Improvement of cardiac function in mouse myocardial infarction after transplantation of Epigenetically-Modified bone marrow progenitor cells

PLoS ONE

Volumn 6, Issue 7, 2011, Pages

  Rajasingh, Johnson ^a,c   Thangavel, Jayakumar ^a,c   Siddiqui, Mohammad R ^a   Gomes, Ignatius ^a   Gao, Xiao pei ^a   Kishore, Raj ^b   Malik, Asrar B ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ALPHA ACTININ; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HISTONE DEACETYLASE 1; HISTONE H3; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; LYSINE SPECIFIC DEMETHYLASE 1; MONOCYTE CHEMOTACTIC PROTEIN 1; MYOCYTE ENHANCER FACTOR 2; MYOCYTE ENHANCER FACTOR 2C; MYOSIN HEAVY CHAIN ALPHA; OCTAMER TRANSCRIPTION FACTOR 4; OXYGENASE; STEM CELL FACTOR RECEPTOR; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR NKX2.5; TRANSCRIPTION FACTOR SOX2; TRICHOSTATIN A; TROPONIN I; TROPONIN T; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN RECEPTOR 2; AZACITIDINE; DRUG DERIVATIVE; HYDROXAMIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; CULTURE MEDIUM; DNA MODIFICATION; ENDOTHELIUM CELL; GENE; GENE EXPRESSION; HEART FUNCTION; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; MOUSE; MULTIPOTENT STEM CELL; NANOG GENE; NONHUMAN; OCT4 GENE; PLURIPOTENT STEM CELL; PROTEIN EXPRESSION; SOX2 GENE; TREATMENT OUTCOME; ANGIOGENESIS; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; HEART; INFLAMMATION; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; STEM CELL; STEM CELL TRANSPLANTATION; TRANSPLANTATION;

MUS;

ANIMALS; AZACITIDINE; BONE MARROW CELLS; CELL DIFFERENTIATION; ENDOTHELIAL CELLS; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; HEART; HYDROXAMIC ACIDS; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; NEOVASCULARIZATION, PHYSIOLOGIC; PLURIPOTENT STEM CELLS; STEM CELL TRANSPLANTATION; STEM CELLS; VENTRICULAR DYSFUNCTION, LEFT;

EID: 79960694099     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022550     Document Type: Article

References (45)

