Effects of emodin extracted from chinese herbs on proliferation of non-small cell lung cancer and underlying mechanisms

Asian Pacific Journal of Cancer Prevention

Volumn 13, Issue 4, 2012, Pages 1505-1510

  He, Lin ^a   Bi, Juan Juan ^a   Guo, Qian ^a   Yu, Yin ^a   Ye, Xiu Feng ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Emodin; Ercc1; Non small lung cell cancer; Rad51; Vacuolar degeneration

Indexed keywords

DNA BINDING PROTEIN; EMODIN; ENDONUCLEASE; ERCC1 PROTEIN, HUMAN; HERBACEOUS AGENT; MESSENGER RNA; PLANT EXTRACT; PROTEIN KINASE INHIBITOR; RAD51 PROTEIN;

ANALYSIS OF VARIANCE; ARTICLE; CELL PROLIFERATION; CELL VACUOLE; DOWN REGULATION; DRUG EFFECT; GENE EXPRESSION; GENETICS; HUMAN; LUNG NON SMALL CELL CANCER; METABOLISM; PATHOLOGY; TUMOR CELL LINE; ULTRASTRUCTURE;

ANALYSIS OF VARIANCE; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; DNA-BINDING PROTEINS; DOWN-REGULATION; DRUGS, CHINESE HERBAL; EMODIN; ENDONUCLEASES; GENE EXPRESSION; HUMANS; PLANT EXTRACTS; PROTEIN KINASE INHIBITORS; RAD51 RECOMBINASE; RNA, MESSENGER; VACUOLES;

EID: 84873021012     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2012.13.4.1505     Document Type: Article

References (25)

1. Altaha R, Liang X, Yu JJ, Reed E (2004). Excision repair cross complementing-group 1: Gene expression and platinum resistance (Review) parameters in human breast cancer. Int J Mol Med, 14, 959-70.
2. Ceppi P, Volante M, Novello S, et al (2006). ERCC1 and RRM1 gene expressions but not EGFR are predictive of shorter survival in advanced non-small-cell lung cancer treated with cisplatin and gemcitabine. Ann Oncol, 17, 1818-25.
3. Chen RS, Jhan JY, Su YJ, et a1 (2009). Emodin enhances gefitinib-induced cytotoxicity via Rad51 downregulation and ERK1/2 inactivation. Exp Cell Res, 315, 2658-72.
4. Chun-Guang W, Jun-Qing Y, Bei-Zhong L, et a1 (2010). Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo. Eur J Pharmacol, 627, 33-41.
5. Fu ZY, Han JX, Huang HY (2007). Effects of emodin on gene expression profile in small cell lung cancer NCI-H446 cells. Chin Med J, 120, l710-5.
6. Heo SK, Yun HJ, Park WH, Park SD (2008). Emodin inhibits TNF-alpha-induced human aortic smooth-muscle cell proliferation via caspase- and mitochondrial-dependent apoptosis. J Cell Biochem, 105, 70-80.
7. Hsu CM, Hsu YA, Tsai Y, Shieh FK, et a1 (2010). Emodin inhibits the growth of hepatoma cells: finding the common anti-cancer pathway using Huh7, Hep3B, and HepG2 cells. Biochem Biophys Res Commun, 392, 473-8.
8. Jemal A, Bray F, Center MM, et a1 (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90.
9. Ko JC, Ciou SC, Cheng CM, et a1 (2008). Involvement of Rad51 in cytotoxicity induced by epidermal growth factor receptor inhibitor (gefitinib, IressaR) and chemotherapeutic agents in human lung cancer cells. Carcinogenesis, 29, 1448-58.
10. Ko JC, Su YJ, Lin ST, et a1 (2010). Suppression of ERCC1 and Rad51 expression through ERK1/2 inactivation is essential in emodin-mediated cytotoxicity in human non-small cell lung cancer cells. Biochem Pharmacol, 79, 655-64.
11. Ko JC, Su YJ, Lin ST, et a1 (2010). Emodin enhances cisplatin-induced cytotoxicity via down-regulation of ERCC1 and inactivation of ERK1/2. Lung Cancer, 69, 155-64.
12. Ko JC, Tsai MS, Kuo YH, et a1 (2011). Modulation of Rad51, ERCC1, and thymidine phosphorylase by emodin result in synergistic cytotoxic effect in combination with capecitabine. Biochem Pharmacol, 81, 680-90.
13. Lai JM, Chang JT, Wen CL, Hsu SL (2009). Emodin induces a reactive oxygen species-dependent and ATM-p53-Bax mediated cytotoxicity in lung cancer cells. Eur J Pharmacol, 623, 1-9.
14. Ma YS, Weng SW, Lin MW, et a1 (2012). Antitumor effects of emodin on LS1034 human colon cancer cells in vitro and in vivo: Roles of apoptotic cell death and LS1034 tumor xenografts model. Food Chem Toxicol, 50, 1271-8.
15. Olaussen KA, Dunant A, Fouret P, et a1 (2006). DNA Repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy. N Engl J Med, 355, 983-91.
16. Qiao GB, Wu YL, Yang XN, et a1 (2005). High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients. Br J Cancer, 93, 137-43.
17. Raderschall E, Stout K, Freier S, et a1 (2002). Elevated levels of Rad51 recombination protein in tumor cells. Cancer Res, 62, 219-25.
18. Soria JC, Mok TS, Cappuzzo F, Jänne PA (2011). EGFR-mutated oncogene-addicted non-small cell lung cancer: Current trends and future prospects. Cancer Treat Rev, 2011 Nov 24.
19. Su YJ, Tsai MS, Kuo YH, et a1 (2010). Role of Rad51 down-regulation and extracellular signal-regulated kinases 1 and 2 inactivation in emodin and mitomycin C-induced synergistic cytotoxicity in human non-small-cell lung cancer cells. Mol Pharmacol, 77, 633-43.
20. Su YT, Chang HL, Shyue SK, Hsu SL (2005). Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway. Biochem Pharmacol, 70, 229-41.
21. Takenaka T, Yoshino I, Kouso H, et a1 (2007). Combined evaluation of Rad51 and ERCC1 expressions for sensitivity to platinum agents in non-small cell lung cancer. Int J Cancer, 121, 895-900.
22. Tsai MS, Kuo YH, Chiu YF, Su YC, Lin YW (2010). Down-regulation of Rad51 expression overcomes drug resistance to gemcitabine in human non-small-cell lung cancer cells. J Pharmacol Exp Ther, 335, 830-40.
23. Vilmar A, Sørensen JB (2009). Excision repair cross-complementation group 1 (ERCC1) in platinum-based treatment of non-small cell lung cancer with special emphasis on carboplatin: a review of current literature. Lung Cancer, 64, 131-9.
24. Wang W, Sun YP, Huang XZ, et a1 (2010). Emodin enhances sensitivity of gallbladder cancer cells to platinum drugs via glutathion depletion and MRP1 downregulation. Biochem Pharmacol, 79, 1134-40.
25. Zhou X, Song B, Jin L, et a1 (2006). Isolation and inhibitory activity against ERK phosphorylation of hydroxyanthraquinones from rhubarb. Bioorg Med Chem Lett, 16, 563-8.