Aberrant synthesis, metabolism, and plasma accumulation of circulating estrogens and estrogen metabolites in preeclampsia implications for vascular dysfunction

Hypertension

Volumn 61, Issue 2, 2013, Pages 480-487

  Jobe, Sheikh O ^a   Tyler, Chanel T ^a,b   Magness, Ronald R ^a,b,c  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c MERITER HOSPITAL   (United States)

Author keywords

estrogen metabolites; estrogens; placenta; preeclampsia; pregnancy; steroid synthesis and metabolism

Indexed keywords

16 KETO ESTRADIOL 17 BETA; 16ALPHA HYDROXYESTRONE; 17 EPIESTRIOL; 2 HYDROXYESTRONE; 2 METHOXYESTRADIOL; 2 METHOXYESTRONE; 4 HYDROXYESTRONE; 4 METHOXYESTRADIOL; 4 METHOXYESTRONE; EPIESTRIOL; ESTRADIOL; ESTRIOL; ESTROGEN; ESTRONE; ESTRONE METHYL ETHER; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; CARDIOVASCULAR FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; ESTRADIOL BLOOD LEVEL; ESTRIOL BLOOD LEVEL; ESTROGEN BLOOD LEVEL; ESTROGEN METABOLISM; ESTROGEN SYNTHESIS; ESTRONE BLOOD LEVEL; FEMALE; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PREECLAMPSIA; PRIORITY JOURNAL;

ADULT; ESTRADIOL; ESTRIOL; ESTROGENS; ESTRONE; FEMALE; HUMANS; MASS SPECTROMETRY; PLACENTA; PRE-ECLAMPSIA; PREGNANCY;

EID: 84873060035     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.201624     Document Type: Article

References (34)

1. Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med. 2004;350:672-683. (Pubitemid 38364626)
2. Barker DJ. The fetal origins of coronary heart disease. Acta Paediatr Suppl. 1997;422:78-82. (Pubitemid 27345469)
3. Cockell AP, Poston L. Flow-mediated vasodilatation is enhanced in normal pregnancy but reduced in preeclampsia. Hypertension. 1997;30(2 Pt 1):247-251. (Pubitemid 27329005)
4. Pipkin FB. Risk factors for preeclampsia. N Engl J Med. 2001;344:925-926.
5. Zamudio S, Palmer SK, Dahms TE, Berman JC, Young DA, Moore LG. Alterations in uteroplacental blood flow precede hypertension in preeclampsia at high altitude. J Appl Physiol. 1995;79:15-22.
6. Magness RR. Maternal cardiovascular and other physiologic responses to the endocrinology of pregnancy. In: Bazer FW, ed. The endocrinology of pregnancy. Totowa, NJ: Humana Press Inc; 1998.
7. Albrecht ED, Pepe GJ. Placental steroid hormone biosynthesis in primate pregnancy. Endocr Rev. 1990;11:124-150. (Pubitemid 20101341)
8. Hertig A, Liere P, Chabbert-Buffet N, Fort J, Pianos A, Eychenne B, Cambourg A, Schumacher M, Berkane N, Lefevre G, Uzan S, Rondeau E, Rozenberg P, Rafestin-Oblin ME. Steroid profiling in preeclamptic women: evidence for aromatase deficiency. Am J Obstet Gynecol. 2010;203:477.e1-477.e9.
9. Shute E. The influence of estrogens on genuine pre-eclampsia and eclampsia. The American Journal of Surgery. 1943;59:478-483.
10. Zeisler H, Jirecek S, Hohlagschwandtner M, Knöfler M, Tempfer C, Livingston JC. Concentrations of estrogens in patients with preeclampsia. Wien Klin Wochenschr. 2002;114:458-461. (Pubitemid 34764238)
11. Duenhoelter JH, Whalley PJ, MacDonald PC. An analysis of the utility of plasma immunoreactive estrogen measurements in determining delivery time of gravidas with a fetus considered at high risk. Am J Obstet Gynecol. 1976;125:889-898.
12. Zhu BT, Conney AH. Functional role of estrogen metabolism in target cells: review and perspectives. Carcinogenesis. 1998;19:1-27. (Pubitemid 28376821)
13. Jobe SO, Ramadoss J, Koch JM, Jiang Y, Zheng J, Magness RR. Estradiol- 17beta and its cytochrome P450- and catechol-O-methyltransferasederived metabolites stimulate proliferation in uterine artery endothelial cells: role of estrogen receptor-alpha versus estrogen receptor-beta. Hypertension. 2010;55:1005-1011.
14. Dubey RK, Tofovic SP, Jackson EK. Cardiovascular pharmacology of estradiol metabolites. J Pharmacol Exp Ther. 2004;308:403-409. (Pubitemid 38134197)
15. Kanasaki K, Palmsten K, Sugimoto H, Ahmad S, Hamano Y, Xie L, Parry S, Augustin HG, Gattone VH, Folkman J, Strauss JF, Kalluri R. Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Nature. 2008;453:1117-1121. (Pubitemid 351871733)
16. Xu X, Roman JM, Issaq HJ, Keefer LK, Veenstra TD, Ziegler RG. Quantitative measurement of endogenous estrogens and estrogen metabolites in human serum by liquid chromatography-tandem mass spectrometry. Anal Chem. 2007;79:7813-7821. (Pubitemid 47622412)
17. Siiteri PK, MacDonald PC. Placental estrogen biosynthesis during human pregnancy. J Clin Endocrinol Metab. 1966;26:751-761.
18. Kowalczyk TD, Cabaniss ML, Cusmano L. Association of low unconjugated estriol in the second trimester and adverse pregnancy outcome. Obstet Gynecol. 1998;91:396-400. (Pubitemid 28119842)
19. Turnipseed MR, Bentley K, Reynolds JW. Serum dehydroepiandrosterone sulfate in premature infants and infants with intrauterine growth retardation. J Clin Endocrinol Metab. 1976;43:1219-1225. (Pubitemid 8011394)
20. Stamilio DM, Sehdev HM, Morgan MA, Propert K, Macones GA. Can antenatal clinical and biochemical markers predict the development of severe preeclampsia? Am J Obstet Gynecol. 2000;182:589-594. (Pubitemid 30207316)
21. Rosenfeld CR, Rivera R. Circulatory responses to systemic infusions of estrone and estradiol-17alpha in nonpregnant, oophorectomized ewes. Am J Obstet Gynecol. 1978;132:442-448. (Pubitemid 8397458)
22. Magness RR, Rosenfeld CR. Local and systemic estradiol-17 beta: effects on uterine and systemic vasodilation. Am J Physiol. 1989;256(4 Pt 1):E536-E542.
23. Magness RR, Phernetton TM, Gibson TC, Chen DB. Uterine blood flow responses to ICI 182 780 in ovariectomized oestradiol-17beta-treated, intact follicular and pregnant sheep. J Physiol (Lond). 2005;565(Pt 1):71-83. (Pubitemid 40723692)
24. Miller NR, Garry D, Cohen HW, Figueroa R. Serum androgen markers in preeclampsia. J Reprod Med. 2003;48:225-229. (Pubitemid 36514621)
25. Lee AJ, Cai MX, Thomas PE, Conney AH, Zhu BT. Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003;144:3382-3398. (Pubitemid 36904414)
26. Blomquist CH, Kotts CE, Hakanson EY. Inhibiton of human placental 17 beta-hydroxysteroid dehydrogenase by steroids and nonsteroidal alcohols: aspects of inhibitor structure and binding specificity. Arch Biochem Biophys. 1978;186:35-41. (Pubitemid 8290481)
27. Rosenfeld CR, Jackson GM. Induction and inhibition of uterine vasodilation by catechol estrogen in oophorectomized, nonpregnant ewes. Endocrinology. 1982;110:1333-1339.
28. Lippert C, Seeger H, Mueck AO, Lippert TH. The effects of A-ring and D-ring metabolites of estradiol on the proliferation of vascular endothelial cells. Life Sci. 2000;67:1653-1658. (Pubitemid 30663020)
29. Seeger H, Mueck AO, Lippert TH. Effect of estradiol metabolites on prostacyclin synthesis in human endothelial cell cultures. Life Sci. 1999;65:PL167-PL170. (Pubitemid 29425985)
30. Jobe SO, Fling SN, Ramadoss J, Magness RR. A novel role for an endothelial adrenergic receptor system in mediating catecholestradiolinduced proliferation of uterine artery endothelial cells. Hypertension. 2011;58:874-881.
31. Miller E, Bates R, Bjorndahl J, Allen D, Burgio D, Bouma C, Stoll J, Latman N. 16-Epiestriol, a novel anti-inflammatory nonglycogenic steroid, does not inhibit IFN-gamma production by murine splenocytes. J Interferon Cytokine Res. 1998;18:921-925. (Pubitemid 28565794)
32. Latman NS, Kishore V, Bruot BC. 16-epiestriol: an anti-inflammatory steroid without glycogenic activity. J Pharm Sci. 1994;83:874-877. (Pubitemid 24233768)
33. Mukherjee TK, Nathan L, Dinh H, Reddy ST, Chaudhuri G. 17-epiestriol, an estrogen metabolite, is more potent than estradiol in inhibiting vascular cell adhesion molecule 1 (VCAM-1) mRNA expression. J Biol Chem. 2003;278:11746-11752. (Pubitemid 36800142)
34. Schiessl B. Inflammatory response in preeclampsia. Mol Aspects Med. 2007;28:210-219. (Pubitemid 46843193)