dose and frequency in relapsing multiple sclerosis: the EVIDENCE study. Arch Neurol 2005; 62: 785-792.
    • (2005) Arch Neurol , vol.62 , pp. 785-792
    • Schwid, S.R.1    Thorpe, J.2    Sharief, M.3
  • 44
    • 0037181634 scopus 로고    scopus 로고
    • Every-other-day interferon beta-1b versus once-weekly interferon beta-1a for multiple sclerosis: results of a 2-year prospective randomised multicentre study (INCOMIN)
    • Durelli L, Verdun E, Barbero P, et al. Every-other-day interferon beta-1b versus once-weekly interferon beta-1a for multiple sclerosis: results of a 2-year prospective randomised multicentre study (INCOMIN). Lancet 2002; 359: 1453-1460.
    • (2002) Lancet , vol.359 , pp. 1453-1460
    • Durelli, L.1    Verdun, E.2    Barbero, P.3
  • 45
    • 33646117499 scopus 로고    scopus 로고
    • A randomized study of two interferon-beta treatments in relapsing-remitting multiple sclerosis
    • Koch-Henriksen N, Sorensen PS, Christensen T, et al. A randomized study of two interferon-beta treatments in relapsing-remitting multiple sclerosis. Neurology 2006; 66: 1056-1060.
    • (2006) Neurology , vol.66 , pp. 1056-1060
    • Koch-Henriksen, N.1    Sorensen, P.S.2    Christensen, T.3
  • 46
    • 51449101000 scopus 로고    scopus 로고
    • Comparison of subcutaneous interferon beta-1a with glatiramer acetate in patients with relapsing multiple sclerosis (the REbif vs Glatiramer Acetate in Relapsing MS Disease [REGARD] study): a multicentre, randomised, parallel, open-label trial
    • Mikol DD, Barkhof F, Chang P, et al. Comparison of subcutaneous interferon beta-1a with glatiramer acetate in patients with relapsing multiple sclerosis (the REbif vs Glatiramer Acetate in Relapsing MS Disease [REGARD] study): a multicentre, randomised, parallel, open-label trial. Lancet Neurol 2008; 7: 903-914.
    • (2008) Lancet Neurol , vol.7 , pp. 903-914
    • Mikol, D.D.1    Barkhof, F.2    Chang, P.3
  • 47
    • 67649476210 scopus 로고    scopus 로고
    • Efficacy of treatment of MS with IFNbeta-1b or glatiramer acetate by monthly brain MRI in the BECOME study
    • Cadavid D, Wolansky LJ, Skurnick J, et al. Efficacy of treatment of MS with IFNbeta-1b or glatiramer acetate by monthly brain MRI in the BECOME study. Neurology 2009; 72: 1976-1983.
    • (2009) Neurology , vol.72 , pp. 1976-1983
    • Cadavid, D.1    Wolansky, L.J.2    Skurnick, J.3
  • 48
    • 69949098534 scopus 로고    scopus 로고
    • 250 microg or 500 microg interferon beta-1b versus 20 mg glatiramer acetate in relapsing-remitting multiple sclerosis: a prospective, randomised, multicentre study
    • O'Connor P, Filippi M, Arnason B, et al. 250 microg or 500 microg interferon beta-1b versus 20 mg glatiramer acetate in relapsing-remitting multiple sclerosis: a prospective, randomised, multicentre study. Lancet Neurol 2009; 8: 889-897.
    • (2009) Lancet Neurol , vol.8 , pp. 889-897
    • O'Connor, P.1    Filippi, M.2    Arnason, B.3
  • 49
    • 76449110495 scopus 로고    scopus 로고
    • Combination therapy in multiple sclerosis
    • Conway D, Cohen JA. Combination therapy in multiple sclerosis. Lancet Neurol 2010; 9: 299-308.
    • (2010) Lancet Neurol , vol.9 , pp. 299-308
    • Conway, D.1    Cohen, J.A.2
  • 50
    • 0028835098 scopus 로고
    • Additive effects of copolymer-1 and interferon beta-1b on the immune response to myelin basic protein
    • Milo R, Panitch H. Additive effects of copolymer-1 and interferon beta-1b on the immune response to myelin basic protein. J Neuroimmunol. 1995; 61: 185-193.
