Insight of current technologies for oral delivery of proteins and peptides

Drug Discovery Today: Technologies

Volumn 9, Issue 2, 2012, Pages

  Chin, Jungwook ^a   Foyez Mahmud, K A ^b   Kim, Sung Eun ^c   Park, Kyeongsoon ^b,d   Byun, Youngro ^b  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

^c Korea University College of Medicine   (South Korea)

^d Korea Basic Science Institute (KBSI)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN; HUMAN GROWTH HORMONE; HUMAN INSULIN; HYBRID PROTEIN; INSULIN; LIPOSOME; METFORMIN; NANOCARRIER; PARATHYROID HORMONE[1-34]; PEPTIDES AND PROTEINS; PIOGLITAZONE; RECOMBINANT HUMAN INSULIN; RECOMBINANT PARATHYROID HORMONE; SULFONYLUREA DERIVATIVE;

ARTICLE; CELL ENGINEERING; CROSS LINKING; CRYSTALLIZATION; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG TRANSPORT; ENZYMATIC DEGRADATION; HUMAN; LIPOSOMAL DELIVERY; MICROEMULSION; MOLECULAR LIBRARY; MUCOADHESION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; TABLET FORMULATION;

EID: 84873081796     PISSN: None     EISSN: 17406749     Source Type: Journal    
DOI: 10.1016/j.ddtec.2012.04.005     Document Type: Review

References (40)

