Lectin-bearing polymerized liposomes as potential oral vaccine carriers

Pharmaceutical Research

Volumn 13, Issue 9, 1996, Pages 1378-1383

  Chen, Hongming ^a   Torchilin, Vladimir ^b   Langer, Robert ^a  

^a USA   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

lectin; Peyer's patches; polymerized liposomes; surface modification; targeted delivery

Indexed keywords

DRUG CARRIER; LECTIN; LIPOSOME; POLYMER; VACCINE;

ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; DRUG FORMULATION; DRUG UPTAKE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL;

EID: 0029905843     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016030202104     Document Type: Article

References (16)

1. Childers, N. K. and Michalek, S. M. Liposomes. Novel delivery systems for oral vaccines. O'Hagan, D. T. ed. CRC Press, Inc., Boca Raton, Florida, 1994.
2. Alving, C. R. Liposomes as carriers for vaccines. Liposomes: from biophysics to therapeutics. Ostro, M. J. ed. Marcel Dekker, Inc., New York, 1987.
3. Okada, J., Cohen, S. and Langer, R. In vitro evaluation of polymerized liposomes as an oral drug delivery system. Pharmaceutical Research. 12:576-582, (1995).
4. Deshmukh, D. S., Bear, W. D. and Brockerhoff, H. Can intact liposomes be absorbed in the gut? Life Science. 28:239-242, (1980).
5. Chen, H., Torchilin, V. and Langer, R. Polymerized liposomes as potential oral vaccine carriers: stability and bioavailability. Journal of Controlled Release. in print (1996).
6. O'Hagan, D. T. Oral immunization and the common mucosal immune system. Novel delivery systems for oral vaccines. O'Hagan, D. T. ed. CRC Press, Inc., Boca Raton, Florida, 1994.
7. Mestecky, J. The Common mucosal immune system and current strategies for induction of immune responses in external secretions. Journal of Clinical Immunology. 7(4):265-276, (1987).
8. O'Hagan, D. T. Microparticles as oral vaccines. Novel delivery systems for oral vaccines. O'Hagan, D. T. ed. CRC Press, Inc., Boca Raton, Florida, 1994.
9. Neutra, M. R., Phillips, T. L., Mayer, E. L. and Fishkind, D. J. Transport of membrane-bound macromolecules by M cells in follicle-associated epithelium of rabbit Peyer's patch. Cell Tissue Res. 247:537-546, (1987).
10. Clark, M. A., Jepson, M. A., Simmons, N. L., Booth, T. A. and Hirst, B. H. Differential expression of lectin-binding sites defines mouse intestinal M-cells. The Journal of Histochemistry and Cytochemistry. 41(11):1679-1687, (1993).
11. Clark, M. A., Jepson, M. A., Simmons, N. L. and Hirst, B. H. Differential surface characteristics of M cells from mouse intestinal Peyer's and caecal patches. Histochemical Journal. 26:271-280, (1994).
12. Weissig, V., Lasch, J., Klibanov, A. L. and Torchilin, V. P. A new hydrophobic anchor for the attachment of proteins to liposome membranes. FEBS Letters. 202(1):86-90, (1986).
13. Waynforth, H. B. and Flecknell, P. A. Experimental and surgical technique in the rat. Academic Press, London, 1992.
14. Fields, R. The measurement of amino groups in proteins and peptides. Biochemistry Journal. 124:581-590, (1971).
15. Okada, J., Cohen, S. and Langer, R. Intestinal uptake of polymerized liposomes in rats. J. Pharmaceutical Sci. Submitted
16. Ratner, B. D. Characterization of biomaterial surfaces, Cardio. Path. 2(3):87S-100S, (1993).