메뉴 건너뛰기




Volumn 10, Issue 11, 2010, Pages 1587-1594

Stem cell-derived neurotrophic support for the neuromuscular junction in spinal muscular atrophy

Author keywords

Acetylcholine receptor; Embryonic stem cells; Motor neurons; Neuromuscular junction; Neurotrophins; Spinal muscular atrophy; Subunit switching

Indexed keywords

NEUROTROPHIN;

EID: 77958473921     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.2010.529895     Document Type: Review
Times cited : (17)

References (73)
  • 1
    • 0036154959 scopus 로고    scopus 로고
    • Quantitative analyses of SMN1 and SMN2 based on real-time lightcycler PCR: Fast and highly reliable carrier testing and prediction of severity of spinal muscular atrophy
    • Feldkotter M, Schwarzer V, Wirth R, et al. Quantitative analyses of SMN1 and SMN2 based on real-time lightcycler PCR: fast and highly reliable carrier testing and prediction of severity of spinal muscular atrophy. Am J Hum Genet 2002;70(2):10
    • (2002) Am J Hum Genet , vol.70 , Issue.2 , pp. 10
    • Feldkotter, M.1    Schwarzer, V.2    Wirth, R.3
  • 2
    • 74249094999 scopus 로고    scopus 로고
    • Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy
    • Baumer D, Lee S, Nicholson G, et al. Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy. PLoS Genet 2009;5(12):e1000773
    • (2009) PLoS Genet , vol.5 , Issue.12
    • Baumer, D.1    Lee, S.2    Nicholson, G.3
  • 3
    • 0028797783 scopus 로고
    • Identification and characterization of a spinal muscular atrophy-determining gene
    • Lefebvre S, Burglen L, Reboullet S, et al. Identification and characterization of a spinal muscular atrophy-determining gene. Cell 1995;80(1):10
    • (1995) Cell , vol.80 , Issue.1 , pp. 10
    • Lefebvre, S.1    Burglen, L.2    Reboullet, S.3
  • 4
    • 77953893282 scopus 로고    scopus 로고
    • Spinal muscular atrophy: Mechanisms and therapeutic strategies
    • Lorson CL, Rindt H, Shababi M. Spinal muscular atrophy: mechanisms and therapeutic strategies. Hum Mol Genet 2010;19(R1):R111-18
    • (2010) Hum Mol Genet , vol.19 , Issue.R1
    • Lorson, C.L.1    Rindt, H.2    Shababi, M.3
  • 5
    • 48249145306 scopus 로고    scopus 로고
    • Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy
    • Kariya S, Park G-H, Maeno-Hikichi Y, et al. Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy. Hum Mol Genet 2008;17(16):2552-2569
    • (2008) Hum Mol Genet , vol.17 , Issue.16 , pp. 2552-2569
    • Kariya, S.1    Park, G.-H.2    Maeno-Hikichi, Y.3
  • 6
    • 37749054939 scopus 로고    scopus 로고
    • Induction of full-length survival motor neuron by polyphenol botanical compounds
    • Sakla M, Lorson C. Induction of full-length survival motor neuron by polyphenol botanical compounds. Hum Genet 2008;122(6):635-643
    • (2008) Hum Genet , vol.122 , Issue.6 , pp. 635-643
    • Sakla, M.1    Lorson, C.2
  • 8
    • 0345332575 scopus 로고    scopus 로고
    • Maturation of the acetylcholine receptor in skeletal muscle: Regulation of the AChR [gamma]-to-[epsilon] switch
    • Missias AC, Chu GC, Klocke BJ, et al. Maturation of the acetylcholine receptor in skeletal muscle: regulation of the AChR [gamma]-to-[epsilon] switch. Dev Biol 1996;179(1):223-238
    • (1996) Dev Biol , vol.179 , Issue.1 , pp. 223-238
    • Missias, A.C.1    Chu, G.C.2    Klocke, B.J.3
  • 9
    • 0029125140 scopus 로고
    • Local neurotrophic repression of gene transcripts encoding fetal AChRs at rat neuromuscular synapses
    • Kues WA, Brenner HR, Sakmann B, Witzemann V. Local neurotrophic repression of gene transcripts encoding fetal AChRs at rat neuromuscular synapses. J Cell Biol 1995;130(4):8
