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Volumn 53, Issue 1, 2013, Pages 27-38

Kinome-wide activity modeling from diverse public high-quality data sets

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; KNOWLEDGE BASED SYSTEMS; MOLECULES; REGRESSION ANALYSIS;

EID: 84873024709     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci300403k     Document Type: Article
Times cited : (57)

References (35)
  • 2
    • 61649114657 scopus 로고    scopus 로고
    • Kinase-targeted libraries: The design and synthesis of novel, potent, and selective kinase inhibitors
    • Akritopoulou-Zanze, I.; Hajduk, P. J. Kinase-targeted libraries: the design and synthesis of novel, potent, and selective kinase inhibitors Drug Discovery Today 2009, 14, 291-297
    • (2009) Drug Discovery Today , vol.14 , pp. 291-297
    • Akritopoulou-Zanze, I.1    Hajduk, P.J.2
  • 3
    • 57749188299 scopus 로고    scopus 로고
    • Targeting cancer with small molecule kinase inhibitors
    • Zhang, J.; Yang, P. L.; Gray, N. S. Targeting cancer with small molecule kinase inhibitors Nat. Rev. Cancer 2009, 9, 28-39
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 28-39
    • Zhang, J.1    Yang, P.L.2    Gray, N.S.3
  • 4
    • 0036527429 scopus 로고    scopus 로고
    • Protein kinases-the major drug targets of the twenty-first century?
    • Cohen, P. Protein kinases-the major drug targets of the twenty-first century? Nat. Rev. Drug Discovery 2002, 1, 309-315
    • (2002) Nat. Rev. Drug Discovery , vol.1 , pp. 309-315
    • Cohen, P.1
  • 5
    • 75149130051 scopus 로고    scopus 로고
    • Targeting the cancer kinome through polypharmacology
    • Knight, Z. A.; Lin, H.; Shokat, K. M. Targeting the cancer kinome through polypharmacology Nat. Rev. Cancer 2010, 10, 130-137
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 130-137
    • Knight, Z.A.1    Lin, H.2    Shokat, K.M.3
  • 6
    • 77649204688 scopus 로고    scopus 로고
    • Selectively Nonselective Kinase Inhibition: Striking the Right Balance
    • Morphy, R. Selectively Nonselective Kinase Inhibition: Striking the Right Balance J. Med. Chem. 2010, 53, 1413-1437
    • (2010) J. Med. Chem. , vol.53 , pp. 1413-1437
    • Morphy, R.1
  • 7
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies, S. P.; Reddy, H.; Caivano, M.; Cohen, P. Specificity and mechanism of action of some commonly used protein kinase inhibitors Biochem. J. 2000, 351, 95-105
    • (2000) Biochem. J. , vol.351 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 8
    • 77950573400 scopus 로고    scopus 로고
    • Through the "gatekeeper door": Exploiting the active kinase conformation
    • Zuccotto, F.; Ardini, E.; Casale, E.; Angiolini, M. Through the "gatekeeper door": exploiting the active kinase conformation J. Med. Chem. 2010, 53, 2681-2694
    • (2010) J. Med. Chem. , vol.53 , pp. 2681-2694
    • Zuccotto, F.1    Ardini, E.2    Casale, E.3    Angiolini, M.4
  • 9
    • 77958567426 scopus 로고    scopus 로고
    • Comprehensive Structural and Functional Characterization of the Human Kinome by Protein Structure Modeling and Ligand Virtual Screening
    • Brylinski, M.; Skolnick, J. Comprehensive Structural and Functional Characterization of the Human Kinome by Protein Structure Modeling and Ligand Virtual Screening J. Chem. Inf. Model 2010, 50, 1839
    • (2010) J. Chem. Inf. Model , vol.50 , pp. 1839
    • Brylinski, M.1    Skolnick, J.2
  • 10
    • 42949150113 scopus 로고    scopus 로고
    • High-throughput kinase profiling as a platform for drug discovery
    • Goldstein, D. M.; Gray, N. S.; Zarrinkar, P. P. High-throughput kinase profiling as a platform for drug discovery Nat. Rev. Drug Discovery 2008, 7, 391-397
    • (2008) Nat. Rev. Drug Discovery , vol.7 , pp. 391-397
    • Goldstein, D.M.1    Gray, N.S.2    Zarrinkar, P.P.3
  • 14
    • 84873052021 scopus 로고    scopus 로고
    • Library of Integrated Network-based Cellular Signatures (LINCS). (accessed Nov 30).
