Umbilical cord blood levels of perfluoroalkyl acids and polybrominated flame retardants

International Journal of Hygiene and Environmental Health

Volumn 216, Issue 2, 2013, Pages 184-194

  Arbuckle, Tye E ^a   Kubwabo, Cariton ^a   Walker, Mark ^b   Davis, Karelyn ^a   Lalonde, Kaela ^a   Kosarac, Ivana ^a   Wen, Shi Wu ^b   Arnold, Douglas L ^c  

^a Health Canada   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^c HEALTH CANADA   (Canada)

Author keywords

Birth weight; Cord blood; Gestational age; Perfluorinated compounds; Perfluoroalkyl acids; Polybrominated diphenyl ethers

Indexed keywords

ALKANESULFONIC ACID; DIPHENYL ETHER DERIVATIVE; FLAME RETARDANT; FLUOROCARBON;

ADULT; ARTICLE; BIRTH WEIGHT; BLOOD; CANADA; CHEMISTRY; ENVIRONMENTAL MONITORING; FEMALE; FETUS BLOOD; GESTATIONAL AGE; HUMAN; MALE; MATERNAL AGE; MIDDLE AGED; NEWBORN; POLLUTANT; PREGNANCY;

ADULT; ALKANESULFONIC ACIDS; BIRTH WEIGHT; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; FEMALE; FETAL BLOOD; FLAME RETARDANTS; FLUOROCARBONS; GESTATIONAL AGE; HALOGENATED DIPHENYL ETHERS; HUMANS; INFANT, NEWBORN; MALE; MATERNAL AGE; MIDDLE AGED; ONTARIO; PREGNANCY; YOUNG ADULT;

EID: 84873056681     PISSN: 14384639     EISSN: 1618131X     Source Type: Journal    
DOI: 10.1016/j.ijheh.2012.03.004     Document Type: Article

References (72)