    • (1995) J Cell Biol , vol.130 , Issue.4 , pp. 8
    • Kues, W.A.1    Brenner, H.R.2    Sakmann, B.3    Witzemann, V.4
  • 10
    • 77955602960 scopus 로고    scopus 로고
    • Histological and functional benefit following transplantation of motor neuron progenitors to the injured rat spinal cord
    • Rossi SL, Nistor G, Wyatt T, et al. Histological and functional benefit following transplantation of motor neuron progenitors to the injured rat spinal cord. PLoS ONE 2010;5(7):e11852
    • (2010) PLoS ONE , vol.5 , Issue.7
    • Rossi, S.L.1    Nistor, G.2    Wyatt, T.3
  • 11
    • 77950462859 scopus 로고    scopus 로고
    • To build a synapse: Signaling pathways in neuromuscular junction assembly
    • Wu H, Xiong WC, Mei L. To build a synapse: signaling pathways in neuromuscular junction assembly. Development 2010;137:1017-1033
    • (2010) Development , vol.137 , pp. 1017-1033
    • Wu, H.1    Xiong, W.C.2    Mei, L.3
  • 12
    • 33748935769 scopus 로고    scopus 로고
    • Development of the neuromuscular junction
    • Witzemann V. Development of the neuromuscular junction. Cell Tissue Res 2006;326(2):8
    • (2006) Cell Tissue Res , vol.326 , Issue.2 , pp. 8
    • Witzemann, V.1
  • 13
    • 18844365359 scopus 로고    scopus 로고
    • The acetylcholine receptor [gamma]-to-[epsilon] switch occurs in individual endplates
    • Yumoto N, Wakatsuki S, Sehara-Fujisawa A. The acetylcholine receptor [gamma]-to-[epsilon] switch occurs in individual endplates. Biochem Biophys Res Commun 2005;331(4):1522-1527
    • (2005) Biochem Biophys Res Commun , vol.331 , Issue.4 , pp. 1522-1527
    • Yumoto, N.1    Wakatsuki, S.2    Sehara-Fujisawa, A.3
  • 14
    • 49849100786 scopus 로고    scopus 로고
    • Implantation of human umbilical cord-derived mesenchymal stem cells as a neuroprotective therapy for ischemic stroke in rats
    • Koh S, Kim KS, Choi MR, et al. Implantation of human umbilical cord-derived mesenchymal stem cells as a neuroprotective therapy for ischemic stroke in rats. Brain Res 2008;1229:233-248
    • (2008) Brain Res , vol.1229 , pp. 233-248
    • Koh, S.1    Kim, K.S.2    Choi, M.R.3
  • 15
    • 0035899304 scopus 로고    scopus 로고
    • Asynchronous synapse elimination in neonatal motor units: Studies using GFP transgenic mice
    • Keller-Peck CR, Walsh MK, Gan WB, et al. Asynchronous synapse elimination in neonatal motor units: studies using GFP transgenic mice. Neuron 2001;31:13
    • (2001) Neuron , vol.31 , pp. 13
    • Keller-Peck, C.R.1    Walsh, M.K.2    Gan, W.B.3
  • 16
    • 0027462315 scopus 로고
    • In vivo obsevations of pre- and postsynaptic changes during the transition from multiple to single innervation at developing neuromuscular junctions
    • Balice-Gordon RJ, Lichtman JW. In vivo obsevations of pre- and postsynaptic changes during the transition from multiple to single innervation at developing neuromuscular junctions. J Neurosci 1993;13:21
    • (1993) J Neurosci , vol.13 , pp. 21
    • Balice-Gordon, R.J.1    Lichtman, J.W.2
  • 17
    • 77958516191 scopus 로고    scopus 로고
    • Reduced expression of nicotinic AChRs in myotubes from spinal muscular atrophy i patients
    • Arnold A, Gueye M, Guettier-Sigrist S, et al. Reduced expression of nicotinic AChRs in myotubes from spinal muscular atrophy I patients. Nature 2004;84(10):7
    • (2004) Nature , vol.84 , Issue.10 , pp. 7
    • Arnold, A.1    Gueye, M.2    Guettier-Sigrist, S.3
  • 18
    • 41149113045 scopus 로고    scopus 로고
