Interleukin-17 enhanced immunoinflammatory lesions in a mouse model of recurrent herpetic keratitis

Microbes and Infection

Volumn 15, Issue 2, 2013, Pages 126-139

  Xia, Likun ^a   Zhang, Shengnan ^b   Cao, Zheyao ^a   Hu, Yuan ^a   Yang, Hongwei ^a   Wang, Dan ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b No 8 Hospital of Zibo   (China)

Author keywords

Delayed type hypersensitivity; Herpes simplex virus; Herpetic stromal keratitis; Interleukin 17; Recurrent mouse model

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 17 ANTIBODY; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; COMPETITIVE INHIBITION; CONTROLLED STUDY; CORNEA OPACITY; DELAYED HYPERSENSITIVITY; DISEASE SEVERITY; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; HERPES SIMPLEX KERATITIS; HERPES SIMPLEX VIRUS 1; IMMUNOFLUORESCENCE; IMMUNOMODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RECURRENT DISEASE; TH17 CELL; ULTRAVIOLET B RADIATION; UPREGULATION; VIRUS REACTIVATION; VIRUS SHEDDING; WESTERN BLOTTING;

ANIMALS; ANTIBODIES; CERCOPITHECUS AETHIOPS; CORNEA; CORNEAL NEOVASCULARIZATION; CORNEAL OPACITY; DISEASE MODELS, ANIMAL; FEMALE; HERPESVIRUS 1, HUMAN; INFLAMMATION; INTERLEUKIN-17; KERATITIS, HERPETIC; MICE; MICE, INBRED BALB C; RECURRENCE; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; TH17 CELLS; TUMOR NECROSIS FACTOR-ALPHA; VERO CELLS; VIRUS ACTIVATION; VIRUS SHEDDING;

MURINAE; MUS; SIMPLEXVIRUS;

EID: 84872865399     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2012.10.017     Document Type: Article

References (47)

