Stem cell research points the way to the cell of origin for intracranial germ cell tumours

Journal of Pathology

Volumn 229, Issue 1, 2013, Pages 4-11

  Tan, Chris ^a   Scotting, Paul J ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

brain; germ cell tumours; induced pluripotency; neural stem cells; teratoma

Indexed keywords

KRUPPEL LIKE FACTOR 4; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR SOX2;

BRAIN CELL; BRAIN TUMOR; CARCINOMA IN SITU; CELL LINEAGE; CELL TRANSFORMATION; CHORIOCARCINOMA; EMBRYONAL CARCINOMA; EMBRYONIC STEM CELL; EPIDERMOID CYST; GENE ACTIVATION; GERM CELL TUMOR; GONADOBLASTOMA; HISTOLOGY; HUMAN; NEURAL STEM CELL; NONHUMAN; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; PRIMARY TUMOR; PRIMORDIAL GERM CELL; PRIORITY JOURNAL; REVIEW; SEMINOMA; SOMATIC CELL; STEM CELL RESEARCH; TERATOMA; THEORETICAL MODEL; TUMOR LOCALIZATION; TUMOR RECURRENCE; YOLK SAC TUMOR;

ANIMALS; BRAIN NEOPLASMS; CELL LINEAGE; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MALE; NEOPLASMS, GERM CELL AND EMBRYONAL; NEOPLASTIC STEM CELLS; NEURAL STEM CELLS; OCTAMER TRANSCRIPTION FACTOR-3; PLURIPOTENT STEM CELLS; STEM CELL RESEARCH;

EID: 84872872320     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4098     Document Type: Review

References (59)

