Estradiol-17β and its cytochrome P450-and catechol-O- methyltransferase-derived metabolites stimulate proliferation in uterine artery endothelial cells: Role of estrogen receptor-α versus estrogen receptor-β

Hypertension

Volumn 55, Issue 4, 2010, Pages 1005-1011

  Jobe, Sheikh O ^a   Ramadoss, Jayanth ^a   Koch, Jill M ^a   Jiang, Yizhou ^a   Zheng, Jing ^a   Magness, Ronald R ^a,b,c  

^a MERITER HOSPITAL   (United States)

^b Departments of Animal Sciences   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Angiogenesis; CYP450s; Endothelium; Estradiol metabolites; Hypertension; Pregnancy

Indexed keywords

2 HYDROXYESTRADIOL; 2 METHOXYESTRADIOL; 4 HYDROXYESTRADIOL; 4 METHOXYESTRADIOL; CATECHOL METHYLTRANSFERASE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 3A4; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; DRUG DERIVATIVE;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ASSAY; ENZYME LOCALIZATION; EWE; FEMALE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UTERINE ARTERY; WESTERN BLOTTING; ANALYSIS OF VARIANCE; ANIMAL; CELL CULTURE; DOSE RESPONSE; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; SHEEP;

ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; CATECHOL O-METHYLTRANSFERASE; CELL PROLIFERATION; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; MICROSCOPY, CONFOCAL; NEOVASCULARIZATION, PHYSIOLOGIC; PREGNANCY; SHEEP; UTERINE ARTERY;

EID: 77950489462     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.109.146399     Document Type: Article

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