1. Lepisto A.J., Frank G.M., Hendricks R.L. How herpes simplex virus type 1 rescinds corneal privilege. Chem. Immunol. Allergy 2007, 92:203-212.
2. Hazlett L.D., Hendricks R.L. Reviews for immune privilege in the year 2010: immune privilege and infection. Ocul. Immunol. Inflamm. 2010, 18:237-243.
3. Streilein J.W., Dana M.R., Ksander B.R. Immunity causing blindness: five different paths to herpes stromal keratitis. Immunol. Today 1997, 18:443-449.
4. Kaye S., Choudhari A. Herpes simplex viruses. Prog. Retin. Eye Res. 2006, 25:355-380.
5. Deshpande S.P., Zheng M., Lee S., Rouse B.T. Mechanisms of pathogenesis in herpetic immunoinflammatory ocular lesions. Vet. Microbiol. 2002, 86:17-26.
6. Hendricks R.L., Tumpey T.M., Finnegan A. IFN-gamma and IL-2 are protective in the skin but pathologic in the corneas of HSV-1-infected mice. J. Immunol. 1992, 149:3023-3028.
7. Niemialtowski M.G., Rouse B.T. Phenotypic and functional studies on ocular T cells during herpetic infections of the eye. J. Immunol. 1992, 148:1864-1870.
8. Niemialtowski M.G., Rouse B.T. Predominance of Th1 cells in ocular tissue during herpetic stromal keratitis. J. Immunol. 1992, 149:3035-3039.
9. Babu J.S., Kanangat S., Rouse B.T. T cell cytokine mRNA expression during the course of the immunopathologic ocular disease herpetic stromal keratitis. J. Immunol. 1995, 154:4822-4829.
10. Tumpey T.M., Elner V.M., Chen S.H., Oakes J.E., Lausch R.N. Interleukin-10 treatment can suppress stromal keratitis induced by herpes simplex virus type 1. J. Immunol. 1994, 153:2258-2265.
11. Keadle T.L., Usui N., Laycock K.A., Kumano Y., Pepose J.S., Stuart P.M. Cytokine expression in murine corneas during recurrent herpetic stromal keratitis. Ocul. Immunol. Inflamm. 2001, 9:193-205.
12. Stumpf T.H., Shimeld C., Easty D.L., Hill T.J. Cytokine production in a murine model of recurrent herpetic stromal keratitis. Invest. Ophthalmol. Vis. Sci. 2001, 42:372-378.
13. Keadle T.L., Alexander D.E., Leib D.A., Stuart P.M. Interferon gamma is not required for recurrent herpetic stromal keratitis. Virology 2008, 380:46-51.
14. + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 2005, 6:1123-1132.
15. Park H., Li Z., Yang X.O., Chang S.H., Nurieva R., Wang Y.H., Wang Y., Hood L., Zhu Z., Tian Q., Dong C. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 2005, 6:1133-1141.
16. Harrington L.E., Mangan P.R., Weaver C.T. Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr. Opin. Immunol. 2006, 18:349-356.
17. Jin D., Zhang L., Zheng J., Zhao Y. The inflammatory Th17 subset in immunity against self and non-self antigens. Autoimmunity 2008, 41:154-162.
18. Bettelli E., Oukka M., Kuchroo V.K. T (H)-17 cells in the circle of immunity and autoimmunity. Nat. Immunol. 2007, 8:345-350.
19. Bettelli E., Korn T., Oukka M., Kuchroo V.K. Induction and effector functions of T (H)17 cells. Nature 2008, 453:1051-1057.
20. Huh J.R., Leung M.W., Huang P., Ryan D.A., Krout M.R., Malapaka R.R., Chow J., Manel N., Ciofani M., Kim S.V., Cuesta A., Santori F.R., Lafaille J.J., Xu H.E., Gin D.Y., Rastinejad F., Littman D.R. Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity. Nature 2011, 472:486-490.
21. Hartigan-O'Connor D.J., Hirao L.A., McCune J.M., Dandekar S. Th17 cells and regulatory T cells in elite control over HIV and SIV. Curr. Opin. HIV AIDS 2011, 6:221-227.
22. Bera M.M., Lu B., Martin T.R., Cui S., Rhein L.M., Gerard C., Gerard N.P. Th17 cytokines are critical for respiratory syncytial virus-associated airway hyperreponsiveness through regulation by complement C3a and tachykinins. J. Immunol. 2011, 187:4245-4255.
23. Maertzdorf J., Osterhaus A.D., Verjans G.M. IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts. J. Immunol. 2002, 169:5897-5903.
24. Molesworth-Kenyon S.J., Yin R., Oakes J.E., Lausch R.N. IL-17 receptor signaling influences virus-induced corneal inflammation. J. Leukoc. Biol. 2008, 83:401-408.
25. Suryawanshi A., Veiga-Parga T., Rajasagi N.K., Reddy P.B., Sehrawat S., Sharma S., Rouse B.T. Role of IL-17 and Th17 cells in HSV induced corneal immunopathology. J. Immunol. 2011, 187:1919-1930.
26. Keadle T.L., Laycock K.A., Miller J.K., Hook K.K., Fenoglio E.D., Francotte M., Slaoui M., Stuart P.M., Pepose J.S. Efficacy of a recombinant glycoprotein D subunit vaccine on the development of primary and recurrent ocular infection with herpes simplex virus type 1 in mice. Infect. Dis. 1997, 76:331-338.
27. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2-delta delta CT method. Methods 2001, 25:402-408.
28. Miller J.K., Laycock K.A., Umphress J.A., Hook K.K., Stuart P.M., Pepose J.S. A comparison of recurrent and primary herpes simplex keratitis in NIH inbred mice. Cornea 1996, 15:497-504.
29. Laycock K.A., Lee S.F., Brady R.H., Pepose J.S. Characterization of a murine model of recurrent herpes simplex viral keratitis induced by ultraviolet B radiation. Invest. Ophthalmol. Vis. Sci. 1991, 32:2741-2746.
30. Lausch R.N., Kleinschradt W.R., Monteiro C., Kayes S.G., Oakes J.E. Resolution of HSV corneal infection in the absence of delayed-type hypersensitivity. Invest. Ophthalmol. Vis. Sci. 1985, 26:1509-1515.
31. Nash A.A., Gell P.G., Wildy P. Tolerance and immunity in mice infected with herpes simplex virus: simultaneous induction of protective immunity and tolerance to delayed-type hypersensitivity. Immunology 1981, 43:153-159.
32. Keadle T.L., Stuart P.M. Interleukin-10 (IL-10) ameliorates corneal disease in a mouse model of recurrent herpetic keratitis. Microb. Pathog. 2005, 38:13-21.
33. + T cells during aging. J. Exp. Med. 2009, 206:1929-1940.
34. Yang H., Troudt J., Grover A., Arnett K., Lucas M., Cho Y.S., Bielefeldt-Ohmann H., Taylor J., Izzo A., Dobos K.M. Three protein cocktails mediate delayed-type hypersensitivity responses indistinguishable from that elicited by purified protein derivative in the guinea pig model of Mycobacterium tuberculosis infection. Infect. Immun. 2011, 79:716-723.
35. Theil D., Derfuss T., Paripovic I., Herberger S., Meinl E., Schueler O., Strupp M., Arbusow V., Brandt T. Latent herpesvirus infection in human trigeminal ganglia causes chronic immune response. Am. J. Pathol. 2003, 163:2179-2184.
36. Liu T., Tang Q., Hendricks R.L. Inflammatory infiltration of the trigeminal ganglion after herpes simplex virus type 1 corneal infection. J. Virol. 1996, 70:264-271.
37. Cunningham E.T., Stalder A., Sanna P.P., Liu S.S., Bloom F.E., Howes E.L., Campbell I.L., Margolis T.P. Localization of tumor necrosis factor receptor messenger RNA in normal and herpes simplex virus-infected mouse eyes. Invest. Ophthalmol. Vis. Sci. 1997, 38:9-15.
38. Dahesia M., Kanangat S., Rouse B.T. Production of key molecules by ocular neutrophils early after herpetic infection of the cornea. Exp. Eye Res. 1998, 67:619-624.
39. Wasmuth S., Bauer D., Yang Y., Steuhl K.P., Heiligenhaus A. Topical treatment with antisense oligonucleotides targeting tumor necrosis factor-alpha in herpetic stromal keratitis. Invest. Ophthalmol. Vis. Sci. 2003, 44:5228-5234.
40. Keadle T.L., Usui N., Laycock K.A., Miller J.K., Pepose J.S., Stuart P.M. IL-1 and TNF-alpha are important key factors in the pathogenesis of murine recurrent herpetic stromal keratitis. Invest. Ophthalmol. Vis. Sci. 2000, 41:96-102.
41. Jovanovic D.V., Di Battista J.A., Martel-Pelletier J., Jolicoeur F.C., He Y., Zhang M., Mineau F., Pelletier J.P. IL-17 stimulates the production and expression of proinflammatory cytokines, IL-1β and TNF-α, by human macrophages. J. Immunol. 1998, 160:3513-3521.
42. Beklen A., Ainola M., Hukkanen M., Gürgan C., Sorsa T., Konttinen Y.T. MMPss, IL-1, and TNF are regulated by IL-17 in periodontitis. J. Dent. Res. 2007, 86:347-351.
43. Parsonage Greg, Filer Andrew, Bik Magdalena, Hardie Debbie, Lax Sian, Howlett K., Church L.D., Raza K., Wong S.H., Trebilcock E., Scheel-Toellner D., Salmon M., Lord J.M., Buckley C.D. Prolonged, granulocyte-macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNF-alpha. Arthritis Res. Ther. 2008, 10:R47.
44. Stuart P.M., Keadle T.L. Recurrent herpetic stromal keratitis in mice: a model for studying human HSK. Clin. Dev. Immunol. 2012, 2012:728480.
45. Zheng M., Deshpande S., Lee S., Ferrara N., Rouse B.T. Contribution of vascular endothelial growth factor in the neovascularization process during the pathogenesis of herpetic stromal keratitis. J. Virol. 2001, 75:9828-9835.
46. Giménez F., Suryawanshi A., Rouse B.T. Pathogenesis of herpes stromal keratitis - a focus on corneal neovascularization. Prog. Retin. Eye Res. 2012, [Epub ahead of print].
47. Suryawanshi A., Veiga-Parga T., Reddy P.B., Rajasagi N.K., Rouse B.T. IL-17A differentially regulates corneal vascular endothelial growth factor (VEGF)-A and soluble VEGF receptor 1 expression and promotes corneal angiogenesis after herpes simplex virus infection. J. Immunol. 2012, 188:3434-3446.