    • (1995) J Neuroimmunol , vol.61 , pp. 185-193
    • Milo, R.1    Panitch, H.2
  • 51
    • 0033960042 scopus 로고    scopus 로고
    • Combination therapy with glatiramer acetate (copolymer-1) and a type I interferon (IFN-alpha) does not improve experimental autoimmune encephalomyelitis
    • Brod SA, Lindsey JW, Wolinsky JS. Combination therapy with glatiramer acetate (copolymer-1) and a type I interferon (IFN-alpha) does not improve experimental autoimmune encephalomyelitis. Ann Neurol 2000; 47: 127-131.
    • (2000) Ann Neurol , vol.47 , pp. 127-131
    • Brod, S.A.1    Lindsey, J.W.2    Wolinsky, J.S.3
  • 52
    • 0034882744 scopus 로고    scopus 로고
    • Glatiramer acetate induces a Th2-biased response and crossreactivity with myelin basic protein in patients with MS
    • Chen M, Gran B, Costello K, et al. Glatiramer acetate induces a Th2-biased response and crossreactivity with myelin basic protein in patients with MS. Mult Scler 2001; 7: 209-219.
    • (2001) Mult Scler , vol.7 , pp. 209-219
    • Chen, M.1    Gran, B.2    Costello, K.3
  • 53
    • 84873112669 scopus 로고    scopus 로고
    • The CombiRx trial: a multi-center, doubleblind, randomized study comparing the combined use of interferon beta-1a and glatiramer acetate to either agent alone in participants with relapsing-remitting multiple sclerosis - clinical outcomes
    • Abstract, PL02.003
    • Lublin F, Cofield S, Cutter G, et al. The CombiRx trial: a multi-center, doubleblind, randomized study comparing the combined use of interferon beta-1a and glatiramer acetate to either agent alone in participants with relapsing-remitting multiple sclerosis - clinical outcomes. Neurology 2012; 78: PL02. 003. Abstract.
    • (2012) Neurology , vol.78
    • Lublin, F.1    Cofield, S.2    Cutter, G.3
  • 54
    • 77953618723 scopus 로고    scopus 로고
    • Methylprednisolone in combination with interferon beta-1a for relapsing-remitting multiple sclerosis (MECOMBIN study): a multicentre, double-blind, randomised, placebo-controlled, parallel-group trial
    • Ravnborg M, Sørensen PS, Andersson M, et al. Methylprednisolone in combination with interferon beta-1a for relapsing-remitting multiple sclerosis (MECOMBIN study): a multicentre, double-blind, randomised, placebo-controlled, parallel-group trial. Lancet Neurol 2010; 9: 672-680.
    • (2010) Lancet Neurol , vol.9 , pp. 672-680
    • Ravnborg, M.1    Sørensen, P.S.2    Andersson, M.3
  • 55
    • 65549144672 scopus 로고    scopus 로고
    • NORdic trial of oral methylprednisolone as add-on therapy to interferon beta-1a for treatment of relapsingremitting multiple sclerosis (NORMIMS study): a randomised, placebo-controlled trial
    • Sorensen PS, Mellgren SI, Svenningsson A, et al. NORdic trial of oral methylprednisolone as add-on therapy to interferon beta-1a for treatment of relapsingremitting multiple sclerosis (NORMIMS study): a randomised, placebo-controlled trial. Lancet Neurol 2009; 8: 519-529.
    • (2009) Lancet Neurol , vol.8 , pp. 519-529
    • Sorensen, P.S.1    Mellgren, S.I.2    Svenningsson, A.3
  • 56
    • 62149143732 scopus 로고    scopus 로고
    • Results of the avonex combination trial (ACT) in relapsing-remitting MS
    • Cohen JA, Imrey PB, Calabresi PA, et al. Results of the avonex combination trial (ACT) in relapsing-remitting MS. Neurology 2009; 72: 535-541.
