Balance of CD8+CD28+/CD8+CD28- T lymphocytes is vital for patients with ulcerative colitis

Digestive Diseases and Sciences

Volumn 58, Issue 1, 2013, Pages 88-96

  Dai, Shi Xue ^a   Wu, Gang ^a   Zou, Ying ^a,b   Feng, Yan Ling ^b   Liu, Hong Bo ^b   Feng, Jin Shan ^a,b   Chi, Hong Gang ^a,b   Lv, Ru Xi ^a,b   Zheng, Xue Bao ^b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

CD8 +CD28 ; CD8+CD28+; Immunological balance; T lymphocytes; Ulcerative colitis

Indexed keywords

CONSENSUS INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1 RECEPTOR ACCESSORY PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 7; JANUS KINASE 3; MONOCYTE CHEMOTACTIC PROTEIN 1; STAT6 PROTEIN; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC2 PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CD8 CD28 T LYMPHOCYTE; CLINICAL ARTICLE; COLON; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; IMMUNODETECTION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; IRRITABLE COLON; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MICROARRAY; T LYMPHOCYTE; ULCERATIVE COLITIS; WESTERN BLOTTING;

ADULT; BLOTTING, WESTERN; CD8-POSITIVE T-LYMPHOCYTES; COLITIS, ULCERATIVE; COLON; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; IRRITABLE BOWEL SYNDROME; MALE; MIDDLE AGED; PROTEIN ARRAY ANALYSIS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; YOUNG ADULT;

EID: 84873140820     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-012-2327-9     Document Type: Article

References (41)

