M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding

Retrovirology

Volumn 10, Issue 1, 2013, Pages

  Selhorst, Philippe ^a   Grupping, Katrijn ^a   Tong, Tommy ^b   Crooks, Ema T ^b   Martin, Loïc ^c   Vanham, Guido ^a,d   Binley, James M ^b   Ariën, Kevin K ^a  

^a INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^b TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^c SERVICE DE CHIMIE BIOORGANIQUE ET DE MARQUAGE   (France)

^d UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

CD4 binding site; Entry; gp120; HIV; Inhibition; Shedding

Indexed keywords

ANTIVIRUS AGENT; C34 CHOLESTEROL; DAPIVIRINE; ENFUVIRTIDE; GRIFFITHSIN; LOPINAVIR; M 48U1; MARAVIROC; N [4 CHLORO 3 (3 METHYL 2 BUTENYLOXY)PHENYL] 2 METHYL 3 FURANCARBOTHIOAMIDE; RALTEGRAVIR; SAQUINAVIR; SOLUBLE CD4 ANTIGEN; TENOFOVIR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INCUBATION TIME; MUCOSA; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; VIRUS CELL INTERACTION; VIRUS INFECTIVITY; VIRUS INHIBITION; VIRUS SHEDDING; VIRUS TRANSMISSION;

ANTI-HIV AGENTS; ANTIGENS, CD4; BIOMIMETICS; DISEASE TRANSMISSION, INFECTIOUS; FEMALE; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; MUCOUS MEMBRANE; VAGINA; VIRION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84873055075     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-10-12     Document Type: Article

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