    • (2009) Neurology , vol.72 , pp. 535-541
    • Cohen, J.A.1    Imrey, P.B.2    Calabresi, P.A.3
  • 57
    • 77955762153 scopus 로고    scopus 로고
    • Analysis of clinical outcomes according to original treatment groups 16 years after the pivotal IFNB-1b trial
    • Ebers GC, Traboulsee A, Li D, et al. Analysis of clinical outcomes according to original treatment groups 16 years after the pivotal IFNB-1b trial. J Neurol Neurosurg Psychiatry 2010; 81: 907-912.
    • (2010) J Neurol Neurosurg Psychiatry , vol.81 , pp. 907-912
    • Ebers, G.C.1    Traboulsee, A.2    Li, D.3
  • 58
    • 84860770990 scopus 로고    scopus 로고
    • Survival in MS: a randomized cohort study 21 years after the start of the pivotal IFNbeta-1b trial
    • Goodin DS, Reder AT, Ebers GC, et al. Survival in MS: a randomized cohort study 21 years after the start of the pivotal IFNbeta-1b trial. Neurology 2012; 78: 1315-1322.
    • (2012) Neurology , vol.78 , pp. 1315-1322
    • Goodin, D.S.1    Reder, A.T.2    Ebers, G.C.3
  • 59
    • 84863186662 scopus 로고    scopus 로고
    • Systematic review of disease-modifying therapies to assess unmet needs in multiple sclerosis: tolerability and adherence
    • Giovannoni G, Southam E, Waubant E. Systematic review of disease-modifying therapies to assess unmet needs in multiple sclerosis: tolerability and adherence. Mult Scler 2012; 18: 932-946.
    • (2012) Mult Scler , vol.18 , pp. 932-946
    • Giovannoni, G.1    Southam, E.2    Waubant, E.3
  • 60
    • 34248597542 scopus 로고    scopus 로고
    • The safety and efficacy of IFN-beta products for the treatment of multiple sclerosis
    • Kremenchutzky M, Morrow S, Rush C. The safety and efficacy of IFN-beta products for the treatment of multiple sclerosis. Expert Opin Drug Saf 2007; 6: 279-288.
    • (2007) Expert Opin Drug Saf , vol.6 , pp. 279-288
    • Kremenchutzky, M.1    Morrow, S.2    Rush, C.3
  • 61
    • 80053424031 scopus 로고    scopus 로고
    • Magnetic resonance active lesions as individual-level surrogate for relapses in multiple sclerosis
    • Sormani MP, Stubinski B, Cornelisse P, et al. Magnetic resonance active lesions as individual-level surrogate for relapses in multiple sclerosis. Mult Scler 2011; 17: 541-549.
    • (2011) Mult Scler , vol.17 , pp. 541-549
    • Sormani, M.P.1    Stubinski, B.2    Cornelisse, P.3
  • 62
    • 4844223606 scopus 로고    scopus 로고
    • Defining interferon beta response status in multiple sclerosis patients
    • Rudick RA, Lee JC, Simon J, Ransohoff RM, Fisher E. Defining interferon beta response status in multiple sclerosis patients. Ann Neurol 2004; 56: 548-555.
    • (2004) Ann Neurol , vol.56 , pp. 548-555
    • Rudick, R.A.1    Lee, J.C.2    Simon, J.3    Ransohoff, R.M.4    Fisher, E.5
  • 63
    • 79953803423 scopus 로고    scopus 로고
    • Determinants of interferon beta efficacy in patients with multiple sclerosis
    • Killestein J, Polman CH. Determinants of interferon beta efficacy in patients with multiple sclerosis. Nat Rev Neurol 2011; 7: 221-228.
    • (2011) Nat Rev Neurol , vol.7 , pp. 221-228
    • Killestein, J.1    Polman, C.H.2
  • 64
    • 84860495711 scopus 로고    scopus 로고
    • Persistency of neutralizing antibodies depends on titer and interferon-beta preparation
    • Hegen H, Schleiser M, Gneiss C, et al. Persistency of neutralizing antibodies depends on titer and interferon-beta preparation. Mult Scler 2012; 18: 610-615.