1. Losordo DW, Dimmeler S, (2004) Therapeutic angiogenesis and vasculogenesis for ischemic disease: part II: cell-based therapies. Circulation 109: 2692-2697.
2. Jujo K, Ii M, Losordo DW, (2008) Endothelial progenitor cells in neovascularization of infarcted myocardium. J Mol Cell Cardiol 45: 530-544.
3. Murry CE, Soonpaa MH, Reinecke H, Nakajima H, Nakajima HO, et al. (2004) Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 428: 664-668.
4. Balsam LB, Wagers AJ, Christensen JL, Kofidis T, Weissman IL, et al. (2004) Haematopoietic stem cells adopt mature haematopoietic fates in ischemic myocardium. Nature 428: 668-673.
5. Perin EC, Silva GV, (2010) Cell-based therapy for chronic ischemic heart disease-a clinical perspective. Cardiovasc Ther 29: 211-217.
6. Ishimaru N, Fukuchi M, Hirai A, Chiba Y, Tamura T, et al. (2010) Differential epigenetic regulation of BDNF and NT-3 genes by trichostatin A and 5-aza-2′-deoxycytidine in Neuro-2a cells. Biochem Biophys Res Commun 394: 173-177.
7. Trojer P, Reinberg D, (2006) Histone Lysine Demethylase and their impact on epigenetics. Cell 125: 213-217.
8. Klose RJ, Bird AP, (2006) Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci 31: 89-97 Review.
9. Ruau D, Ensenat-Waser R, Dinger TC, Vallabhapurapu DS, Rolletschek A, et al. (2008) Pluripotency associated genes are reactivated by chromatin-modifying agents in neurosphere cells. Stem Cells 4: 920-926.
10. Araki H, Yoshinaga K, Boccuni P, Zhao Y, Hoffman R, et al. (2007) Chromatin-modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulating potential. Blood 109: 3570-3578.
11. Makino S, Fukuda K, Miyoshi S, Konishi F, Kodama H, et al. (1999) Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 103: 697-705.
12. Asahara T, Masuda H, Takahashi T, Kalka C, Pastore C, et al. (1999) Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 85: 221-228.
13. Rajasingh J, Bord E, Hamada H, Lambers E, Qin G, et al. (2007) STAT3-dependent mouse embryonic stem cell differentiation into cardiomyocytes: analysis of molecular signaling and therapeutic efficacy of cardiomyocyte precommitted mES transplantation in a mouse model of myocardial infarction. Circ Res 101: 910-918.
14. Rajasingh J, Lambers E, Hamada H, Bord E, Thorne T, et al. (2008) Cell-free Embryonic Stem Cell Extract-mediated derivation of Multipotent Stem Cells from NH3T3 Fibroblasts for Functional and Anatomical Ischemic Tissue Repair. Circ Res 102: e107-117.
15. Kishore R, Qin G, Luedemann C, Bord E, Hanley A, et al. (2005) The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-alpha-induced transcriptional repression of cyclin A. J Clin Invest 115: 1785-1796.
16. Kusano KF, Pola R, Murayama T, Curry C, Kawamoto A, et al. (2005) Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling. Nat Med 11: 1197-1204.
17. Iwakura A, Shastry S, Luedemann C, Hamada H, Kawamoto A, et al. (2006) Estradiol enhances recovery after myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced neovascularization via endothelial nitric oxide synthase-mediated activation of matrix metalloproteinase-9. Circulation 113: 1605-1614.
18. Krishnamurthy P, Rajasingh J, Lambers E, Qin G, Losordo DW, et al. (2009) IL-10 Inhibits Inflammation and Attenuates Left Ventricular Remodeling After Myocardial Infarction via Activation of STAT3 and Suppression of HuR. Circ Res 104: e9-e18.
19. Nakayama J, Rice JC, Strahl BD, Allis CD, Grewal SIS, (2001) Role of Histone H3 Lysine 9 methylation in epigenetic control of heterochromatin assembly. Science 292: 110-113.
20. Gupta R, Losordo DW, (2010) Challenges in; the translation of cardiovascular cell therapy. J Nucl Med 51: 122S-127S.
21. Beitnes JO, Hopp E, Lunde K, Solheim S, Arnesen H, et al. (2009) Long-term results after intracoronary injection of autologous mononuclear bone marrow cells in acute myocardial infarction: the ASTAMI randomized, controlled study. Heart 95: 1983-1989.
22. Schmidt-Lucke C, Rossig L, Fichtlscherer S, Vasa M, Britten M, et al. (2005) Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair. Circulation 111: 2981-2987.
23. Urbich C, Dimmeler S, (2005) Risk factors for coronary artery disease, circulating endothelial progenitor cells, and the role of HMG-CoA reductase inhibitors. Kidney Int 67: 1672-1676 Review.
24. Jenuwein T, Allis CD, (2001) Translating the histone code. Science 293: 1074-1080 Review.
25. Wu X, Li Y, Xue L, Wang L, Yue Y, et al. (2010) Multiple histone site epigenetic modifications in nuclear transfer and in vitro fertilized bovine embryos. Zygote 8: 1-15.
26. Mali P, Chou BK, Yen J, Ye Z, Zou J, et al. (2010) Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells 28: 713-720.
27. Bui HT, Wakayama S, Kishigami S, Park KK, Kim JH, et al. (2010) Effect of trichostatin A on chromatin remodeling, histone modifications, DNA replication, and transcriptional activity in cloned mouse embryos. Biol Reprod 83: 454-463.
28. Bird A, (1999) DNA methylation. Science 286: 2287-2288.
29. Shoemaker R, Wang W, Zhang K, (2010) Mediators and dynamics of DNA methylation. Wiley Interdiscip Rev Syst Biol Med 3: 281-298.
30. Han J, Sachdev PS, Sidhu KS, (2010) A combined epigenetic and non-genetic approach for reprogramming human somatic cells. PLoS One 5: e12297.
31. Ng HH, Jeppesen P, Bird A, (2000) Active repression of methylated genes by the chromosomal protein MBD1. Mol Cell Biol 4: 1394-1406.
32. Cheng X, Blumenthal RM, (2010) Coordinated chromatin control: structural and functional linkage of DNA and histone methylation. Biochemistry 49: 2999-3008 Review.
33. Lyko F, (2001) DNA methylation learns to fly. Trends Genet 17: 169-172.
34. Fry CJ, Peterson CL, (2001) Chromatin remodeling enzymes: who's on first? Curr Biol 11: R185-197.
35. Curradi M, Izzo A, Badaracco G, Landsberger N, (2002) Molecular mechanisms of gene silencing mediated by DNA methylation. Mol Cell Biol 22: 3157-3173.
36. Si J, Boumber YA, Shu J, Qin T, Ahmed S, et al. (2010) Chromatin remodeling is required for gene reactivation after decitabine-mediated DNA hypomethylation. Cancer Res 70: 6968-6977.
37. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, et al. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131: 861-872.
38. Hansen JC, Tse C, Wolffe AP, (1998) Structure and function of the core histone N-termini: more than meets the eye. Biochemistry 37: 17637-17641.
39. Strahl BD, Allis CD, (2000) The language of covalent histone modifications. Nature 403: 41-45.
40. Shi Y, Matson C, Lan F, Iwase S, Baba T, et al. (2005) Regulation of LSD1 histone demethylase activity by its associated factors. Mol Cell 19: 857-864.
41. Lan F, Nottke AC, Shi Y, (2008) Mechanisms involved in the regulation of histone lysine demethylases. Curr Opin Cell Biol 3: 316-325 Review.
42. Huangfu D, Maehr R, Guo W, Eijkelenboom A, Snitow M, et al. (2008) Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol 26: 795-797.
43. Yamashita T, Kawai H, Tian F, Ohta Y, Abe K, (2010) Tumorigenic Development of Induced Pluripotent Stem Cells in Ischemic Mouse Brain. Cell Transplant: Nov 5. [Epub ahead of print].
44. Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, et al. (2010) Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142: 375-386.
45. Szabo E, Rampalli S, Risueño RM, Schnerch A, Mitchell R, et al. (2010) Direct conversion of human fibroblasts to multilineage blood progenitors. Nature 468: 521-526.