    • Library of Integrated Network-based Cellular Signatures (LINCS). http://lincsproject.org/ (accessed Nov 30, 2012).
    • (2012)
  • 15
    • 84873041644 scopus 로고    scopus 로고
    • HMS LINCS DataBase. (accessed Nov 30).
    • HMS LINCS DataBase. http://lincs.hms.harvard.edu/db/ (accessed Nov 30, 2012).
    • (2012)
  • 16
    • 84873024560 scopus 로고    scopus 로고
    • LINCS Information FramEwork (LIFE). (accessed Nov 30).
    • LINCS Information FramEwork (LIFE). http://lifekb.org/ (accessed Nov 30, 2012).
    • (2012)
  • 18
    • 58149102549 scopus 로고    scopus 로고
    • Assessment of Chemical Coverage of Kinome Space and Its Implications for Kinase Drug Discovery
    • Bamborough, P.; Drewry, D.; Harper, G.; Smith, G. K.; Schneider, K. Assessment of Chemical Coverage of Kinome Space and Its Implications for Kinase Drug Discovery J. Med. Chem. 2008, 51, 7898-7914
    • (2008) J. Med. Chem. , vol.51 , pp. 7898-7914
    • Bamborough, P.1    Drewry, D.2    Harper, G.3    Smith, G.K.4    Schneider, K.5
  • 22
    • 4143122120 scopus 로고    scopus 로고
    • Classification of kinase inhibitors using a Bayesian model
    • Xia, X.; Maliski, E. G.; Gallant, P.; Rogers, D. Classification of kinase inhibitors using a Bayesian model J. Med. Chem. 2004, 47, 4463-4470
    • (2004) J. Med. Chem. , vol.47 , pp. 4463-4470
    • Xia, X.1    Maliski, E.G.2    Gallant, P.3    Rogers, D.4
  • 23
    • 20444489197 scopus 로고    scopus 로고
    • Classifying "kinase inhibitor-likeness" by using machine-learning methods
    • Briem, H.; Gunther, J. Classifying "kinase inhibitor-likeness" by using machine-learning methods Chembiochem 2005, 6, 558-566
    • (2005) Chembiochem , vol.6 , pp. 558-566
    • Briem, H.1    Gunther, J.2
  • 24
    • 42949088496 scopus 로고    scopus 로고
    • Chemical Fragments as Foundations for Understanding Target Space and Activity Prediction
    • Sutherland, J. J.; Higgs, R. E.; Watson, I.; Vieth, M. Chemical Fragments as Foundations for Understanding Target Space and Activity Prediction J. Med. Chem. 2008, 51, 2689-2700
    • (2008) J. Med. Chem. , vol.51 , pp. 2689-2700
    • Sutherland, J.J.1    Higgs, R.E.2    Watson, I.3    Vieth, M.4
  • 25
    • 41649105837 scopus 로고    scopus 로고
    • Kinase-likeness and kinase-privileged fragments: Toward virtual polypharmacology
    • Aronov, A. M.; McClain, B.; Moody, C. S.; Murcko, M. A. Kinase-likeness and kinase-privileged fragments: toward virtual polypharmacology J. Med. Chem. 2008, 51, 1214-1222
    • (2008) J. Med. Chem. , vol.51 , pp. 1214-1222
    • Aronov, A.M.1    McClain, B.2    Moody, C.S.3    Murcko, M.A.4
  • 26
    • 84873028415 scopus 로고    scopus 로고
    • Kinase Knowledge Base (Q4). (accessed Nov 30, 2012).
    • Kinase Knowledge Base (Q4 2009). http://eidogen-sertanty.com/kinasekb.php (accessed Nov 30, 2012).
    • (2009)
  • 27
    • 84873038601 scopus 로고    scopus 로고
    • Pipeline Pilot 8.0, version 8.0; Accelrys: San Diego, CA.
    • Pipeline Pilot 8.0, version 8.0; Accelrys: San Diego, CA, 2010.
