TRP channels: Diagnostic markers and therapeutic targets for breast cancer?

Trends in Molecular Medicine

Volumn 19, Issue 2, 2013, Pages 117-124

  Ouadid Ahidouch, Halima ^a   Dhennin Duthille, Isabelle ^a   Gautier, Mathieu ^a   Sevestre, Henri ^a,b   Ahidouch, Ahmed ^a,c  

^a Université Picardie Jules Vernes   (France)

^b UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

^c FACULTÉ DES SCIENCES   (Morocco)

Author keywords

Breast cancer; Cancer biomarkers; Estrogen receptors; Migration; Proliferation; TRP

Indexed keywords

MYOSIN II; PAXILLIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 3; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TRANSIENT RECEPTOR POTENTIAL CHANNEL M1; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2; TRANSIENT RECEPTOR POTENTIAL CHANNEL M5; TRANSIENT RECEPTOR POTENTIAL CHANNEL M7; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 2; VANILLOID RECEPTOR 3; VANILLOID RECEPTOR 4; VANILLOID RECEPTOR 5; VANILLOID RECEPTOR 6;

BREAST CANCER; CANCER GROWTH; CELL MIGRATION; DROSOPHILA MELANOGASTER; DRUG TARGETING; EPITHELIUM CELL; GROWTH; HUMAN; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MILK PRODUCTION; NONHUMAN; PANCREAS CANCER; PROTEIN EXPRESSION; PROTEIN TARGETING; REVIEW;

ANIMALS; BREAST NEOPLASMS; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MAMMARY GLANDS, ANIMAL; MAMMARY GLANDS, HUMAN; MOLECULAR TARGETED THERAPY; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TUMOR MARKERS, BIOLOGICAL;

EID: 84873115810     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2012.11.004     Document Type: Review

References (69)