    • (2012) Mult Scler , vol.18 , pp. 610-615
    • Hegen, H.1    Schleiser, M.2    Gneiss, C.3
  • 65
    • 77953454473 scopus 로고    scopus 로고
    • Recommendations for clinical use of data on neutralising antibodies to interferon-beta therapy in multiple sclerosis
    • Polman CH, Bertolotto A, Deisenhammer F, et al. Recommendations for clinical use of data on neutralising antibodies to interferon-beta therapy in multiple sclerosis. Lancet Neurol 2010; 9: 740-750.
    • (2010) Lancet Neurol , vol.9 , pp. 740-750
    • Polman, C.H.1    Bertolotto, A.2    Deisenhammer, F.3
  • 66
    • 77950534540 scopus 로고    scopus 로고
    • T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis
    • Axtell RC, de Jong BA, Boniface K, et al. T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis. Nat Med 2010; 16: 406-412.
    • (2010) Nat Med , vol.16 , pp. 406-412
    • Axtell, R.C.1    de Jong, B.A.2    Boniface, K.3
  • 67
    • 84862741487 scopus 로고    scopus 로고
    • Serum IL-17F does not predict poor response to IM IFNbeta-1a in relapsing-remitting MS
    • Bushnell SE, Zhao Z, Stebbins CC, et al. Serum IL-17F does not predict poor response to IM IFNbeta-1a in relapsing-remitting MS. Neurology 2012; 79: 531-537.
    • (2012) Neurology , vol.79 , pp. 531-537
    • Bushnell, S.E.1    Zhao, Z.2    Stebbins, C.C.3
  • 68
    • 69449098530 scopus 로고    scopus 로고
    • The challenge of follow-on biologics for treatment of multiple sclerosis
    • Reingold SC, Steiner JP, Polman CH, et al. The challenge of follow-on biologics for treatment of multiple sclerosis. Neurology 2009; 73: 552-559.
    • (2009) Neurology , vol.73 , pp. 552-559
    • Reingold, S.C.1    Steiner, J.P.2    Polman, C.H.3
  • 69
    • 0030013545 scopus 로고    scopus 로고
    • The development of Cop 1 (copaxone), an innovative drug for the treatment of multiple sclerosis: personal reflections
    • Arnon R. The development of Cop 1 (copaxone), an innovative drug for the treatment of multiple sclerosis: personal reflections. Immunol Lett 1996; 50: 1-15.
    • (1996) Immunol Lett , vol.50 , pp. 1-15
    • Arnon, R.1
  • 70
    • 77955442859 scopus 로고    scopus 로고
    • Glatiramer acetate: a review of its use in relapsingremitting multiple sclerosis and in delaying the onset of clinically definite multiple sclerosis
    • Carter NJ, Keating GM. Glatiramer acetate: a review of its use in relapsingremitting multiple sclerosis and in delaying the onset of clinically definite multiple sclerosis. Drugs 2010; 70: 1545-1577.
    • (2010) Drugs , vol.70 , pp. 1545-1577
    • Carter, N.J.1    Keating, G.M.2
  • 71
    • 40349089507 scopus 로고    scopus 로고
    • Glatiramer acetate: evidence for a dual mechanism of action
    • Blanchette F, Neuhaus O. Glatiramer acetate: evidence for a dual mechanism of action. J Neurol 2008; 255: 26-36.
    • (2008) J Neurol , vol.255 , pp. 26-36
    • Blanchette, F.1    Neuhaus, O.2
  • 72
    • 48349114325 scopus 로고    scopus 로고
    • Multiple sclerosis: glatiramer acetate induces anti-inflammatory T cells in the cerebrospinal fluid
    • Hestvik AL, Skorstad G, Price DA, Vartdal F, Holmoy T. Multiple sclerosis: glatiramer acetate induces anti-inflammatory T cells in the cerebrospinal fluid. Mult Scler 2008; 14: 749-758.
