Voltage-gated sodium channels: New targets in cancer therapy?

Current Pharmaceutical Design

Volumn 12, Issue 28, 2006, Pages 3681-3695

  Roger, Sébastien ^a   Potier, Marie ^a   Vandier, Christophe ^a   Besson, Pierre ^a   Le Guennec, Jean Yves ^a  

^a UNIVERSITÉ DE TOURS   (France)

Author keywords

Cancers; Galvanotaxis; Invasivity; Metastasis; Motility; TTX; Voltage gated sodium channels

Indexed keywords

ANTINEOPLASTIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; MESSENGER RNA; TUMOR MARKER; VERAPAMIL; VINCRISTINE; VOLTAGE GATED SODIUM CHANNEL;

BREAST CANCER; CANCER CELL CULTURE; CANCER INVASION; CANCER RESISTANCE; CANCER SURVIVAL; CARCINOGENESIS; CLINICAL PROTOCOL; DRUG MECHANISM; DRUG TARGETING; HUMAN; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; MALIGNANT NEOPLASTIC DISEASE; METASTASIS; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; TREATMENT OUTCOME;

ANTINEOPLASTIC AGENTS; HUMANS; ION CHANNEL GATING; NEOPLASMS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 33749441323     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161206778522047     Document Type: Review

References (77)