1. Donovan, M.D. et al. (1990) Absorption of polyethylene glycols 600 through 2000: the molecular weight dependence of gastrointestinal and nasal absorption. Pharm. Res. 7, 863-868
2. Camenisch, G. et al. (1998) Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight. Eur. J. Pharm. Sci. 6, 317-324
3. Woodley, J.F. (1994) Enzymatic barriers for GI peptide and protein delivery. Crit. Rev. Ther. Drug Carrier Syst. 11, 61-95
4. Aungst, B.J. (2000) Intestinal permeation enhancers. J. Pharm. Sci. 89, 429-442
5. Sakai, M. et al. (1998) Cytotoxicity of absorption enhancers in Caco-2 cell monolayers. J. Pharm. Pharmacol. 50, 1101-1108
6. Fasano, A. and Uzzau, S. (1997) Modulation of intestinal tight junctions by Zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model. J. Clin. Invest. 99, 1158-1164
7. Leone-Bay, A. et al. (2001) Oral delivery of biologically active parathyroid hormone. Pharm. Res. 18, 964-970
8. Mahato, R.I. et al. (2003) Emerging trends in oral delivery of peptide and protein drugs. Crit. Rev. Ther. Drug Carrier Syst. 20, 153-214
9. Henry, C. (2000) Special delivery. Chem. Eng. News 78, 49-65
10. Arbit, E. et al. (2006) Oral heparin: status review. Thrombosis Journal 4, 6
11. Kidron, M. et al. (2004) A novel per-oral insulin formulation: proof of concept study in non-diabetic subjects. Diabet. Med. 21, 354-357
12. Wu, S.J. and Robinson, J.R. (1999) Transport of human growth hormone across Caco-2 cells with novel delivery agents: evidence for P-glycoprotein involvement. J. Control. Release 62, 171-177
13. Buclin, T. et al. (2002) Bioavailability and biological efficacy of a new oral formulation of salmon calcitonin in healthy volunteers. J. Bone Miner. Res. 17, 1478-1485
14. Peppas, N.A. (2004) Devices based on intelligent biopolymers for oral protein delivery. Int. J. Pharm. 277, 11-17
15. Leitner, V.M. et al. (2003) Thiolated polymers: evidence for the formation of disulphide bonds with mucus glycoproteins. Eur. J. Pharm. Biopharm. 56, 207-214
16. Bernkop-Schnurch, A. et al. (2004) Thiolated chitosans. Eur. J. Pharm. Biopharm. 57, 9-17
17. Yin, L. et al. (2009) Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery. Biomaterials 30, 5691-5700
18. Sajeesh, S. et al. (2010) Thiol functionalized polymethacrylic acid-based hydrogel microparticles for oral insulin delivery. Acta Biomater. 6, 3072-3080
19. Eiamtrakarn, S. et al. (2002) Gastrointestinal mucoadhesive patch system (GI-MAPS) for oral administration of G-CSF, a model protein. Biomaterials 23, 145-152
20. Garcia-Celma, M.J. et al. (1994) Solubilization of antifungal drugs in water/ POE(20) sorbitan monooleate/oil systems. Int. J. Pharm. 105, 77-81
21. Toorisaka, E. et al. (2003) Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S/O/W) emulsion. Int. J. Pharm. 252, 271-274
22. Rao, S.V. et al. (2008) Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of protein drugs: III. In vivo oral absorption study. Int. J. Pharm. 362, 16-19
23. Lasic, D.D. (1998) Novel applications of liposomes. Trends Biotechnol. 16, 307-321
24. Chen, H. et al. (1996) Lectin-bearing polymerized liposomes as potential oral vaccine carriers. Pharm. Res. 13, 1378-1383
25. Li, Z. et al. (2010) Investigation of archaeosomes as carriers for oral delivery of peptides. Biochem. Biophys. Res. Commun. 394, 412-417
26. Mohanraj, V.J. et al. (2010) Silica nanoparticle coated liposomes: a new type of hybrid nanocapsule for proteins. Int. J. Pharm. 392, 285-293
27. Sakuma, S. et al. (2001) Design of nanoparticles composed of graft copolymers for oral peptide delivery. Adv. Drug Deliv. Rev. 47, 21-37
28. Thompson, C.J. et al. (2010) The influence of polymer architecture on the protective effect of novel comb shaped amphiphilic poly(allylamine) against in vitro enzymatic degradation of insulin - towards oral insulin delivery. Int. J. Pharm. 383, 216-227
29. Cheng, W.P. et al. (2010) In vitro and in vivo characterisation of a novel peptide delivery system: amphiphilic polyelectrolyte-salmon calcitonin nanocomplexes. J. Control. Release 147, 289-297
30. Woitiski, C.B. et al. (2010) Pharmacological effect of orally delivered insulin facilitated by multilayered stable nanoparticles. Eur. J. Pharm. Sci. 41, 556-563
31. Morcol, T. et al. (2004) Calcium phosphate-PEG-insulin-casein (CAPIC) particles as oral delivery systems for insulin. Int. J. Pharm. 277, 91-97
32. Diaz, A. et al. (2010) Nanoencapsulation of insulin into zirconium phosphate for oral delivery applications. Biomacromolecules 11, 2465-2470
33. Bringley, J.F. and Liebert, N.B. (2003) Controlled chemical and drug delivery via the internal and external surfaces of layered compounds. J. Dispers. Sci. Technol. 24, 589-605
34. Liu, W.R. et al. (1991) Moisture-induced aggregation of lyophilized proteins in the solid state. Biotechnol. Bioeng. 37, 177-184
35. Shenoy, B. et al. (2001) Stability of crystalline proteins. Biotechnol. Bioeng. 73, 358-369
36. Bernstein, G. (2006) Drug Delivery in Diabetes: Oral-lyn Needle-free Buccal Delivery of Insulin. OnDrugDelivery Ltd 15-18
37. Bernstein, G. (2008) Delivery of insulin to the buccal mucosa utilizing the RapidMist system. Expert Opin. Drug Deliv. 5, 1047-1055
38. Amet, N. et al. (2010) Human growth hormone-transferrin fusion protein for oral delivery in hypophysectomized rats. J. Control. Release 141, 177-182
39. Azari, P.R. and Feeney, R.E. (1958) Resistance of metal complexes of conalbumin and transferrin to proteolysis and to thermal denaturation. J. Biol. Chem. 232, 293-302
40. Sun, P.N. et al. (2010) Application of the yeast-surface-display system for orally administered salmon calcitonin and safety assessment. Biotechnol. Prog. 26, 968-974