Vaginal transmission of HIV-1 in hu-SCID mice: A new model for the evaluation of vaginal microbicides

AIDS

Volumn 15, Issue 17, 2001, Pages 2231-2238

  Di Fabio, Simonetta ^a   Giannini, Giacomo ^a   Lapenta, Caterina ^a   Spada, Massimo ^a   Binelli, Andrea ^a   Germinario, Elena ^a   Sestili, Paola ^a   Belardelli, Filippo ^a   Proietti, Enrico ^a   Vella, Stefano ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

HIV; Hu SCID mice; Microbicides; Sexual transmission

Indexed keywords

ANTIGEN P24; ANTIVIRUS AGENT; VIRUS DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LABELING; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTER; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE MIGRATION; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEXUALLY TRANSMITTED DISEASE; STRAIN DIFFERENCE; VIRUS LOAD; VIRUS TRANSMISSION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; DISEASE MODELS, ANIMAL; DNA, VIRAL; FEMALE; FLUORESCENT DYES; GENE PRODUCTS, GAG; HIV INFECTIONS; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; MICE; MICE, SCID; PROVIRUSES; T-LYMPHOCYTE SUBSETS; VAGINA;

EID: 0035941401     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200111230-00003     Document Type: Article

References (28)

1. Heterosexual transmission of human immunodeficiency virus (HIV) in northern California: Results of a ten-year study
2. Sexual transmission of HIV
3. Microbicides and barrier methods in HIV prevention
4. Vaginal microbicides for preventing the sexual transmission of HIV
5. Vaginal Microbicides against HIV: Current state of the art
6. Microbicides in HIV prevention
7. The effects of frequent N-9 use on the vaginal and cervical mucosa
8. Safety study of nonoxynol-9 as a vaginal microbicide: Evidence of adverse effect
9. Safety study of multiple daily applications of COL-1492, a nonoxynol-9 vaginal gel, among female sex workers. Col-1492 phase II study group
10. Microbicides: The UNAIDS-sponsored trial of nonoxynol-9 gel
11. A phase I study of a novel potential intravaginal microbicide, PRO 2000, in healthy sexually inactive women
12. Parameters of human immunodeficiency virus infection of human cervical tissue and inhibition by vaginal viricides
13. Persistent infection of normal mice with human immunodeficiency virus
14. New fluorescent dyes for lymphocyte migration studies. Analysis by flow cytometry and fluorescence microscopy
15. Gonorrhea among men who have sex with men-selected sexually transmitted diseases clinics, 1993-1996
16. HIV prevention in developed countries
17. Human immunodeficiency virus type 1 in the semen of men receiving highly active antiretroviral therapy
18. The association between genital ulcer disease and acquisition of HIV infection in homosexual men
19. Potential for the transmission of HIV-1 despite highly active antiretroviral therapy
20. HIV-1 entry at the mucosal surface: Role of antibodies in protection
21. Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques
22. Sexual transmission and propagation of SIV and HIV in resting and activated CD4 T cells
23. Simian immunodeficiency virus rapidly penetrates the cervicovaginal mucosa after intravaginal inoculation and infects intraepithelial dendritic cells
24. Transcytosis of infectious human immunodeficiency virus across a tight human epithelial cell line barrier
25. Mucosal events in the phatogenesis of human immunodeficiency virus type 1 infection
26. Migration of foreign lymphocytes from the mouse vagina into the cervicovaginal mucosa and to the iliac lymph nodes
27. A role for cell migration in the sexual trasmission of HIV-1
28. HIV-1 selection by epidermal dendritic cells during transmission across human skin