    • Selective vulnerability of motor neurons and dissociation of pre- and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy
    • Murray LM, Comley LH, Thomson D, et al. Selective vulnerability of motor neurons and dissociation of pre- and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy. Hum Mol Genet 2008;17(7):949-962
    • (2008) Hum Mol Genet , vol.17 , Issue.7 , pp. 949-962
    • Murray, L.M.1    Comley, L.H.2    Thomson, D.3
  • 19
    • 29144463310 scopus 로고    scopus 로고
    • Spinal muscular atrophy: A deficiency in a ubiquitous protein; A motor neuron-specific disease
    • Monani UR. Spinal muscular atrophy: a deficiency in a ubiquitous protein; a motor neuron-specific disease. Neuron 2005;48(6):885-895
    • (2005) Neuron , vol.48 , Issue.6 , pp. 885-895
    • Monani, U.R.1
  • 20
    • 0029661887 scopus 로고    scopus 로고
    • Acetylcholine receptor epsilon-subunit deletion causes muscle weakness and atrophy in juvenile and adult mice
    • Witzemann V, Schwarz H, Koenen M, et al. Acetylcholine receptor epsilon-subunit deletion causes muscle weakness and atrophy in juvenile and adult mice. Proc Natl Acad Sci USA 1996;93:5
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5
    • Witzemann, V.1    Schwarz, H.2    Koenen, M.3
  • 21
    • 67651083390 scopus 로고    scopus 로고
    • Spinal muscular atrophy: Why do low levels of survival motor neuron protein make motor neurons sick?
    • Burghes AHBC. Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick? Nat Rev Neurosci 2009;10(8):12
    • (2009) Nat Rev Neurosci , vol.10 , Issue.8 , pp. 12
    • Burghes, A.H.B.C.1
  • 22
    • 77249088647 scopus 로고    scopus 로고
    • Embryonic stem cell-derived neural stem cells improve spinal muscular atrophy phenotype in mice
    • Corti S, Nizzardo M, Nardini M, et al. Embryonic stem cell-derived neural stem cells improve spinal muscular atrophy phenotype in mice. Brain 2010;133(2):465-481
    • (2010) Brain , vol.133 , Issue.2 , pp. 465-481
    • Corti, S.1    Nizzardo, M.2    Nardini, M.3
  • 23
    • 69149108013 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS
    • Karumbayaram S, Kelly TK, Paucar AA, et al. Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS. Dis Model Mechanobiol 2009;2:6
    • (2009) Dis Model Mechanobiol , vol.2 , pp. 6
    • Karumbayaram, S.1    Kelly, T.K.2    Paucar, A.A.3
  • 24
    • 69249202573 scopus 로고    scopus 로고
    • Highly efficient differentiation and enrichment of spinal motor neurons derived from human and monkey embryonic stem cells
    • Wada T, Honda M, Minami I, et al. Highly efficient differentiation and enrichment of spinal motor neurons derived from human and monkey embryonic stem cells. PLoS One 2009;4(8):e6722
    • (2009) PLoS One , vol.4 , Issue.8
    • Wada, T.1    Honda, M.2    Minami, I.3
  • 25
    • 13844271605 scopus 로고    scopus 로고
    • Specification of motoneurons from human embryonic stem cells
    • Li XJ, Du ZW, Zarnowska ED, et al. Specification of motoneurons from human embryonic stem cells. Nat Biotechnol 2005;23:6
    • (2005) Nat Biotechnol , vol.23 , pp. 6
    • Li, X.J.1    Du, Z.W.2    Zarnowska, E.D.3
  • 26
    • 27744438009 scopus 로고    scopus 로고
    • Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cells
    • Roy NS, Nakano T, Xuing L, et al. Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cells. Exp Neurol 2005;196:10
    • (2005) Exp Neurol , vol.196 , pp. 10
    • Roy, N.S.1    Nakano, T.2    Xuing, L.3
  • 27
    • 74949087489 scopus 로고    scopus 로고
    • Stem cells in human neurodegenerative disorders, Ai time for clinical translation?
