A novel methotrexate delivery system based on chitosan-methotrexate covalently conjugated nanoparticles

Journal of Biomedical Nanotechnology

Volumn 5, Issue 5, 2009, Pages 557-564

  Wu, Ping ^a   He, Xiaoxiao ^a   Wang, Kemin ^a   Tan, Weihong ^a   He, Chunmei ^a   Zheng, Mingbin ^a  

^a HUNAN UNIVERSITY   (China)

Author keywords

Anticancer drugs delivery; Anticancer efficacy; Chitosan; Covalently conjugated nanoparticles; Methotrexate

Indexed keywords

ANTICANCER DRUG; ANTICANCER DRUGS DELIVERY; ANTICANCER EFFICACY; CANCER CELLS; CELLULAR TOXICITIES; COVALENT BONDING; DELIVERY SYSTEMS; ENCAPSULATION EFFICIENCY; GLUTARALDEHYDES; HYDRODYNAMIC DIAMETER; IN-VITRO; MILD REACTION CONDITIONS; SLOW RELEASE; SODIUM TRIPOLYPHOSPHATE; SPHERICAL SHAPE; WEIGHT RATIOS;

ALDEHYDES; ATOMIC FORCE MICROSCOPY; ATOMIC SPECTROSCOPY; CHITIN; CHITOSAN; COAGULATION; ENCAPSULATION; FLUID DYNAMICS; GELATION; HYDRODYNAMICS; PHOTON CORRELATION SPECTROSCOPY; SODIUM; ZETA POTENTIAL;

NANOPARTICLES;

CHITOSAN; METHOTREXATE; NANOPARTICLE; TRIPOLYPHOSPHATE;

ARTICLE; ATOMIC FORCE MICROSCOPY; CELL STRAIN MCF 7; CONTROLLED STUDY; COVALENT BOND; CROSS LINKING; CYTOTOXICITY; DISPERSION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; ENCAPSULATION; GELATION; HUMAN; HUMAN CELL; HYDRODYNAMICS; IN VITRO STUDY; PHOTON CORRELATION SPECTROSCOPY; SUSTAINED DRUG RELEASE; ZETA POTENTIAL;

BREAST NEOPLASMS; CELL LINE, TUMOR; CHITOSAN; CRYSTALLIZATION; DIFFUSION; HUMANS; MACROMOLECULAR SUBSTANCES; MATERIALS TESTING; METHOTREXATE; MOLECULAR CONFORMATION; NANOCAPSULES; NANOMEDICINE; PARTICLE SIZE; SURFACE PROPERTIES;

EID: 76749093193     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2009.1073     Document Type: Article

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