1. Andersen C.S., Fei C., Gamborg M., Nohr E.A., Sørensen T.I., Olsen J. Prenatal exposures to perfluorinated chemicals and anthropometric measures in infancy. Am. J. Epidemiol. 2010, 172:1230-1237.
2. Antignac J.-P., Cariou R., Zalko D., Berrebi A., Cravedi J.-P., Maume D., Marchand P., Monteau F., Riu A., Andre F., Le Bizec B. Exposure assessment of French women and their newborn to brominated flame retardants: determination of tri- to deca-polybromodiphenylethers (PBDE) in maternal adipose tissue, serum, breast milk and cord serum. Environ. Pollut. 2009, 157:164-173.
3. Apelberg B.J., Witter F.R., Herbstman J.B., Calafat A.M., Halden R.U., Needham L.L., Goldman L.R. Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth. Environ. Health Perspect. 2007, 115:1670-1676.
4. ATSDR, 2009, May. Agency for Toxic Substances & Disease Registry. TOXFAQs for Perfluoroalkyls. (accessed 18.10.10). http://www.atsdr.cdc.gov/toxfaqs/tf.asp%3Fid=1116%26tid=237.
5. Austin M.E., Kasturi B.S., Barber M., Kannan K., MohanKumar P.S., MohanKuman S.M. Neuroendocrine effects of perfluorooctane sulfonate in rats. Environ. Health Perspect. 2003, 111:1485-1489.
6. Beesoon S., Webster G.M., Shoeib M., Harner T., Benskin J.P., Martin J.W. Isomer profiles of perfluorochemicals in matched maternal, cord and house dust samples: manufacturing sources and transplacental transfer. Environ. Health Perspect. 2011, 119:1659-1664.
7. Bi X., Qu W., Sheng G., Zhang W., Mai B., Chen D., Yu L., Fu J. Polybrominated diphenyl ethers in South China maternal and fetal blood and breast milk. Environ. Pollut. 2006, 144:1024-1030.
8. Calafat A.M., Wong L.Y., Kuklenyik Z., Reidy J.A., Needham L.L. Polyfluoroalkyl chemicals in the U.S. population: data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000. Environ. Health Perspect. 2007, 115:1595-1602.
9. Centers for Disease Control and Prevention, 2009. Fourth National Report on Human Exposure to Environmental Chemicals. (accessed 14.12.09). http://www.cdec.gov/exposurereport/data_tables/PFCs_ChemicalInformation.html.
10. Chan E., Sandhu M., Benskin J.P., Ralitsch M., Thibault N., Birkholz D., Martin J.W. Endogenous high-performance liquid chromatography/tandem mass spectrometry interferences and the case of perfluorhexane sulfonate (PFHxS) in human serum; are we overestimating exposure?. Rapid Commun. Mass Spectrom. 2009, 23:1405-1410.
11. Clark S.L., Cotton D.B., Hankins G.D., Phelan J.P. Critical Care Obstetrics. Pregnancy-Induced Physiologic Alterations 1997, Blackwell Science, Massachusetts, pp. 3-32. 3rd edition.
12. Darnerud P.O. Toxic effects of brominated flame retardants in man and wildlife. Environ. Int. 2003, 29:841-853.
13. D'eon J.C., Maybury S.A. Exploring indirect sources of human exposure to perfluoroalkyl carboxylates (PFCAs): evaluating uptake, elimination and biotransformation of polyfluoroalkyl phosphate esters (PAPs) in the rat. Environ. Health Perspect. 2011, 119:344-350.
14. Domingo J.L. Health risks of dietary exposure to perfluorinated compounds. Environ. Int. 2012, 40:187-195.
15. Dyer J.S., Rosenfeld C.R. Metabolic imprinting by prenatal, perinatal, and postnatal overnutrition: a review. Semin. Reprod. Med. 2011, 29:266-276.
16. Ehresman D.J., Froehlich J.W., Olsen G.W., Chang S.-C., Butenhoff J.L. Comparison of human whole blood, plasma, and serum matrices for the determination of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and other fluorochemicals. Environ. Res. 2007, 103:176-184.
17. Eriksen K.T., Sørensen M., McLaughlin J.K., Tjønneland A., Overvad K., Raaschou-Nielsen O. Determinants of plasma PFOA and PFOS levels among 652 Danish men. Environ. Sci. Technol. 2011, 45:8137-8143.
18. Fei C., McLaughlin J.K., Tarone R.E., Olsen J. Perfluorinated chemicals and fetal growth: a study within the Danish National Birth Cohort. Environ. Health Perspect. 2007, 115:1677-1682.
19. Fei C., McLaughlin J.K., Tarone R.E., Olsen J. Fetal growth indicators and perfluorinated chemicals: a study in the Danish National Birth Cohort. Am. J. Epidemiol. 2008, 168:66-72.