    • (2008) Mult Scler , vol.14 , pp. 749-758
    • Hestvik, A.L.1    Skorstad, G.2    Price, D.A.3    Vartdal, F.4    Holmoy, T.5
  • 73
    • 0017286723 scopus 로고
    • Molecular requirements involved in suppression of EAE by synthetic basic copolymers of amino acids
    • Webb C, Teitelbaum D, Herz A, Arnon R, Sela M. Molecular requirements involved in suppression of EAE by synthetic basic copolymers of amino acids. Immunochemistry 1976; 13: 333-337.
    • (1976) Immunochemistry , vol.13 , pp. 333-337
    • Webb, C.1    Teitelbaum, D.2    Herz, A.3    Arnon, R.4    Sela, M.5
  • 74
    • 18144387626 scopus 로고    scopus 로고
    • Induction of CD4 + CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3
    • Hong J, Li N, Zhang X, Zheng B, Zhang JZ. Induction of CD4 + CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3. Proc Natl Acad Sci U S A 2005; 102: 6449-6454.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 6449-6454
    • Hong, J.1    Li, N.2    Zhang, X.3    Zheng, B.4    Zhang, J.Z.5
  • 75
    • 0344098868 scopus 로고    scopus 로고
    • Antibodies to glatiramer acetate do not interfere with its biological functions and therapeutic efficacy
    • Teitelbaum D, Brenner T, Abramsky O, et al. Antibodies to glatiramer acetate do not interfere with its biological functions and therapeutic efficacy. Mult Scler 2003; 9: 592-599.
    • (2003) Mult Scler , vol.9 , pp. 592-599
    • Teitelbaum, D.1    Brenner, T.2    Abramsky, O.3
  • 76
    • 0035795018 scopus 로고    scopus 로고
    • Humoral and cellular immune responses to copolymer 1 in multiple sclerosis patients treated with copaxone
    • Brenner T, Arnon R, Sela M, et al. Humoral and cellular immune responses to copolymer 1 in multiple sclerosis patients treated with copaxone. J Neuroimmunol 2001; 115: 152-160.
    • (2001) J Neuroimmunol , vol.115 , pp. 152-160
    • Brenner, T.1    Arnon, R.2    Sela, M.3
  • 77
    • 79953890862 scopus 로고    scopus 로고
    • Glatiramer acetate in the treatment of multiple sclerosis: emerging concepts regarding its mechanism of action
    • Lalive PH, Neuhaus O, Benkhoucha et al. Glatiramer acetate in the treatment of multiple sclerosis: emerging concepts regarding its mechanism of action. CNS Drugs 2011; 25: 401-414.
    • (2011) CNS Drugs , vol.25 , pp. 401-414
    • Lalive, P.H.1    Neuhaus, O.2    Benkhoucha3
  • 78
    • 34248177331 scopus 로고    scopus 로고
    • Production of brain-derived neurotrophic factor by mononuclear cells of patients with multiple sclerosis treated with glatiramer acetate, interferon-beta 1a, and high doses of immunoglobulins
    • Sarchielli P, Zaffaroni M, Floridi A, et al. Production of brain-derived neurotrophic factor by mononuclear cells of patients with multiple sclerosis treated with glatiramer acetate, interferon-beta 1a, and high doses of immunoglobulins. Mult Scler 2007; 13: 313-331.
    • (2007) Mult Scler , vol.13 , pp. 313-331
    • Sarchielli, P.1    Zaffaroni, M.2    Floridi, A.3
  • 79
    • 30044451754 scopus 로고    scopus 로고
    • The immunomodulator glatiramer acetate augments the expression of neurotrophic factors in brains of experimental autoimmune encephalomyelitis mice
    • Aharoni R, Eilam R, Domev H, et al. The immunomodulator glatiramer acetate augments the expression of neurotrophic factors in brains of experimental autoimmune encephalomyelitis mice. Proc Natl Acad Sci U S A 2005; 102: 19045-19050.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 19045-19050
    • Aharoni, R.1    Eilam, R.2    Domev, H.3
  • 80
    • 70349815768 scopus 로고    scopus 로고
    • Promoting oligodendrogenesis and myelin repair using the multiple sclerosis medication glatiramer acetate
    • Skihar V, Silva C, Chojnacki A, et al. Promoting oligodendrogenesis and myelin repair using the multiple sclerosis medication glatiramer acetate. Proc Natl Acad Sci U S A 2009; 106: 17992-17997.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 17992-17997
    • Skihar, V.1    Silva, C.2    Chojnacki, A.3
  • 81
    • 0017341548 scopus 로고
    • Effect of a synthetic polypeptide (COP 1) on patients with multiple sclerosis and with acute disseminated encephalomeylitis. Preliminary report
    • Abramsky O, Teitelbaum D, Arnon R. Effect of a synthetic polypeptide (COP 1) on patients with multiple sclerosis and with acute disseminated encephalomeylitis. Preliminary report. J Neurol Sci 1977; 31: 433-438.
