Bridging the gap between old and new concepts in drug-induced liver injury

Clinics and Research in Hepatology and Gastroenterology

Volumn 37, Issue 1, 2013, Pages 6-9

  Fromenty, B ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; CYTOCHROME P450; GAP JUNCTION PROTEIN; PARACETAMOL; REACTIVE OXYGEN METABOLITE; THIOACETAMIDE;

ARTICLE; CELL DEATH; DRUG INDUSTRY; GAP JUNCTION; HUMAN; INFLAMMATION; LIVER CELL; LIVER PROTECTION; LIVER REGENERATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; TOXIC HEPATITIS;

DRUG-INDUCED LIVER INJURY; HUMANS;

EID: 84873151119     PISSN: 22107401     EISSN: 2210741X     Source Type: Journal    
DOI: 10.1016/j.clinre.2012.12.003     Document Type: Article

References (35)

1. Baillie T.A., Rettie A.E. Role of biotransformation in drug-induced toxicity: influence of intra- and inter-species differences in drug metabolism. Drug Metab Pharmacokinet 2011, 26:15-29.
2. Porceddu M., Buron N., Roussel C., et al. Prediction of liver injury induced by chemicals in human with a multiparametric assay on isolated mouse liver mitochondria. Toxicol Sci 2012, 129:332-345.
3. Begriche K., Massart J., Robin M.A., et al. Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver. J Hepatol 2011, 54:773-794.
4. Pessayre D., Fromenty B., Berson A., et al. Central role of mitochondria in drug-induced liver injury. Drug Metab Rev 2012, 44:34-87.
5. Wang X., Sun R., Wei H., et al. HMGB1-TLR4-IL-23-IL-17A axis in drug-induced damage-associated lethal hepatitis: interaction of γδ T cells with macrophages. Hepatology 2013, 57:373-384.
6. Jaeschke H., Williams C.D., Ramachandran A., et al. Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity. Liver Int 2012, 32:8-20.
7. Lieu H.T., Batteux F., Simon M.T., et al. HIP/PAP accelerates liver regeneration and protects against acetaminophen injury in mice. Hepatology 2005, 42:618-626.
8. Patel S.J., Milwid J.M., King K.R., et al. Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure. Nat Biotechnol 2012, 30:179-183.
9. Hajovsky H., Hu G., Koen Y., et al. Metabolism and toxicity of thioacetamide and thioacetamide S-oxide in rat hepatocytes. Chem Res Toxicol 2012, 25:1955-1963.
10. Staňková P., Kučera O., Lotková H., et al. The toxic effect of thioacetamide on rat liver in vitro. Toxicol In Vitro 2010, 24:2097-2103.
11. Aubert J., Begriche K., Delannoy M., et al. Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice. J Pharmacol Exp Ther 2012, 342:676-687.
12. Landin J.S., Cohen S.D., Khairallah E.A. Identification of a 54-kDa mitochondrial acetaminophen-binding protein as aldehyde dehydrogenase. Toxicol Appl Pharmacol 1996, 141:299-307.
13. Qiu Y., Benet L.Z., Burlingame A.L. Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry. J Biol Chem 1998, 273:17940-17953.
14. Dai Y., Cederbaum A.I. Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfected HepG2 cells. J Pharmacol Exp Ther 1995, 273:1497-1505.
15. Ferner R.E., Dear J.W., Bateman D.N. Management of paracetamol poisoning. BMJ 2011, 342:d2218.
16. Yin H., Cheng L., Holt M., et al. Lactoferrin protects against acetaminophen-induced liver injury in mice. Hepatology 2010, 51:1007-1016.
17. Donahower B.C., McCullough S.S., Hennings L., et al. Human recombinant vascular endothelial growth factor reduces necrosis and enhances hepatocyte regeneration in a mouse model of acetaminophen toxicity. J Pharmacol Exp Ther 2010, 334:33-43.
18. Michael Brown J., Ball J.G., Wright M.S., et al. Novel protective mechanisms for S-adenosyl-L-methionine against acetaminophen hepatotoxicity: improvement of key antioxidant enzymatic function. Toxicol Lett 2012, 212:320-328.
19. Park J.H., Seo K.S., Tadi S., et al. An indole-derivative protects against acetaminophen-induced liver injury by directly binding to N-acetyl-p-benzoquinone imine in mice. Antioxid Redox Signal 2012, 10.1089/ars.2012.4677.
20. Patterson A.D., Shah Y.M., Matsubara T., et al. Peroxisome proliferator-activated receptor-α induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity. Hepatology 2012, 56:281-290.
21. Burke A.S., MacMillan-Crow L.A., Hinson J.A. Reactive nitrogen species in acetaminophen-induced mitochondrial damage and toxicity in mouse hepatocytes. Chem Res Toxicol 2010, 23:1286-1292.
22. Chinopoulos C., Starkov A.A., Fiskum G. Cyclosporin A-insensitive permeability transition in brain mitochondria: inhibition by 2-aminoethoxydiphenyl borate. J Biol Chem 2003, 278:27382-27389.
23. Masubuchi Y., Suda C., Horie T. Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice. J Hepatol 2005, 42:110-116.
24. 2+ channels. J Gastroenterol Hepatol 2004, 19:1128-1134.
25. Wang P., Umeda P.K., Sharifov O.F., et al. Evidence that 2-aminoethoxydiphenyl borate provokes fibrillation in perfused rat hearts via voltage-independent calcium channels. Eur J Pharmacol 2012, 681:60-67.
26. Larosche I., Lettéron P., Fromenty B., et al. Tamoxifen inhibits topoisomerases, depletes mitochondrial DNA, and triggers steatosis in mouse liver. J Pharmacol Exp Ther 2007, 321:526-535.
27. Fromenty B., Fisch C., Berson A., et al. Dual effect of amiodarone on mitochondrial respiration. Initial protonophoric uncoupling effect followed by inhibition of the respiratory chain at the levels of complex I and complex II. J Pharmacol Exp Ther 1990, 255:1377-1384.
28. Bai D., del Corsso C., Srinivas M., Spray D.C. Block of specific gap junction channel subtypes by 2-aminoethoxydiphenyl borate (2-APB). J Pharmacol Exp Ther 2006, 319:1452-1458.
29. Tao L., Harris A.L. 2-Aminoethoxydiphenyl borate directly inhibits channels composed of connexin26 and/or connexin32. Mol Pharmacol 2007, 71:570-579.
30. Goodenough D.A., Paul D.L. Gap junctions. Cold Spring Harb Perspect Biol 2009, 1:a002576.
31. Colton C.K., Zhu M.X. 2-Aminoethoxydiphenyl borate as a common activator of TRPV1, TRPV2, and TRPV3 channels. Handb Exp Pharmacol 2007, 179:173-187.
32. 2+. J Biol Chem 1985, 260:13035-13040.
33. Beales D., Hue D.P., McLean A.E. Lipid peroxidation, protein synthesis, and protection by calcium EDTA in paracetamol injury to isolated hepatocytes. Biochem Pharmacol 1985, 34:19-23.
34. Leite M.F., Hirata K., Pusl T., et al. Molecular basis for pacemaker cells in epithelia. J Biol Chem 2002, 277:16313-16323.
35. Paemeleire K., Martin P.E., Coleman S.L., et al. Intercellular calcium waves in HeLa cells expressing GFP-labeled connexin 43, 32, or 26. Mol Biol Cell 2000, 11:1815-1827.