1. + channel expression in human breast cancer cells: involvement in cell cycle regulation and carcinogenesis. J. Membr. Biol. 2008, 221:1-6.
2. Potier M., et al. Identification of SK3 channel as a new mediator of breast cancer cell migration. Mol. Cancer Ther. 2006, 5:2946-2953.
3. Zhang L., et al. Potassium channels and proliferation and migration of breast cancer cells. Sheng Li Xue Bao 2009, 61:15-20.
4. Fraser S.P., et al. Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis. Clin. Cancer Res. 2005, 11:5381-5389.
5. Roger S., et al. Voltage-gated sodium channels: new targets in cancer therapy?. Curr. Pharm. Des. 2006, 12:3681-3695.
6. Prevarskaya N., et al. TRP channels in cancer. Biochim. Biophys. Acta 2007, 1772:937-946.
7. Nilius B. TRP channels in disease. Biochim. Biophys. Acta 2007, 1772:805-812.
8. Gkika D., Prevarskaya N. TRP channels in prostate cancer: the good, the bad and the ugly?. Asian J. Androl. 2011, 13:673-676.
9. Ding X., et al. Targeting TRPC6 channels in oesophageal carcinoma growth. Expert Opin. Ther. Targets 2010, 14:513-527.
10. Montell C., et al. Rescue of the Drosophila phototransduction mutation trp by germline transformation. Science 1985, 230:1040-1043.
11. Minke B. Drosophila mutant with a transducer defect. Biophys. Struct. Mech. 1977, 3:59-64.
12. Cheng W., et al. Heteromerization of TRP channel subunits: extending functional diversity. Protein Cell 2010, 1:802-810.
13. Nilius B., Owsianik G. The transient receptor potential family of ion channels. Genome Biol. 2011, 12:218.
14. Wu L.J., et al. International Union of Basic and Clinical Pharmacology: LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol. Rev. 2010, 62:381-404.
15. Venkatachalam K., Montell C. TRP channels. Annu. Rev. Biochem. 2007, 76:387-417.
16. Yamada T., et al. TRPV2 activation induces apoptotic cell death in human T24 bladder cancer cells: a potential therapeutic target for bladder cancer. Urology 2010, 76:509.e1-509.e7.
17. Monet M., et al. Role of cationic channel TRPV2 in promoting prostate cancer migration and progression to androgen resistance. Cancer Res. 2010, 70:1225-1235.
18. Berridge M.J., et al. Calcium signalling: dynamics, homeostasis and remodelling. Nat. Rev. Mol. Cell Biol. 2003, 4:517-529.
19. McAndrew D., et al. ORAI1-mediated calcium influx in lactation and in breast cancer. Mol. Cancer Ther. 2011, 10:448-460.
20. VanHouten J.N., Wysolmerski J.J. Transcellular calcium transport in mammary epithelial cells. J. Mammary Gland Biol. Neoplasia 2007, 12:223-235.
21. Lee W.J., et al. Calcium transport and signaling in the mammary gland: targets for breast cancer. Biochim. Biophys. Acta 2006, 1765:235-255.
22. 2+ entry pathways with different permeabilities to divalent cations. J. Cell. Biochem. 2003, 88:1265-1272.
23. 2+ signaling microdomains: platforms for the assembly and regulation of TRPC channels. Trends Pharmacol. Sci. 2006, 27:25-32.
24. Smyth J.T., et al. Activation and regulation of store-operated calcium entry. J. Cell. Mol. Med. 2010, 14:2337-2349.
25. Duncan L.M., et al. Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis. Cancer Res. 1998, 58:1515-1520.
26. Middelbeek J., et al. The alpha-kinase family: an exceptional branch on the protein kinase tree. Cell. Mol. Life Sci. 2010, 67:875-890.
27. Runnels L.W. TRPM6 and TRPM7: a Mul-TRP-PLIK-cation of channel functions. Curr. Pharm. Biotechnol. 2011, 12:42-53.
28. Sumoza-Toledo A., Penner R. TRPM2: a multifunctional ion channel for calcium signalling. J. Physiol. 2011, 589:1515-1525.
29. Toth B., Csanady L. Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel. J. Biol. Chem. 2010, 285:30091-30102.
30. Guinamard R., et al. The nonselective monovalent cationic channels TRPM4 and TRPM5. Adv. Exp. Med. Biol. 2011, 704:147-171.
31. Latorre R., et al. A cool channel in cold transduction. Physiology (Bethesda) 2011, 26:273-285.
32. Anantamongkol U., et al. Transcriptome analysis of mammary tissues reveals complex patterns of transporter gene expression during pregnancy and lactation. Cell Biol. Int. 2010, 34:67-74.
33. Reiter B., et al. TRPV4-mediated regulation of epithelial permeability. FASEB J. 2006, 20:1802-1812.
34. Homann V., et al. Calcium transport in human salivary glands: a proposed model of calcium secretion into saliva. Histochem. Cell Biol. 2006, 125:583-591.
35. Zhuang L., et al. Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies. Lab. Invest. 2002, 82:1755-1764.
36. Aydar E., et al. Abnormal expression, localization and interaction of canonical transient receptor potential ion channels in human breast cancer cell lines and tissues: a potential target for breast cancer diagnosis and therapy. Cancer Cell Int. 2009, 9:23.