    • Lindvall O, Kokaia Z. Stem cells in human neurodegenerative disorders, Ai time for clinical translation? J Clin Invest 2010;120(1):29-40
    • (2010) J Clin Invest , vol.120 , Issue.1 , pp. 29-40
    • Lindvall, O.1    Kokaia, Z.2
  • 28
    • 61449171881 scopus 로고    scopus 로고
    • Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient
    • Amariglio NHA, Scheithauer BW, Cohen Y, et al. Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient. PLoS Med 2009;6(2):e1000029
    • (2009) PLoS Med , vol.6 , Issue.2
    • Amariglio, N.H.A.1    Scheithauer, B.W.2    Cohen, Y.3
  • 29
    • 18644384444 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury
    • Keirstead HS, Nistor G, Bernal G, et al. Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J Neurosci 2005;25(19):4694-4705
    • (2005) J Neurosci , vol.25 , Issue.19 , pp. 4694-4705
    • Keirstead, H.S.1    Nistor, G.2    Bernal, G.3
  • 30
    • 33745686121 scopus 로고    scopus 로고
    • Recovery from paralysis in adult rats using embryonic stem cells
    • Deshpande DMKY, Martinez T, Carmen J, et al. Recovery from paralysis in adult rats using embryonic stem cells. Ann Neurol 2006;60(1):12
    • (2006) Ann Neurol , vol.60 , Issue.1 , pp. 12
    • Deshpande, D.M.K.Y.1    Martinez, T.2    Carmen, J.3
  • 31
    • 0037183512 scopus 로고    scopus 로고
    • Human marrow stromal cell therapy for stroke in rat: Neurotrophins and functional recovery
    • Li Y, Chen J, Chen XG, et al. Human marrow stromal cell therapy for stroke in rat: neurotrophins and functional recovery. Neurology 2002;59(4):514-523
    • (2002) Neurology , vol.59 , Issue.4 , pp. 514-523
    • Li, Y.1    Chen, J.2    Chen, X.G.3
  • 32
    • 33745601099 scopus 로고    scopus 로고
    • Stem cells for the treatment of neurological disorders
    • Lindvall O, Kokaia Z. Stem cells for the treatment of neurological disorders. Nature 2006;441(7097):1094-1096
    • (2006) Nature , vol.441 , Issue.7097 , pp. 1094-1096
    • Lindvall, O.1    Kokaia, Z.2
  • 33
    • 37849022487 scopus 로고    scopus 로고
    • Stem cell treatment in amyotrophic lateral sclerosis
    • Mazzini L, Mareschi K, Ferrero I, et al. Stem cell treatment in amyotrophic lateral sclerosis. J Neurol Sci 2008;265(1-2):78-83
    • (2008) J Neurol Sci , vol.265 , Issue.1-2 , pp. 78-83
    • Mazzini, L.1    Mareschi, K.2    Ferrero, I.3
  • 34
    • 0038054469 scopus 로고    scopus 로고
    • Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury
    • Lu P, Jones LL, Snyder EY, Tuszynski MH. Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury. Exp Neurol 2002;181:14
    • (2002) Exp Neurol , vol.181 , pp. 14
    • Lu, P.1    Jones, L.L.2    Snyder, E.Y.3    Tuszynski, M.H.4
  • 36
    • 32644451922 scopus 로고    scopus 로고
    • Neurotrophin signalling in health and disease
    • Chao MV, Rajagopal R, Lee FS. Neurotrophin signalling in health and disease. Clin Sci 2006;110:6
    • (2006) Clin Sci , vol.110 , pp. 6
    • Chao, M.V.1    Rajagopal, R.2    Lee, F.S.3
  • 37
    • 35048855131 scopus 로고    scopus 로고
    • Axonal degeneration in motor neuron disease
    • Fischer LR, Glass JD. Axonal degeneration in motor neuron disease. Neurogenerative Dis 2007;4:11
    • (2007) Neurogenerative Dis , vol.4 , pp. 11
    • Fischer, L.R.1    Glass, J.D.2
  • 38
    • 58849103600 scopus 로고    scopus 로고
