A novel role for an endothelial adrenergic receptor system in mediating catecholestradiol-induced proliferation of uterine artery endothelial cells

Hypertension

Volumn 58, Issue 5, 2011, Pages 874-881

  Jobe, Sheikh O ^a   Fling, Sean N ^a,d   Ramadoss, Jayanth ^a   Magness, Ronald R ^a,b,c  

^a MERITER HOSPITAL   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d SPELMAN COLLEGE   (United States)

Author keywords

Adrenergic receptors; Catecholamines; Catecholestradiols; Endothelial proliferation

Indexed keywords

1 (2 ETHYLPHENOXY) 3 (1,2,3,4 TETRAHYDRO 1 NAPHTHYLAMINO) 2 PROPANOL OXALATE; 2 HYDROXYESTRADIOL; 3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; 4 HYDROXYESTRADIOL; ADRENALIN; ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; CATECHOLAMINE; FORMOTEROL; NORADRENALIN; PHENTOLAMINE; PROPRANOLOL;

ANIMAL CELL; ARTERY ENDOTHELIUM; ARTICLE; CELL PROLIFERATION; ENDOTHELIUM; FEMALE; MITOGENESIS; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; UTERINE ARTERY;

ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; CELL PROLIFERATION; CELLS, CULTURED; ENDOTHELIAL CELLS; ESTROGENS, CATECHOL; FEMALE; MODELS, ANIMAL; PREGNANCY; PREGNANCY, ANIMAL; RECEPTORS, ADRENERGIC; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; SHEEP; UTERINE ARTERY;

EID: 83155180440     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.178046     Document Type: Article

References (35)