    • (1977) J Neurol Sci , vol.31 , pp. 433-438
    • Abramsky, O.1    Teitelbaum, D.2    Arnon, R.3
  • 83
    • 0023248694 scopus 로고
    • A pilot trial of Cop 1 in exacerbatingremitting multiple sclerosis
    • Bornstein MB, Miller A, Slagle S, et al. A pilot trial of Cop 1 in exacerbatingremitting multiple sclerosis. N Engl J Med 1987; 317: 408-414.
    • (1987) N Engl J Med , vol.317 , pp. 408-414
    • Bornstein, M.B.1    Miller, A.2    Slagle, S.3
  • 84
    • 0029082566 scopus 로고
    • Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multicenter, double-blind placebo-controlled trial. The copolymer 1 multiple sclerosis study group
    • Johnson KP, Brooks BR, Cohen JA, et al. Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multicenter, double-blind placebo-controlled trial. The copolymer 1 multiple sclerosis study group. Neurology 1995; 45: 1268-1276.
    • (1995) Neurology , vol.45 , pp. 1268-1276
    • Johnson, K.P.1    Brooks, B.R.2    Cohen, J.A.3
  • 85
    • 6844254570 scopus 로고    scopus 로고
    • Extended use of glatiramer acetate (copaxone) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability. Copolymer 1 multiple sclerosis study group
    • Johnson KP, Brooks BR, Cohen JA, et al. Extended use of glatiramer acetate (copaxone) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability. Copolymer 1 multiple sclerosis study group. Neurology 1998; 50: 701-708.
    • (1998) Neurology , vol.50 , pp. 701-708
    • Johnson, K.P.1    Brooks, B.R.2    Cohen, J.A.3
  • 86
    • 18344409394 scopus 로고    scopus 로고
    • Glatiramer acetate (copaxone) treatment in relapsing-remitting MS: quantitative MR assessment
    • Ge Y, Grossman RI, Udupa JK, et al. Glatiramer acetate (copaxone) treatment in relapsing-remitting MS: quantitative MR assessment. Neurology 2000; 54: 813-817.
    • (2000) Neurology , vol.54 , pp. 813-817
    • Ge, Y.1    Grossman, R.I.2    Udupa, J.K.3
  • 87
    • 0031900415 scopus 로고    scopus 로고
    • Effect of copolymer-1 on serial gadolinium-enhanced MRI in relapsing remitting multiple sclerosis
    • Mancardi GL, Sardanelli F, Parodi RC, et al. Effect of copolymer-1 on serial gadolinium-enhanced MRI in relapsing remitting multiple sclerosis. Neurology 1998; 50: 1127-1133.
    • (1998) Neurology , vol.50 , pp. 1127-1133
    • Mancardi, G.L.1    Sardanelli, F.2    Parodi, R.C.3
  • 88
    • 0035091667 scopus 로고    scopus 로고
    • European/Canadian multicenter, double-blind, randomized, placebo-controlled study of the effects of glatiramer acetate on magnetic resonance imaging--measured disease activity and burden in patients with relapsing multiple sclerosis. European/Canadian glatiramer acetate study group
    • Comi G, Filippi M, Wolinsky JS. European/Canadian multicenter, double-blind, randomized, placebo-controlled study of the effects of glatiramer acetate on magnetic resonance imaging--measured disease activity and burden in patients with relapsing multiple sclerosis. European/Canadian glatiramer acetate study group. Ann Neurol 2001; 49: 290-297.