    • Impaired synaptic vesicle release and immaturity of neuromuscular junctions in spinal muscular atrophy mice
    • Kong L, Wang X, Choe DW, et al. Impaired synaptic vesicle release and immaturity of neuromuscular junctions in spinal muscular atrophy mice. J Neuroscience 2009;29(3):9
    • (2009) J Neuroscience , vol.29 , Issue.3 , pp. 9
    • Kong, L.1    Wang, X.2    Choe, D.W.3
  • 39
    • 36448939830 scopus 로고    scopus 로고
    • Synaptic dysfunction in disease and following injury in the developing and adult nervous system: Caveats in the choice of therapeutic intervention
    • Gould TW, Oppenheim RW. Synaptic dysfunction in disease and following injury in the developing and adult nervous system: caveats in the choice of therapeutic intervention. Neurosci Biobehav Rev 2007;31(8):1073-1087
    • (2007) Neurosci Biobehav Rev , vol.31 , Issue.8 , pp. 1073-1087
    • Gould, T.W.1    Oppenheim, R.W.2
  • 40
    • 0027281189 scopus 로고
    • Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF
    • Lohof AM, Ip NY, Poo M-M. Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF. Nature 1993;363(6427):350-353
    • (1993) Nature , vol.363 , Issue.6427 , pp. 350-353
    • Lohof, A.M.1    Ip, N.Y.2    Poo, M.-M.3
  • 41
    • 14744272637 scopus 로고    scopus 로고
    • Neurotrophin-mediated rapid signaling in the central nervous system: Mechanisms and functions
    • Blum R, Konnerth A. Neurotrophin-mediated rapid signaling in the central nervous system: mechanisms and functions. Physiology 2005;20(1):70-78
    • (2005) Physiology , vol.20 , Issue.1 , pp. 70-78
    • Blum, R.1    Konnerth, A.2
  • 42
    • 77958488761 scopus 로고    scopus 로고
    • Arabidopsis thaliana, a plant model organism for the neuronal microtubule cytoskeleton?
    • [Epub ahead of print, doi 10.1093/jxb/erq278]
    • Gardiner J, Marc J. Arabidopsis thaliana, a plant model organism for the neuronal microtubule cytoskeleton? J Exp Bot 2010. [Epub ahead of print, doi: 10.1093/jxb/erq278]
    • (2010) J Exp Bot
    • Gardiner, J.1    Marc, J.2
  • 43
    • 0347694856 scopus 로고    scopus 로고
    • Neurotrophins elevate cAMP to reach a threshold required to overcome inhibition by MAG through extracellular signal-regulated kinase-dependent inhibition of phosphodiesterase
    • Gao Y, Nikulina E, Mellado W, Filbin MT. Neurotrophins elevate cAMP to reach a threshold required to overcome inhibition by MAG through extracellular signal-regulated kinase-dependent inhibition of phosphodiesterase. J Neurosci 2003;23(37):7
    • (2003) J Neurosci , vol.23 , Issue.37 , pp. 7
    • Gao, Y.1    Nikulina, E.2    Mellado, W.3    Filbin, M.T.4
  • 44
    • 2342472526 scopus 로고    scopus 로고
    • Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats
    • Harper JMKC, Darman JS, Deshpande DM, et al. Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats. Proc Natl Acad Sci USA 2004;101(18):5
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.18 , pp. 5
    • Harper, J.M.K.C.1    Darman, J.S.2    Deshpande, D.M.3
  • 45
    • 1542754063 scopus 로고    scopus 로고
    • MT. A role for cAMP in regeneration of the adult mammalian CNS
    • Spencer TAF, MT. A role for cAMP in regeneration of the adult mammalian CNS. J Anat 2004;204:5
    • (2004) J Anat , vol.204 , pp. 5
    • Spencer, T.A.F.1
  • 46
    • 26244434407 scopus 로고    scopus 로고
    • Is spinal muscular atrophy the result of defects in motor neuron processes?