1. Miller VM, Duckles SP. Vascular actions of estrogens: functional implications. Pharmacol Rev. 2008;60:210-241. (Pubitemid 351962010)
2. Dubey RK, Tofovic SP, Jackson EK. Cardiovascular pharmacology of estradiol metabolites. J Pharmacol Exp Ther. 2004;308:403-409. (Pubitemid 38134197)
3. Tofovic SP, Dubey RK, Jackson EK. 2-Hydroxyestradiol attenuates the development of obesity, metabolic syndrome, and vascular and renal dysfunction in obese ZSF1 rats, J Pharmacol Exp Ther. 2001;299: 973-977. (Pubitemid 33104968)
4. Jobe SO, Ramadoss J, Koch JM, Jiang Y, Zheng J, Magness RR. Estradiol-17/3 and its cytochrome P450-and catechol-O-methyltransferase-derived metabolites stimulate proliferation in uterine artery endothelial cells: role of estrogen receptor-a versus estrogen receptor-/3. Hypertension. 2010;55:1005-1011.
5. Ball P, Knuppen R, Haupt M, Breuer H. Interactions between estrogens and catechol amines III: studies on the methylation of catechol estrogens, catechol amines and other catechols by the catechol-o-methyltransferase of human liver. J Clin Endocrinol Metab. 1972;34:736-746.
6. Lloyd T, Weisz J. Direct inhibition of tyrosine hydroxylase activity by catechol estrogens. J Biol Chem. 1978;253:4841-4843. (Pubitemid 8382146)
7. Mannisto PT, Kaakkola S. Catechol-O-methytransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors. Pharmacol Rev. 1999;51:593-628.
8. Foreman MM, Porter JC. Effects of catechol estrogens and catecholamines on hypothalamic and corpus striatal tyrosine hydroxylase activity. J Neurochem. 1980;34:1175-1183. (Pubitemid 10098054)
9. Paden CM, McEwen BS, Fishman J, Snyder L, DeGroff V. Competition by estrogens for catecholamine receptor binding in vitro. J Neurochem. 1982;39:512-520. (Pubitemid 12013631)
10. Etchegoyen GS, Cardinali DP, Perez AE, Tamayo J, Perez-Palacios G. Binding and effects of catecholestrogens on adenylate cyclase activity, and adrenoceptors, benzodiazepine and GABA receptors in guinea-pig hypothalamic membranes. Eur J Pharmacol. 1986;129:1-10. (Pubitemid 16033000)
11. Freddolino PL, Kalani MY, Vaidehi N, Floriano WB, Hall SE, Trabanino RJ, Kam VWT, Goddard WA III. Predicted 3D structure for the human/32 adrenergic receptor and its binding site for agonists and antagonists. Proc Natl Acad Sci USA. 2004;101:2736-2741. (Pubitemid 38327680)
12. 2-adrenergic receptor ligands. Proc Natl Acad Sci USA. 2009;106:6843-6848.
13. Bird IM, Sullivan JA, Di T, Cale JM, Zhang L, Zheng J, Magness RR. Pregnancy-dependent changes in cell signaling underlie changes in differential control of vasodilator production in uterine artery endothelial cells. Endocrinology. 2000;141:1107-1117. (Pubitemid 32260453)
14. Sherline P, and Mascardo R. Catecholamines are mitogenic in 3T3 and bovine aortic endothelial cells. J Clin Invest. 1984;74:483.
15. Sexl V, Mancusi G, Baumgartner-Parzer S, Schütz W, Freissmuth M. Stimulation of human umbilical vein endothelial cell proliferation by A2-adenosine and/32-adrenoceptors. Br J Pharmacol. 1995;114: 1577-1586.
16. 2-adrenoceptors in human umbilical vein endothelium in vitro. Br J Pharmacol. 1999;126: 1872-1880. (Pubitemid 29213107)
17. Xu B, Li J, Gao L, Ferro A. Nitric oxide-dependent vasodilatation of rabbit femoral artery by/3(2)-adrenergic stimulation or cyclic AMP elevation in vivo. Br J Pharmacol. 2000;129:969-974. (Pubitemid 30142910)
18. Steinle JJ, Booz GW, Meininger CJ, Day JN, Granger HJ./33-Adrenergic receptors regulate retinal endothelial cell migration and proliferation. J Biol Chem. 2003;278:20681-20686. (Pubitemid 36806369)
19. Steinle JJ, Zamora DO, Rosenbaum JT, Granger HJ./33-Adrenergic receptors mediate choroidal endothelial cell invasion, proliferation, and cell elongation. Exp Eye Res. 2005;80:83-91. (Pubitemid 40126516)
20. Izzo JL. The sympathetic nervous system in human hypertension. In: Izzo JL, Black HR, eds. Hypertension Primer. 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1999:109-112.
21. Zacharia LC, Jackson EK, Gillespie DG, Dubey RK. Catecholamines block 2-hydroxyestradiol-induced antimitogenesis in mesangial cells. Hypertension. 2002;39:854-859. (Pubitemid 34437539)
22. Dubey RK, Jackson EK, Gillespie DG, Zacharia LC, Imthurn B. Catecholamines block the antimitogenic effect of estradiol on human coronary artery smooth muscle cells. J Clin Endocrinol Metab. 2004;89:3922-3931. (Pubitemid 39089120)
23. Chalothorn D, Zhang H, Clayton JA, Thomas SA, Faber JE. Catecholamines augment collateral vessel growth and angiogenesis in hindlimb ischemia. Am J Physiol Heart Circ Physiol. 2005;289:H947-H959. (Pubitemid 41129414)
24. ia2. J Biol Chem. 1993;268:19528-19533. (Pubitemid 23270736)
25. Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B. Ischemic neoangiogenesis enhanced by/32-adrenergic receptor overexpression: a novel role for the endothelial adrenergic system. Circ Res. 2005;97: 1182-1189.
26. Whalen EJ, Foster MW, Matsumoto A, Ozawa K, Violin JD, Que LG, Nelson CD, Benhar M, Keys JR, Rockman HA, Koch WJ, Daaka Y, Lefkowitz RJ, Stamler JS. Regulation of/3-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell. 2007; 129:511-522. (Pubitemid 46660966)
27. i-mediated in brown adipocytes. J Biol Chem. 2000;275:22670-22677. (Pubitemid 30646148)
28. i or G^y in adult mouse cardiomyocytes. J Biol Chem. 2000;275:40635-40640. (Pubitemid 32064704)
29. 2-adrenergic receptor internalization and ERK signaling efficacy. J Biol Chem. 2002;277: 35402-35410.
30. 2-adrenergic receptor-induced IL-6 production in neonatal mouse cardiac fibroblasts. J Mol Cell Cardiol. 2006;40:384-393. (Pubitemid 43277840)
31. Rosenfeld CR. Distribution of cardiac output in ovine pregnancy. Am J Physiol. 1977;232:H231-H235. (Pubitemid 8108755)
32. Magness RR. Maternal cardiovascular and other physiologic responses to the endocrinology of pregnancy. In: Bazer F, ed. The Endocrinology of Pregnancy. Totowa, NJ: Humana Press Inc; 1998:507-539.
33. Morriss FH Jr, Rosenfeld CR, Resnik R, Meschia G, Makowski EL, Battaglia FC. Growth of uterine oxygen and glucose uptakes during pregnancy in sheep. Gynecol Invest. 1974;5:230-241.
34. Magness RR, Rosenfeld CR. Systemic and uterine responses to a-adrenergic stimulation in pregnant and nonpregnant ewes. Am J Obstet Gynecol. 1986;155:897-904. (Pubitemid 17178353)
35. Magness RR, Rosenfeld CR. The role of steroid hormones in the control of uterine blood flow. In: Rosenfeld CR, ed. The Uterine Circulation. Ithaca, NY: Perinatology Press; 1989:239-271.