37. Dhennin-Duthille I., et al. High expression of transient receptor potential channels in human breast cancer epithelial cells and tissues: correlation with pathological parameters. Cell. Physiol. Biochem. 2011, 28:813-822.
38. Bolanz K.A., et al. The role of TRPV6 in breast carcinogenesis. Mol. Cancer Ther. 2008, 7:271-279.
39. Chodon D., et al. Estrogen regulation of TRPM8 expression in breast cancer cells. BMC Cancer 2010, 10:212.
40. Guilbert A., et al. Expression of TRPC6 channels in human epithelial breast cancer cells. BMC Cancer 2008, 8:125.
41. Guilbert A., et al. Evidence that TRPM7 is required for breast cancer cell proliferation. Am. J. Physiol. Cell Physiol. 2009, 297:C493-C502.
42. Tsavaler L., et al. Trp-p8, a novel prostate-specific gene, is upregulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res. 2001, 61:3760-3769.
43. Strobl J.S., et al. Mitogenic signal transduction in human breast cancer cells. Gen. Pharmacol. 1995, 26:1643-1649.
44. + channels in breast cancer cells. Biochem. Biophys. Res. Commun. 2004, 316:244-251.
45. Sergeev I.N., Rhoten W.B. Regulation of intracellular calcium in human breast cancer cells. Endocrine 1998, 9:321-327.
46. Bertolesi G.E., et al. The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms. Mol. Pharmacol. 2002, 62:210-219.
47. Guo L., et al. Carboxyamido-triazole inhibits proliferation of human breast cancer cells via G(2)/M cell cycle arrest and apoptosis. Eur. J. Pharmacol. 2006, 538:15-22.
48. El Hiani Y., et al. Activation of the calcium-sensing receptor by high calcium induced breast cancer cell proliferation and TRPC1 cation channel overexpression potentially through EGFR pathways. Arch. Biochem. Biophys. 2009, 486:58-63.
49. Bolanz K.A., et al. Tamoxifen inhibits TRPV6 activity via estrogen receptor-independent pathways in TRPV6-expressing MCF-7 breast cancer cells. Mol. Cancer Res. 2009, 7:2000-2010.
50. Middelbeek J., et al. TRPM7 is required for breast tumor cell metastasis. Cancer Res. 2012, 72:4250-4261.
51. Yang H.L., et al. Anti-metastatic activities of Antrodia camphorata against human breast cancer cells mediated through suppression of the MAPK signaling pathway. Food Chem. Toxicol. 2011, 49:290-298.
52. Yang S., et al. Orai1 and STIM1 are critical for breast tumor cell migration and metastasis. Cancer Cell 2009, 15:124-134.
53. Lehen'kyi V., et al. The role of the TRPV6 channel in cancer. J. Physiol. 2012, 590:1369-1376.
54. Van Haute C., et al. TRP channels in human prostate. Sci. World J. 2010, 10:1597-1611.
55. Rybarczyk P., et al. Transient receptor potential melastatin-related 7 channel is overexpressed in human pancreatic ductal adenocarcinomas and regulates human pancreatic cancer cell migration. Int. J. Cancer 2012, 131:E851-E861.
56. Jehle J., et al. Novel roles for hERG K(+) channels in cell proliferation and apoptosis. Cell Death Dis. 2011, 2:e193.
57. Gillet L., et al. Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells. J. Biol. Chem. 2009, 284:8680-8691.
58. Pardo L.A., Stuhmer W. Eag1: an emerging oncological target. Cancer Res. 2008, 68:1611-1613.
59. Onkal R., Djamgoz M.B. Molecular pharmacology of voltage-gated sodium channel expression in metastatic disease: clinical potential of neonatal Nav1.5 in breast cancer. Eur. J. Pharmacol. 2009, 625:206-219.
60. Naylor J., et al. Production of a specific extracellular inhibitor of TRPM3 channels. Br. J. Pharmacol. 2008, 155:567-573.
61. Ding X., et al. Essential role of TRPC6 channels in G2/M phase transition and development of human glioma. J. Natl. Cancer Inst. 2010, 102:1052-1068.
62. Downie B.R., et al. Eag1 expression interferes with hypoxia homeostasis and induces angiogenesis in tumors. J. Biol. Chem. 2008, 283:36234-36240.
63. 2+ transport. Nat. Rev. Cancer 2007, 7:519-530.
64. Varnai P., et al. STIM and Orai: the long-awaited constituents of store-operated calcium entry. Trends Pharmacol. Sci. 2009, 30:118-128.
65. Parkash J., Asotra K. Calcium wave signaling in cancer cells. Life Sci. 2010, 87:587-595.
66. Mattson M.P., Chan S.L. Calcium orchestrates apoptosis. Nat. Cell Biol. 2003, 5:1041-1043.
67. El Hiani Y., et al. Calcium-sensing receptor stimulation induces nonselective cation channel activation in breast cancer cells. J. Membr. Biol. 2006, 211:127-137.
68. Jung C., et al. The progesterone receptor regulates the expression of TRPV4 channel. Pflugers Arch. 2009, 459:105-113.
69. El Hiani Y., et al. Extracellular signal-regulated kinases 1 and 2 and TRPC1 channels are required for calcium-sensing receptor-stimulated MCF-7 breast cancer cell proliferation. Cell. Physiol. Biochem. 2009, 23:335-346.