    • Briese M, Esmaeili B, Sattelle DB. Is spinal muscular atrophy the result of defects in motor neuron processes? BioEssays 2005;27(9):946-957
    • (2005) BioEssays , vol.27 , Issue.9 , pp. 946-957
    • Briese, M.1    Esmaeili, B.2    Sattelle, D.B.3
  • 47
    • 0029020311 scopus 로고
    • Neurotrophins promote maturation of developing neuromuscular synapses
    • Wang T, Xie K, Lu B. Neurotrophins promote maturation of developing neuromuscular synapses. J Neurosci 1995;15(7):4796-4805
    • (1995) J Neurosci , vol.15 , Issue.7 , pp. 4796-4805
    • Wang, T.1    Xie, K.2    Lu, B.3
  • 48
    • 3042622278 scopus 로고    scopus 로고
    • Neurotrophic regulation of the development and function of the neuromuscular synapses
    • Lu B, Je HS. Neurotrophic regulation of the development and function of the neuromuscular synapses. J Neurocytol 2003;32:931-941
    • (2003) J Neurocytol , vol.32 , pp. 931-941
    • Lu, B.1    Je, H.S.2
  • 49
    • 68249134222 scopus 로고    scopus 로고
    • Neurotrophic factors improve motoneuron survival and function of muscle reinnervated by embryonic neurons
    • Grumbles RM, Sesodia S, Wood PM, Thomas CK. Neurotrophic factors improve motoneuron survival and function of muscle reinnervated by embryonic neurons. J Neuropathol Exp Neurol 2009;68(7):736-746
    • (2009) J Neuropathol Exp Neurol , vol.68 , Issue.7 , pp. 736-746
    • Grumbles, R.M.1    Sesodia, S.2    Wood, P.M.3    Thomas, C.K.4
  • 50
    • 0033118385 scopus 로고    scopus 로고
    • Expression of neurotrophins in the adult spinal cord in vivo
    • Dreyfus CF, Dai X, Lercher LD, et al. Expression of neurotrophins in the adult spinal cord in vivo. J Neurosci Res 1999;56:7
    • (1999) J Neurosci Res , vol.56 , pp. 7
    • Dreyfus, C.F.1    Dai, X.2    Lercher, L.D.3
  • 51
    • 16644391766 scopus 로고    scopus 로고
    • CNS neurotrophins are biologically active and expressed by multiple cell types
    • Riley CP, Cope TC, Buck CR. CNS neurotrophins are biologically active and expressed by multiple cell types. J Mol Histol 2004;35(8-9):771-783
    • (2004) J Mol Histol , vol.35 , Issue.8-9 , pp. 771-783
    • Riley, C.P.1    Cope, T.C.2    Buck, C.R.3
  • 52
    • 41249086987 scopus 로고    scopus 로고
    • Combining growth factor and stem cell therapy for amyotrophic lateral sclerosis
    • Suzuki M, Svendsen CN. Combining growth factor and stem cell therapy for amyotrophic lateral sclerosis. Trends Neurosci 2008;31(4):6
    • (2008) Trends Neurosci , vol.31 , Issue.4 , pp. 6
    • Suzuki, M.1    Svendsen, C.N.2
  • 53
    • 0023257693 scopus 로고
    • Control of end-plate channel properties by neurotrophic effects and by muscle activity in rats
    • Brenner HR, Lomo T, Williamson R. Control of end-plate channel properties by neurotrophic effects and by muscle activity in rats. J Physiol 1987;388:367-381
    • (1987) J Physiol , vol.388 , pp. 367-381
    • Brenner, H.R.1    Lomo, T.2    Williamson, R.3
  • 54
    • 0025783907 scopus 로고
    • Functional adult acetylcholine receptor develops independently of motor innervation in Sol 8 mouse muscle cell line
    • Pinset C, Mulle C, Benoit P, et al. Functional adult acetylcholine receptor develops independently of motor innervation in Sol 8 mouse muscle cell line. EMBO J 1991;10(9):7
    • (1991) EMBO J , vol.10 , Issue.9 , pp. 7
    • Pinset, C.1    Mulle, C.2    Benoit, P.3
  • 55
    • 77949889554 scopus 로고    scopus 로고
    • Pre-symptomatic development of lower motor neuron connectivity in a mouse model of severe spinal muscular atrophy