1. Catterall W. From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron 2000; 26: 13-25.
2. Isom L. Sodium channel beta subunits: anything but auxiliary. Neuroscientist 2001; 7: 42-54.
3. Yu F, Westenbroek R, Silos-Santiago I, McCormick K, Lawson D, Ge P, et al. Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2. J Neurosci 2003; 23: 7577-85.
4. Goldin A, Barchi R, Caldwell J, Hofmann F, Howe J, Hunter J, et al. Nomenclature of voltage-gated sodium channels. Neuron 2000; 28: 365-8.
5. Goldin A. Resurgence of sodium channel research. Annu Rev Physiol 2001; 63: 871-94.
6. DeCoursey T, Chandy K, Gupta S, Cahalan M. Voltage-dependent ion channels in T-lymphocytes. J Neuroimmunol 1985; 10(1): 71-95.
7. Hamill O, Marty A, Neher E, Sackman B, Sigworth F. Improved patch-clamp techniques for bigh-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 1981; 391(2): 85-100.
8. Parker S, Tong T, Bolden S, Wingo P. Cancer statistics. CA Cancer J Clin 1996; 46: 5-27.
9. + currents in two prostatic tumour cell lines: contribution to invasiveness in vitro. FEBS Lett 1995; 369: 290-4.
10. + channels in human prostate cancer cell lines and their contribution to invasion in vitro. Am J Pathol 1997; 150(4): 1213-21.
11. Smith P, Rhodes N, Shortland A, Fraser S, Djamgoz M, Ke Y, et al. Sodium channel protein expression enhances the invasiveness of rat and human prostate cancer cells. FEBS Lett 1998; 423: 19-24.
12. + channels confer invasive properties on human prostate cancer cells. Pflügers Arch 2004; 447: 908-14.
13. + current expressed in the highly metastatic Mat-Ly-Lu cell line of rat prostate cancer. J Cell Physiol 1998; 175: 50-8.
14. + channel in rat and human prostate cancer cell lines. FEBS Lett 1998; 427: 5-10.
15. + channels α-subunit genes in rat and human prostate cancer cell lines. Prostate 2001; 48: 165-78.
16. Jaffe L, Nuccitelli R. Electrical controls of development. Annu Rev Biophys Bioeng 1977; 6: 445-76.
17. Chiang M, Robinson K, Vanable J. Electrical fields in the vicinity of epithelial wounds in the isolated bovine eye. Exp Eye Res 1992; 54: 999-1003.
18. + channel activity. J Cell Sci 2001; 114: 2697-705.
19. Szatkowski M, Mycielska M, Knowles R, Kho A, Djamgoz M. Electrophysiological recordings from the rat prostate gland in vitro: identified single-cell and transepithelial (lumen) potentials. BJI Int 2000; 86: 1068-75.
20. Mycielska M, Djamgoz M. Cellular mechanisms of direct-current electric field effects: galvanotaxis and metastatic disease. J Cell Sci 2004; 117: 1631-9.
21. Fraser S, Ding Y, Liu A, Foster C, Djamgoz M. Tetrodotoxin suppresses morphological enhancement of the metastatic Mat-Ly-Lu rat prostate cancer cell line. Cell Tissue Res 1999; 295: 505-12.
22. + channel expression to cell behaviours involved in the metastatic cascade in rat prostate cancer: I. Lateral motility. J Cell Physiol 2003; 195: 479-87.
23. Fraser S, Grimes J, Djamgoz M. Effects of voltage-gated ion channel modulators on rat prostatic cancer cell proliferation: comparison of strongly and weakly metastatic cell lines. Prostate 2000; 44: 61-76.
24. Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2002; 2: 161-74.
25. + channel expression to cell behaviors involved in the metastatic cascade in rat prostate cancer: II. Secretory membrane activity. J Cell Physiol 2003; 195: 461-9.
26. + channels activity in rat prostate cancer cells: fractal analyses. Eur Biophys J 2004; 33: 353-42.
27. Costello L, Franklin R. The intermediary metabolism of the prostate: a key to understanding the pathogenesis and progression of prostate malignancy. Oncology 2000; 59: 269-82.
28. Mycielska M, Djamgoz M. Citrate transport in the human prostate epithelial PNT2-C2 cell line: electrophysiological analyses. J Physiol 2004; 559: 821-33.
29. + channels activity. J Physiol 2005; 563: 393-408.
30. + current in the Mat-Ly-Lu cell line of rat prostate cancer. Int J Biochem Cell Biol 2004; 36: 1249-60.
31. Abdul M, Hoosein N. Voltage-gated sodium ion channels in prostate cancer: expression and activity. Anticancer Res 2002; 22: 1727-30.
32. Diss J, Stewart D, Pani F, Foster C, Walker M, Patel A, et al. A potential novel marker for human prostate cancer: voltage-gated sodium channel expression in vivo. Prostate cancer and Prostatic disease 2005; 8: 266-73.
33. Sikes R, Walls A, Brennen W, Anderson J, Choudhury I, Schenk H, et al. Therapeutic approaches targeting prostate cancer progression using novel voltage-gated ion channel blockers. Clin Prostate Cancer 2003; 2: 181-7.
34. Anderson J, Hansen T, Lenkowski P, Walls A, Choudhury I, Schenck H, et al. Voltage-gated sodium channel blockers as cytostatic inhibitors of the androgen-independent prostate cancer cell line PC-3. Mol Cancer Ther 2003; 2: 1149-54.
35. Wonderlin W, Woodfork K, Strobl J. Changes in membrane potential during the progression of MCF-7 human mammary tumour cells through the cell cycle. J Cell Physiol 1995; 165: 177-85.
36. + channels identification in human breast carcinoma cells: involvement in cell proliferation. Biochem Biophys Res Comm 2000; 278: 272-7.
37. + channel. Recept Channels 2001; 7: 345-56.
38. Mu D, Chen L, Zhang X, See L, Koch C, Yen C, et al. Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. Cancer Cell 2003; 3: 297-302.
39. Roger S, Potier M, Vandier C, Le Guennec J-Y, Besson P. Description and role in proliferation of IbTx sensitive-currents in different human mammary epithelial normal and cancerous cells. Biophys Biochim Acts, 2004; 1667: 190-9.
40. 2+-activated chloride channel CLCA2. Cancer Res 1999; 59: 5488-91.
41. Roger S, Besson P, Le Guennec J-Y. Involvement of a novel fast inward sodium current in the invasion capacity of a breast cancer cell line. Biochim Biophys Acts, 2003; 1616: 107-11.