    • (2010)
  • 28
    • 33244482848 scopus 로고    scopus 로고
    • Enrichment of high-throughput screening data with increasing levels of noise using support vector machines, recursive partitioning, and Laplacian-modified naive Bayesian classifiers
    • Glick, M.; Jenkins, J. L.; Nettles, J. H.; Hitchings, H.; Davies, J. W. Enrichment of high-throughput screening data with increasing levels of noise using support vector machines, recursive partitioning, and Laplacian-modified naive Bayesian classifiers J. Chem. Inf. Model. 2006, 46, 193-200
    • (2006) J. Chem. Inf. Model. , vol.46 , pp. 193-200
    • Glick, M.1    Jenkins, J.L.2    Nettles, J.H.3    Hitchings, H.4    Davies, J.W.5
  • 29
    • 34250078600 scopus 로고
    • Partial Least Squares (PLS): Its strengths and limitations
    • Cramer, R. D., III Partial Least Squares (PLS): Its strengths and limitations Perspect. Drug Discovery Des. 1993, 1, 269-278
    • (1993) Perspect. Drug Discovery Des. , vol.1 , pp. 269-278
    • Cramer III, R.D.1
  • 30
    • 10244222365 scopus 로고    scopus 로고
    • Comparison of topological descriptors for similarity-based virtual screening using multiple bioactive reference structures
    • Hert, J.; Willett, P.; Wilton, D. J.; Acklin, P.; Azzaoui, K.; Jacoby, E.; Schuffenhauer, A. Comparison of topological descriptors for similarity-based virtual screening using multiple bioactive reference structures Org. Biomol. Chem. 2004, 2, 3256-3266
    • (2004) Org. Biomol. Chem. , vol.2 , pp. 3256-3266
    • Hert, J.1    Willett, P.2    Wilton, D.J.3    Acklin, P.4    Azzaoui, K.5    Jacoby, E.6    Schuffenhauer, A.7
  • 31
    • 26944503021 scopus 로고    scopus 로고
    • Using extended-connectivity fingerprints with Laplacian-modified Bayesian analysis in high-throughput screening follow-up
    • Rogers, D.; Brown, R. D.; Hahn, M. Using extended-connectivity fingerprints with Laplacian-modified Bayesian analysis in high-throughput screening follow-up J. Biomol. Screen. 2005, 10, 682-686
    • (2005) J. Biomol. Screen. , vol.10 , pp. 682-686
    • Rogers, D.1    Brown, R.D.2    Hahn, M.3
  • 32
    • 77952780755 scopus 로고    scopus 로고
    • Large-Scale Systematic Analysis of 2D Fingerprint Methods and Parameters to Improve Virtual Screening Enrichments
    • Sastry, M.; Lowrie, J. F.; Dixon, S. L.; Sherman, W. Large-Scale Systematic Analysis of 2D Fingerprint Methods and Parameters to Improve Virtual Screening Enrichments J. Chem. Inf. Model. 2010, 50, 771-784
    • (2010) J. Chem. Inf. Model. , vol.50 , pp. 771-784
    • Sastry, M.1    Lowrie, J.F.2    Dixon, S.L.3    Sherman, W.4
  • 33
    • 77952772341 scopus 로고    scopus 로고
    • Extended-Connectivity Fingerprints
    • Rogers, D.; Hahn, M. Extended-Connectivity Fingerprints Chem. Inf. Model 2010, 50, 742-754
    • (2010) Chem. Inf. Model , vol.50 , pp. 742-754
    • Rogers, D.1    Hahn, M.2
  • 34
    • 78649633211 scopus 로고    scopus 로고
    • PubChem as a public resource for drug discovery
    • Li, Q.; Cheng, T.; Wang, Y.; Bryant, S. H. PubChem as a public resource for drug discovery Drug Discovery Today 2010, 15, 1052-1057
    • (2010) Drug Discovery Today , vol.15 , pp. 1052-1057
    • Li, Q.1    Cheng, T.2    Wang, Y.3    Bryant, S.H.4
  • 35
    • 33745298429 scopus 로고    scopus 로고
    • Rational design of inhibitors that bind to inactive kinase conformations
    • Liu, Y.; Gray, N. S. Rational design of inhibitors that bind to inactive kinase conformations Nat. Chem. Biol. 2006, 2, 358-364
    • (2006) Nat. Chem. Biol. , vol.2 , pp. 358-364
    • Liu, Y.1    Gray, N.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.