    • Murray LMLS, Baumer D, Parson SH, et al. Pre-symptomatic development of lower motor neuron connectivity in a mouse model of severe spinal muscular atrophy. Hum Mol Genet 2010;19(3):13
    • (2010) Hum Mol Genet , vol.19 , Issue.3 , pp. 13
    • Murray, L.M.L.S.1    Baumer, D.2    Parson, S.H.3
  • 56
    • 0027180752 scopus 로고
    • Possible consequences of disruption of neuromuscular contacts in early development for motoneurone survival
    • Greensmith L, Sieradzan K, Vrbova G. Possible consequences of disruption of neuromuscular contacts in early development for motoneurone survival. Acta Neurobiol Exp (Wars) 1993;53:319-324
    • (1993) Acta Neurobiol Exp (Wars) , vol.53 , pp. 319-324
    • Greensmith, L.1    Sieradzan, K.2    Vrbova, G.3
  • 57
    • 58249110796 scopus 로고    scopus 로고
    • Induced pluripotent stem cells from a spinal muscular atrophy patient
    • Ebert AD, Yu J, Rose FF, et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 2009;457(7227):277-280
    • (2009) Nature , vol.457 , Issue.7227 , pp. 277-280
    • Ebert, A.D.1    Yu, J.2    Rose, F.F.3
  • 58
    • 38049187707 scopus 로고    scopus 로고
    • Reprogramming of human somatic cells to pluripotency with defined factors
    • Park I-H, Zhao R, West JA, et al. Reprogramming of human somatic cells to pluripotency with defined factors. Nature 2008;451(7175):141-146
    • (2008) Nature , vol.451 , Issue.7175 , pp. 141-146
    • Park, I.-H.1    Zhao, R.2    West, J.A.3
  • 59
    • 39149130361 scopus 로고    scopus 로고
    • Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming
    • Jaenisch R, Young R. Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell 2008;132(4):567-582
    • (2008) Cell , vol.132 , Issue.4 , pp. 567-582
    • Jaenisch, R.1    Young, R.2
  • 60
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131(5):861-872
    • (2007) Cell , vol.131 , Issue.5 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3
  • 61
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • Yu J, Vodyanik MA, Smuga-Otto K, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007;318(5858):1917-1920
    • (2007) Science , vol.318 , Issue.5858 , pp. 1917-1920
    • Yu, J.1    Vodyanik, M.A.2    Smuga-Otto, K.3
  • 62
    • 77954113167 scopus 로고    scopus 로고
    • Therapy development in spinal muscular atrophy
    • Sendtner M. Therapy development in spinal muscular atrophy. Nat Neurosci 2010;13(7):795-799
    • (2010) Nat Neurosci , vol.13 , Issue.7 , pp. 795-799
    • Sendtner, M.1
  • 63
    • 50149098605 scopus 로고    scopus 로고
    • Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons
    • Dimos JT, Rodolfa KT, Niakan KK, et al. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science 2008;321(5893):1218-1221
    • (2008) Science , vol.321 , Issue.5893 , pp. 1218-1221
    • Dimos, J.T.1    Rodolfa, K.T.2    Niakan, K.K.3
  • 64
    • 50549089957 scopus 로고    scopus 로고
    • Disease-specific induced pluripotent stem cells
    • Park I-H, Arora N, Huo H, et al. Disease-specific induced pluripotent stem cells. Cell 2008;134(5):877-886
    • (2008) Cell , vol.134 , Issue.5 , pp. 877-886
    • Park, I.-H.1    Arora, N.2    Huo, H.3
  • 65
    • 72849144528 scopus 로고    scopus 로고
    • Clone- and gene-specific aberrations of parental imprinting in human induced pluripotent stem cells
    • Pick M, Stelzer Y, Bar-Nur O, et al. Clone- and gene-specific aberrations of parental imprinting in human induced pluripotent stem cells. Stem Cells 2009;27(11):2686-2690