    • (2001) Ann Neurol , vol.49 , pp. 290-297
    • Comi, G.1    Filippi, M.2    Wolinsky, J.S.3
  • 89
    • 70350786389 scopus 로고    scopus 로고
    • Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial
    • Comi G. Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial. The Lancet (British edition) 2009; 374: 1503-1511.
    • (2009) The Lancet (British Edition) , vol.374 , pp. 1503-1511
    • Comi, G.1
  • 90
    • 0025817469 scopus 로고
    • A placebo-controlled, double-blind, randomized, two-center, pilot trial of Cop 1 in chronic progressive multiple sclerosis
    • Bornstein MB, Miller A, Slagle S, et al. A placebo-controlled, double-blind, randomized, two-center, pilot trial of Cop 1 in chronic progressive multiple sclerosis. Neurology 1991; 41: 533-539.
    • (1991) Neurology , vol.41 , pp. 533-539
    • Bornstein, M.B.1    Miller, A.2    Slagle, S.3
  • 91
    • 33846833929 scopus 로고    scopus 로고
    • Glatiramer acetate in primary progressive multiple sclerosis: results of a multinational, multicenter, double-blind, placebo-controlled trial
    • Wolinsky JS, Narayana PA, O'Connor P, et al. Glatiramer acetate in primary progressive multiple sclerosis: results of a multinational, multicenter, double-blind, placebo-controlled trial. Ann Neurol 2007; 61: 14-24.
    • (2007) Ann Neurol , vol.61 , pp. 14-24
    • Wolinsky, J.S.1    Narayana, P.A.2    O'Connor, P.3
  • 92
    • 70349781937 scopus 로고    scopus 로고
    • Glatiramer acetate treatment in PPMS: why males appear to respond favorably
    • PROMiSe Trial Study Group
    • Wolinsky JS, Shochat T, Weiss S, Ladkani D, PROMiSe Trial Study Group. Glatiramer acetate treatment in PPMS: why males appear to respond favorably. J Neurol Sci 2009; 286: 92-98.
    • (2009) J Neurol Sci , vol.286 , pp. 92-98
    • Wolinsky, J.S.1    Shochat, T.2    Weiss, S.3    Ladkani, D.4
  • 94
    • 59249089860 scopus 로고    scopus 로고
    • Concepts of induction and escalation therapy in multiple sclerosis
    • Rieckmann P. Concepts of induction and escalation therapy in multiple sclerosis. J Neurol Sci 2009; 277: S42-S45.
    • (2009) J Neurol Sci , vol.277
    • Rieckmann, P.1
  • 95
    • 62849118791 scopus 로고    scopus 로고
    • GLANCE: results of a phase 2, randomized, double-blind, placebo-controlled study
    • Goodman AD, Rossman H, Bar-Or A, et al. GLANCE: results of a phase 2, randomized, double-blind, placebo-controlled study. Neurology 2009; 72: 806-812.
    • (2009) Neurology , vol.72 , pp. 806-812
    • Goodman, A.D.1    Rossman, H.2    Bar-Or, A.3
  • 96
    • 0033842848 scopus 로고    scopus 로고
    • Sustained clinical benefits of glatiramer acetate in relapsing multiple sclerosis patients observed for 6 years. Copolymer 1 multiple sclerosis study group
    • Johnson KP, Brooks BR, Ford CC, et al. Sustained clinical benefits of glatiramer acetate in relapsing multiple sclerosis patients observed for 6 years. Copolymer 1 multiple sclerosis study group. Mult Scler 2000; 6: 255-266.
    • (2000) Mult Scler , vol.6 , pp. 255-266
    • Johnson, K.P.1    Brooks, B.R.2    Ford, C.C.3
  • 97
    • 12744273688 scopus 로고    scopus 로고
    • Neurologic consequence of delaying glatiramer acetate therapy for multiple sclerosis: 8-year data
    • Johnson KP, Ford CC, Lisak RP, Wolinsky JS. Neurologic consequence of delaying glatiramer acetate therapy for multiple sclerosis: 8-year data. Acta Neurol Scand 2005; 111: 42-47.