20. Foster W.G., Gregorovich S., Morrison K.M., Atkinson S.A., Kubwabo C., Stewart B., Teo K. Human maternal and umbilical cord blood concentrations of polybrominated diphenyl ethers. Chemosphere 2011, 84:1301-1309.
21. Fromme H., Mosch C., Morovitz M., Alba-Alejandre I., Boehmer S., Kiranoglu M., Faber F., Hannibal I., Genzel-Boroviczény O., Koletzko B., Volkel W. Pre- and postnatal exposure to perfluorinated compounds (PFCs). Environ. Sci. Technol. 2010, 44:7123-7129.
22. Gómara B., Herrero L., Ramos J.J., Mateo J.R., Fernández M.A., Garcia J.F., González M.J. Distribution of polybrominated diphenyl ethers in human umbilical cord serum, paternal serum, maternal serum, placentas, and breast milk from Madrid population, Spain. Environ. Sci. Technol. 2007, 41:6961-6968.
23. Guvenius D.M., Aronsson A., Ekman-Ordeberg G., Bergman A., Noren K. Human prenatal and postnatal exposure to polybrominated diphenyl ethers, polychlorinated diphenyls, polychlorobiphenylols, and pentachlorophenol. Environ. Health Perspect. 2003, 111:1235-1241.
24. Hamm M.P., Cherry N.M., Chan E., Martin J.W., Burstyn I. Maternal exposure to perfluorinated acids and fetal growth. J. Expos. Sci. Environ. Epidemiol. 2010, 20:589-597.
25. Hanssen L., Röllin H., Odland J.Ø., Moe M.K., Sandanger T.M. Perfluorinated compounds in maternal serum and cord blood from selected areas of South Africa: results of a pilot study. J. Environ. Monit. 2010, 12:1355-1361.
26. Harrison K.A., Ibeziako P.A. Maternal anaemia and fetal birthweight. J. Obstet. Gynaecol. Br. Commonw. 1973, 80:798-804.
27. Haug L.S., Thomsen C., Brantsaeter A.L., Kvalem H.E., Haugen M., Becher G., Alexander J., Meltzer H.M., Knutsen H.K. Diet and particularly seafood are major sources of perfluorinated compounds in humans. Environ. Int. 2010, 36:772-778.
28. Haug L.S., Thomsen C., Becher G. Time trends and the influence of age and gender on serum concentrations of perfluorinated compounds in archived human samples. Environ. Sci. Technol. 2009, 43:2131-2136.
29. Health Canada, 2010. Report on Human Biomonitoring of Environmental Chemicals in Canada. Results of the Canadian Health Measures Survey Cycle 1 (2007-2009). http://www.hc-sc.gc.ca/ewh-semt/pubs/contaminants/chms-ecms/index-eng.php.
30. Hites R.A. Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. Environ. Sci. Technol. 2004, 38:945-956.
31. Huwe J.K., Hakk H., Birnbaum L.S. Tissue distribution of polybrominated diphenyl ethers in male rats and implications for biomonitoring. Environ. Sci. Technol. 2008, 42:7018-7024.
32. Inoue K., Okada F., Ito R., Kato S., Sasaki S., Nakajima S., Uno A., Saijo Y., Sata F., Yoshimura Y., Kishi R., Nakazawa H. Perfluorooctane sulfonate (PFOS) and related perfluorinated compounds in human maternal and cord blood samples: assessment of PFOS exposure in a susceptible population during pregnancy. Environ. Health Perspect. 2004, 112:1204-1207.
33. Jakobsson K., Thuresson K., Rylander L., Sjodin A., Hagmar L., Bergman A. Exposure to polybrominated diphenyl ethers and tetrabromobishpenol A among computer technicians. Chemosphere 2002, 46:709-716.
34. Kato K., Basden B.J., Needham L.L., Calafat A.M. Improved selectivity for the analysis of maternal serum and cord serum for polyfluoroalkyl chemicals. J. Chromatogr. A 2011, 1218:2133-2137.
35. Kato K., Wong L.-Y., Jia L.T., Kuklenyik Z., Calafat A.M. Trends in exposure to polycluoroalkyl chemicals in the U.S. population: 1999-2008. Environ. Sci. Technol. 2011, 45:8037-8045.
36. Kawashiro Y., Fukata H., Omori-Inoue M., Kubonoya K., Jotaki T., Takigami H., Sakai S.-I., Mori C. Perinatal exposure to brominated flame retardants and polychlorinated biphenyls in Japan. Endocr. J. 2008, 55:1071-1084.
37. Kim S.-K., Lee K.T., Kang C.S., Tao L., Kannan K., Kim K.-R., Kim C.-K., Lee J.S., Park P.S., Yoo Y.W., Ha J.Y., Shin Y.-S., Lee J.-H. Distribution of perfluorochemicals between sera and milk from the same mothers and implications for prenatal and postnatal exposures. Environ. Pollut. 2011, 159:169-174.