    • (2009) Stem Cells , vol.27 , Issue.11 , pp. 2686-2690
    • Pick, M.1    Stelzer, Y.2    Bar-Nur, O.3
  • 66
    • 77953879152 scopus 로고    scopus 로고
    • Pluripotent stem cells in neurodegenerative and neurodevelopmental diseses
    • Marchetto MCN, Winner B, Gage FH. Pluripotent stem cells in neurodegenerative and neurodevelopmental diseses. Hum Mol Genet 2010;19(R1):5
    • (2010) Hum Mol Genet , vol.19 , Issue.R1 , pp. 5
    • Marchetto, M.C.N.1    Winner, B.2    Gage, F.H.3
  • 67
    • 77953623111 scopus 로고    scopus 로고
    • Stem cell model of spinal muscular atrophy
    • Ebert AD, Svendsen CN. Stem cell model of spinal muscular atrophy. Arch Neurol 2010;67(6):665-669
    • (2010) Arch Neurol , vol.67 , Issue.6 , pp. 665-669
    • Ebert, A.D.1    Svendsen, C.N.2
  • 68
    • 77949909934 scopus 로고    scopus 로고
    • Review: Neuromuscular synaptic vulnerability in motor neurone disease: Amyotrophic lateral sclerosis and spinal muscular atrophy
    • Murray LM, Talbot K, Gillingwater TH. Review: neuromuscular synaptic vulnerability in motor neurone disease: amyotrophic lateral sclerosis and spinal muscular atrophy. Neuropathol Appl Neurobiol 2010;36(2):133-156
    • (2010) Neuropathol Appl Neurobiol , vol.36 , Issue.2 , pp. 133-156
    • Murray, L.M.1    Talbot, K.2    Gillingwater, T.H.3
  • 69
    • 34548157546 scopus 로고    scopus 로고
    • Animal models of spinal muscular atrophy
    • DiDonato CJ, Schmid A. Animal models of spinal muscular atrophy. J Child Neurol 2007;22:8
    • (2007) J Child Neurol , vol.22 , pp. 8
    • Didonato, C.J.1    Schmid, A.2
  • 70
    • 77958497676 scopus 로고    scopus 로고
    • Effects of 2,4-diaminoquinazoline derivatives on SMN expression and phenotype in a mouse model for spinal muscular atrophy
    • Butchbach ME, Singh J, Thorsteinsdottir M, et al. Effects of 2,4-diaminoquinazoline derivatives on SMN expression and phenotype in a mouse model for spinal muscular atrophy. Hum Mol Genet 2010;14:15
    • Hum Mol Genet , vol.2010 , Issue.14 , pp. 15
    • Butchbach, M.E.1    Singh, J.2    Thorsteinsdottir, M.3
  • 71
    • 33847358736 scopus 로고    scopus 로고
    • Trichostatin A incrases SMN expression and survival in a mouse model of spinal muscular atrophy
    • Avila AM, Burnett BG, Taye AA, et al. Trichostatin A incrases SMN expression and survival in a mouse model of spinal muscular atrophy. J Clin Invest 2007;117:12
    • (2007) J Clin Invest , vol.117 , pp. 12
    • Avila, A.M.1    Burnett, B.G.2    Taye, A.A.3
  • 72
    • 77952295831 scopus 로고    scopus 로고
    • SAHA ameliorates the SMA phenotype in two mouse models for spinal muscular atrophy
    • Riessland M, Ackermann B, Forster B, et al. SAHA ameliorates the SMA phenotype in two mouse models for spinal muscular atrophy. Hum Mol Genet 2010;19:14
    • Hum Mol Genet , vol.2010 , Issue.19 , pp. 14
    • Riessland, M.1    Ackermann, B.2    Forster, B.3
  • 73
    • 70350749543 scopus 로고    scopus 로고
    • LBH589 induces up to 10-fold SMN protein levels by several independent mechanisms and is effective even in cells from SMA patients non-responsive to valproate
    • Garbes L, Riessland M, Holker I, et al. LBH589 induces up to 10-fold SMN protein levels by several independent mechanisms and is effective even in cells from SMA patients non-responsive to valproate. Hum Mol Genet 2009;18:13
    • (2009) Hum Mol Genet , vol.18 , pp. 13
    • Garbes, L.1    Riessland, M.2    Holker, I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.