42. Fraser S, Salvador V, Manning E, Mizal J, Altun S, Reza M, et al. Voltage-gated sodium channel expression in human breast cancer cells: possible functional role in metastasis. Breast Cancer Res Trends 2002; 76: S142.
43. + channels. Am J Physiol 2000; 279: H35-46.
44. Zhang R, Fidler I, Price J. Relative malignant potential of human breast carcinoma cell lines established from pleural effusions and a brain metastasis. Invasion Metastasis 1991; 11: 204-15.
45. Roger S, Le Guennec J-Y, Besson P. Particular sensitivity to calcium channel blockers of the fast inward voltage-dependent sodium current involved in the invasive properties of a metastatic breast cancer cell line. Br J Pharmacol 2004; 141: 610-5.
46. Fraser S, Diss J, Chioni A-M, Mycielska M, Pan H, Yamaci R, et al. Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis. Clin Cancer Res 2005; 11: 5381-9.
47. Belpomme D, Gauthier S, Pujade-Lauraine E, Facchini T, Goudier M, Krakowski I, et al. Verapamil increases the survival of patients with anthracyclin-resistant metastatic breast carcinoma. Ann Oncol 2000; 11: 1471-6.
48. Judé S, Roger S, Martel E, Besson P, Richard S, Bougnoux P, et al. Dietary long-chain omega-3 fatty acids of marine origin: a comparison of their protective effects on coronary heart disease and breast cancers. Prog Biophys Mol Biol 2005; 90: 299-325.
49. + channel "neonatal" splice form. J Neurosci Methods 2005; 147(2): 88-98.
50. Roger S, Besson P, Le Guennec J-Y. Influence of the whole-cell patch-clamp configuration on electrophysiological properties of the voltage-dependent sodium current expressed in MDA-MB-231 breast cancer cells. Eur Biophys J 2004; 33: 274-79.
51. 2+ current in rat ventricular myocytes: perforated patch-clamp recordings. Am J Physiol 1998; 274: H2203-7.
52. Cameron I, Smith N, Pool T, Sparks R. Intracellular concentration of sodium and other elements as related to mitogenesis and oncogenesis in vivo. Cancer Res 1980; 40: 1493-1500.
53. Travis W, Colby T, Corrin B, Shimasoto Y, Brambilla E. World Health Organization. Histological typing of lung and pleural tumors. International histological classification of tumors. Third edition. Berlin, Springer Verlag 1999.
54. Elmqvist D, Lambert E. Detailed analysis of neuromuscular transmission in a patient with the myasthenic syndrome sometimes associated with bronchogenic carcinoma. Mayo Clin Proc 1968; 43: 689-713.
55. Tischler A, Dichter M, Biales B. Electrical excitability of oat cell carcinoma. J Pathol 1977; 122: 153-6.
56. Pietra G. The pathology of carcinoma of the lung. Semin Roentgen 1990; 25: 25-33.
57. Pancrazio J, Viglione M, Tabbara I, Kim Y. Voltage-dependent ion channels in small-cell lung cancer cells. Cancer Res 1989; 49: 5901-6.
58. Blandino J, Viglione M, Bradley W, Oie H, Kim Y. Voltage-dependent sodium channels in human small-cell lung cancer cells: role in action potentials and inhibition by Lambert-Eaton syndrome IgG. J Membr Biol 1995; 143: 153-63.
59. Onganer P, Djamgoz M. Small-cell lung cancer (human): potentiation of endocytic membrane activity by voltage-gated Na+ channel expression in vitro. J Membr Biol 2005; 204: 67-75.
60. Roger S, Rollin J, Barascu A, Besson P, Iochmann S, Gruel Y, Le Guennec J-Y. Voltage-gated sodium channels activity is involved in the metastatic process of human non-small cell lung cancer. J Biol Chem. Submitted.
61. Schlichter L, Sidell N, Hagiwara S. Potassium channels mediate killing by human natural killer cells. Proc Natl Acad Sci USA 1986; 83: 451-5.
62. + channel current associated with multidrug resistance in human leukemia cells. Cancer Res 1987; 47: 3736-41.
63. Lee S, Deutsch C, Beck W. Comparison of ion channels in multidrug-resistant and -sensitive human leukemic cells. Proc Natl Acad Sci USA 1988; 85: 2019-23.
64. + channel activity. FEBS Lett 2004; 569: 191-4.
65. Kim D-Y, Ingano L, Carey B, Pettingell W, Kovacs D. Presenilin/ γ-secretase-mediated cleavage of the voltage-gated sodium channels β2 subunit regulates cell adhesion and migration. J Biol Chem 2005; 280: 23251-61.
66. Monk M, Holding C. Human embryogenic genes re-expressed in cancer cells. Oncogene 2001; 20: 8085-91.
67. + channels: multiplicity of expression, plasticity, functional implications and pathophysiological aspects. Eur Biophys J 2004; 33: 180-93.
68. + current in cultured human retinal pigment epithelial cells. J Physiol 1994; 476.2: 187-96.
69. Choby C, Mangoni M, Boccara G, Nargeot J, Richard S. Evidence for tetrodotoxin-sensitive sodium currents in primary cultured myocytes from human, pig and rabbit arteries. Pflügers Arch 2000; 440: 149-52.
70. Walsh K, Wolf M, Fan J. Voltage-gated sodium channels in cardiac microvascular endothelial cells. Am J Physiol 1998; 274: H506-12.
71. + currents in a cultured endothelial cell line derived from rat interlobar artery and human umbilical vein. Pflügers Arch 1994; 428: 91-3.
72. Vargas F, Caviedes P, Grant S. Electrophysiological characterisation of cultured human umbilical vein endothelial cells. Microvasc Res 1994; 47: 153-65.
73. Braga E, Senchenko V, Bazov I, Loginov W, Liu J, Ermilova V, et al. Critical tumor-suppressor gene regions on chromosome 3p in major human epithelial malignancies: allelotyping and quantitative real-time PCR. Int J Cancer 2002; 100: 534-41.
74. Senchenko V, Liu J, Loginov W, Bazov I, Angeloni D, Seryogin Y, et al. Discovery of frequent homozygous deletions in chromosome 3p21.3 LUCA and AP20 regions in renal, lung and breast carcinomas. Oncogene 2004; 23: 5719-28.
75. Fozzard HA, Lee PJ, Lipkind GM. Mechanism of local anesthetic drug action on voltage-gated sodium channels. Curr Pharm Des 2005; 11(21): 2671-86.
76. Kalso E. Sodium channel blockers in neuropathic pain. Curr Pharm Des 2005; 11(23): 3005-11.
77. Lerche H, Weber YG, Jurkat-Rott K, Lehmann-Horn F. Ion channel defects in idiopathic epilepsies. Curr Pharm Des 2005; 11(21): 2737-52.