Overexpression of CYP2E1 induces HepG2 cells death by the AMP kinase activator 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR)

Cell Biology and Toxicology

Volumn 25, Issue 3, 2009, Pages 253-263

  Zhuge, Jian ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

5 Aminoimidazole 4 carboxamide 1 d ribofuranoside; 5 AMP activated protein kinase; Apoptosis; CYP2E1; HepG2 cells

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; 5' ADENOSINE MONOPHOSPHATE ACTIVATED PROTEIN KINASE; CYTOCHROME P450 2E1; LACTATE DEHYDROGENASE; PROTEIN KINASE; PROTEIN P21; PROTEIN P53; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CELL GROWTH; CELL LINE; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DNA CONTENT; DNA DETERMINATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

AMINOIMIDAZOLE CARBOXAMIDE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYTOCHROME P-450 CYP2E1; DNA, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HEPATOCYTES; HUMANS; L-LACTATE DEHYDROGENASE; NECROSIS; RATS; REACTIVE OXYGEN SPECIES; RIBONUCLEOTIDES; TRANSFECTION; TUBERCIDIN;

RATTUS;

EID: 67349203541     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10565-008-9075-9     Document Type: Article

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