1. Kochi M, Itoyama Y, Shiraishi S, et al,. Successful treatment of intracranial nongerminomatous malignant germ cell tumors by administering neoadjuvant chemotherapy and radiotherapy before excision of residual tumors. J Neurosurg 2003; 99: 106-114.
2. Louis DN. International Agency for Research on Cancer. WHO Classification of Tumours of the Central Nervous System (4th edn). International Agency for Research on Cancer: Lyon, 2007.
3. Wang HW, Wu YH, Hsieh JY, et al,. Pediatric primary central nervous system germ cell tumors of different prognosis groups show characteristic miRNome traits and chromosome copy number variations. BMC Genomics 2010; 11: 132.
4. Oosterhuis JW, Stoop H, Honecker F, et al,. Why human extragonadal germ cell tumours occur in the midline of the body: old concepts, new perspectives. Int J Androl 2007; 30: 256-263.
5. Damjanov I, Andrews PW., The terminology of teratocarcinomas and teratomas. Nature Biotechnol 2007; 25: 1212.
6. Arora RS, Alston RD, Eden TO, et al,. Comparative incidence patterns and trends of gonadal and extragonadal germ cell tumors in England, 1979 to 2003. Cancer 2012; 118: 4290-4297.
7. Isaacs H Jr,. Perinatal (fetal and neonatal) germ cell tumors. J Pediatr Surg 2004; 39: 1003-1013.
8. Wakai S, Arai T, Nagai M,. Congenital brain tumors. Surg Neurol 1984; 21: 597-609.
9. Schlembach D, Bornemann A, Rupprecht T, et al,. Fetal intracranial tumors detected by ultrasound: a report of two cases and review of the literature. Ultrasound Obstet Gynecol 1999; 14: 407-418.
10. Travis LB, Fossa SD, Schonfeld SJ, et al,. Second cancers among 40,576 testicular cancer patients: focus on long-term survivors. J Natl Cancer Inst 2005; 97: 1354-1365.
11. van den Belt-Dusebout AW, de Wit R, Gietema JA, et al,. Treatment-specific risks of second malignancies and cardiovascular disease in 5-year survivors of testicular cancer. J Clin Oncol 2007; 25: 4370-4378.
12. Teilum G,. Classification of endodermal sinus tumour (mesoblatoma vitellinum) and so-called 'embryonal carcinoma' of the ovary. Acta Pathol Microbiol Scand 1965; 64: 407-429.
13. Sakuma Y, Sakurai S, Oguni S, et al,. c-kit gene mutations in intracranial germinomas. Cancer Sci 2004; 95: 716-720.
14. Takahashi K, Yamanaka S,. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126: 663-676.
15. Kim JB, Greber B, Arauzo-Bravo MJ, et al,. Direct reprogramming of human neural stem cells by OCT4. Nature 2009; 461: 649-653.
16. Lee SH, Jeyapalan JN, Appleby V, et al,. Dynamic methylation and expression of Oct4 in early neural stem cells. J Anat 2010; 217: 203-213.
17. Zhang HJ, Siu MK, Wong ES, et al,. Oct4 is epigenetically regulated by methylation in normal placenta and gestational trophoblastic disease. Placenta 2008; 29: 549-554.
18. Rajasingh J, Thangavel J, Siddiqui MR, et al,. Improvement of cardiac function in mouse myocardial infarction after transplantation of epigenetically-modified bone marrow progenitor cells. PLoS One 2011; 6: e22550.
19. Lim ML, Vassiliev I, Richings NM, et al,. A novel, efficient method to derive bovine and mouse embryonic stem cells with in vivo differentiation potential by treatment with 5-azacytidine. Theriogenology 2011; 76: 133-142.
20. Greenow K, Clarke AR,. Controlling the stem cell compartment and regeneration in vivo: the role of pluripotency pathways. Physiol Rev 2012; 92: 75-99.
21. Ezeh UI, Turek PJ, Reijo RA, et al,. Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. Cancer 2005; 104: 2255-2265.
22. Hoei-Hansen CE, Sehested A, Juhler M, et al,. New evidence for the origin of intracranial germ cell tumours from primordial germ cells: expression of pluripotency and cell differentiation markers. J Pathol 2006; 209: 25-33.
23. Palmer RD, Barbosa-Morais NL, Gooding EL, et al,. Pediatric malignant germ cell tumors show characteristic transcriptome profiles. Cancer Res 2008; 68: 4239-4247.
24. Ngan KW, Jung SM, Lee LY, et al,. Immunohistochemical expression of OCT4 in primary central nervous system germ cell tumours. J Clin Neurosci 2008; 15: 149-152.
25. Houldsworth J, Heath SC, Bosl GJ, et al,. Expression profiling of lineage differentiation in pluripotential human embryonal carcinoma cells. Cell Growth Differ 2002; 13: 257-264.
26. Looijenga LH,. Human testicular (non)seminomatous germ cell tumours: the clinical implications of recent pathobiological insights. J Pathol 2009; 218: 146-162.
27. Krag Jacobsen G, Barlebo H, Olsen J, et al,. Testicular germ cell tumours in Denmark 1976-1980. Pathology of 1058 consecutive cases. Acta Radiol Oncol 1984; 23: 239-247.
28. Taccagni GL, Parafioriti A, Dell'Antonio G, et al,. Mixed germ cell tumour of the mediastinum (seminoma, embryonal carcinoma, choriocarcinoma and teratoma). Light and electron microscopic cytology and histological investigation. Pathol Res Pract 1989; 185: 506-510.
29. Bohara M, Hirano H, Tokimura H, et al,. Pineal mixed germ cell tumor with a synchronous sellar lesion in the sixth decade. Brain Tumor Pathol 2011; 28: 163-166.
