Stability of crystalline proteins

Biotechnology and Bioengineering

Volumn 73, Issue 5, 2001, Pages 358-369

  Shenoy, Bhami ^a   Wang, Yi ^a   Shan, Weizhong ^a   Margolin, Alexey L ^a  

^a Altus Pharmaceuticals Inc   (United States)

Author keywords

Drug formulation; Protein crystals; Protein stability

Indexed keywords

CHROMATOGRAPHY; CRYSTALLINE MATERIALS; CRYSTALLIZATION; FOURIER TRANSFORMS; GLUCOSE;

CRYSTALLINE PROTEINS;

PROTEINS;

GLUCOSE OXIDASE; TRIACYLGLYCEROL LIPASE;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG FORMULATION; ENZYME ASSAY; FREEZE DRYING; INFRARED SPECTROSCOPY; MOLECULAR MODEL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY;

CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLIZATION; GLUCOSE OXIDASE; PROTEIN STRUCTURE, SECONDARY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 0035811233     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.1069     Document Type: Article

References (38)

1. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
2. Chemical stability of insulin. 1. Hydrolytic degradation during storage of pharmaceutical preparations
3. Rational design of stable lyophilized protein formulations: Some practical advice
4. The development of stable protein formulations: A closer look at protein aggregation, deamidation and oxidation
5. Solid phase aggregation of proteins under pharmaceutically relevant conditions
6. The upper limit of enzyme thermal stability
7. Infrared methods for study of hemoglobin reactions and structures
8. Protein secondary structures in water from second-derivative amide I infrared spectra
9. Extremozymes for industry - From nature and by design
10. Lyophilization-induced reversible changes in the secondary structures of proteins
11. Insights into interfacial activation from an open structure of Candida rugosa lipase
12. Characteristics and significance of the amorphous state in pharmaceutical systems
13. Crystal structure of glucose oxidase from Aspergillus niger refined at 2.3 A resolution
14. The use and misuse of FTIR spectroscopy in the determination of protein structure
15. Protein-protein interaction at crystal contacts
16. Packing forces in nine crystal forms of cutinase
17. The effect of protein impurities on lysozyme crystal growth
18. A simple method for displaying the hydropathic character of a protein
19. Molecular interactions in protein crystals: Solvent accessible surface and stability
20. Solid-state stability of proteins and peptides
21. Novel crystalline catalysts
22. Mechanism-based strategies for protein stabilization
23. Role of water in plasticity, stability, and action of proteins; the crystal structure of lysozyme at very low levels of hydration
24. Quantitative crystallinity determinations for beta-lactam antibiotics by solution calorimetry: Correlations with stability
25. The stability of insulin in crystalline and amorphous solids: Observation of greater stability for the amorphous form
26. Separation of freezing- and drying-induced denaturation of lyophilized proteins using stress-specific stabilization: II. Structural studies using infrared spectroscopy
27. Dehydration-induced conformational transitions in proteins and their inhibition by stabilizers
28. Improving protein therapeutics with sustained-release formulations
29. The enzymic behavior of carboxypeptidase A in the solid state
30. Purification and characterization of two distinct lipases from Candida cylindracea
31. Cross-linked enzyme crystals as robust biocatalysts
32. Cross-linked protein crystals for vaccine delivery
33. New insight into protein secondary structure from resolution-enhanced infrared spectra
34. Great expectations