38. Kubwabo C., Vais N., Benoit F.M. A pilot study on the determination of perfluorooctanesulfonate and other perfluorinated compounds in blood of Canadians. J. Environ. Monit. 2004, 6:540-545.
39. Lien G.-W., Wen T.-W., Hsieh W.-S., Wu K.-Y., Chen C.-Y., Chen P.-C. Analysis of perfluorinated chemicals in umbilical cord blood by ultra-high performance liquid chromatography/tandem mass spectrometry. J. Chromatogr. B 2011, 879:641-646.
40. Lindström G., Kärrman A., van Bavel B. Accuracy and precision in the determination of perfluorinated chemicals in human blood verified by interlaboratory comparisons. J. Chromatogr. A 2009, 1216:394-400.
41. Longnecker M.P., Smith C.S., Kissling G.E., Hoppin J.A., Butenhoff J.L., Decker E., Ehresman D.J., Ellefson M.E., Flaherty J., Gardner M.S., Langlois E., LeBlanc A., Lindstrom A.B., Reagen W.K., Strynar M.J., Studabaker W.B. An interlaboratory study of perfluorinated alkyl compound levels in human plasma. Environ. Res. 2008, 107:152-159.
42. Lowe E.R., Poet T.S., Rick D.L., Marty S., Mattsson J.L., Timchalk C., Bartels M.J. The effect of plasma lipids on the pharmacokinetics of chlorpyrifos and the impact on interpretation of blood monitoring data. Toxicol. Sci. 2009, 108:258-272.
43. Mazdai A., Dodder N.G., Abernathy M.P., Hites R.A., Bigsby R.M. Polybrominated diphenyl ethers in maternal and fetal blood samples. Environ. Health Perspect. 2003, 111:1249-1252.
44. Meijer L., Weiss J., Van Velzen M., Brouwer A., Bergman å., Sauer P.J. Serum concentrations of neutral and phenolic organohalogens in pregnant women and some of their infants in The Netherlands. Environ. Sci. Technol. 2008, 42:3428-3433.
45. Midasch O., Drexler H., Hart N., Beckmann M.W., Angerer J. Transplacental exposure of neonates to perfluorooctanesulfonate and perfluorooctanoate: a pilot study. Int. Arch. Occup. Environ. Health 2007, 80:643-648.
46. Monroy R., Morrison K., Teo K., Atkinson S., Kubwabo C., Stewart B., Foster W.G. Serum levels of perfluoroalkyl compounds in human maternal and umbilical cord blood samples. Environ. Res. 2008, 108:56-62.
47. Nilsson H., Kärrman A., Westberg H., Rotander A., van Bavel B., Lindström G. A time trend study of significantly elevated perfluorocarboxylate levels in humans after using fluorinated ski wax. Environ. Sci. Technol. 2010, 44:2150-2155.
48. Noorlander C.W., van Leeuwen S.P., Te Biesebeek J.D., Mengelers M.J., Zeilmaker M.J. Levels of perfluorinated compounds in food and dietary intake of PFOS and PFOA in the Netherlands. J. Agric. Food Chem. 2011, 59:7496-7505.
49. Olsen G.W., Burris J.M., Ehresman D.J., Froehlich J.W., Seacat A.M., Butenhoff J.L., Zobel L.R. Half-life of serum elimination of perfluorooctanesulfonate in retired fluorochemical production workers. Environ. Health Perspect. 2007, 115:1298-1305.
50. Olsen G.W., Mair D.C., Church T.R., Ellefson M.E., Reagen W.K., Boyd T.M., Herron R.M., Medhdizadehkashi Z., Nobiletti J.B., Rios J.A., Butenhoff J.L., Zobel L.R. Decline in perfluorooctanesulfonate and other polyfluoroalkyl chemicals in American Red Cross adult blood donors, 2000-2006. Environ. Sci. Technol. 2008, 42:4989-4995.
51. Roosens L., D'Hollander W., Bervoets L., Reynders H., Van Campenhout K., Cornelis C., Van Den Heuvel R., Koppen G., Covaci A. Brominated flame retardants and perfluorinated chemicals, two groups of persistent contaminants in Belgian human blood and milk. Environ. Pollut. 2010, 158:2546-2552.
52. Saarelainen H., Laitenen T., Raitakari O.T., Juonala M., Heiskanen N., Lyyra-Laitinen T., Viikari J.S., Vanninen E., Heinonen S. Pregnancy-related hyperlipidemia and endothelial function in healthy women. Circ. J. 2006, 70:768-772.
53. Sattar N., Greer I.A., Louden J., Lindsay G., McConnell M., Shepherd J., Packard C.J. Lipoprotein subfraction changes in normal pregnancy: threshold effect of plasma triglyceride on appearance of small, dense low density lipoprotein. J. Clin. Endocrinol. Metab. 1997, 82:2483-2491.
