An ent-kaurane diterpenoid from Croton tonkinensis induces apoptosis by regulating AMP-activated protein kinase in SK-HEP1 human hepatocellular carcinoma cells

Biological and Pharmaceutical Bulletin

Volumn 36, Issue 1, 2013, Pages 158-164

  Sul, Young Hoon ^a,b   Lee, Myung Sun ^a   Cha, Eun Young ^a   Thuong, Phuong Thien ^b   Khoi, Nguyen Minh ^b   Song, In Sang ^a  

^a Chungnam National University College of Medicine   (South Korea)

^b Vietnam National Institute of Medicinal Materials   (Viet Nam)

Author keywords

AMP activated protein kinase; Ent Kaurane diterpenoid; Hepatocellular carcinoma

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CYTOCHROME C; ENT 18 ACETOXY 7BETA HYDROXY KAUR 15 OXO 16 ENE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; KAURANE DERIVATIVE; MAMMALIAN TARGET OF RAPAMYCIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; S6 KINASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROTON; CROTON TONKINENSIS; CYTOPLASM; DRUG POTENTIATION; DRUG TARGETING; ENZYME ACTIVATION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PROTEIN TRANSPORT;

AMP-ACTIVATED PROTEIN KINASES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CROTON; DITERPENES, KAURANE; HUMANS; PLANT LEAVES;

EID: 84872742897     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b12-00873     Document Type: Article

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