    • (2005) Acta Neurol Scand , vol.111 , pp. 42-47
    • Johnson, K.P.1    Ford, C.C.2    Lisak, R.P.3    Wolinsky, J.S.4
  • 98
    • 33744814611 scopus 로고    scopus 로고
    • A prospective open-label study of glatiramer acetate: over a decade of continuous use in multiple sclerosis patients
    • Ford CC, Johnson KP, Lisak RP, et al. A prospective open-label study of glatiramer acetate: over a decade of continuous use in multiple sclerosis patients. Mult Scler 2006; 12: 309-320.
    • (2006) Mult Scler , vol.12 , pp. 309-320
    • Ford, C.C.1    Johnson, K.P.2    Lisak, R.P.3
  • 99
    • 77949885488 scopus 로고    scopus 로고
    • Continuous long-term immunomodulatory therapy in relapsing multiple sclerosis: results from the 15-year analysis of the US prospective open-label study of glatiramer acetate
    • Ford C, Goodman AD, Johnson K, et al. Continuous long-term immunomodulatory therapy in relapsing multiple sclerosis: results from the 15-year analysis of the US prospective open-label study of glatiramer acetate. Mult Scler 2010; 16: 342-350.
    • (2010) Mult Scler , vol.16 , pp. 342-350
    • Ford, C.1    Goodman, A.D.2    Johnson, K.3
  • 100
    • 17644382987 scopus 로고    scopus 로고
    • Severe anaphylactic reaction to glatiramer acetate with specific IgE
    • Rauschka H, Farina C, Sator P, et al. Severe anaphylactic reaction to glatiramer acetate with specific IgE. Neurology 2005; 64: 1481-1482.
    • (2005) Neurology , vol.64 , pp. 1481-1482
    • Rauschka, H.1    Farina, C.2    Sator, P.3
  • 101
    • 82055175126 scopus 로고    scopus 로고
    • Anaphylactic reaction after injection of glatiramer acetate (copaxone(R)) in patients with relapsing-remitting multiple sclerosis
    • Baumgartner A, Stich O, Rauer S. Anaphylactic reaction after injection of glatiramer acetate (copaxone(R)) in patients with relapsing-remitting multiple sclerosis. Eur Neurol 2011; 66: 368-370.
    • (2011) Eur Neurol , vol.66 , pp. 368-370
    • Baumgartner, A.1    Stich, O.2    Rauer, S.3
  • 102
    • 32544449771 scopus 로고    scopus 로고
    • Effects of oral glatiramer acetate on clinical and MRI-monitored disease activity in patients with relapsing multiple sclerosis: a multicentre, double-blind, randomised, placebo-controlled study
    • CORAL Study Group
    • Filippi M, Wolinsky JS, Comi G, CORAL Study Group. Effects of oral glatiramer acetate on clinical and MRI-monitored disease activity in patients with relapsing multiple sclerosis: a multicentre, double-blind, randomised, placebo-controlled study. Lancet Neurol 2006; 5: 213-220.
    • (2006) Lancet Neurol , vol.5 , pp. 213-220
    • Filippi, M.1    Wolinsky, J.S.2    Comi, G.3
  • 103
    • 59349105358 scopus 로고    scopus 로고
    • The results of two multicenter, openlabel studies assessing efficacy, tolerability and safety of protiramer, a high molecular weight synthetic copolymeric mixture, in patients with relapsing-remitting multiple sclerosis
    • De Stefano N, Filippi M, Confavreux C, et al. The results of two multicenter, openlabel studies assessing efficacy, tolerability and safety of protiramer, a high molecular weight synthetic copolymeric mixture, in patients with relapsing-remitting multiple sclerosis. Mult Scler 2009; 15: 238-243.
    • (2009) Mult Scler , vol.15 , pp. 238-243
    • de Stefano, N.1    Filippi, M.2    Confavreux, C.3


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