54. Savitz D.A. Biomarkers of perfluorinated chemicals and birth weight. Environ. Health Perspect. 2007, 115:A528-A529.
55. Schecter A., Pavuk M., Papke O., Ryan J.J., Birnbaum L., Rosen R. Polybrominated diphenyl ethers (PBDEs) in US mothers' milk. Environ. Health Perspect. 2003, 111:1723-1729.
56. Scialli A.R. Perfluoroalkane acids and fetal growth. Environ. Health Perspect. 2008, 116:A238.
57. Shoeib M., Harner T., Ikonomou M., Kannan K. Indoor and outdoor air concentrations and phase partitioning of perfluoroalkyl sulfonamides and polybrominated diphenyl ethers. Environ. Sci. Technol. 2004, 38:1313-1320.
58. Sjodin A., Jones R.S., Focant J.F., Lapeza C., Wang R.Y., McGahee E.E., Zhang Y., Turner W.E., Slazyk B., Needham L.L., Patterson D.G. Retrospective time-trend study of polybrominated diphenyl ether and polychlorinated biphenyl levels in human serum from the United States. Environ. Health Perspect. 2004, 112:654-658.
59. Sjodin A., Patterson D.G., Bergman A. Brominated flame retardants in serum from US blood donors. Environ. Sci. Technol. 2001, 35:3830-3833.
60. Spliethoff H.M., Tao L., Shaver S.M., Aldous K.M., Pass K.A., Kannan K., Eadon G.A. Use of newborn screening program blood spots for exposure assessment: declining levels of perfluorinated compounds in New York State infants. Environ. Sci. Technol. 2008, 42:5361-5367.
61. Stein C.R., Savitz D.A., Dougan M. Serum levels of perfluorooctanoic acid and perfluorooctane sulfonate and pregnancy outcome. Am. J. Epidemiol. 2009, 170:837-846.
62. Thibodeaux J.R., Hanson R.G., Rogers J.M., Grey B.E., Barbee B.D., Richards J.H., Butenhoff J.L., Stevenson L.A., Lau C. Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. 1. Maternal and prenatal evaluations. Toxicol. Sci. 2003, 74:369-381.
63. Tittlemier S.A., Pepper K., Edwards L., Cao X.-L. Concentrations of perfluorooctanesulfonamides in Canadian Total Diet Study composite food samples collected between 1992 and 2004. J. Agric. Food Chem. 2006, 54:8385-8389.
64. Tittlemier S.A., Pepper K., Seymour C., Moisey J., Bronson R., Cao X.L., Dabeka R.W. Dietary exposure of Canadians to perfluorinated carboxylates and perfluorooctane sulfonate via consumption of meat, fish, fast foods, and food items prepared in their packaging. J. Agric. Food Chem. 2007, 55:3203-3210.
65. Tittlemier S., Ryan J.J., Van Oostdam J. Presence of anionic perfluorinated organic compounds in serum collected from Northern Canadian populations. Organohalogen Compd. 2004, 66:3959-3964.
66. Toms L.-M.L., Calafat A.M., Kato K., Thompson J., Harden F., Hobson P., Sjödin A., Mueller J.F. Polyfluoroalkyl chemicals in pooled blood serum from infants, children, and adults in Australia. Environ. Sci. Technol. 2009, 43:4194-4199.
67. van Leeuwen S., Strub M.-P., Cofino W., Lindström G., van Bavel B. Third Interlaboratory Study on Perfluorinated Compounds in Environmental and Human Matrices 2011, p. 39.
68. Washino N., Saijo Y., Sasaki S., Kato S., Ban S., Konishi K., Ito R., Nakata A., Iwasaki Y., Saito K., Nakazawa H., Kishi R. Correlations between prenatal exposure to perfluorinated chemicals and reduced fetal growth. Environ. Health Perspect. 2009, 117:660-667.
69. Wenning R.J. Uncertainties and data needs in risk assessment of three commercial polybrominated diphenyl ethers: probabilistic exposure analysis and comparison with European Commission results. Chemosphere 2002, 46:779-796.
70. Whittaker P.G., Macphail S., Lind T. Serial hematologic changes and pregnancy outcome. Obstet. Gyncol. 1996, 88:33-39.
71. Wu L.L., Gao H.W., Gao N.Y., Chen F.F., Chen L. Interaction of perfluorooctanoic acid with human serum albumin. BMC Struct. Biol. 2009, 9:31.
72. Zhang X., Chen L., Fei X.C., Ma Y.S., Gao H.W. Binding of PFOS to serum albumin and DNA: insight into the molecular toxicity of perfluorochemicals. BMC Mol. Biol. 2009, 10:16.