Immunohistochemical expression of OCT4 in primary central nervous system germ cell tumours

Journal of Clinical Neuroscience

Volumn 15, Issue 2, 2008, Pages 149-152

  Ngan, Kah Wai ^a   Jung, Shih Ming ^a   Lee, Li Yu ^a   Chuang, Wen Yu ^a   Yeh, Chi Ju ^a   Hsieh, Yi Yueh ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Central nervous system; Embryonal carcinoma; Germinoma; Mixed germ cell tumours; OCT4

Indexed keywords

FORMALDEHYDE; OCTAMER TRANSCRIPTION FACTOR 4; PARAFFIN; TRANSCRIPTION FACTOR PIT 1;

ADOLESCENT; ADULT; ARTICLE; CAUSE OF DEATH; CENTRAL NERVOUS SYSTEM TUMOR; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; EMBRYONAL CARCINOMA; EMBRYONIC STEM CELL; FEMALE; GERM CELL TUMOR; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFANT; MALE; NEUROECTODERM; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SCHOOL CHILD; SEMINOMA; STAINING; TERATOMA; YOLK SAC TUMOR;

ADOLESCENT; ADULT; CENTRAL NERVOUS SYSTEM NEOPLASMS; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; MALE; NEOPLASMS, GERM CELL AND EMBRYONAL; OCTAMER TRANSCRIPTION FACTOR-3;

EID: 37349009654     PISSN: 09675868     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jocn.2006.08.013     Document Type: Article

References (20)

1. Scholer H.R., Hatzopoulos A.K., Balling R., et al. A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor. EMBO J 8 (1989) 2543-2550
2. Scholer H.R., Ruppert S., Suzuki N., et al. New type of POU domain in germ line-specific protein Oct-4. Nature 344 (1990) 435-439
3. Scholer H.R., Dressler G.R., Balling R., et al. Oct-4: a germline-specific transcription factor mapping to the mouse t-complex. EMBO J 9 (1990) 2185-2195
4. Okamoto K., Okazawa H., Okuda A., et al. A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell 60 (1990) 461-472
5. Hansis C., Grifo J.A., and Krey L.C. Oct-4 expression in inner cell mass and trophectoderm of human blastocysts. Mol Hum Reprod 6 (2000) 999-1004
6. Hansis C., Tang Y.X., Grifo J.A., et al. Analysis of Oct4 expression and ploidy in individual human blastomeres. Mol Hum Reprod 7 (2001) 155-161
7. Rosner M.H., Vigano M.A., Ozato K., et al. A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature 345 (1990) 686-692
8. Kehler J., Tolkunova E., Koschorz B., et al. Oct4 is required for primordial germ cell survival. EMBO Rep 5 (2004) 1078-1083
9. Jones T.D., Ulbright T.M., Eble J.N., et al. OCT4 staining in testicular tumors: a sensitive and specific marker for seminoma and embryonal carcinoma. Am J Surg Pathol 28 (2004) 935-940
10. Looijenga L.H., Stoop H., de Leeuw H.P., et al. POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors. Cancer Res 63 (2003) 2244-2250
11. Jones T.D., Ulbright T.M., Eble J.N., et al. OCT4: A sensitive and specific biomarker for intratubular germ cell neoplasia of the testis. Clin Cancer Res 10 (2004) 8544-8547
12. Cheng L., Thomas A., Roth L.M., et al. OCT4: a novel biomarker for dysgerminoma of the ovary. Am J Surg Pathol 28 (2004) 1341-1346
13. Hattab E.M., Tu P.H., Wilson J.D., et al. OCT 4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma. Am J Surg Pathol 29 (2005) 368-371
14. Cheng L. Establishing a germ cell origin for metastatic tumors using OCT4 immunohistochemistry. Cancer 101 (2004) 2006-2010
15. Kleihues P., and Cavenee W.K. WHO Classification of Tumors. Tumors of the Nervous System (2000), International Agency for Research on Cancer Press, Lyon
16. Ho D.M., and Liu H.C. Primary intracranial germ cell tumor: pathologic study of 51 patients. Cancer 70 (1992) 1577-1584
17. Jennings M.T., Gelman R., and Hochberg F. Intracranial germ cell tumor: natural history and pathogenesis. J Neurosurg 63 (1985) 155-167
18. Hoffman H.J., Otsubo H., Hendrick E.B., et al. Intracranial germ cell tumors in children. J Neurosurg 74 (1991) 545-551
19. Schild S.E., Scheithauer B.W., Haddock M.G., et al. Histologically confirmed pineal tumors and other germ cell tumors of the brain. Cancer 78 (1996) 2564-2571
20. Packer R.J., Cohen B.H., and Cooney K. Intracranial germ cell tumors. Oncologist 5 (2000) 312-320