1. Fowkes L, Krishna K, Menon A, et al. Laparoscopic emergency and elective surgery for ulcerative colitis. Colorectal Dis. 2008;10:373-378.
2. Arseneau KO, Tamagawa H, Pizarro TT, et al. Innate and adaptive immune responses related to IBD pathogenesis. Curr Gastroenterol Rep. 2007;9:508-512.
3. Kanai T, Kawamura T, Dohi T, et al. TH1/TH2-mediated colitis induced by adoptive transfer of CD4+ CD45RBhigh T lymphocytes into nude mice. Inflamm Bowel Dis. 2006;12:89-99.
4. Pastorelli L, Garg RR, Hoang SB, et al. Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis. Proc Natl Acad Sci USA. 2010;107:8017-8022.
5. Fuss IJ. Is the Th1/Th2 paradigm of immune regulation applicable to IBD? Inflamm Bowel Dis. 2008;14:S110-S112.
6. Anichini A, Mortarini R, Romagnoli L, et al. Skewed T-cell differentiation in patients with indolent non-Hodgkin lymphoma reversed by ex vivo T-cell culture with gammac cytokines. Blood. 2006;107:602-609.
7. - regulatory T lymphocytes prevent experimental inflammatory bowel disease in mice. Gastroenterology. 2006;131:1775-1785.
8. + T cells in inflammatory bowel disease and their recruitment as intraepithelial lymphocytes. Inflamm Bowel Dis. 2007;13:837-846.
9. Tang X, Maricic I, Purohit N, et al. Regulation of immunity by a novel population of Qa-1-restricted CD8alphaalpha + TCRalphabeta + T cells. J Immunol. 2006;177:7645-7655.
10. Park WR, Park CS, Tomura M, et al. CD28 costimulation is required not only to induce IL-12 receptor but also to render Janus kinases/STAT4 responsive to IL-12 stimulation in TCR-triggered T cells. Eur J Immunol. 2001;31:1456-1464.
11. Førland DT, Johnson E, Saetre L, et al. Effect of an extract based on the medicinal mushroom Agaricus blazei Murill on expression of cytokines and calprotectin in patients with ulcerative colitis and Crohn's disease. Scand J Immunol. 2011;73:66-75.
12. Poritz LS, Zhang WJ, Thompson J, et al. Impaired IL-4 phosphorylation of STAT6 in EBV transformed B-cells. J Surg Res. 2010;162:290-298.
13. Yao X, Yang Y, He HY, et al. GATA3 siRNA inhibits the binding of NFAT1 to interleukin-13 promoter in human T cells. Chin Med J (Engl). 2010;123:739-744.
14. Scheinman EJ, Avni O. Transcriptional regulation of GATA3 in T helper cells by the integrated activities of transcription factors downstream of the interleukin-4 receptor and T cell receptor. J Biol Chem. 2009;284:3037-3048.
15. Xue L, Ouyang Q. Diagnostic criteria of inflammatory bowel disease. Clin Immunol. 2011;139:102-103.
16. Hou JK, Abraham B, El-Serag H. Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature. Am J Gastroenterol. 2011;106:563-573.
17. Yokoyama Y, Fukunaga K, Fukuda Y, et al. Demonstration of low-regulatory CD25High + CD4 + and high-pro-inflammatory CD28-CD4+ T-Cell subsets in patients with ulcerative colitis: modified by selective granulocyte and monocyte adsorption apheresis. Dig Dis Sci. 2007;5:2725-2731.
18. Roda G, Dahan S, Mezzanotte L, et al. Defect in CEACAM family member expression in Crohn's disease IECs is regulated by the transcription factor SOX9. Inflamm Bowel Dis. 2009;15:1775-1783.
19. Kim BG, Li C, Qiao W, et al. Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Nature. 2006;441:1015-1019.
20. Rahman FZ, Smith AM, Hayee B, et al. Delayed resolution of acute inflammation in ulcerative colitis is associated with elevated cytokine release downstream of TLR4. PLoS One. 2010;26:e9891.
21. Fukui H, Sekikawa A, Tanaka H, et al. DMBT1 is a novel gene induced by IL-22 in ulcerative colitis. Inflamm Bowel Dis. 2011;17:1177-1188.
22. Cavalcanti E, Gigante M, Mancini V, et al. JAK3/STAT5/6 pathway alterations are associated with immune deviation in CD8 T cells in renal cell carcinoma patients. J Biomed Biotechnol. 2010;2010:935764.
23. Walker JG, Ahern MJ, Coleman M, et al. Expression of Jak3, STAT1, STAT4, and STAT6 in inflammatory arthritis: unique Jak3 and STAT4 expression in dendritic cells in seropositive rheumatoid arthritis. Ann Rheum Dis. 2006;65:149-156.
24. Banks C, Bateman A, Payne R, et al. Chemokine expression in IBD. Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn's disease. J Pathol. 2003;199:28-35.
25. Sáez-Cirión A, Sinet M, Shin SY, et al. Heterogeneity in HIV suppression by CD8 T cells from HIV controllers: association with Gag-specific CD8 T cell responses. J Immunol. 2009;182:7828-7837.
26. Rout N, Else JG, Yue S, Connole M, et al. Heterogeneity in phenotype and function of CD8+ and CD4/CD8 double-negative natural killer T cell subsets in sooty mangabeys. J Med Primatol. 2010;39:224-234.
27. Bai S, Siegal GP, Jhala NC. Foxp3 expression patterns in microscopic colitides: a clinicopathologic study of 69 patients. Am J Clin Pathol. 2012;137:931-936.
28. Allez M, Brimnes J, Dotan I, et al. Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells. Gastroenterology. 2002;123:1516-1526.
29. Ohta N, Hiroi T, Kweon MN, et al. IL-15-dependent activation-induced cell death-resistant Th1 type CD8 alpha beta+ NK1.1+ T cells for the development of small intestinal inflammation. J Immunol. 2002;169:460-468.
30. Wang Y, Chaudhri G, Jackson RJ, et al. IL-12p40 and IL-18 play pivotal roles in orchestrating the cell-mediated immune response to a poxvirus infection. J Immunol. 2009;183:3324-3331.
31. Elliott M, Benson J, Blank M, et al. Ustekinumab: lessons learned from targeting interleukin-12/23p40 in immune-mediated diseases. Ann NY Acad Sci. 2009;1182:97-110.
32. Sandborn WJ, Feagan BG, Fedorak RN, et al. A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease. Gastroenterology. 2008;135:1130-1141.
33. Gulzar N, Diker B, Balasubramanian S, et al. Human immunodeficiency virus-1 infection protects against a Tc1-to-Tc2 shift in CD8(+) T cells. Hum Immunol. 2011;72:995-1000.
34. Kudo T, Nagata S, Aoyagi Y, et al. Polarized production of T-helper cell type 1 cells in Peyer's patches in Crohn's disease. Digestion. 2004;70:214-225.
35. Oliver-Martos B, Órpez T, Pinto-Medel MJ, et al. Gene expression in IFNß signalling pathway differs between monocytes, CD4 and CD8 T cells from MS patients. J Neuroimmunol. 2011;230:153-159.
36. Jin D, Takamoto M, Hu T, et al. STAT6 signalling is important in CD8 T-cell activation and defence against Toxoplasma gondii infection in the brain. Immunology. 2009;127:187-195.
37. Maxeiner JH, Karwot R, Sauer K, et al. A key regulatory role of the transcription factor NFATc2 in bronchial adenocarcinoma via CD8+ T lymphocytes. Cancer Res. 2009;69:3069-3076.
38. Weigmann B, Lehr HA, Yancopoulos G, et al. The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis. J Exp Med. 2008;205:2099-2110.
39. Ohtani K, Ohtsuka Y, Ikuse T, et al. Increased mucosal expression of GATA-3 and STAT-4 in pediatric ulcerative colitis. Pediatr Int. 2010;52:584-589.
40. Jöhrens K, Grünbaum M, Anagnostopoulos I. Differences in the T-bet and GATA-3 expression patterns between lymphocytic colitis and coeliac disease. Virchows Arch. 2010;457:451-456.
41. Ohman L, Isaksson S, Lindmark AC, et al. T-cell activation in patients with irritable bowel syndrome. Am J Gastroenterol. 2009;104:1205-1212.