30. Akahira J, Ito K, Kosuge S, et al,. Ovarian mixed germ cell tumor composed of dysgerminoma, endodermal sinus tumor, choriocarcinoma and mature teratoma in a 44-year-old woman: case report and literature review. Pathol Int 1998; 48: 471-474.
31. Rescorla FJ, Sawin RS, Coran AG, et al,. Long-term outcome for infants and children with sacrococcygeal teratoma: a report from the Children's Cancer Group. J Pediatr Surg 1998; 33: 171-176.
32. Swamy R, Embleton N, Hale J,. Sacrococcygeal teratoma over two decades: birth prevalence, prenatal diagnosis and clinical outcomes. Prenat Diagn 2008; 28: 1048-1051.
33. Brait M, Maldonado L, Begum S, et al,. DNA methylation profiles delineate epigenetic heterogeneity in seminoma and non-seminoma. Br J Cancer 2012; 106: 414-423.
34. Jeyapalan JN, Noor DA, Lee SH, et al,. Methylator phenotype of malignant germ cell tumours in children identifies strong candidates for chemotherapy resistance. Br J Cancer 2011; 105: 575-585.
35. Scotting PJ, Walker DA, Perilongo G,. Childhood solid tumours: a developmental disorder. Nature Rev Cancer 2005; 5: 481-488.
36. Anderton JA, Lindsey JC, Lusher ME, et al,. Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2. Neuro Oncol 2008; 10: 981-994.
37. Laffaire J, Everhard S, Idbaih A, et al,. Methylation profiling identifies 2 groups of gliomas according to their tumorigenesis. Neuro Oncol 2011; 13: 84-98.
38. Rogers HA, Kilday JP, Mayne C, et al,. Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death. Acta Neuropathol 2012; 123: 711-725.
39. Swartling FJ, Savov V, Persson AI, et al,. Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC. Cancer Cell 2012; 21: 601-613.
40. Lustig M, Erskine L, Mason CA, et al,. Nr-CAM expression in the developing mouse nervous system: ventral midline structures, specific fiber tracts, and neuropilar regions. J Comp Neurol 2001; 434: 13-28.
41. Runko E, Wideman C, Kaprielian Z,. Cloning and expression of VEMA: a novel ventral midline antigen in the rat CNS. Mol Cell Neurosci 1999; 14: 428-443.
42. Hemberger M, Redies C, Krause R, et al,. H19 and Igf2 are expressed and differentially imprinted in neuroectoderm-derived cells in the mouse brain. Dev Genes Evol 1998; 208: 393-402.
43. Lee SH, Appleby V, Jeyapalan JN, et al,. Variable methylation of the imprinted gene, SNRPN, supports a relationship between intracranial germ cell tumours and neural stem cells. J Neurooncol 2011; 101: 419-428.
44. Cambray N, Wilson V,. Two distinct sources for a population of maturing axial progenitors. Development 2007; 134: 2829-2840.
45. Cambray N, Wilson V,. Axial progenitors with extensive potency are localised to the mouse chordoneural hinge. Development 2002; 129: 4855-4866.
46. Sugimoto K, Nakahara I, Nishikawa M., Bilateral metachronous germinoma of the basal ganglia occurring long after total removal of a mature pineal teratoma: case report. Neurosurgery 2002; 50: 613-616.
47. Ikeda J, Sawamura Y, Kato T, et al,. Metachronous neurohypophyseal germinoma occurring 8 years after total resection of pineal mature teratoma. Surg Neurol 1998; 49: 205-208.
48. Janzarik WG, Muller K, Lubbert M, et al,. Occurrence of a germinoma 22 years after resection of a mature cerebral teratoma. J Neurooncol 2008; 88: 217-219.
49. Mao Q, Ma L, Pang Z, et al,. Germinoma occurring 2 years after total resection of an intracranial epidermoid cyst in the pineal region. J Neurooncol 2012; 106: 437-439.
50. Czirjak S, Pasztor E, Slowik F, et al,. Third ventricle germinoma after total removal of intrasellar teratoma. Case report. J Neurosurg 1992; 77: 643-647.
51. Gilcrease MZ, Brandt ML, Hawkins EP,. Yolk sac tumor identified at autopsy after surgical excision of immature sacrococcygeal teratoma. J Pediatr Surg 1995; 30: 875-877.
52. Ono N, Isobe I, Uki J, et al,. Recurrence of primary intracranial germinomas after complete response with radiotherapy: recurrence patterns and therapy. Neurosurgery 1994; 35: 615-620.
53. Benesch M, Schreibmayer N, Ratschek M, et al,. Mediastinal yolk sac tumor ten years after treatment of intracranial germinoma. Med Pediatr Oncol 2003; 40: 54-56.
54. Back MR, Hu B, Rutgers J, et al,. Metastasis of an intracranial germinoma through a ventriculoperitoneal shunt: recurrence as a yolk-sac tumor. Pediatr Surg Int 1996; 12: 24-27.
55. Bi WL, Bannykh SI, Baehring J,. The growing teratoma syndrome after subtotal resection of an intracranial nongerminomatous germ cell tumor in an adult: case report. Neurosurgery 2005; 56: 188.
56. Satgé D, Monteil P, Sasco AJ, et al,. Aspects of intracranial and spinal tumors in patients with Down syndrome and report of a rapidly progressing grade 2 astrocytoma. Cancer 2001; 91: 1458-1466.
57. Hasle H, Mellemgaard A, Nielsen J, et al,. Cancer incidence in men with Klinefelter syndrome. Br J Cancer 1995; 71: 416-420.
58. Queipo G, Aguirre D, Nieto K, et al,. Intracranial germ cell tumors: association with Klinefelter syndrome and sex chromosome aneuploidies. Cytogenet Genome Res 2008; 121: 211-214.
59. Moldrich RX, Dauphinot L, Laffaire J, et al,. Proliferation deficits and gene expression dysregulation in Down's syndrome (Ts1Cje) neural progenitor cells cultured from neurospheres. J Neurosci Res 2009; 87: 3143-3152.