CHP1002, a novel andrographolide derivative, inhibits pro-inflammatory inducible nitric oxide synthase and cyclooxygenase-2 expressions in RAW264.7 macrophages via up-regulation of heme oxygenase-1 expression

International Immunopharmacology

Volumn 15, Issue 2, 2013, Pages 289-295

  Zhang, Bo ^a   Yan, Lingdi ^a   Zhou, Peilan ^a   Dong, Zhaoqi ^a,b   Feng, Siliang ^a   Liu, Keliang ^a   Gong, Zehui ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b JIANGNAN UNIVERSITY   (China)

Author keywords

CHP1002; Heme oxygenase 1(HO 1); Inflammation; Pro inflammatory mediators; RAW264.7 macrophages

Indexed keywords

ANDROGRAPHOLIDE; CHP 1002; CYCLOOXYGENASE 2; HEME OXYGENASE 1; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; PROTOPORPHYRIN ZINC; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME ACTIVATION; MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; UPREGULATION;

ANIMALS; CELL LINE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; DITERPENES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; HEME OXYGENASE-1; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGES; MEMBRANE PROTEINS; MICE; NF-E2-RELATED FACTOR 2; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; POLYETHYLENE GLYCOLS; PROTOPORPHYRINS; RATS; SIGNAL TRANSDUCTION;

EID: 84872803992     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2012.12.003     Document Type: Article

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